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The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice.

Solon-Biet SM, McMahon AC, Ballard JWO, Ruohonen K, Wu LE, Cogger VC, Warren A, Huang X, Pichaud N, Melvin RG, Gokarn R, Khalil M, Turner N, Cooney GJ, Sinclair DA, Raubenheimer D, Le Couteur DG, Simpson SJ.

Cell Metab. 2020 Mar 3;31(3):654. doi: 10.1016/j.cmet.2020.01.010. No abstract available.


Rapid Intestinal Uptake and Targeted Delivery to the Liver Endothelium Using Orally Administered Silver Sulfide Quantum Dots.

Hunt NJ, Lockwood GP, Le Couteur FH, McCourt PAG, Singla N, Kang SWS, Burgess A, Kuncic Z, Le Couteur DG, Cogger VC.

ACS Nano. 2020 Feb 25;14(2):1492-1507. doi: 10.1021/acsnano.9b06071. Epub 2020 Jan 24.


Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice.

Wahl D, Gokarn R, Mitchell SJ, Solon-Biet SM, Cogger VC, Simpson SJ, Le Couteur DG, de Cabo R.

Nutr Healthy Aging. 2019 Sep 23;5(2):111-117. doi: 10.3233/NHA-180059.


Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control.

Solon-Biet SM, Cogger VC, Pulpitel T, Wahl D, Clark X, Bagley E, Gregoriou GC, Senior AM, Wang QP, Brandon AE, Perks R, O'Sullivan J, Koay YC, Bell-Anderson K, Kebede M, Yau B, Atkinson C, Svineng G, Dodgson T, Wali JA, Piper MDW, Juricic P, Partridge L, Rose AJ, Raubenheimer D, Cooney GJ, Le Couteur DG, Simpson SJ.

Nat Metab. 2019 May;1(5):532-545. doi: 10.1038/s42255-019-0059-2. Epub 2019 Apr 29.


Hallmarks of Aging in the Liver.

Hunt NJ, Kang SWS, Lockwood GP, Le Couteur DG, Cogger VC.

Comput Struct Biotechnol J. 2019 Aug 7;17:1151-1161. doi: 10.1016/j.csbj.2019.07.021. eCollection 2019. Review.


Aging Influences Hepatic Microvascular Biology and Liver Fibrosis in Advanced Chronic Liver Disease.

Maeso-Díaz R, Ortega-Ribera M, Lafoz E, Lozano JJ, Baiges A, Francés R, Albillos A, Peralta C, García-Pagán JC, Bosch J, Cogger VC, Gracia-Sancho J.

Aging Dis. 2019 Aug 1;10(4):684-698. doi: 10.14336/AD.2019.0127. eCollection 2019 Aug.


Of Older Mice and Men: Branched-Chain Amino Acids and Body Composition.

Ribeiro RV, Solon-Biet SM, Pulpitel T, Senior AM, Cogger VC, Clark X, O'Sullivan J, Koay YC, Hirani V, Blyth FM, Seibel MJ, Waite LM, Naganathan V, Cumming RG, Handelsman DJ, Simpson SJ, Le Couteur DG.

Nutrients. 2019 Aug 13;11(8). pii: E1882. doi: 10.3390/nu11081882.


Multiple cellular pathways regulate lipid droplet homeostasis for the establishment of polarity in collagen sandwich-cultured hepatocytes.

Kang SWS, Cogger VC, Le Couteur DG, Fu D.

Am J Physiol Cell Physiol. 2019 Nov 1;317(5):C942-C952. doi: 10.1152/ajpcell.00051.2019. Epub 2019 Aug 14.


Cystathionine-Gamma-Lyase-Derived Hydrogen Sulfide-Regulated Substance P Modulates Liver Sieve Fenestrations in Caecal Ligation and Puncture-Induced Sepsis.

Gaddam RR, Chambers S, Fraser R, Cogger VC, Le Couteur DG, Ishii I, Bhatia M.

Int J Mol Sci. 2019 Jun 29;20(13). pii: E3191. doi: 10.3390/ijms20133191.


