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Items: 1 to 50 of 224

1.

SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-κB Activation.

Kim ET, Roche KL, Kulej K, Spruce LA, Seeholzer SH, Coen DM, Diaz-Griffero F, Murphy EA, Weitzman MD.

Cell Rep. 2019 Jul 9;28(2):434-448.e6. doi: 10.1016/j.celrep.2019.06.027.

2.

Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity.

Patel CD, Backes IM, Taylor SA, Jiang Y, Marchant A, Pesola JM, Coen DM, Knipe DM, Ackerman ME, Leib DA.

Sci Transl Med. 2019 Apr 10;11(487). pii: eaau6039. doi: 10.1126/scitranslmed.aau6039.

PMID:
30971454
3.

Herpes Simplex Virus 1 Lytic Infection Blocks MicroRNA (miRNA) Biogenesis at the Stage of Nuclear Export of Pre-miRNAs.

Pan D, Li G, Morris-Love J, Qi S, Feng L, Mertens ME, Jurak I, Knipe DM, Coen DM.

MBio. 2019 Feb 12;10(1). pii: e02856-18. doi: 10.1128/mBio.02856-18.

4.

HSV-1 DNA polymerase 3'-5' exonuclease-deficient mutant D368A exhibits severely reduced viral DNA synthesis and polymerase expression.

Lawler JL, Coen DM.

J Gen Virol. 2018 Oct;99(10):1432-1437. doi: 10.1099/jgv.0.001138. Epub 2018 Sep 3.

PMID:
30176164
5.

CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection.

Lee JS, Raja P, Pan D, Pesola JM, Coen DM, Knipe DM.

MBio. 2018 Feb 6;9(1). pii: e02372-17. doi: 10.1128/mBio.02372-17.

6.

A Role for Myosin Va in Human Cytomegalovirus Nuclear Egress.

Wilkie AR, Sharma M, Pesola JM, Ericsson M, Fernandez R, Coen DM.

J Virol. 2018 Feb 26;92(6). pii: e01849-17. doi: 10.1128/JVI.01849-17. Print 2018 Mar 15.

7.

Herpes Simplex Virus 1 DNA Polymerase RNase H Activity Acts in a 3'-to-5' Direction and Is Dependent on the 3'-to-5' Exonuclease Active Site.

Lawler JL, Mukherjee P, Coen DM.

J Virol. 2018 Feb 12;92(5). pii: e01813-17. doi: 10.1128/JVI.01813-17. Print 2018 Mar 1.

8.

Viral Ubiquitin Ligase Stimulates Selective Host MicroRNA Expression by Targeting ZEB Transcriptional Repressors.

Lutz G, Jurak I, Kim ET, Kim JY, Hackenberg M, Leader A, Stoller ML, Fekete DM, Weitzman MD, Coen DM, Wilson AC.

Viruses. 2017 Aug 7;9(8). pii: E210. doi: 10.3390/v9080210.

9.

A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions.

Chen H, Coseno M, Ficarro SB, Mansueto MS, Komazin-Meredith G, Boissel S, Filman DJ, Marto JA, Hogle JM, Coen DM.

ACS Infect Dis. 2017 Feb 10;3(2):112-118. doi: 10.1021/acsinfecdis.6b00079. Epub 2016 Dec 6.

10.

Getting to and through the inner nuclear membrane during herpesvirus nuclear egress.

Lye MF, Wilkie AR, Filman DJ, Hogle JM, Coen DM.

Curr Opin Cell Biol. 2017 Jun;46:9-16. doi: 10.1016/j.ceb.2016.12.007. Epub 2017 Jan 10. Review.

11.

Mutations Inactivating Herpes Simplex Virus 1 MicroRNA miR-H2 Do Not Detectably Increase ICP0 Gene Expression in Infected Cultured Cells or Mouse Trigeminal Ganglia.

Pan D, Pesola JM, Li G, McCarron S, Coen DM.

J Virol. 2017 Jan 3;91(2). pii: e02001-16. doi: 10.1128/JVI.02001-16. Print 2017 Jan 15.

12.

A Role for Nuclear F-Actin Induction in Human Cytomegalovirus Nuclear Egress.

Wilkie AR, Lawler JL, Coen DM.

MBio. 2016 Aug 23;7(4). pii: e01254-16. doi: 10.1128/mBio.01254-16.

13.

Neuronal IFN signaling is dispensable for the establishment of HSV-1 latency.

Rosato PC, Katzenell S, Pesola JM, North B, Coen DM, Leib DA.

Virology. 2016 Oct;497:323-327. doi: 10.1016/j.virol.2016.06.016. Epub 2016 Aug 10.

14.

High-Throughput Small Interfering RNA Screening Identifies Phosphatidylinositol 3-Kinase Class II Alpha as Important for Production of Human Cytomegalovirus Virions.

Polachek WS, Moshrif HF, Franti M, Coen DM, Sreenu VB, Strang BL.

J Virol. 2016 Aug 26;90(18):8360-71. doi: 10.1128/JVI.01134-16. Print 2016 Sep 15.

