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Items: 1 to 50 of 61

1.

Evaluation of automated malaria diagnosis using the Sysmex XN-30 analyser in a clinical setting.

Pillay E, Khodaiji S, Bezuidenhout BC, Litshie M, Coetzer TL.

Malar J. 2019 Jan 22;18(1):15. doi: 10.1186/s12936-019-2655-8.

2.

Structure-activity relationship studies and Plasmodium life cycle profiling identifies pan-active N-aryl-3-trifluoromethyl pyrido[1,2-a]benzimidazoles which are efficacious in an in vivo mouse model of malaria.

Mayoka G, Njoroge M, Okombo J, Gibhard L, Sanches-Vaz M, Fontinha D, Birkholtz LM, Reader J, van der Watt M, Coetzer TL, Lauterbach S, Churchyard A, Bezuidenhout B, Egan TJ, Yeates CL, Wittlin S, Prudêncio M, Chibale K.

J Med Chem. 2018 Dec 18. doi: 10.1021/acs.jmedchem.8b01769. [Epub ahead of print]

PMID:
30562027
3.

Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action.

Kumar M, Okombo J, Mambwe D, Taylor D, Lawrence N, Reader J, van der Watt M, Fontinha D, Sanches-Vaz M, Bezuidenhout BC, Lauterbach SB, Liebenberg D, Birkholtz LM, Coetzer TL, Prudêncio M, Egan TJ, Wittlin S, Chibale K.

ACS Infect Dis. 2019 Feb 8;5(2):303-315. doi: 10.1021/acsinfecdis.8b00272. Epub 2019 Jan 7.

PMID:
30525439
4.

Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".

Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Gonzàlez Cabrera D, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz LM, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibale K.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01941-18. doi: 10.1128/AAC.01941-18. Print 2018 Nov. No abstract available.

5.

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.

Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Cabrera DG, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz LM, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibale K.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00012-18. doi: 10.1128/AAC.00012-18. Print 2018 Sep. Erratum in: Antimicrob Agents Chemother. 2018 Oct 24;62(11):.

PMID:
29941635
6.

Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials.

van der Watt ME, Reader J, Churchyard A, Nondaba SH, Lauterbach SB, Niemand J, Abayomi S, van Biljon RA, Connacher JI, van Wyk RDJ, Le Manach C, Paquet T, González Cabrera D, Brunschwig C, Theron A, Lozano-Arias S, Rodrigues JFI, Herreros E, Leroy D, Duffy J, Street LJ, Chibale K, Mancama D, Coetzer TL, Birkholtz LM.

J Antimicrob Chemother. 2018 May 1;73(5):1279-1290. doi: 10.1093/jac/dky008.

PMID:
29420756
7.

Absence of Acanthocytosis in Huntington's Disease-like 2: A Prospective Comparison with Huntington's Disease.

Anderson DG, Carmona S, Naidoo K, Coetzer TL, Carr J, Rudnicki DD, Walker RH, Margolis RL, Krause A.

Tremor Other Hyperkinet Mov (N Y). 2017 Dec 5;7:512. doi: 10.7916/D81J9PDX. eCollection 2017.

8.

Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.

Singh K, Okombo J, Brunschwig C, Ndubi F, Barnard L, Wilkinson C, Njogu PM, Njoroge M, Laing L, Machado M, Prudêncio M, Reader J, Botha M, Nondaba S, Birkholtz LM, Lauterbach S, Churchyard A, Coetzer TL, Burrows JN, Yeates C, Denti P, Wiesner L, Egan TJ, Wittlin S, Chibale K.

J Med Chem. 2017 Feb 23;60(4):1432-1448. doi: 10.1021/acs.jmedchem.6b01641. Epub 2017 Feb 7.

PMID:
28094524
9.

Plasmodium falciparum exhibits markers of regulated cell death at high population density in vitro.

Engelbrecht D, Coetzer TL.

Parasitol Int. 2016 Dec;65(6 Pt A):715-727. doi: 10.1016/j.parint.2016.07.007. Epub 2016 Jul 15.

PMID:
27425600
10.

Discovering New Transmission-Blocking Antimalarial Compounds: Challenges and Opportunities.

Birkholtz LM, Coetzer TL, Mancama D, Leroy D, Alano P.

Trends Parasitol. 2016 Sep;32(9):669-681. doi: 10.1016/j.pt.2016.04.017. Epub 2016 May 18. Review.

PMID:
27209388
11.

Localization and interactions of Plasmodium falciparum SWIB/MDM2 homologues.

Vieira WA, Coetzer TL.

Malar J. 2016 Jan 20;15:32. doi: 10.1186/s12936-015-1065-9.

12.

A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines.

Le Manach C, Paquet T, Brunschwig C, Njoroge M, Han Z, Gonzàlez Cabrera D, Bashyam S, Dhinakaran R, Taylor D, Reader J, Botha M, Churchyard A, Lauterbach S, Coetzer TL, Birkholtz LM, Meister S, Winzeler EA, Waterson D, Witty MJ, Wittlin S, Jiménez-Díaz MB, Santos Martínez M, Ferrer S, Angulo-Barturen I, Street LJ, Chibale K.

