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Items: 45

1.

The regulatory G4 motif of the Kirsten ras (KRAS) gene is sensitive to guanine oxidation: implications on transcription.

Cogoi S, Ferino A, Miglietta G, Pedersen EB, Xodo LE.

Nucleic Acids Res. 2018 Jan 25;46(2):661-676. doi: 10.1093/nar/gkx1142.

2.

RNA G-Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation.

Miglietta G, Cogoi S, Marinello J, Capranico G, Tikhomirov AS, Shchekotikhin A, Xodo LE.

J Med Chem. 2017 Dec 14;60(23):9448-9461. doi: 10.1021/acs.jmedchem.7b00622. Epub 2017 Dec 1.

PMID:
29140695
3.

Lipid-modified G4-decoy oligonucleotide anchored to nanoparticles: delivery and bioactivity in pancreatic cancer cells.

Cogoi S, Jakobsen U, Pedersen EB, Vogel S, Xodo LE.

Sci Rep. 2016 Dec 8;6:38468. doi: 10.1038/srep38468.

4.

Critical role of hnRNP A1 in activating KRAS transcription in pancreatic cancer cells: A molecular mechanism involving G4 DNA.

Cogoi S, Rapozzi V, Cauci S, Xodo LE.

Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1389-1398. doi: 10.1016/j.bbagen.2016.11.031. Epub 2016 Nov 22. Review.

PMID:
27888145
5.

G4 DNA in ras genes and its potential in cancer therapy.

Cogoi S, Xodo LE.

Biochim Biophys Acta. 2016 Apr;1859(4):663-74. doi: 10.1016/j.bbagrm.2016.02.002. Epub 2016 Feb 4. Review.

PMID:
26855080
6.

Photosensitizers binding to nucleic acids as anticancer agents.

Xodo LE, Cogoi S, Rapozzi V.

Future Med Chem. 2016;8(2):179-94. doi: 10.4155/fmc.15.180. Epub 2016 Jan 25. Review.

PMID:
26807879
7.

Nucleic Acid Targeted Therapy: G4 Oligonucleotides Downregulate HRAS in Bladder Cancer Cells through a Decoy Mechanism.

Miglietta G, Gouda AS, Cogoi S, Pedersen EB, Xodo LE.

ACS Med Chem Lett. 2015 Oct 18;6(12):1179-83. doi: 10.1021/acsmedchemlett.5b00315. eCollection 2015 Dec 10.

8.

GC-elements controlling HRAS transcription form i-motif structures unfolded by heterogeneous ribonucleoprotein particle A1.

Miglietta G, Cogoi S, Pedersen EB, Xodo LE.

Sci Rep. 2015 Dec 17;5:18097. doi: 10.1038/srep18097.

9.

Potent Apoptotic Response Induced by Chloroacetamidine Anthrathiophenediones in Bladder Cancer Cells.

Cogoi S, Zorzet S, Shchekotikhin AE, Xodo LE.

J Med Chem. 2015 Jul 23;58(14):5476-85. doi: 10.1021/acs.jmedchem.5b00409. Epub 2015 Jun 30.

PMID:
26057859
10.

HRAS is silenced by two neighboring G-quadruplexes and activated by MAZ, a zinc-finger transcription factor with DNA unfolding property.

Cogoi S, Shchekotikhin AE, Xodo LE.

Nucleic Acids Res. 2014 Jul;42(13):8379-88. doi: 10.1093/nar/gku574. Epub 2014 Jul 10.

11.

Anticancer activity of cationic porphyrins in melanoma tumour-bearing mice and mechanistic in vitro studies.

Rapozzi V, Zorzet S, Zacchigna M, Della Pietra E, Cogoi S, Xodo LE.

Mol Cancer. 2014 Apr 1;13:75. doi: 10.1186/1476-4598-13-75.

12.

MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice.

Cogoi S, Zorzet S, Rapozzi V, Géci I, Pedersen EB, Xodo LE.

Nucleic Acids Res. 2013 Apr;41(7):4049-64. doi: 10.1093/nar/gkt127. Epub 2013 Mar 6.

