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Items: 1 to 50 of 178

1.

Epigenetic drug screen identifies the histone deacetylase inhibitor NSC3852 as a potential novel drug for the treatment of pediatric acute myeloid leukemia.

Wiggers CRM, Govers AMAP, Lelieveld D, Egan DA, Zwaan CM, Sonneveld E, Coffer PJ, Bartels M.

Pediatr Blood Cancer. 2019 Aug;66(8):e27785. doi: 10.1002/pbc.27785. Epub 2019 May 1.

PMID:
31044544
2.

Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells.

Fleskens V, Minutti CM, Wu X, Wei P, Pals CEGM, McCrae J, Hemmers S, Groenewold V, Vos HJ, Rudensky A, Pan F, Li H, Zaiss DM, Coffer PJ.

Cell Rep. 2019 Mar 26;26(13):3600-3612.e6. doi: 10.1016/j.celrep.2019.02.087.

3.

Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis.

Vervoort SJ, de Jong OG, Roukens MG, Frederiks CL, Vermeulen JF, Lourenço AR, Bella L, Vidakovic AT, Sandoval JL, Moelans C, van Amersfoort M, Dallman MJ, Bruna A, Caldas C, Nieuwenhuis E, van der Wall E, Derksen P, van Diest P, Verhaar MC, Lam EW, Mokry M, Coffer PJ.

Elife. 2018 Dec 3;7. pii: e27706. doi: 10.7554/eLife.27706.

4.

SOX4 inhibits oligodendrocyte differentiation of embryonic neural stem cells in vitro by inducing Hes5 expression.

Braccioli L, Vervoort SJ, Puma G, Nijboer CH, Coffer PJ.

Stem Cell Res. 2018 Dec;33:110-119. doi: 10.1016/j.scr.2018.10.005. Epub 2018 Oct 4.

5.

The Role of WNT Signaling in Mature T Cells: T Cell Factor Is Coming Home.

van Loosdregt J, Coffer PJ.

J Immunol. 2018 Oct 15;201(8):2193-2200. doi: 10.4049/jimmunol.1800633. Review.

PMID:
30301837
6.

PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation.

Petrelli A, Mijnheer G, Hoytema van Konijnenburg DP, van der Wal MM, Giovannone B, Mocholi E, Vazirpanah N, Broen JC, Hijnen D, Oldenburg B, Coffer PJ, Vastert SJ, Prakken BJ, Spierings E, Pandit A, Mokry M, van Wijk F.

J Clin Invest. 2018 Oct 1;128(10):4669-4681. doi: 10.1172/JCI96107. Epub 2018 Aug 2.

7.

STAT5 is essential for IL-7-mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells.

Ribeiro D, Melão A, van Boxtel R, Santos CI, Silva A, Silva MC, Cardoso BA, Coffer PJ, Barata JT.

Blood Adv. 2018 Sep 11;2(17):2199-2213. doi: 10.1182/bloodadvances.2018021063.

8.

Forkhead box transcription factors as context-dependent regulators of lymphocyte homeostasis.

Zaiss DMW, Coffer PJ.

Nat Rev Immunol. 2018 Nov;18(11):703-715. doi: 10.1038/s41577-018-0048-9. Review.

PMID:
30177790
9.

Transcriptional and epigenetic profiling of nutrient-deprived cells to identify novel regulators of autophagy.

Peeters JGC, Picavet LW, Coenen SGJM, Mauthe M, Vervoort SJ, Mocholi E, de Heus C, Klumperman J, Vastert SJ, Reggiori F, Coffer PJ, Mokry M, van Loosdregt J.

Autophagy. 2019 Jan;15(1):98-112. doi: 10.1080/15548627.2018.1509608. Epub 2018 Sep 11.

10.

SOX4 can redirect TGF-β-mediated SMAD3-transcriptional output in a context-dependent manner to promote tumorigenesis.

Vervoort SJ, Lourenço AR, Tufegdzic Vidakovic A, Mocholi E, Sandoval JL, Rueda OM, Frederiks C, Pals C, Peeters JGC, Caldas C, Bruna A, Coffer PJ.

