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Items: 1 to 50 of 69

1.

Pharmacokinetics, Safety, and Tolerability of Oxfendazole in Healthy Volunteers: a Randomized, Placebo-Controlled First-in-Human Single-Dose Escalation Study.

An G, Murry DJ, Gajurel K, Bach T, Deye G, Stebounova LV, Codd EE, Horton J, Gonzalez AE, Garcia HH, Ince D, Hodgson-Zingman D, Nomicos EYH, Conrad T, Kennedy J, Jones W, Gilman RH, Winokur P.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02255-18. doi: 10.1128/AAC.02255-18. Print 2019 Apr.

2.

Oxfendazole: a promising agent for the treatment and control of helminth infections in humans.

Gonzalez AE, Codd EE, Horton J, Garcia HH, Gilman RH.

Expert Rev Anti Infect Ther. 2019 Jan;17(1):51-56. doi: 10.1080/14787210.2018.1555241. Epub 2018 Dec 10. Review.

3.

Preclinical studies on the pharmacokinetics, safety, and toxicology of oxfendazole: toward first in human studies.

Codd EE, Ng HH, McFarlane C, Riccio ES, Doppalapudi R, Mirsalis JC, Horton RJ, Gonzalez AE, Garcia HH, Gilman RH; Cysticercosis Working Group in Peru.

Int J Toxicol. 2015 Mar-Apr;34(2):129-37. doi: 10.1177/1091581815569582. Epub 2015 Feb 20.

4.

Dynamic mass redistribution as a means to measure and differentiate signaling via opioid and cannabinoid receptors.

Codd EE, Mabus JR, Murray BS, Zhang SP, Flores CM.

Assay Drug Dev Technol. 2011 Aug;9(4):362-72. doi: 10.1089/adt.2010.0347. Epub 2011 Feb 16.

PMID:
21323580
5.

Diabetogenic effect of a series of tricyclic delta opioid agonists structurally related to cyproheptadine.

Codd EE, Baker J, Brandt MR, Bryant S, Cai C, Carson JR, Chevalier KM, Colburn RW, Coogan TP, Dax SL, Decorte B, Kemmerer M, Legrand EK, Lenhard JM, Leone AM, Lin L, Mabus JR, McDonnell ME, McMillian MK, McNally JJ, Stone DJ Jr, Wang CY, Zhang SP, Flores CM.

Toxicol Sci. 2010 Oct;117(2):493-504. doi: 10.1093/toxsci/kfq200. Epub 2010 Jul 8.

PMID:
20616206
6.

Ex vivo delta opioid receptor autoradiography: CNS receptor occupancy of two novel compounds over their antihyperalgesic dose range.

Codd EE, Ma J, Zhang SP, Stone DJ Jr, Colburn RW, Brandt MR, Chevalier KM, Zhu Y, Peng S, Cai C, Acton PD, Flores CM.

Pharmacol Biochem Behav. 2010 Aug;96(2):130-5. doi: 10.1016/j.pbb.2010.04.020. Epub 2010 May 12.

PMID:
20438745
7.

JNJ-20788560 [9-(8-azabicyclo[3.2.1]oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide], a selective delta opioid receptor agonist, is a potent and efficacious antihyperalgesic agent that does not produce respiratory depression, pharmacologic tolerance, or physical dependence.

Codd EE, Carson JR, Colburn RW, Stone DJ, Van Besien CR, Zhang SP, Wade PR, Gallantine EL, Meert TF, Molino L, Pullan S, Razler CM, Dax SL, Flores CM.

J Pharmacol Exp Ther. 2009 Apr;329(1):241-51. doi: 10.1124/jpet.108.146969. Epub 2009 Jan 16.

PMID:
19151246
8.

N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1).

Jetter MC, McNally JJ, Youngman MA, McDonnell ME, Dubin AE, Nasser N, Zhang SP, Codd EE, Colburn RW, Stone DR, Brandt MR, Flores CM, Dax SL.

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. doi: 10.1016/j.bmcl.2008.02.075. Epub 2008 Mar 5. Erratum in: Bioorg Med Chem Lett. 2008 Jul 15;18(14):4254.