13.

Guanidino anthrathiophenediones as G-quadruplex binders: uptake, intracellular localization, and anti-Harvey-Ras gene activity in bladder cancer cells.

Cogoi S, Shchekotikhin AE, Membrino A, Sinkevich YB, Xodo LE.

J Med Chem. 2013 Apr 11;56(7):2764-78. doi: 10.1021/jm3019063. Epub 2013 Mar 21.

PMID:
23458775
14.

Photoactivated cationic alkyl-substituted porphyrin binding to g4-RNA in the 5'-UTR of KRAS oncogene represses translation.

Faudale M, Cogoi S, Xodo LE.

Chem Commun (Camb). 2012 Jan 21;48(6):874-6. doi: 10.1039/c1cc15850c. Epub 2011 Nov 29.

PMID:
22127206
15.

G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy.

Membrino A, Cogoi S, Pedersen EB, Xodo LE.

PLoS One. 2011;6(9):e24421. doi: 10.1371/journal.pone.0024421. Epub 2011 Sep 8.

16.

Primer extension reactions as a tool to uncover folding motifs within complex G-rich sequences: analysis of the human KRAS NHE.

Paramasivam M, Cogoi S, Xodo LE.

Chem Commun (Camb). 2011 May 7;47(17):4965-7. doi: 10.1039/c1cc10269a. Epub 2011 Mar 22.

PMID:
21424008
17.

Enhanced G4-DNA binding of 5,10,15,20 (N-propyl-4-pyridyl) porphyrin (TPrPyP4): a comparative study with TMPyP4.

Cogoi S, Xodo LE.

Chem Commun (Camb). 2010 Oct 21;46(39):7364-6. doi: 10.1039/c0cc01912g. Epub 2010 Sep 6.

PMID:
20820515
18.

The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-element.

Cogoi S, Paramasivam M, Membrino A, Yokoyama KK, Xodo LE.

J Biol Chem. 2010 Jul 16;285(29):22003-16. doi: 10.1074/jbc.M110.101923. Epub 2010 May 10.

19.

Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRAS G-quadruplexes.

Membrino A, Paramasivam M, Cogoi S, Alzeer J, Luedtke NW, Xodo LE.

Chem Commun (Camb). 2010 Jan 28;46(4):625-7. doi: 10.1039/b918964e. Epub 2009 Nov 20.

20.

Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription.

Paramasivam M, Membrino A, Cogoi S, Fukuda H, Nakagama H, Xodo LE.

Nucleic Acids Res. 2009 May;37(9):2841-53. doi: 10.1093/nar/gkp138. Epub 2009 Mar 12.

21.

Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells.

Cogoi S, Paramasivam M, Filichev V, Géci I, Pedersen EB, Xodo LE.

J Med Chem. 2009 Jan 22;52(2):564-8. doi: 10.1021/jm800874t.

PMID:
19099510
22.

Protein hnRNPA1 binds to a critical G-rich element of KRAS and unwinds G-quadruplex structures: implications in transcription.

Xodo L, Paramasivam M, Membrino A, Cogoi S.

Nucleic Acids Symp Ser (Oxf). 2008;(52):159-60. doi: 10.1093/nass/nrn081.

PMID:
18776302
23.

Triplex glue by synthesizing conjugated flexible intercalators.

Pedersen EB, Osman AM, Globisch D, Paramasivam M, Cogoi S, Bomholt N, Jørgensen PT, Xodo LE, Filichev VV.

Nucleic Acids Symp Ser (Oxf). 2008;(52):37-8. doi: 10.1093/nass/nrn019.

PMID:
18776241
24.

The neonate brain detects speech structure.

Gervain J, Macagno F, Cogoi S, Peña M, Mehler J.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14222-7. doi: 10.1073/pnas.0806530105. Epub 2008 Sep 3.

25.

Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins.

Cogoi S, Paramasivam M, Spolaore B, Xodo LE.

Nucleic Acids Res. 2008 Jun;36(11):3765-80. doi: 10.1093/nar/gkn120. Epub 2008 May 19.