Nucleic Acids Res. 2018 Oct 12;46(18):9578-9590. doi: 10.1093/nar/gky755.

11.

Autophagy Is a Tolerance-Avoidance Mechanism that Modulates TCR-Mediated Signaling and Cell Metabolism to Prevent Induction of T Cell Anergy.

Mocholi E, Dowling SD, Botbol Y, Gruber RC, Ray AK, Vastert S, Shafit-Zagardo B, Coffer PJ, Macian F.

Cell Rep. 2018 Jul 31;24(5):1136-1150. doi: 10.1016/j.celrep.2018.06.065.

12.

Forkhead box protein P1, a key player in neuronal development?

Braccioli L, Nijboer CH, Coffer PJ.

Neural Regen Res. 2018 May;13(5):801-802. doi: 10.4103/1673-5374.232467. No abstract available.

13.

Megakaryocyte lineage development is controlled by modulation of protein acetylation.

Bartels M, Govers A, Polak R, Vervoort S, van Boxtel R, Pals C, Bierings M, van Solinge W, Egberts T, Nieuwenhuis E, Mokry M, Coffer PJ.

PLoS One. 2018 Apr 26;13(4):e0196400. doi: 10.1371/journal.pone.0196400. eCollection 2018.

14.

Intestinal Failure and Aberrant Lipid Metabolism in Patients With DGAT1 Deficiency.

van Rijn JM, Ardy RC, Kuloğlu Z, Härter B, van Haaften-Visser DY, van der Doef HPJ, van Hoesel M, Kansu A, van Vugt AHM, Thian M, Kokke FTM, Krolo A, Başaran MK, Kaya NG, Aksu AÜ, Dalgıç B, Ozcay F, Baris Z, Kain R, Stigter ECA, Lichtenbelt KD, Massink MPG, Duran KJ, Verheij JBGM, Lugtenberg D, Nikkels PGJ, Brouwer HGF, Verkade HJ, Scheenstra R, Spee B, Nieuwenhuis EES, Coffer PJ, Janecke AR, van Haaften G, Houwen RHJ, Müller T, Middendorp S, Boztug K.

Gastroenterology. 2018 Jul;155(1):130-143.e15. doi: 10.1053/j.gastro.2018.03.040. Epub 2018 Mar 29.

15.

Mesenchymal Stromal/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration In Vitro.

Vonk LA, van Dooremalen SFJ, Liv N, Klumperman J, Coffer PJ, Saris DBF, Lorenowicz MJ.

Theranostics. 2018 Jan 1;8(4):906-920. doi: 10.7150/thno.20746. eCollection 2018.

16.

FOXP1 Promotes Embryonic Neural Stem Cell Differentiation by Repressing Jagged1 Expression.

Braccioli L, Vervoort SJ, Adolfs Y, Heijnen CJ, Basak O, Pasterkamp RJ, Nijboer CH, Coffer PJ.

Stem Cell Reports. 2017 Nov 14;9(5):1530-1545. doi: 10.1016/j.stemcr.2017.10.012.

17.

Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.

Minutti CM, Drube S, Blair N, Schwartz C, McCrae JC, McKenzie AN, Kamradt T, Mokry M, Coffer PJ, Sibilia M, Sijts AJ, Fallon PG, Maizels RM, Zaiss DM.

Immunity. 2017 Oct 17;47(4):710-722.e6. doi: 10.1016/j.immuni.2017.09.013.

18.

SOX4: Joining the Master Regulators of Epithelial-to-Mesenchymal Transition?

Lourenço AR, Coffer PJ.

Trends Cancer. 2017 Aug;3(8):571-582. doi: 10.1016/j.trecan.2017.06.002. Epub 2017 Jul 8. Review.

PMID:
28780934
19.

Inhibition of autophagy as a treatment strategy for p53 wild-type acute myeloid leukemia.

Folkerts H, Hilgendorf S, Wierenga ATJ, Jaques J, Mulder AB, Coffer PJ, Schuringa JJ, Vellenga E.

Cell Death Dis. 2017 Jul 13;8(7):e2927. doi: 10.1038/cddis.2017.317.

20.

