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Items: 27

1.

Design considerations for chiral frustrated Lewis pairs: B/N FLPs derived from 3,5-bicyclic aryl piperidines.

Lam J, Sampaolesi S, LaFortune JHW, Coe JW, Stephan DW.

Dalton Trans. 2018 Dec 18;48(1):133-141. doi: 10.1039/c8dt04070b.

PMID:
30484790
2.

Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors.

Casimiro-Garcia A, Trujillo JI, Vajdos F, Juba B, Banker ME, Aulabaugh A, Balbo P, Bauman J, Chrencik J, Coe JW, Czerwinski R, Dowty M, Knafels JD, Kwon S, Leung L, Liang S, Robinson RP, Telliez JB, Unwalla R, Yang X, Thorarensen A.

J Med Chem. 2018 Dec 13;61(23):10665-10699. doi: 10.1021/acs.jmedchem.8b01308. Epub 2018 Nov 30.

PMID:
30423248
3.

Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.

Jones P, Storer RI, Sabnis YA, Wakenhut FM, Whitlock GA, England KS, Mukaiyama T, Dehnhardt CM, Coe JW, Kortum SW, Chrencik JE, Brown DG, Jones RM, Murphy JR, Yeoh T, Morgan P, Kilty I.

J Med Chem. 2017 Jan 26;60(2):767-786. doi: 10.1021/acs.jmedchem.6b01634. Epub 2017 Jan 4.

PMID:
27983835
4.

Access to Highly Substituted 7-Azaindoles from 2-Fluoropyridines via 7-Azaindoline Intermediates.

Nuhant P, Allais C, Chen MZ, Coe JW, Dermenci A, Fadeyi OO, Flick AC, Mousseau JJ.

Org Lett. 2015 Sep 4;17(17):4292-5. doi: 10.1021/acs.orglett.5b02098. Epub 2015 Aug 20.

PMID:
26290951
5.

Direct activation of relatively unstrained carbon-carbon bonds in homogeneous systems.

Dermenci A, Coe JW, Dong G.

Org Chem Front. 2014 Jul 1;1(5):567-581. doi: 10.1039/c4qo00053f. Epub 2014 Mar 27.

6.

Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice.

Pryde DC, Jones LH, Gervais DP, Stead DR, Blakemore DC, Selby MD, Brown AD, Coe JW, Badland M, Beal DM, Glen R, Wharton Y, Miller GJ, White P, Zhang N, Benoit M, Robertson K, Merson JR, Davis HL, McCluskie MJ.

PLoS One. 2013 Oct 1;8(10):e76557. doi: 10.1371/journal.pone.0076557. eCollection 2013.

7.

Access to 7β-analogs of codeine with mixed μ/δ agonist activity via 6,7-α-epoxide opening.

Magnus P, Ghavimi B, Coe JW.

Bioorg Med Chem Lett. 2013 Sep 1;23(17):4870-4. doi: 10.1016/j.bmcl.2013.06.084. Epub 2013 Jul 4.

PMID:
23880538
8.

α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties.

Mineur YS, Einstein EB, Seymour PA, Coe JW, O'neill BT, Rollema H, Picciotto MR.

Behav Pharmacol. 2011 Aug;22(4):291-9. doi: 10.1097/FBP.0b013e328347546d.

9.

Partial agonists of the α3β4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats.

Chatterjee S, Steensland P, Simms JA, Holgate J, Coe JW, Hurst RS, Shaffer CL, Lowe J, Rollema H, Bartlett SE.

Neuropsychopharmacology. 2011 Feb;36(3):603-15. doi: 10.1038/npp.2010.191. Epub 2010 Nov 3.

10.

A novel series of [3.2.1] azabicyclic biaryl ethers as alpha3beta4 and alpha6/4beta4 nicotinic receptor agonists.

Lowe JA 3rd, DeNinno SL, Coe JW, Zhang L, Mente S, Hurst RS, Mather RJ, Ward KM, Shrikhande A, Rollema H, Johnson DE, Horner W, Gorczyca R, Tingley FD 3rd, Kozak R, Majchrzak MJ, Tritto T, Sadlier J, Shaffer CL, Ellerbrock B, Osgood SM, MacDougall MC, McDowell LL.

Bioorg Med Chem Lett. 2010 Aug 15;20(16):4749-52. doi: 10.1016/j.bmcl.2010.06.142.

PMID:
20663668
11.

Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence.

Rollema H, Shrikhande A, Ward KM, Tingley FD 3rd, Coe JW, O'Neill BT, Tseng E, Wang EQ, Mather RJ, Hurst RS, Williams KE, de Vries M, Cremers T, Bertrand S, Bertrand D.

Br J Pharmacol. 2010 May;160(2):334-45. doi: 10.1111/j.1476-5381.2010.00682.x. Epub 2010 Mar 22.

12.

Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.

O'Donnell CJ, Rogers BN, Bronk BS, Bryce DK, Coe JW, Cook KK, Duplantier AJ, Evrard E, Hajós M, Hoffmann WE, Hurst RS, Maklad N, Mather RJ, McLean S, Nedza FM, O'Neill BT, Peng L, Qian W, Rottas MM, Sands SB, Schmidt AW, Shrikhande AV, Spracklin DK, Wong DF, Zhang A, Zhang L.

