Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 56

1.

Composition and Orientation of the Core Region of Novel HIV-1 Entry Inhibitors Influences Metabolic Stability.

Karadsheh R, Meuser ME, Cocklin S.

Molecules. 2020 Mar 21;25(6). pii: E1430. doi: 10.3390/molecules25061430.

2.

Bioisosteric Replacement as a Tool in Anti-HIV Drug Design.

Dick A, Cocklin S.

Pharmaceuticals (Basel). 2020 Feb 28;13(3). pii: E36. doi: 10.3390/ph13030036. Review.

3.

Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors.

Jiang X, Wu G, Zalloum WA, Meuser ME, Dick A, Sun L, Chen CH, Kang D, Jing L, Jia R, Cocklin S, Lee KH, Liu X, Zhan P.

RSC Adv. 2019;9(50):28961-28986. doi: 10.1039/c9ra05869a. Epub 2019 Sep 16.

4.

Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities.

Sun L, Huang T, Dick A, Meuser ME, Zalloum WA, Chen CH, Ding X, Gao P, Cocklin S, Lee KH, Zhan P, Liu X.

Eur J Med Chem. 2020 Mar 15;190:112085. doi: 10.1016/j.ejmech.2020.112085. Epub 2020 Jan 24.

PMID:
32066010
5.

Atomic-scale interface engineering of Majorana edge modes in a 2D magnet-superconductor hybrid system.

Palacio-Morales A, Mascot E, Cocklin S, Kim H, Rachel S, Morr DK, Wiesendanger R.

Sci Adv. 2019 Jul 26;5(7):eaav6600. doi: 10.1126/sciadv.aav6600. eCollection 2019 Jul.

6.

Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor.

Meuser ME, Rashad AA, Ozorowski G, Dick A, Ward AB, Cocklin S.

Molecules. 2019 Apr 22;24(8). pii: E1581. doi: 10.3390/molecules24081581.

7.

Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action.

Xu JP, Francis AC, Meuser ME, Mankowski M, Ptak RG, Rashad AA, Melikyan GB, Cocklin S.

J Drug Des Res. 2018;5(2). pii: 1070. Epub 2018 Aug 13.

8.

Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library.

Wu G, Zalloum WA, Meuser ME, Jing L, Kang D, Chen CH, Tian Y, Zhang F, Cocklin S, Lee KH, Liu X, Zhan P.

Eur J Med Chem. 2018 Oct 5;158:478-492. doi: 10.1016/j.ejmech.2018.09.029. Epub 2018 Sep 11.

9.

Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency.

Meuser ME, Murphy MB, Rashad AA, Cocklin S.

Molecules. 2018 Aug 3;23(8). pii: E1940. doi: 10.3390/molecules23081940.

10.

Interaction between the AAA+ ATPase p97 and its cofactor ataxin3 in health and disease: Nucleotide-induced conformational changes regulate cofactor binding.

Rao MV, Williams DR, Cocklin S, Loll PJ.

J Biol Chem. 2017 Nov 10;292(45):18392-18407. doi: 10.1074/jbc.M117.806281. Epub 2017 Sep 22.

11.

The spliceosomal proteins PPIH and PRPF4 exhibit bi-partite binding.

Rajiv C, Jackson SR, Cocklin S, Eisenmesser EZ, Davis TL.

Biochem J. 2017 Oct 25;474(21):3689-3704. doi: 10.1042/BCJ20170366.

12.

Role of Defects and Surface States in the Carrier Transport and Nonlinearity of the Diode Characteristics in PbS/ZnO Quantum Dot Solar Cells.

Cheng Y, Whitaker MDC, Makkia R, Cocklin S, Whiteside VR, Bumm LA, Adcock-Smith E, Roberts KP, Hari P, Sellers IR.

ACS Appl Mater Interfaces. 2017 Apr 19;9(15):13269-13277. doi: 10.1021/acsami.7b00141. Epub 2017 Apr 7.

PMID:
28362079
13.

Biophysical and Functional Characterization of Rhesus Macaque IgG Subclasses.

Boesch AW, Osei-Owusu NY, Crowley AR, Chu TH, Chan YN, Weiner JA, Bharadwaj P, Hards R, Adamo ME, Gerber SA, Cocklin SL, Schmitz JE, Miles AR, Eckman JW, Belli AJ, Reimann KA, Ackerman ME.