J Med Chem. 2015 Nov 12;58(21):8713-22. doi: 10.1021/acs.jmedchem.5b01605. Epub 2015 Nov 2.

PMID:
26502160
13.

Sunlight inhibits growth and induces markers of programmed cell death in Plasmodium falciparum in vitro.

Engelbrecht D, Coetzer TL.

Malar J. 2015 Sep 29;14:378. doi: 10.1186/s12936-015-0867-0.

14.

Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination.

Reader J, Botha M, Theron A, Lauterbach SB, Rossouw C, Engelbrecht D, Wepener M, Smit A, Leroy D, Mancama D, Coetzer TL, Birkholtz LM.

Malar J. 2015 May 22;14:213. doi: 10.1186/s12936-015-0718-z.

15.

Intrinsic disorder within the erythrocyte binding-like proteins from Plasmodium falciparum.

Blanc M, Coetzer TL, Blackledge M, Haertlein M, Mitchell EP, Forsyth VT, Jensen MR.

Biochim Biophys Acta. 2014 Dec;1844(12):2306-14. doi: 10.1016/j.bbapap.2014.09.023. Epub 2014 Oct 5.

PMID:
25288451
16.

Turning up the heat: heat stress induces markers of programmed cell death in Plasmodium falciparum in vitro.

Engelbrecht D, Coetzer TL.

Cell Death Dis. 2013 Dec 19;4:e971. doi: 10.1038/cddis.2013.505.

17.

Novel exon 2 α spectrin mutation and intragenic crossover: three morphological phenotypes associated with four distinct α spectrin defects.

Swierczek S, Agarwal AM, Naidoo K, Lorenzo FR, Whisenant J, Nussenzveig RH, Agarwal N, Coetzer TL, Prchal JT.

Haematologica. 2013 Dec;98(12):1972-9. doi: 10.3324/haematol.2013.086629. Epub 2013 Sep 27.

18.

Reduced glycerol incorporation into phospholipids contributes to impaired intra-erythrocytic growth of glycerol kinase knockout Plasmodium falciparum parasites.

Naidoo K, Coetzer TL.

Biochim Biophys Acta. 2013 Nov;1830(11):5326-34. doi: 10.1016/j.bbagen.2013.08.006. Epub 2013 Aug 16.

PMID:
23954205
19.

The walking dead: is hydroethidine a suitable viability dye for intra-erythrocytic Plasmodium falciparum?

Engelbrecht D, Coetzer TL.

Parasitol Int. 2012 Dec;61(4):731-4. doi: 10.1016/j.parint.2012.07.002. Epub 2012 Jul 15.

PMID:
22809890
20.

On Programmed Cell Death in Plasmodium falciparum: Status Quo.

Engelbrecht D, Durand PM, Coetzer TL.

J Trop Med. 2012;2012:646534. doi: 10.1155/2012/646534. Epub 2012 Jan 12.

21.

Identification of a specific region of Plasmodium falciparum EBL-1 that binds to host receptor glycophorin B and inhibits merozoite invasion in human red blood cells.

Li X, Marinkovic M, Russo C, McKnight CJ, Coetzer TL, Chishti AH.

Mol Biochem Parasitol. 2012 May;183(1):23-31. doi: 10.1016/j.molbiopara.2012.01.002. Epub 2012 Jan 16.

22.

Evolutionary rates at codon sites may be used to align sequences and infer protein domain function.

Durand PM, Hazelhurst S, Coetzer TL.

BMC Bioinformatics. 2010 Mar 24;11:151. doi: 10.1186/1471-2105-11-151.

23.

Evolutionary patterning: a novel approach to the identification of potential drug target sites in Plasmodium falciparum.

Durand PM, Naidoo K, Coetzer TL.

PLoS One. 2008;3(11):e3685. doi: 10.1371/journal.pone.0003685. Epub 2008 Nov 10.

24.

Heterologous expression of plasmodial proteins for structural studies and functional annotation.

Birkholtz LM, Blatch G, Coetzer TL, Hoppe HC, Human E, Morris EJ, Ngcete Z, Oldfield L, Roth R, Shonhai A, Stephens L, Louw AI.

Malar J. 2008 Oct 1;7:197. doi: 10.1186/1475-2875-7-197. Review.

25.

Receptor-based identification of an inhibitory peptide against blood stage malaria.

Li X, Chen H, Khan AA, Lauterbach SB, Lanzillotti R, Rai PR, Kane RS, Coetzer TL, Chishti AH.

Biochem Biophys Res Commun. 2008 Nov 21;376(3):489-93. doi: 10.1016/j.bbrc.2008.09.011. Epub 2008 Sep 13.

26.

The M18 aspartyl aminopeptidase of Plasmodium falciparum binds to human erythrocyte spectrin in vitro.

Lauterbach SB, Coetzer TL.

Malar J. 2008 Aug 22;7:161. doi: 10.1186/1475-2875-7-161.

27.