The Effects of Metformin on Age-Related Changes in the Liver Sinusoidal Endothelial Cell.

Hunt NJ, Lockwood GP, Kang SWS, Pulpitel T, Clark X, Mao H, McCourt PAG, Cooney GJ, Wali JA, Le Couteur FH, Le Couteur DG, Cogger VC.

J Gerontol A Biol Sci Med Sci. 2020 Jan 20;75(2):278-285. doi: 10.1093/gerona/glz153.


Aging, lifestyle and dementia.

Wahl D, Solon-Biet SM, Cogger VC, Fontana L, Simpson SJ, Le Couteur DG, Ribeiro RV.

Neurobiol Dis. 2019 Oct;130:104481. doi: 10.1016/j.nbd.2019.104481. Epub 2019 May 25. Review.


Dietary macronutrient content, age-specific mortality and lifespan.

Senior AM, Solon-Biet SM, Cogger VC, Le Couteur DG, Nakagawa S, Raubenheimer D, Simpson SJ.

Proc Biol Sci. 2019 May 15;286(1902):20190393. doi: 10.1098/rspb.2019.0393.


Ingestion of resistant starch by mice markedly increases microbiome-derived metabolites.

Koay YC, Wali JA, Luk AWS, Macia L, Cogger VC, Pulpitel TJ, Wahl D, Solon-Biet SM, Holmes A, Simpson SJ, O'Sullivan JF.

FASEB J. 2019 Jul;33(7):8033-8042. doi: 10.1096/fj.201900177R. Epub 2019 Mar 29.


Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis.

Morimoto J, Senior A, Ruiz K, Wali JA, Pulpitel T, Solon-Biet SM, Cogger VC, Raubenheimer D, Le Couteur DG, Simpson SJ, Eberhard J.

PLoS One. 2019 Mar 13;14(3):e0212796. doi: 10.1371/journal.pone.0212796. eCollection 2019.


Ischemia/Reperfusion Injury in the Aged Liver: The Importance of the Sinusoidal Endothelium in Developing Therapeutic Strategies for the Elderly.

Hide D, Warren A, Fernández-Iglesias A, Maeso-Díaz R, Peralta C, Le Couteur DG, Bosch J, Cogger VC, Gracia-Sancho J.

J Gerontol A Biol Sci Med Sci. 2020 Jan 20;75(2):268-277. doi: 10.1093/gerona/glz012.


Editorial: Drug delivery in older people - unique challenges and important opportunities.

McLachlan AJ, Cogger VC.

Adv Drug Deliv Rev. 2018 Oct;135:1-2. doi: 10.1016/j.addr.2018.11.002. No abstract available.


Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice.

Wahl D, Solon-Biet SM, Wang QP, Wali JA, Pulpitel T, Clark X, Raubenheimer D, Senior AM, Sinclair DA, Cooney GJ, de Cabo R, Cogger VC, Simpson SJ, Le Couteur DG.

Cell Rep. 2018 Nov 20;25(8):2234-2243.e6. doi: 10.1016/j.celrep.2018.10.070.


Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations.

Choi JP, Wang R, Yang X, Wang X, Wang L, Ting KK, Foley M, Cogger V, Yang Z, Liu F, Han Z, Liu R, Baell J, Zheng X.

Sci Adv. 2018 Nov 7;4(11):eaau0731. doi: 10.1126/sciadv.aau0731. eCollection 2018 Nov.


Manipulating fenestrations in young and old liver sinusoidal endothelial cells.

Hunt NJ, Lockwood GP, Warren A, Mao H, McCourt PAG, Le Couteur DG, Cogger VC.

Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G144-G154. doi: 10.1152/ajpgi.00179.2018. Epub 2018 Oct 4.


Effects of aging on liver microcirculatory function and sinusoidal phenotype.

Maeso-Díaz R, Ortega-Ribera M, Fernández-Iglesias A, Hide D, Muñoz L, Hessheimer AJ, Vila S, Francés R, Fondevila C, Albillos A, Peralta C, Bosch J, Tacke F, Cogger VC, Gracia-Sancho J.