PMID:
18359227
9.

Heteroaryl beta-tetralin ureas as novel antagonists of human TRPV1.

Jetter MC, Youngman MA, McNally JJ, McDonnell ME, Zhang SP, Dubin AE, Nasser N, Codd EE, Flores CM, Dax SL.

Bioorg Med Chem Lett. 2007 Nov 15;17(22):6160-3. Epub 2007 Sep 12.

PMID:
17892935
10.

Tramadol and several anticonvulsants synergize in attenuating nerve injury-induced allodynia.

Codd EE, Martinez RP, Molino L, Rogers KE, Stone DJ, Tallarida RJ.

Pain. 2008 Feb;134(3):254-62. Epub 2007 May 25.

PMID:
17532139
11.

High-throughput screening for N-type calcium channel blockers using a scintillation proximity assay.

Zhang SP, Kauffman J, Yagel SK, Codd EE.

J Biomol Screen. 2006 Sep;11(6):672-7. Epub 2006 Jul 10.

PMID:
16831862
12.

Metabolism of two analgesic agents, tramadol-n-oxide and tramadol, in specific pathogen-free and axenic mice.

Wu WN, McKown LA, Codd EE, Raffa RB.

Xenobiotica. 2006 Jun;36(6):551-65.

PMID:
16769648
13.

The novel, orally active, delta opioid RWJ-394674 is biotransformed to the potent mu opioid RWJ-413216.

Codd EE, Carson JR, Colburn RW, Dax SL, Desai-Krieger D, Martinez RP, McKown LA, Neilson LA, Pitis PM, Stahle PL, Stone DJ, Streeter AJ, Wu WN, Zhang SP.

J Pharmacol Exp Ther. 2006 Sep;318(3):1273-9. Epub 2006 Jun 9.

PMID:
16766719
14.

Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.

Swanson DM, Dubin AE, Shah C, Nasser N, Chang L, Dax SL, Jetter M, Breitenbucher JG, Liu C, Mazur C, Lord B, Gonzales L, Hoey K, Rizzolio M, Bogenstaetter M, Codd EE, Lee DH, Zhang SP, Chaplan SR, Carruthers NI.

J Med Chem. 2005 Mar 24;48(6):1857-72.

PMID:
15771431
15.

Parallel methods for the preparation and SAR exploration of N-ethyl-4-[(8-alkyl-8-aza-bicyclo[3.2.1]oct-3-ylidene)-aryl-methyl]-benzamides, powerful mu and delta opioid agonists.

Coats SJ, Schulz MJ, Carson JR, Codd EE, Hlasta DJ, Pitis PM, Stone DJ Jr, Zhang SP, Colburn RW, Dax SL.

Bioorg Med Chem Lett. 2004 Nov 15;14(22):5493-8.

PMID:
15482911
16.

N-alkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, micro and delta opioid agonists: a micro address.

Carson JR, Coats SJ, Codd EE, Dax SL, Lee J, Martinez RP, McKown LA, Anne Neilson L, Pitis PM, Wu WN, Zhang SP.

Bioorg Med Chem Lett. 2004 May 3;14(9):2113-6.

PMID:
15080990
17.

N,N-dialkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, potent, selective delta opioid agonists.

Carson JR, Coats SJ, Codd EE, Dax SL, Lee J, Martinez RP, Neilson LA, Pitis PM, Zhang SP.

Bioorg Med Chem Lett. 2004 May 3;14(9):2109-12.

PMID:
15080989
18.

Molecular cloning and functional expression of the human sodium channel beta1B subunit, a novel splicing variant of the beta1 subunit.

Qin N, D'Andrea MR, Lubin ML, Shafaee N, Codd EE, Correa AM.

Eur J Biochem. 2003 Dec;270(23):4762-70.

19.

Design and synthesis of novel pyrrolidine-containing bradykinin antagonists.

Lee J, Reynolds C, Jetter MC, Youngman MA, Hlasta DJ, Dax SL, Stone DJ, Zhang SP, Codd EE.

Bioorg Med Chem Lett. 2003 Jun 2;13(11):1879-82.