Pyruvate kinase deficiency in a South African kindred caused by a 1529A mutation in the PK-LR gene.

Durand PM, Coetzer TL.

S Afr Med J. 2008 Jun;98(6):456-7. No abstract available.

PMID:
18683378
28.

Hereditary red cell disorders and malaria resistance.

Durand PM, Coetzer TL.

Haematologica. 2008 Jul;93(7):961-3. doi: 10.3324/haematol.13371. No abstract available.

29.

Pyruvate kinase deficiency protects against malaria in humans.

Durand PM, Coetzer TL.

Haematologica. 2008 Jun;93(6):939-40. doi: 10.3324/haematol.12450. Epub 2008 May 6. No abstract available.

30.
31.

Phage display: a useful tool for malaria research?

Lanzillotti R, Coetzer TL.

Trends Parasitol. 2008 Jan;24(1):18-23. Epub 2007 Nov 26.

PMID:
18037345
32.
34.

Idiopathic myelofibrosis without dacryocytes.

Chen GL, Liu E, Naidoo K, Popat U, Coetzer TL, Prchal JT.

Haematologica. 2006 Jun;91(6 Suppl):ECR29.

35.
36.
37.

Real-time quantitative PCR of telomere length.

Gil ME, Coetzer TL.

Mol Biotechnol. 2004 Jun;27(2):169-72.

PMID:
15208457
38.
39.

Automated detection of malaria-associated intraleucocytic haemozoin by Cell-Dyn CD4000 depolarization analysis.

Scott CS, van Zyl D, Ho E, Meyersfeld D, Ruivo L, Mendelow BV, Coetzer TL.

Clin Lab Haematol. 2003 Apr;25(2):77-86. Erratum in: Clin Lab Haematol. 2003 Jun;25(3):205-7.

PMID:
12641610
40.

Reverse slot blot for the verification of cDNAs identified through differential display.

Meyersfeld DR, Coetzer TL.

Biotechniques. 2003 Feb;34(2):270-2. No abstract available.

41.

Thrombocytopenia in patients with malaria: automated analysis of optical platelet counts and platelet clumps with the Cell Dyn CD4000 analyser.

Scott CS, Van Zyl D, Ho E, Ruivo L, Mendelow B, Coetzer TL.

Clin Lab Haematol. 2002 Oct;24(5):295-302.

PMID:
12358891
42.

Patterns of pseudo-reticulocytosis in malaria: fluorescent analysis with the Cell-Dyn CD4000.

Scott CS, Van Zyl D, Ho E, Ruivo L, Kunz D, Coetzer TL.

Clin Lab Haematol. 2002 Feb;24(1):15-20.

PMID:
11843893
43.

Band 3 Cape Town (E90K) causes severe hereditary spherocytosis in combination with band 3 Prague III.

Bracher NA, Lyons CA, Wessels G, Mansvelt E, Coetzer TL.

Br J Haematol. 2001 Jun;113(3):689-93.

PMID:
11380459
44.

Automated malaria detection

Mendelow BV, Coetzer TL.

Br J Haematol. 1999 Jul;106(1):257-8. No abstract available.

PMID:
10444325
45.

Automated malaria detection by depolarization of laser light.

Mendelow BV, Lyons C, Nhlangothi P, Tana M, Munster M, Wypkema E, Liebowitz L, Marshall L, Scott S, Coetzer TL.

Br J Haematol. 1999 Mar;104(3):499-503.

PMID:
10086786
46.

Reduced spectrin-ankyrin binding in a South African hereditary elliptocytosis kindred homozygous for spectrin St Claude.

Burke JP, Van Zyl D, Zail SS, Coetzer TL.

Blood. 1998 Oct 1;92(7):2591-2. No abstract available.

47.

Southeast Asian ovalocytosis in a South African kindred with hemolytic anemia.

Coetzer TL, Beeton L, van Zyl D, Field SP, Agherdien A, Smart E, Daniels GL.

Blood. 1996 Feb 15;87(4):1656-7. No abstract available.

48.

A TaqI polymorphism in the human erythroid beta spectrin gene.

Beeton L, Prchal JT, Coetzer TL.

Hum Genet. 1995 Mar;95(3):365-6.

PMID:
7868137
49.

A novel mobile element inserted in the alpha spectrin gene: spectrin dayton. A truncated alpha spectrin associated with hereditary elliptocytosis.

Hassoun H, Coetzer TL, Vassiliadis JN, Sahr KE, Maalouf GJ, Saad ST, Catanzariti L, Palek J.

J Clin Invest. 1994 Aug;94(2):643-8.

50.

Spectrin cagliari. an Ala-->Gly substitution in helix 1 of beta spectrin repeat 17 that severely disrupts the structure and self-association of the erythrocyte spectrin heterodimer.

Sahr KE, Coetzer TL, Moy LS, Derick LH, Chishti AH, Jarolim P, Lorenzo F, Miraglia del Giudice E, Iolascon A, Gallanello R, et al.

J Biol Chem. 1993 Oct 25;268(30):22656-62.

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