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Items: 19

1.

SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase.

Duplantier AJ, Bachert EL, Cheng JB, Cohan VL, Jenkinson TH, Kraus KG, McKechney MW, Pillar JD, Watson JW.

J Med Chem. 2007 Jan 25;50(2):344-9.

PMID:
17228876
2.

Pim serine/threonine kinases regulate the stability of Socs-1 protein.

Chen XP, Losman JA, Cowan S, Donahue E, Fay S, Vuong BQ, Nawijn MC, Capece D, Cohan VL, Rothman P.

Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2175-80.

3.

7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as novel inhibitors of human eosinophil phosphodiesterase.

Duplantier AJ, Andresen CJ, Cheng JB, Cohan VL, Decker C, DiCapua FM, Kraus KG, Johnson KL, Turner CR, UmLand JP, Watson JW, Wester RT, Williams AS, Williams JA.

J Med Chem. 1998 Jun 18;41(13):2268-77.

PMID:
9632360
4.

Striking effect of hydroxamic acid substitution on the phosphodiesterase type 4 (PDE4) and TNF alpha inhibitory activity of two series of rolipram analogues: implications for a new active site model of PDE4.

Kleinman EF, Campbell E, Giordano LA, Cohan VL, Jenkinson TH, Cheng JB, Shirley JT, Pettipher ER, Salter ED, Hibbs TA, DiCapua FM, Bordner J.

J Med Chem. 1998 Jan 29;41(3):266-70. No abstract available.

PMID:
9464356
5.

The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy.

Cheng JB, Watson JW, Pazoles CJ, Eskra JD, Griffiths RJ, Cohan VL, Turner CR, Showell HJ, Pettipher ER.

J Pharmacol Exp Ther. 1997 Feb;280(2):621-6.

PMID:
9023272
6.

In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633.

Cohan VL, Showell HJ, Fisher DA, Pazoles CJ, Watson JW, Turner CR, Cheng JB.

J Pharmacol Exp Ther. 1996 Sep;278(3):1356-61.

PMID:
8819523
7.

The in vivo pharmacology of CP-80, 633, a selective inhibitor of phosphodiesterase 4.

Turner CR, Cohan VL, Cheng JB, Showell HJ, Pazoles CJ, Watson JW.

J Pharmacol Exp Ther. 1996 Sep;278(3):1349-55.

PMID:
8819522
8.

Production and characterization of guinea pig IL-5 in baculovirus-infected insect cells.

Mansour M, Karmilowicz M, Hawrylik SJ, Nalcerio B, Angilly J, Conklyn MJ, Lilly CM, Drazen JM, Lee SE, Auperin DD, De Wet JR, Cohan VL, Showell HJ, Danley DE.

Am J Physiol. 1996 Jun;270(6 Pt 1):L1002-7.

PMID:
8764226
9.
10.
11.

Protein kinase C modulates immunoglobulin E-mediated activation of human mast cells from lung and skin. I. Pharmacologic inhibition.

Massey WA, Cohan VL, MacGlashan DW Jr, Gittlen SW, Kagey-Sobotka A, Lichtenstein LM, Warner JA.

J Pharmacol Exp Ther. 1991 Sep;258(3):824-9.

PMID:
1716311
12.

Interleukin-1 is a mucus secretagogue.

Cohan VL, Scott AL, Dinarello CA, Prendergast RA.

Cell Immunol. 1991 Sep;136(2):425-34.

PMID:
1873825
13.

Human uterine mast cells. Isolation, purification, characterization, ultrastructure, and pharmacology.

Massey WA, Guo CB, Dvorak AM, Hubbard WC, Bhagavan BS, Cohan VL, Warner JA, Kagey-Sobotka A, Lichtenstein LM.

J Immunol. 1991 Sep 1;147(5):1621-7.

PMID:
1715365
14.

Mechanisms of mediator release from human skin mast cells upon stimulation by the bradykinin analog, [DArg0-Hyp3-DPhe7]bradykinin.

Cohan VL, MacGlashan DW Jr, Warner JA, Lichtenstein LM, Proud D.

Biochem Pharmacol. 1991 Jan 15;41(2):293-300.

PMID:
1703413
15.

Dexamethasone does not inhibit the release of mediators from human mast cells residing in airway, intestine, or skin.

Cohan VL, Undem BJ, Fox CC, Adkinson NF Jr, Lichtenstein LM, Schleimer RP.

Am Rev Respir Dis. 1989 Oct;140(4):951-4.

PMID:
2478059
16.

Induction of histamine release from human skin mast cells by bradykinin analogs.

Lawrence ID, Warner JA, Cohan VL, Lichtenstein LM, Kagey-Sobotka A, Vavrek RJ, Stewart JM, Proud D.

Biochem Pharmacol. 1989 Jan 15;38(2):227-33.

PMID:
2464345
17.

Bradykinin analog induce histamine release from human skin mast cells.

Lawrence ID, Warner JA, Cohan VL, Lichtenstein LM, Kagey-Sobotka A, Vavrek RJ, Stewart JM, Proud D.

Adv Exp Med Biol. 1989;247A:225-9. No abstract available.

PMID:
2481386
18.

Purification and characterization of human skin mast cells. Evidence for human mast cell heterogeneity.

Lawrence ID, Warner JA, Cohan VL, Hubbard WC, Kagey-Sobotka A, Lichtenstein LM.

J Immunol. 1987 Nov 1;139(9):3062-9.

PMID:
2444649
19.

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