Front Immunol. 2016 Dec 13;7:589. doi: 10.3389/fimmu.2016.00589. eCollection 2016.

14.

IgG Binding Characteristics of Rhesus Macaque FcγR.

Chan YN, Boesch AW, Osei-Owusu NY, Emileh A, Crowley AR, Cocklin SL, Finstad SL, Linde CH, Howell RA, Zentner I, Cocklin S, Miles AR, Eckman JW, Alter G, Schmitz JE, Ackerman ME.

J Immunol. 2016 Oct 1;197(7):2936-47. doi: 10.4049/jimmunol.1502252. Epub 2016 Aug 24.

15.

Phosphorylation of the RNA-binding protein Dazl by MAPKAP kinase 2 regulates spermatogenesis.

Williams PA, Krug MS, McMillan EA, Peake JD, Davis TL, Cocklin S, Strochlic TI.

Mol Biol Cell. 2016 Aug 1;27(15):2341-50. doi: 10.1091/mbc.E15-11-0773. Epub 2016 Jun 8.

16.

Insertion of perilipin 3 into a glycero(phospho)lipid monolayer depends on lipid headgroup and acyl chain species.

Mirheydari M, Rathnayake SS, Frederick H, Arhar T, Mann EK, Cocklin S, Kooijman EE.

J Lipid Res. 2016 Aug;57(8):1465-76. doi: 10.1194/jlr.M068205. Epub 2016 Jun 2.

17.

Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors.

Huang F, Goyal N, Sullivan K, Hanamshet K, Patel M, Mazina OM, Wang CX, An WF, Spoonamore J, Metkar S, Emmitte KA, Cocklin S, Skorski T, Mazin AV.

Nucleic Acids Res. 2016 May 19;44(9):4189-99. doi: 10.1093/nar/gkw087. Epub 2016 Feb 11.

18.

Identification of a small molecule HIV-1 inhibitor that targets the capsid hexamer.

Xu JP, Branson JD, Lawrence R, Cocklin S.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):824-828. doi: 10.1016/j.bmcl.2015.12.087. Epub 2015 Dec 25.

19.

The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain.

Fossati S, Giannoni P, Solesio ME, Cocklin SL, Cabrera E, Ghiso J, Rostagno A.

Neurobiol Dis. 2016 Feb;86:29-40. doi: 10.1016/j.nbd.2015.11.006. Epub 2015 Nov 12.

20.

Core chemotype diversification in the HIV-1 entry inhibitor class using field-based bioisosteric replacement.

Tuyishime M, Lawrence R, Cocklin S.

Bioorg Med Chem Lett. 2016 Jan 1;26(1):228-34. doi: 10.1016/j.bmcl.2015.10.080. Epub 2015 Oct 27.

21.

Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques.

Santra S, Tomaras GD, Warrier R, Nicely NI, Liao HX, Pollara J, Liu P, Alam SM, Zhang R, Cocklin SL, Shen X, Duffy R, Xia SM, Schutte RJ, Pemble Iv CW, Dennison SM, Li H, Chao A, Vidnovic K, Evans A, Klein K, Kumar A, Robinson J, Landucci G, Forthal DN, Montefiori DC, Kaewkungwal J, Nitayaphan S, Pitisuttithum P, Rerks-Ngarm S, Robb ML, Michael NL, Kim JH, Soderberg KA, Giorgi EE, Blair L, Korber BT, Moog C, Shattock RJ, Letvin NL, Schmitz JE, Moody MA, Gao F, Ferrari G, Shaw GM, Haynes BF.

PLoS Pathog. 2015 Aug 3;11(8):e1005042. doi: 10.1371/journal.ppat.1005042. eCollection 2015 Aug.

22.

Discovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement.

Tuyishime M, Danish M, Princiotto A, Mankowski MK, Lawrence R, Lombart HG, Esikov K, Berniac J, Liang K, Ji J, Ptak RG, Madani N, Cocklin S.

Bioorg Med Chem Lett. 2014 Dec 1;24(23):5439-45.

23.

Structure-activity relationships of a novel capsid targeted inhibitor of HIV-1 replication.

Kortagere S, Xu JP, Mankowski MK, Ptak RG, Cocklin S.

J Chem Inf Model. 2014 Nov 24;54(11):3080-90. doi: 10.1021/ci500437r. Epub 2014 Oct 28.

24.