A tumor suppressor role for C/EBPα in solid tumors: more than fat and blood.

Lourenço AR, Coffer PJ.

Oncogene. 2017 Sep 14;36(37):5221-5230. doi: 10.1038/onc.2017.151. Epub 2017 May 15. Review.

PMID:
28504718
21.

Ankyrin repeat and zinc-finger domain-containing 1 mutations are associated with infantile-onset inflammatory bowel disease.

van Haaften-Visser DY, Harakalova M, Mocholi E, van Montfrans JM, Elkadri A, Rieter E, Fiedler K, van Hasselt PM, Triffaux EMM, van Haelst MM, Nijman IJ, Kloosterman WP, Nieuwenhuis EES, Muise AM, Cuppen E, Houwen RHJ, Coffer PJ.

J Biol Chem. 2017 May 12;292(19):7904-7920. doi: 10.1074/jbc.M116.772038. Epub 2017 Mar 16.

22.

Delayed administration of neural stem cells after hypoxia-ischemia reduces sensorimotor deficits, cerebral lesion size, and neuroinflammation in neonatal mice.

Braccioli L, Heijnen CJ, Coffer PJ, Nijboer CH.

Pediatr Res. 2017 Jan;81(1-1):127-135. doi: 10.1038/pr.2016.172. Epub 2016 Sep 15.

PMID:
27632779
23.

Activation of autophagy by FOXO3 regulates redox homeostasis during osteogenic differentiation.

Gómez-Puerto MC, Verhagen LP, Braat AK, Lam EW, Coffer PJ, Lorenowicz MJ.

Autophagy. 2016 Oct 2;12(10):1804-1816. Epub 2016 Aug 17.

24.

Autophagy Proteins ATG5 and ATG7 Are Essential for the Maintenance of Human CD34(+) Hematopoietic Stem-Progenitor Cells.

Gomez-Puerto MC, Folkerts H, Wierenga AT, Schepers K, Schuringa JJ, Coffer PJ, Vellenga E.

Stem Cells. 2016 Jun;34(6):1651-63. doi: 10.1002/stem.2347. Epub 2016 Mar 28.

25.

In Vitro Evaluation of Spider Silk Meshes as a Potential Biomaterial for Bladder Reconstruction.

Steins A, Dik P, Müller WH, Vervoort SJ, Reimers K, Kuhbier JW, Vogt PM, van Apeldoorn AA, Coffer PJ, Schepers K.

PLoS One. 2015 Dec 21;10(12):e0145240. doi: 10.1371/journal.pone.0145240. eCollection 2015.

26.

Context-Specific Effects of TGF-β/SMAD3 in Cancer Are Modulated by the Epigenome.

Tufegdzic Vidakovic A, Rueda OM, Vervoort SJ, Sati Batra A, Goldgraben MA, Uribe-Lewis S, Greenwood W, Coffer PJ, Bruna A, Caldas C.

Cell Rep. 2015 Dec 22;13(11):2480-2490. doi: 10.1016/j.celrep.2015.11.040. Epub 2015 Dec 10.

27.

FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2.

Fleskens V, Mokry M, van der Leun AM, Huppelschoten S, Pals CE, Peeters J, Coenen S, Cardoso BA, Barata JT, van Loosdregt J, Coffer PJ.

Oncogene. 2016 Aug 4;35(31):4141-8. doi: 10.1038/onc.2015.481. Epub 2015 Dec 21.

PMID:
26686090
28.

Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression.

Peeters JG, Vervoort SJ, Tan SC, Mijnheer G, de Roock S, Vastert SJ, Nieuwenhuis EE, van Wijk F, Prakken BJ, Creyghton MP, Coffer PJ, Mokry M, van Loosdregt J.

Cell Rep. 2015 Sep 29;12(12):1986-96. doi: 10.1016/j.celrep.2015.08.046. Epub 2015 Sep 17.

29.

Inhibition of FOXP3/NFAT Interaction Enhances T Cell Function after TCR Stimulation.