26.

Purine twisted-intercalating nucleic acids: a new class of anti-gene molecules resistant to potassium-induced aggregation.

Paramasivam M, Cogoi S, Filichev VV, Bomholt N, Pedersen EB, Xodo LE.

Nucleic Acids Res. 2008 Jun;36(10):3494-507. doi: 10.1093/nar/gkn242. Epub 2008 May 2.

27.

Small interfering RNA-mediated silencing of glutathione-S-transferase A1 sensitizes hepatic carcinoma cells to photodynamic therapy with pentaphyrins.

Rapozzi V, Lombardo C, Cogoi S, Comuzzi C, Xodo L.

ChemMedChem. 2008 Apr;3(4):565-8. doi: 10.1002/cmdc.200700273. No abstract available.

PMID:
18186096
28.

PNA conjugated to high-molecular weight poly(ethylene glycol): synthesis and properties.

Bonora GM, Drioli S, Ballico M, Faccini A, Corradini R, Cogoi S, Xodo L.

Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):661-4.

PMID:
18066875
29.

The effect of INA [(R)-1-O-(1-pyrenylmethyl)glycerol] insertions on the structure and biological activity of a G-quadruplex from a critical KRAS G-rich sequence.

Cogoi S, Paramasivan M, Xodo LE, Filichev VV, Pedersen EB.

Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1641-3.

PMID:
18066843
30.
31.

G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription.

Cogoi S, Xodo LE.

Nucleic Acids Res. 2006 May 10;34(9):2536-49. Print 2006.

32.

Synthesis and biological evaluation of new pentaphyrin macrocycles for photodynamic therapy.

Comuzzi C, Cogoi S, Overhand M, Van der Marel GA, Overkleeft HS, Xodo LE.

J Med Chem. 2006 Jan 12;49(1):196-204.

PMID:
16392804
33.

Antigene property of PNA conjugated to the nuclear localization signal peptide.

Cogoi S, Codognotto A, Rapozzi V, Xodo LE.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):971-4.

PMID:
16248074
34.

Transcription inhibition of oncogenic KRAS by a mutation-selective peptide nucleic acid conjugated to the PKKKRKV nuclear localization signal peptide.

Cogoi S, Codognotto A, Rapozzi V, Meeuwenoord N, van der Marel G, Xodo LE.

Biochemistry. 2005 Aug 9;44(31):10510-9.

PMID:
16060660
35.
36.

Anti-gene strategies to down-regulate gene expression in mammalian cells.

Xodo LE, Cogoi S, Rapozzi V.

Curr Pharm Des. 2004;10(7):805-19. Review.

PMID:
15032705
38.

Inhibition of gene expression by peptide nucleic acids in cultured cells.

Cogoi S, Rapozzi V, Xodo LE.

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1615-8.

PMID:
14565479
39.
40.

Antiproliferative effect in chronic myeloid leukaemia cells by antisense peptide nucleic acids.

Rapozzi V, Burm BE, Cogoi S, van der Marel GA, van Boom JH, Quadrifoglio F, Xodo LE.

Nucleic Acids Res. 2002 Sep 1;30(17):3712-21.

41.

Antigene effect in K562 cells of a PEG-conjugated triplex-forming oligonucleotide targeted to the bcr/abl oncogene.

Rapozzi V, Cogoi S, Spessotto P, Risso A, Bonora GM, Quadrifoglio F, Xodo LE.

Biochemistry. 2002 Jan 15;41(2):502-10.

PMID:
11781088
42.
43.

Downregulation of c-Ki-ras promoter activity by triplex-forming oligonucleotides endogenously generated in human 293 cells.

Cogoi S, Suraci C, Del Terra E, Diviacco S, van der Marel G, van Boom J, Quadrifoglio F, Xodo L.

Antisense Nucleic Acid Drug Dev. 2000 Aug;10(4):283-95.

PMID:
10984122
44.
45.

Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor.

Calligaris R, Bottardi S, Cogoi S, Apezteguia I, Santoro C.

Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11598-602.

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