PMID:
12749889
20.

Synthesis and structure--activity relationships of aroylpyrrole alkylamide bradykinin (B2) antagonists.

Youngman MA, Carson JR, Lee JS, Dax SL, Zhang SP, Colburn RW, Stone DJ, Codd EE, Jetter MC.

Bioorg Med Chem Lett. 2003 Apr 7;13(7):1341-4.

PMID:
12657278
21.

In vitro metabolism of the analgesic agent, tramadol-N-oxide, in mouse, rat, and human.

Wu WN, McKown LA, Codd EE, Raffa RB.

Eur J Drug Metab Pharmacokinet. 2002 Jul-Sep;27(3):193-7.

PMID:
12365201
22.

Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit.

Qin N, Yagel S, Momplaisir ML, Codd EE, D'Andrea MR.

Mol Pharmacol. 2002 Sep;62(3):485-96.

PMID:
12181424
23.

Differential tramadol and O-desmethyl metabolite levels in brain vs. plasma of mice and rats administered tramadol hydrochloride orally.

Tao Q, Stone DJ, Borenstein MR, Codd EE, Coogan TP, Desai-Krieger D, Liao S, Raffa RB.

J Clin Pharm Ther. 2002 Apr;27(2):99-106.

PMID:
11975693
24.

Gas chromatographic method using nitrogen-phosphorus detection for the measurement of tramadol and its O-desmethyl metabolite in plasma and brain tissue of mice and rats.

Tao Q, Stone DJ Jr, Borenstein MR, Jean-Bart V, Codd EE, Coogan TP, Desai-Krieger D, Liao S, Raffa RB.

J Chromatogr B Biomed Sci Appl. 2001 Nov 5;763(1-2):165-71.

PMID:
11710575
25.

Piperazinyl benzamidines: synthesis and affinity for the delta opioid receptor.

Nortey SO, Baxter EW, Codd EE, Zhang SP, Reitz AB.

Bioorg Med Chem Lett. 2001 Jul 9;11(13):1741-3.

PMID:
11425550
26.

Functional studies of bradykinin receptors in Chinese hamster ovary cells stably expressing the human B2 bradykinin receptor.

Zhang SP, Wang HY, Lovenberg TW, Codd EE.

Int Immunopharmacol. 2001 May;1(5):955-65.

PMID:
11379050
27.

Alpha(2) adrenoceptor agonists as potential analgesic agents. 3. Imidazolylmethylthiophenes.

Boyd RE, Press JB, Rasmussen CR, Raffa RB, Codd EE, Connelly CD, Li QS, Martinez RP, Lewis MA, Almond HR, Reitz AB.

J Med Chem. 2001 Mar 15;44(6):863-72.

PMID:
11300868
28.

Determination of the adsorption of tramadol hydrochloride by activated charcoal in vitro and in vivo.

Raffa RB, Wu C, Stone DJ, Borenstein MR, Codd EE, Coogan TP.

J Pharmacol Toxicol Methods. 2000 May-Jun;43(3):205-10.

PMID:
11257485
29.

Alpha(2) adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-imidazo)-1,3-dimethyl-6,7-dihydro-thianaphthene as a high-affinity ligand for the alpha(2D) adrenergic receptor.

Ross TM, Jetter MC, McDonnell ME, Boyd RE, Connelly CD, Martinez RP, Lewis MA, Codd EE, Raffa RB, Reitz AB.

J Med Chem. 2000 Apr 6;43(7):1423-6. No abstract available.

PMID:
10753480
30.

Method for comparison of the hemodynamic effects of equi-antinociceptive oral doses of drugs in anesthetized rats.

Li QS, Connelly CD, Codd EE, Raffa RB.

J Pharmacol Toxicol Methods. 1999 Nov;42(3):127-33.

PMID:
10964010
31.

Synthesis and binding affinities of 4-diarylaminotropanes, a new class of delta opioid agonists.

Boyd RE, Carson JR, Codd EE, Gauthier AD, Neilson LA, Zhang SP.

Bioorg Med Chem Lett. 2000 May 15;10(10):1109-11.