Lozano T, Villanueva L, Durántez M, Gorraiz M, Ruiz M, Belsúe V, Riezu-Boj JI, Hervás-Stubbs S, Oyarzábal J, Bandukwala H, Lourenço AR, Coffer PJ, Sarobe P, Prieto J, Casares N, Lasarte JJ.

J Immunol. 2015 Oct 1;195(7):3180-9. doi: 10.4049/jimmunol.1402997. Epub 2015 Aug 31.

30.

The forkhead transcription factor FOXP1 represses human plasma cell differentiation.

van Keimpema M, Grüneberg LJ, Mokry M, van Boxtel R, van Zelm MC, Coffer P, Pals ST, Spaargaren M.

Blood. 2015 Oct 29;126(18):2098-109. doi: 10.1182/blood-2015-02-626176. Epub 2015 Aug 19.

31.

Acetylation of C/EBPε is a prerequisite for terminal neutrophil differentiation.

Bartels M, Govers AM, Fleskens V, Lourenço AR, Pals CE, Vervoort SJ, van Gent R, Brenkman AB, Bierings MB, Ackerman SJ, van Loosdregt J, Coffer PJ.

Blood. 2015 Mar 12;125(11):1782-92. doi: 10.1182/blood-2013-12-543850. Epub 2015 Jan 7.

32.

FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells.

van Keimpema M, Grüneberg LJ, Mokry M, van Boxtel R, Koster J, Coffer PJ, Pals ST, Spaargaren M.

Blood. 2014 Nov 27;124(23):3431-40. doi: 10.1182/blood-2014-01-553412. Epub 2014 Sep 29.

33.

Post-translational modification networks regulating FOXP3 function.

van Loosdregt J, Coffer PJ.

Trends Immunol. 2014 Aug;35(8):368-78. doi: 10.1016/j.it.2014.06.005. Epub 2014 Jul 18. Review.

PMID:
25047417
34.

The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway.

Coomans de Brachène A, Bollaert E, Eijkelenboom A, de Rocca Serra A, van der Vos KE, Burgering BM, Coffer PJ, Essaghir A, Demoulin JB.

Biochem J. 2014 May 15;460(1):25-34. doi: 10.1042/BJ20131467.

PMID:
24762137
35.

Differential effects of nitrostyrene derivatives on myelopoiesis involve regulation of C/EBPα and p38MAPK activity.

Bartels M, Calgarotto AK, Martens AC, Maso V, da Silva SL, Bierings MB, de Souza Queiroz ML, Coffer PJ.

PLoS One. 2014 Mar 10;9(3):e90586. doi: 10.1371/journal.pone.0090586. eCollection 2014.

36.

In vitro induction of alkaline phosphatase levels predicts in vivo bone forming capacity of human bone marrow stromal cells.

Prins HJ, Braat AK, Gawlitta D, Dhert WJ, Egan DA, Tijssen-Slump E, Yuan H, Coffer PJ, Rozemuller H, Martens AC.

Stem Cell Res. 2014 Mar;12(2):428-40. doi: 10.1016/j.scr.2013.12.001. Epub 2013 Dec 12.

37.

Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion.

van der Burgh R, Nijhuis L, Pervolaraki K, Compeer EB, Jongeneel LH, van Gijn M, Coffer PJ, Murphy MP, Mastroberardino PG, Frenkel J, Boes M.

J Biol Chem. 2014 Feb 21;289(8):5000-12. doi: 10.1074/jbc.M113.536920. Epub 2013 Dec 19.

38.

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.

Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P, Liu H, Cross JR, Pfeffer K, Coffer PJ, Rudensky AY.

Nature. 2013 Dec 19;504(7480):451-5. doi: 10.1038/nature12726. Epub 2013 Nov 13.

39.

Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60.

Gao Y, Koppen A, Rakhshandehroo M, Tasdelen I, van de Graaf SF, van Loosdregt J, van Beekum O, Hamers N, van Leenen D, Berkers CR, Berger R, Holstege FC, Coffer PJ, Brenkman AB, Ovaa H, Kalkhoven E.

Nat Commun. 2013;4:2656. doi: 10.1038/ncomms3656.

PMID:
24141283
40.

Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity.

van Loosdregt J, Fleskens V, Fu J, Brenkman AB, Bekker CP, Pals CE, Meerding J, Berkers CR, Barbi J, Gröne A, Sijts AJ, Maurice MM, Kalkhoven E, Prakken BJ, Ovaa H, Pan F, Zaiss DM, Coffer PJ.

Immunity. 2013 Aug 22;39(2):259-71. doi: 10.1016/j.immuni.2013.05.018.

41.

Canonical Wnt signaling negatively modulates regulatory T cell function.

van Loosdregt J, Fleskens V, Tiemessen MM, Mokry M, van Boxtel R, Meerding J, Pals CE, Kurek D, Baert MR, Delemarre EM, Gröne A, Koerkamp MJ, Sijts AJ, Nieuwenhuis EE, Maurice MM, van Es JH, Ten Berge D, Holstege FC, Staal FJ, Zaiss DM, Prakken BJ, Coffer PJ.

Immunity. 2013 Aug 22;39(2):298-310. doi: 10.1016/j.immuni.2013.07.019. Epub 2013 Aug 15.

42.

FOXP1 acts through a negative feedback loop to suppress FOXO-induced apoptosis.

van Boxtel R, Gomez-Puerto C, Mokry M, Eijkelenboom A, van der Vos KE, Nieuwenhuis EE, Burgering BM, Lam EW, Coffer PJ.

Cell Death Differ. 2013 Sep;20(9):1219-29. doi: 10.1038/cdd.2013.81. Epub 2013 Jul 5.

43.

Hepatic autophagy is differentially regulated in periportal and pericentral zones - a general mechanism relevant for other tissues?

Gebhardt R, Coffer PJ.

Cell Commun Signal. 2013 Mar 26;11(1):21. doi: 10.1186/1478-811X-11-21.

44.

Signal inhibitory receptor on leukocytes-1 (SIRL-1) negatively regulates the oxidative burst in human phagocytes.

Steevels TA, van Avondt K, Westerlaken GH, Stalpers F, Walk J, Bont L, Coffer PJ, Meyaard L.

Eur J Immunol. 2013 May;43(5):1297-308. doi: 10.1002/eji.201242916. Epub 2013 Apr 9.

45.

Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor.

Zaiss DM, van Loosdregt J, Gorlani A, Bekker CP, Gröne A, Sibilia M, van Bergen en Henegouwen PM, Roovers RC, Coffer PJ, Sijts AJ.

Immunity. 2013 Feb 21;38(2):275-84. doi: 10.1016/j.immuni.2012.09.023. Epub 2013 Jan 17.

46.

The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity.

Tasdelen I, van Beekum O, Gorbenko O, Fleskens V, van den Broek NJ, Koppen A, Hamers N, Berger R, Coffer PJ, Brenkman AB, Kalkhoven E.

Biochem J. 2013 Apr 1;451(1):45-53. doi: 10.1042/BJ20121113.

PMID:
23320500
47.

SOX4 mediates TGF-β-induced expression of mesenchymal markers during mammary cell epithelial to mesenchymal transition.

Vervoort SJ, Lourenço AR, van Boxtel R, Coffer PJ.

PLoS One. 2013;8(1):e53238. doi: 10.1371/journal.pone.0053238. Epub 2013 Jan 3.

48.

The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe?

Vervoort SJ, van Boxtel R, Coffer PJ.

Oncogene. 2013 Jul 18;32(29):3397-409. doi: 10.1038/onc.2012.506. Epub 2012 Dec 17. Review.

PMID:
23246969
49.

Valproic acid treatment is associated with altered leukocyte subset development.

Bartels M, van Solinge WW, den Breeijen HJ, Bierings MB, Coffer PJ, Egberts TC.

J Clin Psychopharmacol. 2012 Dec;32(6):832-4. doi: 10.1097/JCP.0b013e318270e5e2.

PMID:
23131880
50.

PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function.

van de Laar L, van den Bosch A, Boonstra A, Binda RS, Buitenhuis M, Janssen HL, Coffer PJ, Woltman AM.

Blood. 2012 Dec 13;120(25):4982-91. doi: 10.1182/blood-2012-02-413229. Epub 2012 Oct 22.

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