Aging Cell. 2018 Dec;17(6):e12829. doi: 10.1111/acel.12829. Epub 2018 Sep 8.


Novel targets for delaying aging: The importance of the liver and advances in drug delivery.

Hunt NJ, McCourt PAG, Le Couteur DG, Cogger VC.

Adv Drug Deliv Rev. 2018 Oct;135:39-49. doi: 10.1016/j.addr.2018.09.006. Epub 2018 Sep 21. Review.


Role of hypochlorous acid (HOCl) and other inflammatory mediators in the induction of macrophage extracellular trap formation.

Rayner BS, Zhang Y, Brown BE, Reyes L, Cogger VC, Hawkins CL.

Free Radic Biol Med. 2018 Dec;129:25-34. doi: 10.1016/j.freeradbiomed.2018.09.001. Epub 2018 Sep 4.


Corrigendum to: The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats.

Mach J, Huizer-Pajkos A, Cogger VC, McKenzie C, Le Couteur DG, Jones BE, de Cabo R, Hilmer SN.

J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):332. doi: 10.1093/gerona/gly160. No abstract available.


The Relationship Between Dietary Macronutrients and Hepatic Telomere Length in Aging Mice.

Gokarn R, Solon-Biet S, Youngson NA, Wahl D, Cogger VC, McMahon AC, Cooney GJ, Ballard JWO, Raubenheimer D, Morris MJ, Simpson SJ, Le Couteur DG.

J Gerontol A Biol Sci Med Sci. 2018 Mar 14;73(4):446-449. doi: 10.1093/gerona/glx186.


Long-term Dietary Macronutrients and Hepatic Gene Expression in Aging Mice.

Gokarn R, Solon-Biet SM, Cogger VC, Cooney GJ, Wahl D, McMahon AC, Mitchell JR, Mitchell SJ, Hine C, de Cabo R, Raubenheimer D, Simpson SJ, Le Couteur DG.

J Gerontol A Biol Sci Med Sci. 2018 Nov 10;73(12):1618-1625. doi: 10.1093/gerona/gly065.


Health benefits of late-onset metformin treatment every other week in mice.

Alfaras I, Mitchell SJ, Mora H, Lugo DR, Warren A, Navas-Enamorado I, Hoffmann V, Hine C, Mitchell JR, Le Couteur DG, Cogger VC, Bernier M, de Cabo R.

NPJ Aging Mech Dis. 2017 Nov 20;3:16. doi: 10.1038/s41514-017-0018-7. eCollection 2017.


It's the holes that matter.

Cogger VC, Mohamad M, Le Couteur DG.

Aging (Albany NY). 2017 Nov 15;9(11):2237-2238. doi: 10.18632/aging.101330. No abstract available.


The nutritional geometry of liver disease including non-alcoholic fatty liver disease.

Simpson SJ, Raubenheimer D, Cogger VC, Macia L, Solon-Biet SM, Le Couteur DG, George J.

J Hepatol. 2018 Feb;68(2):316-325. doi: 10.1016/j.jhep.2017.10.005. Epub 2017 Nov 6. Review.


Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia.

Wahl D, Coogan SC, Solon-Biet SM, de Cabo R, Haran JB, Raubenheimer D, Cogger VC, Mattson MP, Simpson SJ, Le Couteur DG.

Clin Interv Aging. 2017 Sep 8;12:1419-1428. doi: 10.2147/CIA.S145247. eCollection 2017. Review.


Correction: Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis.

Gaddam RR, Fraser R, Badiei A, Chambers S, Cogger VC, Le Couteur DG, Ishii I, Bhatia M.

PLoS One. 2017 Aug 10;12(8):e0183304. doi: 10.1371/journal.pone.0183304. eCollection 2017.


Targeting Vascular Endothelial-Cadherin in Tumor-Associated Blood Vessels Promotes T-cell-Mediated Immunotherapy.

