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Monocyte procoagulant responses to anthrax peptidoglycan are reinforced by proinflammatory cytokine signaling.

Popescu NI, Girton A, Burgett T, Lovelady K, Coggeshall KM.

Blood Adv. 2019 Aug 27;3(16):2436-2447. doi: 10.1182/bloodadvances.2019000513.


Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways.

Popescu NI, Silasi R, Keshari RS, Girton A, Burgett T, Zeerleder SS, Gailani D, Gruber A, Lupu F, Coggeshall KM.

Blood. 2018 Aug 23;132(8):849-860. doi: 10.1182/blood-2017-10-813618. Epub 2018 Jun 19.


Gene expression profiling of primary human type I alveolar epithelial cells exposed to Bacillus anthracis spores reveals induction of neutrophil and monocyte chemokines.

Booth JL, Duggan ES, Patel VI, Wu W, Burian DM, Hutchings DC, White VL, Coggeshall KM, Dozmorov MG, Metcalf JP.

Microb Pathog. 2018 Aug;121:9-21. doi: 10.1016/j.micpath.2018.04.039. Epub 2018 Apr 25.


Serum Amyloid P and IgG Exhibit Differential Capabilities in the Activation of the Innate Immune System in Response to Bacillus anthracis Peptidoglycan.

Girton AW, Popescu NI, Keshari RS, Burgett T, Lupu F, Coggeshall KM.

Infect Immun. 2018 Apr 23;86(5). pii: e00076-18. doi: 10.1128/IAI.00076-18. Print 2018 May.


Neither Lys- and DAP-type peptidoglycans stimulate mouse or human innate immune cells via Toll-like receptor 2.

Langer M, Girton AW, Popescu NI, Burgett T, Metcalf JP, Coggeshall KM.

PLoS One. 2018 Feb 23;13(2):e0193207. doi: 10.1371/journal.pone.0193207. eCollection 2018.


Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis.

Keshari RS, Silasi R, Popescu NI, Patel MM, Chaaban H, Lupu C, Coggeshall KM, Mollnes TE, DeMarco SJ, Lupu F.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6390-E6399. doi: 10.1073/pnas.1706818114. Epub 2017 Jul 18.


Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan.

Wolf AJ, Reyes CN, Liang W, Becker C, Shimada K, Wheeler ML, Cho HC, Popescu NI, Coggeshall KM, Arditi M, Underhill DM.

Cell. 2016 Jul 28;166(3):624-636. doi: 10.1016/j.cell.2016.05.076. Epub 2016 Jun 30.


Bacillus anthracis spore movement does not require a carrier cell and is not affected by lethal toxin in human lung models.

Booth JL, Duggan ES, Patel VI, Langer M, Wu W, Braun A, Coggeshall KM, Metcalf JP.

Microbes Infect. 2016 Oct;18(10):615-626. doi: 10.1016/j.micinf.2016.06.004. Epub 2016 Jun 16.


Interleukin-6 deficiency corrects nephritis, lymphocyte abnormalities, and secondary Sjögren's syndrome features in lupus-prone Sle1.Yaa mice.

Maier-Moore JS, Horton CG, Mathews SA, Confer AW, Lawrence C, Pan Z, Coggeshall KM, Farris AD.

Arthritis Rheumatol. 2014 Sep;66(9):2521-31. doi: 10.1002/art.38716.


Crosstalk between the coagulation and complement systems in sepsis.

Lupu F, Keshari RS, Lambris JD, Coggeshall KM.

Thromb Res. 2014 May;133 Suppl 1:S28-31. doi: 10.1016/j.thromres.2014.03.014. Review.


Human SAP is a novel peptidoglycan recognition protein that induces complement-independent phagocytosis of Staphylococcus aureus.

An JH, Kurokawa K, Jung DJ, Kim MJ, Kim CH, Fujimoto Y, Fukase K, Coggeshall KM, Lee BL.

J Immunol. 2013 Sep 15;191(6):3319-27. doi: 10.4049/jimmunol.1300940. Epub 2013 Aug 21.


Toxin inhibition of antimicrobial factors induced by Bacillus anthracis peptidoglycan in human blood.

Barua S, Iyer JK, Larabee JL, Raisley B, Hughes MA, Coggeshall KM, Ballard JD.

Infect Immun. 2013 Oct;81(10):3693-702. doi: 10.1128/IAI.00709-13. Epub 2013 Jul 22.


The sepsis model: an emerging hypothesis for the lethality of inhalation anthrax.

Coggeshall KM, Lupu F, Ballard J, Metcalf JP, James JA, Farris D, Kurosawa S.