15.

A Herpesviral Lytic Protein Regulates the Structure of Latent Viral Chromatin.

Raja P, Lee JS, Pan D, Pesola JM, Coen DM, Knipe DM.

MBio. 2016 May 17;7(3). pii: e00633-16. doi: 10.1128/mBio.00633-16.

16.

Potency and Stereoselectivity of Cyclopropavir Triphosphate Action on Human Cytomegalovirus DNA Polymerase.

Chen H, Li C, Zemlicka J, Gentry BG, Bowlin TL, Coen DM.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):4176-82. doi: 10.1128/AAC.00449-16. Print 2016 Jul.

17.

Preparation of the Human Cytomegalovirus Nuclear Egress Complex and Associated Proteins.

Sharma M, Kamil JP, Coen DM.

Methods Enzymol. 2016;569:517-26. doi: 10.1016/bs.mie.2015.08.020. Epub 2015 Sep 11.

18.

History and genomic sequence analysis of the herpes simplex virus 1 KOS and KOS1.1 sub-strains.

Colgrove RC, Liu X, Griffiths A, Raja P, Deluca NA, Newman RM, Coen DM, Knipe DM.

Virology. 2016 Jan;487:215-21. doi: 10.1016/j.virol.2015.09.026. Epub 2015 Nov 5. Review.

19.

Unexpected features and mechanism of heterodimer formation of a herpesvirus nuclear egress complex.

Lye MF, Sharma M, El Omari K, Filman DJ, Schuermann JP, Hogle JM, Coen DM.

EMBO J. 2015 Dec 2;34(23):2937-52. doi: 10.15252/embj.201592651. Epub 2015 Oct 28.

20.

Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication.

Leigh KE, Sharma M, Mansueto MS, Boeszoermenyi A, Filman DJ, Hogle JM, Wagner G, Coen DM, Arthanari H.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9010-5. doi: 10.1073/pnas.1511140112. Epub 2015 Jul 6.

21.

Mechanism of ganciclovir-induced chain termination revealed by resistant viral polymerase mutants with reduced exonuclease activity.

Chen H, Beardsley GP, Coen DM.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17462-7. doi: 10.1073/pnas.1405981111. Epub 2014 Nov 24.

22.

Human cytomegalovirus UL97 phosphorylates the viral nuclear egress complex.

Sharma M, Bender BJ, Kamil JP, Lye MF, Pesola JM, Reim NI, Hogle JM, Coen DM.

J Virol. 2015 Jan;89(1):523-34. doi: 10.1128/JVI.02426-14. Epub 2014 Oct 22.

23.

Dynamic and nucleolin-dependent localization of human cytomegalovirus UL84 to the periphery of viral replication compartments and nucleoli.

Bender BJ, Coen DM, Strang BL.

J Virol. 2014 Oct;88(20):11738-47. doi: 10.1128/JVI.01889-14. Epub 2014 Jul 30.

24.

HIV integrase inhibitors block replication of alpha-, beta-, and gammaherpesviruses.

Yan Z, Bryant KF, Gregory SM, Angelova M, Dreyfus DH, Zhao XZ, Coen DM, Burke TR Jr, Knipe DM.

MBio. 2014 Jul 1;5(4):e01318-14. doi: 10.1128/mBio.01318-14.

25.
26.

A neuron-specific host microRNA targets herpes simplex virus-1 ICP0 expression and promotes latency.

Pan D, Flores O, Umbach JL, Pesola JM, Bentley P, Rosato PC, Leib DA, Cullen BR, Coen DM.

Cell Host Microbe. 2014 Apr 9;15(4):446-56. doi: 10.1016/j.chom.2014.03.004.

27.

Roles of conserved residues within the pre-NH2-terminal domain of herpes simplex virus 1 DNA polymerase in replication and latency in mice.

Terrell SL, Pesola JM, Coen DM.

J Gen Virol. 2014 Apr;95(Pt 4):940-7. doi: 10.1099/vir.0.061903-0. Epub 2014 Jan 10.

28.

Expression of herpes simplex virus 1 microRNAs in cell culture models of quiescent and latent infection.

Jurak I, Hackenberg M, Kim JY, Pesola JM, Everett RD, Preston CM, Wilson AC, Coen DM.

J Virol. 2014 Feb;88(4):2337-9. doi: 10.1128/JVI.03486-13. Epub 2013 Dec 4.

29.

Human cytomegalovirus UL50 and UL53 recruit viral protein kinase UL97, not protein kinase C, for disruption of nuclear lamina and nuclear egress in infected cells.

Sharma M, Kamil JP, Coughlin M, Reim NI, Coen DM.

J Virol. 2014 Jan;88(1):249-62. doi: 10.1128/JVI.02358-13. Epub 2013 Oct 23.

30.

Common and new acyclovir resistant herpes simplex virus-1 mutants causing bilateral recurrent herpetic keratitis in an immunocompetent patient.