Zhao Y, Ting KK, Li J, Cogger VC, Chen J, Johansson-Percival A, Ngiow SF, Holst J, Grau G, Goel S, Muller T, Dejana E, McCaughan G, Smyth MJ, Ganss R, Vadas MA, Gamble JR.

Cancer Res. 2017 Aug 15;77(16):4434-4447. doi: 10.1158/0008-5472.CAN-16-3129. Epub 2017 Jun 27. Erratum in: Cancer Res. 2018 Oct 1;78(19):5718.


Non-alcoholic fatty liver disease, vascular inflammation and insulin resistance are exacerbated by TRAIL deletion in mice.

Cartland SP, Harith HH, Genner SW, Dang L, Cogger VC, Vellozzi M, Di Bartolo BA, Thomas SR, Adams LA, Kavurma MM.

Sci Rep. 2017 May 15;7(1):1898. doi: 10.1038/s41598-017-01721-4.


SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study.

Razi S, Cogger VC, Kennerson M, Benson VL, McMahon AC, Blyth FM, Handelsman DJ, Seibel MJ, Hirani V, Naganathan V, Waite L, de Cabo R, Cumming RG, Le Couteur DG.

J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):870-876. doi: 10.1093/gerona/glx018.


Dietary protein, aging and nutritional geometry.

Simpson SJ, Le Couteur DG, Raubenheimer D, Solon-Biet SM, Cooney GJ, Cogger VC, Fontana L.

Ageing Res Rev. 2017 Oct;39:78-86. doi: 10.1016/j.arr.2017.03.001. Epub 2017 Mar 6. Review.


Diet-Microbiome Interactions in Health Are Controlled by Intestinal Nitrogen Source Constraints.

Holmes AJ, Chew YV, Colakoglu F, Cliff JB, Klaassens E, Read MN, Solon-Biet SM, McMahon AC, Cogger VC, Ruohonen K, Raubenheimer D, Le Couteur DG, Simpson SJ.

Cell Metab. 2017 Jan 10;25(1):140-151. doi: 10.1016/j.cmet.2016.10.021. Epub 2016 Nov 23.


Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework.

Solon-Biet SM, Cogger VC, Pulpitel T, Heblinski M, Wahl D, McMahon AC, Warren A, Durrant-Whyte J, Walters KA, Krycer JR, Ponton F, Gokarn R, Wali JA, Ruohonen K, Conigrave AD, James DE, Raubenheimer D, Morrison CD, Le Couteur DG, Simpson SJ.

Cell Metab. 2016 Oct 11;24(4):555-565. doi: 10.1016/j.cmet.2016.09.001. Epub 2016 Sep 29.


Differential Effects of Kupffer Cell Inactivation on Inflammation and The Liver Sieve Following Caecal-Ligation and Puncture-Induced Sepsis in Mice.

Gaddam RR, Fraser R, Badiei A, Chambers S, Cogger VC, Le Couteur DG, Bhatia M.

Shock. 2017 Apr;47(4):480-490. doi: 10.1097/SHK.0000000000000755.


Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis.

Gaddam RR, Fraser R, Badiei A, Chambers S, Cogger VC, Le Couteur DG, Ishii I, Bhatia M.

PLoS One. 2016 Aug 12;11(8):e0160521. doi: 10.1371/journal.pone.0160521. eCollection 2016. Erratum in: PLoS One. 2017 Aug 10;12 (8):e0183304.


Nutritional strategies to optimise cognitive function in the aging brain.

Wahl D, Cogger VC, Solon-Biet SM, Waern RV, Gokarn R, Pulpitel T, Cabo Rd, Mattson MP, Raubenheimer D, Simpson SJ, Le Couteur DG.

Ageing Res Rev. 2016 Nov;31:80-92. doi: 10.1016/j.arr.2016.06.006. Epub 2016 Jun 26. Review.


Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration.

Lo TH, Silveira PA, Fromm PD, Verma ND, Vu PA, Kupresanin F, Adam R, Kato M, Cogger VC, Clark GJ, Hart DN.

J Immunol. 2016 Aug 1;197(3):885-98. doi: 10.4049/jimmunol.1600259. Epub 2016 Jun 17.