J Med Chem. 2010 Feb 11;53(3):1222-37. doi: 10.1021/jm9015075.

PMID:
20043678
13.

Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect.

Rollema H, Guanowsky V, Mineur YS, Shrikhande A, Coe JW, Seymour PA, Picciotto MR.

Eur J Pharmacol. 2009 Mar 1;605(1-3):114-6. doi: 10.1016/j.ejphar.2009.01.002. Epub 2009 Jan 10.

14.

Structural and rate studies of the formation of substituted benzynes.

Riggs JC, Ramirez A, Cremeens ME, Bashore CG, Candler J, Wirtz MC, Coe JW, Collum DB.

J Am Chem Soc. 2008 Mar 19;130(11):3406-12. doi: 10.1021/ja0754655. Epub 2008 Feb 23.

PMID:
18293971
15.

Rationale, pharmacology and clinical efficacy of partial agonists of alpha4beta2 nACh receptors for smoking cessation.

Rollema H, Coe JW, Chambers LK, Hurst RS, Stahl SM, Williams KE.

Trends Pharmacol Sci. 2007 Jul;28(7):316-25. Epub 2007 Jun 18. Review.

PMID:
17573127
16.

Varenicline: new treatment with efficacy in smoking cessation.

Reus VI, Obach RS, Coe JW, Faessel H, Rollema H, Watsky E, Reeves K.

Drugs Today (Barc). 2007 Feb;43(2):65-75. Review.

PMID:
17353944
17.

Enantioselective synthesis of nicotinic receptor probe 7,8-difluoro-1,2,3,4,5,6- hexahydro-1,5-methano-3-benzazocine.

Bashore CG, Vetelino MG, Wirtz MC, Brooks PR, Frost HN, McDermott RE, Whritenour DC, Ragan JA, Rutherford JL, Makowski TW, Brenek SJ, Coe JW.

Org Lett. 2006 Dec 21;8(26):5947-50.

PMID:
17165901
18.

Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid.

Rollema H, Chambers LK, Coe JW, Glowa J, Hurst RS, Lebel LA, Lu Y, Mansbach RS, Mather RJ, Rovetti CC, Sands SB, Schaeffer E, Schulz DW, Tingley FD 3rd, Williams KE.

Neuropharmacology. 2007 Mar;52(3):985-94. Epub 2006 Dec 8.

PMID:
17157884
19.

Metabolism and disposition of varenicline, a selective alpha4beta2 acetylcholine receptor partial agonist, in vivo and in vitro.

Obach RS, Reed-Hagen AE, Krueger SS, Obach BJ, O'Connell TN, Zandi KS, Miller S, Coe JW.

Drug Metab Dispos. 2006 Jan;34(1):121-30. Epub 2005 Oct 12.

PMID:
16221753
20.

3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation.

Coe JW, Brooks PR, Wirtz MC, Bashore CG, Bianco KE, Vetelino MG, Arnold EP, Lebel LA, Fox CB, Tingley FD 3rd, Schulz DW, Davis TI, Sands SB, Mansbach RS, Rollema H, O'Neill BT.

Bioorg Med Chem Lett. 2005 Nov 15;15(22):4889-97.

PMID:
16171993
21.

In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine.

Coe JW, Vetelino MG, Bashore CG, Wirtz MC, Brooks PR, Arnold EP, Lebel LA, Fox CB, Sands SB, Davis TI, Schulz DW, Rollema H, Tingley FD 3rd, O'Neill BT.

Bioorg Med Chem Lett. 2005 Jun 15;15(12):2974-9.

PMID:
15908213
22.

Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation.

Coe JW, Brooks PR, Vetelino MG, Wirtz MC, Arnold EP, Huang J, Sands SB, Davis TI, Lebel LA, Fox CB, Shrikhande A, Heym JH, Schaeffer E, Rollema H, Lu Y, Mansbach RS, Chambers LK, Rovetti CC, Schulz DW, Tingley FD 3rd, O'Neill BT.

J Med Chem. 2005 May 19;48(10):3474-7.

PMID:
15887955
23.

Formation of benzynes from 2,6-dihaloaryllithiums: mechanistic basis of the regioselectivity.

Ramírez A, Candler J, Bashore CG, Wirtz MC, Coe JW, Collum DB.

J Am Chem Soc. 2004 Nov 17;126(45):14700-1.

PMID:
15535677
24.

Formation of 3-halobenzyne: solvent effects and cycloaddition adducts.

Coe JW, Wirtz MC, Bashore CG, Candler J.

Org Lett. 2004 May 13;6(10):1589-92.

PMID:
15128243
25.

Unexpected migration and oxidative cyclization of substituted 2-acetophenone triflates under basic conditions: synthetic and mechanistic insights.

Coe JW, Bianco KE, Boscoe BP, Brooks PR, Cox ED, Vetelino MG.

J Org Chem. 2003 Dec 26;68(26):9964-70.

PMID:
14682689
26.

Twisted amide reduction under Wolff-Kishner conditions: synthesis of a benzo-1-aza-adamantane derivative.

Bashore CG, Samardjiev IJ, Bordner J, Coe JW.

J Am Chem Soc. 2003 Mar 19;125(11):3268-72.

PMID:
12630882

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