J Cell Mol Med. 2013 Jul;17(7):914-20. doi: 10.1111/jcmm.12075. Epub 2013 Jun 7.


Bacillus anthracis peptidoglycan activates human platelets through FcγRII and complement.

Sun D, Popescu NI, Raisley B, Keshari RS, Dale GL, Lupu F, Coggeshall KM.

Blood. 2013 Jul 25;122(4):571-9. doi: 10.1182/blood-2013-02-486613. Epub 2013 Jun 3.


Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function.

Langer M, Duggan ES, Booth JL, Patel VI, Zander RA, Silasi-Mansat R, Ramani V, Veres TZ, Prenzler F, Sewald K, Williams DM, Coggeshall KM, Awasthi S, Lupu F, Burian D, Ballard JD, Braun A, Metcalf JP.

Infect Immun. 2012 Dec;80(12):4374-87. doi: 10.1128/IAI.01011-12. Epub 2012 Oct 1.


Anti-peptidoglycan antibodies and Fcγ receptors are the key mediators of inflammation in Gram-positive sepsis.

Sun D, Raisley B, Langer M, Iyer JK, Vedham V, Ballard JL, James JA, Metcalf J, Coggeshall KM.

J Immunol. 2012 Sep 1;189(5):2423-31. doi: 10.4049/jimmunol.1201302. Epub 2012 Jul 18.


Cutting edge: primary innate immune cells respond efficiently to polymeric peptidoglycan, but not to peptidoglycan monomers.

Iyer JK, Coggeshall KM.

J Immunol. 2011 Apr 1;186(7):3841-5. doi: 10.4049/jimmunol.1004058. Epub 2011 Feb 25.


TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.

Peng Q, Malhotra S, Torchia JA, Kerr WG, Coggeshall KM, Humphrey MB.

Sci Signal. 2010 May 18;3(122):ra38. doi: 10.1126/scisignal.2000500.


IL-6 increases B-cell IgG production in a feed-forward proinflammatory mechanism to skew hematopoiesis and elevate myeloid production.

Maeda K, Mehta H, Drevets DA, Coggeshall KM.

Blood. 2010 Jun 10;115(23):4699-706. doi: 10.1182/blood-2009-07-230631. Epub 2010 Mar 29.


Inflammatory cytokine response to Bacillus anthracis peptidoglycan requires phagocytosis and lysosomal trafficking.

Iyer JK, Khurana T, Langer M, West CM, Ballard JD, Metcalf JP, Merkel TJ, Coggeshall KM.

Infect Immun. 2010 Jun;78(6):2418-28. doi: 10.1128/IAI.00170-10. Epub 2010 Mar 22.


E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling.

Yago T, Shao B, Miner JJ, Yao L, Klopocki AG, Maeda K, Coggeshall KM, McEver RP.

Blood. 2010 Jul 22;116(3):485-94. doi: 10.1182/blood-2009-12-259556. Epub 2010 Mar 18.


Human lung innate immune cytokine response to adenovirus type 7.

Wu W, Booth JL, Duggan ES, Patel KB, Coggeshall KM, Metcalf JP.

J Gen Virol. 2010 May;91(Pt 5):1155-63. doi: 10.1099/vir.0.017905-0. Epub 2010 Jan 13.


Innate immune response to H3N2 and H1N1 influenza virus infection in a human lung organ culture model.

Wu W, Booth JL, Duggan ES, Wu S, Patel KB, Coggeshall KM, Metcalf JP.

Virology. 2010 Jan 20;396(2):178-88. doi: 10.1016/j.virol.2009.10.016. Epub 2009 Nov 12.


Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB.

Malhotra S, Kovats S, Zhang W, Coggeshall KM.

J Biol Chem. 2009 Dec 25;284(52):36202-12. doi: 10.1074/jbc.M109.040089. Epub 2009 Oct 26.


Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin.

Wu W, Mehta H, Chakrabarty K, Booth JL, Duggan ES, Patel KB, Ballard JD, Coggeshall KM, Metcalf JP.

J Immunol. 2009 Nov 1;183(9):5799-806. doi: 10.4049/jimmunol.0803406. Epub 2009 Oct 7.


Gene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-alpha and NF-kappab are key components of the innate immune response to the pathogen.

Dozmorov M, Wu W, Chakrabarty K, Booth JL, Hurst RE, Coggeshall KM, Metcalf JP.

BMC Infect Dis. 2009 Sep 10;9:152. doi: 10.1186/1471-2334-9-152.


B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin.

Malhotra S, Kovats S, Zhang W, Coggeshall KM.