An optimized, synthetic DNA vaccine encoding the toxin A and toxin B receptor binding domains of Clostridium difficile induces protective antibody responses in vivo.

Baliban SM, Michael A, Shammassian B, Mudakha S, Khan AS, Cocklin S, Zentner I, Latimer BP, Bouillaut L, Hunter M, Marx P, Sardesai NY, Welles SL, Jacobson JM, Weiner DB, Kutzler MA.

Infect Immun. 2014 Oct;82(10):4080-91. doi: 10.1128/IAI.01950-14. Epub 2014 Jul 14.

25.

The role of Fc receptors in HIV infection and vaccine efficacy.

Cocklin SL, Schmitz JE.

Curr Opin HIV AIDS. 2014 May;9(3):257-62. doi: 10.1097/COH.0000000000000051. Review.

26.

The high resolution structure of tyrocidine A reveals an amphipathic dimer.

Loll PJ, Upton EC, Nahoum V, Economou NJ, Cocklin S.

Biochim Biophys Acta. 2014 May;1838(5):1199-207. doi: 10.1016/j.bbamem.2014.01.033. Epub 2014 Feb 11.

27.

Analysis of the activities of RAD54, a SWI2/SNF2 protein, using a specific small-molecule inhibitor.

Deakyne JS, Huang F, Negri J, Tolliday N, Cocklin S, Mazin AV.

J Biol Chem. 2013 Nov 1;288(44):31567-80. doi: 10.1074/jbc.M113.502195. Epub 2013 Sep 16.

28.

High-resolution crystal structure reveals molecular details of target recognition by bacitracin.

Economou NJ, Cocklin S, Loll PJ.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14207-12. doi: 10.1073/pnas.1308268110. Epub 2013 Aug 12.

29.

Structure of the complex between teicoplanin and a bacterial cell-wall peptide: use of a carrier-protein approach.

Economou NJ, Zentner IJ, Lazo E, Jakoncic J, Stojanoff V, Weeks SD, Grasty KC, Cocklin S, Loll PJ.

Acta Crystallogr D Biol Crystallogr. 2013 Apr;69(Pt 4):520-33. doi: 10.1107/S0907444912050469. Epub 2013 Mar 14.

30.

Identification of a small-molecule inhibitor of HIV-1 assembly that targets the phosphatidylinositol (4,5)-bisphosphate binding site of the HIV-1 matrix protein.

Zentner I, Sierra LJ, Fraser AK, Maciunas L, Mankowski MK, Vinnik A, Fedichev P, Ptak RG, Martín-García J, Cocklin S.

ChemMedChem. 2013 Mar;8(3):426-32. doi: 10.1002/cmdc.201200577. Epub 2013 Jan 29.

31.

Reevaluation of the requirement for TIP47 in human immunodeficiency virus type 1 envelope glycoprotein incorporation.

Checkley MA, Luttge BG, Mercredi PY, Kyere SK, Donlan J, Murakami T, Summers MF, Cocklin S, Freed EO.

J Virol. 2013 Mar;87(6):3561-70. doi: 10.1128/JVI.03299-12. Epub 2013 Jan 16.

32.

Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein.

Zentner I, Sierra LJ, Maciunas L, Vinnik A, Fedichev P, Mankowski MK, Ptak RG, Martín-García J, Cocklin S.

Bioorg Med Chem Lett. 2013 Feb 15;23(4):1132-5. doi: 10.1016/j.bmcl.2012.11.041. Epub 2012 Nov 29.

33.

Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid.

Kortagere S, Madani N, Mankowski MK, Schön A, Zentner I, Swaminathan G, Princiotto A, Anthony K, Oza A, Sierra LJ, Passic SR, Wang X, Jones DM, Stavale E, Krebs FC, Martín-García J, Freire E, Ptak RG, Sodroski J, Cocklin S, Smith AB 3rd.

J Virol. 2012 Aug;86(16):8472-81. doi: 10.1128/JVI.05006-11. Epub 2012 May 30.

34.

Solution structure studies of monomeric human TIP47/perilipin-3 reveal a highly extended conformation.

Hynson RM, Jeffries CM, Trewhella J, Cocklin S.

Proteins. 2012 Aug;80(8):2046-55. doi: 10.1002/prot.24095. Epub 2012 May 25.

35.

Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.

Huang F, Mazina OM, Zentner IJ, Cocklin S, Mazin AV.