New Horizons: Dietary protein, ageing and the Okinawan ratio.

Le Couteur DG, Solon-Biet S, Wahl D, Cogger VC, Willcox BJ, Willcox DC, Raubenheimer D, Simpson SJ.

Age Ageing. 2016 Jul;45(4):443-7. doi: 10.1093/ageing/afw069. Epub 2016 Apr 28. Review.


Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance.

Mohamad M, Mitchell SJ, Wu LE, White MY, Cordwell SJ, Mach J, Solon-Biet SM, Boyer D, Nines D, Das A, Catherine Li SY, Warren A, Hilmer SN, Fraser R, Sinclair DA, Simpson SJ, de Cabo R, Le Couteur DG, Cogger VC.

Aging Cell. 2016 Aug;15(4):706-15. doi: 10.1111/acel.12481. Epub 2016 Apr 20.


Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo-/- mice.

Aumailley L, Warren A, Garand C, Dubois MJ, Paquet ER, Le Couteur DG, Marette A, Cogger VC, Lebel M.

Aging (Albany NY). 2016 Mar;8(3):458-83.


Dietary macronutrients and the aging liver sinusoidal endothelial cell.

Cogger VC, Mohamad M, Solon-Biet SM, Senior AM, Warren A, O'Reilly JN, Tung BT, Svistounov D, McMahon AC, Fraser R, Raubenheimer D, Holmes AJ, Simpson SJ, Le Couteur DG.

Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1064-70. doi: 10.1152/ajpheart.00949.2015. Epub 2016 Feb 26.


N-Acetyl cysteine does not prevent liver toxicity from chronic low-dose plus subacute high-dose paracetamol exposure in young or old mice.

Kane AE, Huizer-Pajkos A, Mach J, McKenzie C, Mitchell SJ, de Cabo R, Jones B, Cogger V, Le Couteur DG, Hilmer SN.

Fundam Clin Pharmacol. 2016 Jun;30(3):263-75. doi: 10.1111/fcp.12184. Epub 2016 Feb 17.


Short- and Long-Term Tracking of Anionic Ultrasmall Nanoparticles in Kidney.

Liang X, Wang H, Zhu Y, Zhang R, Cogger VC, Liu X, Xu ZP, Grice JE, Roberts MS.

ACS Nano. 2016 Jan 26;10(1):387-95. doi: 10.1021/acsnano.5b05066. Epub 2016 Jan 13.


The impact of low-protein high-carbohydrate diets on aging and lifespan.

Le Couteur DG, Solon-Biet S, Cogger VC, Mitchell SJ, Senior A, de Cabo R, Raubenheimer D, Simpson SJ.

Cell Mol Life Sci. 2016 Mar;73(6):1237-52. doi: 10.1007/s00018-015-2120-y. Epub 2015 Dec 30. Review.


Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type.

Kane AE, Mitchell SJ, Mach J, Huizer-Pajkos A, McKenzie C, Jones B, Cogger V, Le Couteur DG, de Cabo R, Hilmer SN.

Exp Gerontol. 2016 Jan;73:95-106. doi: 10.1016/j.exger.2015.11.013. Epub 2015 Nov 23.


The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats.

Mach J, Huizer-Pajkos A, Mitchell SJ, McKenzie C, Phillips L, Kane A, Jones B, de Cabo R, Cogger V, Le Couteur DG, Hilmer SN.

Fundam Clin Pharmacol. 2016 Feb;30(1):23-34. doi: 10.1111/fcp.12157. Epub 2015 Nov 9.


Dietary Protein to Carbohydrate Ratio and Caloric Restriction: Comparing Metabolic Outcomes in Mice.

Solon-Biet SM, Mitchell SJ, Coogan SC, Cogger VC, Gokarn R, McMahon AC, Raubenheimer D, de Cabo R, Simpson SJ, Le Couteur DG.

Cell Rep. 2015 Jun 16;11(10):1529-34. doi: 10.1016/j.celrep.2015.05.007. Epub 2015 May 28.

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