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Items: 27


Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia.

Vaz RL, Chapela D, Coelho JE, Lopes LV, Ferreira JJ, Afonso ND, Sousa S, Outeiro TF.

Neuroscience. 2019 Nov 1. pii: S0306-4522(19)30628-1. doi: 10.1016/j.neuroscience.2019.08.046. [Epub ahead of print]


Meningeal γδ T cell-derived IL-17 controls synaptic plasticity and short-term memory.

Ribeiro M, Brigas HC, Temido-Ferreira M, Pousinha PA, Regen T, Santa C, Coelho JE, Marques-Morgado I, Valente CA, Omenetti S, Stockinger B, Waisman A, Manadas B, Lopes LV, Silva-Santos B, Ribot JC.

Sci Immunol. 2019 Oct 11;4(40). pii: eaay5199. doi: 10.1126/sciimmunol.aay5199.


Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor.

Carvalho K, Faivre E, Pietrowski MJ, Marques X, Gomez-Murcia V, Deleau A, Huin V, Hansen JN, Kozlov S, Danis C, Temido-Ferreira M, Coelho JE, Mériaux C, Eddarkaoui S, Gras SL, Dumoulin M, Cellai L; NeuroCEB Brain Bank, Landrieu I, Chern Y, Hamdane M, Buée L, Boutillier AL, Levi S, Halle A, Lopes LV, Blum D.

Brain. 2019 Nov 1;142(11):3636-3654. doi: 10.1093/brain/awz288.


Novel Players in the Aging Synapse: Impact on Cognition.

Temido-Ferreira M, Coelho JE, Pousinha PA, Lopes LV.

J Caffeine Adenosine Res. 2019 Sep 1;9(3):104-127. doi: 10.1089/caff.2019.0013. Epub 2019 Sep 17. Review.


Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions.

Canas PM, Porciúncula LO, Simões AP, Augusto E, Silva HB, Machado NJ, Gonçalves N, Alfaro TM, Gonçalves FQ, Araújo IM, Real JI, Coelho JE, Andrade GM, Almeida RD, Chen JF, Köfalvi A, Agostinho P, Cunha RA.

eNeuro. 2018 Dec 26;5(6). pii: ENEURO.0385-18.2018. doi: 10.1523/ENEURO.0385-18.2018. eCollection 2018 Nov-Dec.


Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease.

Faivre E, Coelho JE, Zornbach K, Malik E, Baqi Y, Schneider M, Cellai L, Carvalho K, Sebda S, Figeac M, Eddarkaoui S, Caillierez R, Chern Y, Heneka M, Sergeant N, Müller CE, Halle A, Buée L, Lopes LV, Blum D.

Front Mol Neurosci. 2018 Jul 12;11:235. doi: 10.3389/fnmol.2018.00235. eCollection 2018.


Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors.

Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE, Pereira P, Gomes R, Pinto A, Carvalho S, Canas PM, Cuvelier L, Buée-Scherrer V, Faivre E, Baqi Y, Müller CE, Pimentel J, Schiffmann SN, Buée L, Bader M, Outeiro TF, Blum D, Cunha RA, Marie H, Pousinha PA, Lopes LV.

Mol Psychiatry. 2018 Jun 27. doi: 10.1038/s41380-018-0110-9. [Epub ahead of print]


α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B.

Ferreira DG, Temido-Ferreira M, Vicente Miranda H, Batalha VL, Coelho JE, Szegö ÉM, Marques-Morgado I, Vaz SH, Rhee JS, Schmitz M, Zerr I, Lopes LV, Outeiro TF.

Nat Neurosci. 2017 Nov;20(11):1569-1579. doi: 10.1038/nn.4648. Epub 2017 Sep 25.


Chronic and acute adenosine A2A receptor blockade prevents long-term episodic memory disruption caused by acute cannabinoid CB1 receptor activation.

Mouro FM, Batalha VL, Ferreira DG, Coelho JE, Baqi Y, Müller CE, Lopes LV, Ribeiro JA, Sebastião AM.

Neuropharmacology. 2017 May 1;117:316-327. doi: 10.1016/j.neuropharm.2017.02.021. Epub 2017 Feb 21.


Mutant A53T α-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways.

Guerreiro PS, Coelho JE, Sousa-Lima I, Macedo P, Lopes LV, Outeiro TF, Pais TF.

Neuromolecular Med. 2017 Mar;19(1):113-121. doi: 10.1007/s12017-016-8435-5. Epub 2016 Aug 17.


The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.

Batalha VL, Ferreira DG, Coelho JE, Valadas JS, Gomes R, Temido-Ferreira M, Shmidt T, Baqi Y, Buée L, Müller CE, Hamdane M, Outeiro TF, Bader M, Meijsing SH, Sadri-Vakili G, Blum D, Lopes LV.

Sci Rep. 2016 Aug 11;6:31493. doi: 10.1038/srep31493.


Adenosine A2A Receptors Modulate α-Synuclein Aggregation and Toxicity.

Ferreira DG, Batalha VL, Vicente Miranda H, Coelho JE, Gomes R, Gonçalves FQ, Real JI, Rino J, Albino-Teixeira A, Cunha RA, Outeiro TF, Lopes LV.

Cereb Cortex. 2017 Jan 1;27(1):718-730. doi: 10.1093/cercor/bhv268.