PMID:
10843229
32.

alpha(2) Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene [corrected] as a high-affinity ligand for the alpha(2D) adrenergic receptor.

Ross TM, Jetter MC, McDonnell ME, Boyd RE, Connelly CD, Martinez RP, Lewis MA, Codd EE, Raffa RB, Reitz AB.

J Med Chem. 2000 Mar 9;43(5):765-8. No abstract available. Corrected and republished in: J Med Chem. 2000 Apr 6;43(7):1423-6.

PMID:
10715142
33.

Alpha(2) adrenoceptor agonists as potential analgesic agents. 1. (Imidazolylmethyl)oxazoles and -thiazoles.

Boyd RE, Press JB, Rasmussen CR, Raffa RB, Codd EE, Connelly CD, Bennett DJ, Kirifides AL, Gardocki JF, Reynolds B, Hortenstein JT, Reitz AB.

J Med Chem. 1999 Dec 16;42(25):5064-71.

PMID:
10602691
35.

Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors.

Reitz AB, Baxter EW, Codd EE, Davis CB, Jordan AD, Maryanoff BE, Maryanoff CA, McDonnell ME, Powell ET, Renzi MJ, Schott MR, Scott MK, Shank RP, Vaught JL.

J Med Chem. 1998 Jun 4;41(12):1997-2009.

PMID:
9622541
36.

Unexpected antinociceptive effect of the N-oxide (RWJ 38705) of tramadol hydrochloride.

Raffa RB, Haslego ML, Maryanoff CA, Villani FJ, Codd EE, Connelly CD, Martinez RP, Schupsky JJ, Buben JA, Wu WN, Takacs AN, Mckown LA.

J Pharmacol Exp Ther. 1996 Sep;278(3):1098-104.

PMID:
8819491
37.
38.

N-aryl-N'-benzylpiperazines as potential antipsychotic agents.

Reitz AB, Baxter EW, Bennett DJ, Codd EE, Jordan AD, Malloy EA, Maryanoff BE, McDonnell ME, Ortegon ME, Renzi MJ, et al.

J Med Chem. 1995 Oct 13;38(21):4211-22.

PMID:
7473548
39.

Piperazinylalkyl heterocycles as potential antipsychotic agents.

Scott MK, Baxter EW, Bennett DJ, Boyd RE, Blum PS, Codd EE, Kukla MJ, Malloy E, Maryanoff BE, Maryanoff CA, et al.

J Med Chem. 1995 Oct 13;38(21):4198-210.

PMID:
7473547
40.
41.

LiCl uncouples signal transduction in morphine-induced supraspinal antinociception in mice.

Raffa RB, Martinez RP, Renzi MJ, Codd EE.

Gen Pharmacol. 1995 Mar;26(2):317-20.

PMID:
7590080
43.

High affinity ibogaine binding to a mu opioid agonist site.

Codd EE.

Life Sci. 1995;57(20):PL315-20.

PMID:
7475926
45.

A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects.

Reitz AB, Bennett DJ, Blum PS, Codd EE, Maryanoff CA, Ortegon ME, Renzi MJ, Scott MK, Shank RP, Vaught JL.

J Med Chem. 1994 Apr 15;37(8):1060-2. No abstract available.

PMID:
7909336
47.

Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol.

Raffa RB, Friderichs E, Reimann W, Shank RP, Codd EE, Vaught JL, Jacoby HI, Selve N.

J Pharmacol Exp Ther. 1993 Oct;267(1):331-40.

PMID:
8229760
48.

1,3-Di(2-[5-3H]tolyl)guanidine labels more than one site in rat forebrain.

Codd EE, Shank RP.

Eur J Pharmacol. 1992 Jul 7;217(2-3):149-52.

PMID:
1425936
49.

Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic.

Raffa RB, Friderichs E, Reimann W, Shank RP, Codd EE, Vaught JL.

J Pharmacol Exp Ther. 1992 Jan;260(1):275-85.

PMID:
1309873
50.

Intranasal activity of the growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in conscious dogs.

Nelson AH, Walker RF, Codd EE, Barone FC.

Life Sci. 1991;48(23):2283-8.

PMID:
2046459

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