J Biol Chem. 2009 Sep 4;284(36):24088-97. doi: 10.1074/jbc.M109.014209. Epub 2009 Jul 8.


Adaptor protein SLAT modulates Fcgamma receptor-mediated phagocytosis in murine macrophages.

Mehta H, Glogauer M, Bécart S, Altman A, Coggeshall KM.

J Biol Chem. 2009 May 1;284(18):11882-91. doi: 10.1074/jbc.M809712200. Epub 2009 Feb 27.


Interleukin-6 aborts lymphopoiesis and elevates production of myeloid cells in systemic lupus erythematosus-prone B6.Sle1.Yaa animals.

Maeda K, Malykhin A, Teague-Weber BN, Sun XH, Farris AD, Coggeshall KM.

Blood. 2009 May 7;113(19):4534-40. doi: 10.1182/blood-2008-12-192559. Epub 2009 Feb 17.


Bacillus anthracis peptidoglycan stimulates an inflammatory response in monocytes through the p38 mitogen-activated protein kinase pathway.

Langer M, Malykhin A, Maeda K, Chakrabarty K, Williamson KS, Feasley CL, West CM, Metcalf JP, Coggeshall KM.

PLoS One. 2008;3(11):e3706. doi: 10.1371/journal.pone.0003706. Epub 2008 Nov 12.


Human lung innate immune response to Bacillus anthracis spore infection.

Chakrabarty K, Wu W, Booth JL, Duggan ES, Nagle NN, Coggeshall KM, Metcalf JP.

Infect Immun. 2007 Aug;75(8):3729-38. Epub 2007 May 21.


Calcium-dependent viral internalization is required for adenovirus type 7 induction of IL-8 protein.

Wu W, Booth JL, Coggeshall KM, Metcalf JP.

Virology. 2006 Nov 10;355(1):18-29. Epub 2006 Aug 4.


A unique CD72 epitope suggests a potential interaction with Fc gamma RII/CD32 on B lineage lymphocytes.

Yamashita Y, Phee H, Tudor KS, Rossi MI, Parnes JR, Coggeshall KM, Kincade PW.

Hybridoma (Larchmt). 2006 Jun;25(3):107-14.


IL-6 blocks a discrete early step in lymphopoiesis.

Maeda K, Baba Y, Nagai Y, Miyazaki K, Malykhin A, Nakamura K, Kincade PW, Sakaguchi N, Coggeshall KM.

Blood. 2005 Aug 1;106(3):879-85. Epub 2005 Apr 14.


Adenovirus type 7 induces interleukin-8 in a lung slice model and requires activation of Erk.

Booth JL, Coggeshall KM, Gordon BE, Metcalf JP.

J Virol. 2004 Apr;78(8):4156-64.


CD95 rapidly clusters in cells of diverse origins.

Fanzo JC, Lynch MP, Phee H, Hyer M, Cremesti A, Grassme H, Norris JS, Coggeshall KM, Rueda BR, Pernis AB, Kolesnick R, Gulbins E.

Cancer Biol Ther. 2003 Jul-Aug;2(4):392-5.


How do inhibitory phosphatases work?

Coggeshall KM, Nakamura K, Phee H.

Mol Immunol. 2002 Dec;39(9):521-9. Review.


Negative signaling.

Coggeshall KM.

Mol Immunol. 2002 Dec;39(9):519-20. No abstract available.


Convergence of signaling pathways on the activation of ERK in B cells.

Jacob A, Cooney D, Pradhan M, Coggeshall KM.

J Biol Chem. 2002 Jun 28;277(26):23420-6. Epub 2002 Apr 25.


Activation of nuclear factor of activated T cells by human T-lymphotropic virus type 1 accessory protein p12(I).

Albrecht B, D'Souza CD, Ding W, Tridandapani S, Coggeshall KM, Lairmore MD.

J Virol. 2002 Apr;76(7):3493-501.


C-reactive protein induces signaling through Fc gamma RIIa on HL-60 granulocytes.

Chi M, Tridandapani S, Zhong W, Coggeshall KM, Mortensen RF.

J Immunol. 2002 Feb 1;168(3):1413-8.


Visualization of negative signaling in B cells by quantitative confocal microscopy.

Phee H, Rodgers W, Coggeshall KM.

Mol Cell Biol. 2001 Dec;21(24):8615-25.


Adenovirus type 7 induces interleukin-8 production via activation of extracellular regulated kinase 1/2.

Alcorn MJ, Booth JL, Coggeshall KM, Metcalf JP.

J Virol. 2001 Jul;75(14):6450-9.

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