A2A adenosine receptor deletion is protective in a mouse model of Tauopathy.

Laurent C, Burnouf S, Ferry B, Batalha VL, Coelho JE, Baqi Y, Malik E, Marciniak E, Parrot S, Van der Jeugd A, Faivre E, Flaten V, Ledent C, D'Hooge R, Sergeant N, Hamdane M, Humez S, Müller CE, Lopes LV, Buée L, Blum D.

Mol Psychiatry. 2016 Jan;21(1):149. doi: 10.1038/mp.2015.115. Epub 2015 Jul 28. No abstract available.


Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains.

Bai G, Cheung I, Shulha HP, Coelho JE, Li P, Dong X, Jakovcevski M, Wang Y, Grigorenko A, Jiang Y, Hoss A, Patel K, Zheng M, Rogaev E, Myers RH, Weng Z, Akbarian S, Chen JF.

Hum Mol Genet. 2015 Mar 1;24(5):1441-56. doi: 10.1093/hmg/ddu561. Epub 2014 Dec 5.


A2A adenosine receptor deletion is protective in a mouse model of Tauopathy.

Laurent C, Burnouf S, Ferry B, Batalha VL, Coelho JE, Baqi Y, Malik E, Mariciniak E, Parrot S, Van der Jeugd A, Faivre E, Flaten V, Ledent C, D'Hooge R, Sergeant N, Hamdane M, Humez S, Müller CE, Lopes LV, Buée L, Blum D.

Mol Psychiatry. 2016 Jan;21(1):97-107. doi: 10.1038/mp.2014.151. Epub 2014 Dec 2. Erratum in: Mol Psychiatry. 2016 Jan;21(1):149. Mariciniak, E [Corrected to Marciniak, E].


Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety.

Coelho JE, Alves P, Canas PM, Valadas JS, Shmidt T, Batalha VL, Ferreira DG, Ribeiro JA, Bader M, Cunha RA, do Couto FS, Lopes LV.

Front Psychiatry. 2014 Jun 13;5:67. doi: 10.3389/fpsyt.2014.00067. eCollection 2014.


From epidemiology to pathophysiology: what about caffeine in Alzheimer's disease?

Flaten V, Laurent C, Coelho JE, Sandau U, Batalha VL, Burnouf S, Hamdane M, Humez S, Boison D, Lopes LV, Buée L, Blum D.

Biochem Soc Trans. 2014 Apr;42(2):587-92. doi: 10.1042/BST20130229. Review.


Neuroprotection afforded by adenosine A2A receptor blockade is modulated by corticotrophin-releasing factor (CRF) in glutamate injured cortical neurons.

Valadas JS, Batalha VL, Ferreira DG, Gomes R, Coelho JE, Sebastião AM, Diógenes MJ, Lopes LV.

J Neurochem. 2012 Dec;123(6):1030-40. doi: 10.1111/jnc.12050. Epub 2012 Nov 1.


Uncovering multiple molecular targets for caffeine using a drug target validation strategy combining A 2A receptor knockout mice with microarray profiling.

Yu L, Coelho JE, Zhang X, Fu Y, Tillman A, Karaoz U, Fredholm BB, Weng Z, Chen JF.

Physiol Genomics. 2009 May 13;37(3):199-210. doi: 10.1152/physiolgenomics.90353.2008. Epub 2009 Mar 3.


A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs.

Shen HY, Coelho JE, Ohtsuka N, Canas PM, Day YJ, Huang QY, Rebola N, Yu L, Boison D, Cunha RA, Linden J, Tsien JZ, Chen JF.

J Neurosci. 2008 Mar 19;28(12):2970-5. doi: 10.1523/JNEUROSCI.5255-07.2008.


Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms.

Yu L, Shen HY, Coelho JE, Araújo IM, Huang QY, Day YJ, Rebola N, Canas PM, Rapp EK, Ferrara J, Taylor D, Müller CE, Linden J, Cunha RA, Chen JF.

Ann Neurol. 2008 Mar;63(3):338-46. doi: 10.1002/ana.21313.


Hypoxia-induced desensitization and internalization of adenosine A1 receptors in the rat hippocampus.

Coelho JE, Rebola N, Fragata I, Ribeiro JA, de Mendonça A, Cunha RA.

Neuroscience. 2006;138(4):1195-203. Epub 2006 Jan 25.


Decrease of adenosine A1 receptor density and of adenosine neuromodulation in the hippocampus of kindled rats.

Rebola N, Coelho JE, Costenla AR, Lopes LV, Parada A, Oliveira CR, Soares-da-Silva P, de Mendonça A, Cunha RA.

Eur J Neurosci. 2003 Aug;18(4):820-8.


Effects of carbamazepine and novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives on synaptic transmission in rat hippocampal slices.

Cunha RA, Coelho JE, Costenla AR, Lopes LV, Parada A, de Mendonça A, Sebastião AM, Ribeiro JA.

Pharmacol Toxicol. 2002 Apr;90(4):208-13.


Presynaptic inhibitory receptors mediate the depression of synaptic transmission upon hypoxia in rat hippocampal slices.

Coelho JE, de Mendonça A, Ribeiro JA.

Brain Res. 2000 Jun 30;869(1-2):158-65.


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