Pan D, Kaye SB, Hopkins M, Kirwan R, Hart IJ, Coen DM.

J Infect Dis. 2014 Feb 1;209(3):345-9. doi: 10.1093/infdis/jit437. Epub 2013 Aug 14.

31.

Inactivation of retinoblastoma protein does not overcome the requirement for human cytomegalovirus UL97 in lamina disruption and nuclear egress.

Reim NI, Kamil JP, Wang D, Lin A, Sharma M, Ericsson M, Pesola JM, Golan DE, Coen DM.

J Virol. 2013 May;87(9):5019-27. doi: 10.1128/JVI.00007-13. Epub 2013 Feb 20.

32.
33.

Herpes simplex viruses: mechanisms of DNA replication.

Weller SK, Coen DM.

Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a013011. doi: 10.1101/cshperspect.a013011. Review.

34.

Net -1 frameshifting on a noncanonical sequence in a herpes simplex virus drug-resistant mutant is stimulated by nonstop mRNA.

Pan D, Coen DM.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14852-7. doi: 10.1073/pnas.1206582109. Epub 2012 Aug 27.

36.

A mutation deleting sequences encoding the amino terminus of human cytomegalovirus UL84 impairs interaction with UL44 and capsid localization.

Strang BL, Bender BJ, Sharma M, Pesola JM, Sanders RL, Spector DH, Coen DM.

J Virol. 2012 Oct;86(20):11066-77. Epub 2012 Aug 1.

37.

Herpes simplex virus is equipped with RNA- and protein-based mechanisms to repress expression of ATRX, an effector of intrinsic immunity.

Jurak I, Silverstein LB, Sharma M, Coen DM.

J Virol. 2012 Sep;86(18):10093-102. doi: 10.1128/JVI.00930-12. Epub 2012 Jul 11.

38.

Antiviral drugs and antiviral drug resistance.

Coen DM, Whitley RJ.

Curr Opin Virol. 2011 Dec;1(6):545-7. doi: 10.1016/j.coviro.2011.10.024. Epub 2011 Nov 15. No abstract available.

39.

Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments.

Strang BL, Boulant S, Kirchhausen T, Coen DM.

MBio. 2012 Feb 7;3(1). pii: e00301-11. doi: 10.1128/mBio.00301-11. Print 2012.

40.
41.

Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis.

Strang BL, Boulant S, Chang L, Knipe DM, Kirchhausen T, Coen DM.

J Virol. 2012 Feb;86(4):2089-95. doi: 10.1128/JVI.06720-11. Epub 2011 Dec 7.

42.

Sites and roles of phosphorylation of the human cytomegalovirus DNA polymerase subunit UL44.

Silva LA, Strang BL, Lin EW, Kamil JP, Coen DM.

Virology. 2011 Sep 1;417(2):268-80. doi: 10.1016/j.virol.2011.06.008. Epub 2011 Jul 23.

43.

Herpes simplex virus 1 microRNAs expressed abundantly during latent infection are not essential for latency in mouse trigeminal ganglia.

Kramer MF, Jurak I, Pesola JM, Boissel S, Knipe DM, Coen DM.

Virology. 2011 Sep 1;417(2):239-47. doi: 10.1016/j.virol.2011.06.027. Epub 2011 Jul 23.

44.

Mammalian alphaherpesvirus miRNAs.

Jurak I, Griffiths A, Coen DM.

Biochim Biophys Acta. 2011 Nov-Dec;1809(11-12):641-53. doi: 10.1016/j.bbagrm.2011.06.010. Epub 2011 Jun 28. Review.

45.

HATs on for drug resistance.

Kamil JP, Coen DM.

Cell Host Microbe. 2011 Feb 17;9(2):85-7. doi: 10.1016/j.chom.2011.02.001.

46.

The carboxy-terminal segment of the human cytomegalovirus DNA polymerase accessory subunit UL44 is crucial for viral replication.

Silva LA, Loregian A, Pari GS, Strang BL, Coen DM.

J Virol. 2010 Nov;84(21):11563-8. doi: 10.1128/JVI.01033-10. Epub 2010 Aug 25.

48.

Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir.

Gentry BG, Kamil JP, Coen DM, Zemlicka J, Drach JC.

Antimicrob Agents Chemother. 2010 Aug;54(8):3093-8. doi: 10.1128/AAC.00468-10. Epub 2010 Jun 14.

49.

Association of human cytomegalovirus proteins IRS1 and TRS1 with the viral DNA polymerase accessory subunit UL44.

Strang BL, Geballe AP, Coen DM.

J Gen Virol. 2010 Sep;91(Pt 9):2167-75. doi: 10.1099/vir.0.022640-0. Epub 2010 May 5.

50.

Interaction of the human cytomegalovirus uracil DNA glycosylase UL114 with the viral DNA polymerase catalytic subunit UL54.

Strang BL, Coen DM.

J Gen Virol. 2010 Aug;91(Pt 8):2029-33. doi: 10.1099/vir.0.022160-0. Epub 2010 Apr 21.

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