J Med Chem. 2012 Apr 12;55(7):3011-20. doi: 10.1021/jm201173g. Epub 2012 Mar 19.

PMID:
22380680
36.

A carrier protein strategy yields the structure of dalbavancin.

Economou NJ, Nahoum V, Weeks SD, Grasty KC, Zentner IJ, Townsend TM, Bhuiya MW, Cocklin S, Loll PJ.

J Am Chem Soc. 2012 Mar 14;134(10):4637-45. doi: 10.1021/ja208755j. Epub 2012 Mar 1.

37.

Alkaline phosphatase is increased in both brain and plasma in Alzheimer's disease.

Vardy ER, Kellett KA, Cocklin SL, Hooper NM.

Neurodegener Dis. 2012;9(1):31-7. doi: 10.1159/000329722. Epub 2011 Oct 20.

PMID:
22024719
38.

Conformational and structural features of HIV-1 gp120 underlying the dual receptor antagonism by cross-reactive neutralizing antibody m18.

Gift SK, Zentner IJ, Schön A, McFadden K, Umashankara M, Rajagopal S, Contarino M, Duffy C, Courter JR, Zhang MY, Gershoni JM, Cocklin S, Dimitrov DS, Smith AB 3rd, Freire E, Chaiken IM.

Biochemistry. 2011 Apr 12;50(14):2756-68. doi: 10.1021/bi101160r. Epub 2011 Mar 18.

39.

Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein.

Taylor DR, Parkin ET, Cocklin SL, Ault JR, Ashcroft AE, Turner AJ, Hooper NM.

J Biol Chem. 2009 Aug 21;284(34):22590-600. doi: 10.1074/jbc.M109.032599. Epub 2009 Jun 29.

40.

The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitors.

Rossi F, Querido B, Nimmagadda M, Cocklin S, Navas-Martín S, Martín-García J.

Retrovirology. 2008 Oct 6;5:89. doi: 10.1186/1742-4690-5-89.

41.

Introducing metallocene into a triazole peptide conjugate reduces its off-rate and enhances its affinity and antiviral potency for HIV-1 gp120.

Gopi H, Cocklin S, Pirrone V, McFadden K, Tuzer F, Zentner I, Ajith S, Baxter S, Jawanda N, Krebs FC, Chaiken IM.

J Mol Recognit. 2009 Mar-Apr;22(2):169-74. doi: 10.1002/jmr.892.

42.

Enhanced EGFR inhibition and distinct epitope recognition by EGFR antagonistic mAbs C225 and 425.

Kamat V, Donaldson JM, Kari C, Quadros MR, Lelkes PI, Chaiken I, Cocklin S, Williams JC, Papazoglou E, Rodeck U.

Cancer Biol Ther. 2008 May;7(5):726-33. Epub 2008 May 14.

PMID:
18424917
43.

Structural determinants for affinity enhancement of a dual antagonist peptide entry inhibitor of human immunodeficiency virus type-1.

Gopi H, Umashankara M, Pirrone V, LaLonde J, Madani N, Tuzer F, Baxter S, Zentner I, Cocklin S, Jawanda N, Miller SR, Schön A, Klein JC, Freire E, Krebs FC, Smith AB, Sodroski J, Chaiken I.

J Med Chem. 2008 May 8;51(9):2638-47. doi: 10.1021/jm070814r. Epub 2008 Apr 11.

44.

A recombinant allosteric lectin antagonist of HIV-1 envelope gp120 interactions.

McFadden K, Cocklin S, Gopi H, Baxter S, Ajith S, Mahmood N, Shattock R, Chaiken I.

Proteins. 2007 May 15;67(3):617-29.

PMID:
17348010
45.

Broad-spectrum anti-human immunodeficiency virus (HIV) potential of a peptide HIV type 1 entry inhibitor.

Cocklin S, Gopi H, Querido B, Nimmagadda M, Kuriakose S, Cicala C, Ajith S, Baxter S, Arthos J, Martín-García J, Chaiken IM.

J Virol. 2007 Apr;81(7):3645-8. Epub 2007 Jan 24.

46.

Antibody binding is a dominant determinant of the efficiency of human immunodeficiency virus type 1 neutralization.

Yang X, Lipchina I, Cocklin S, Chaiken I, Sodroski J.

J Virol. 2006 Nov;80(22):11404-8. Epub 2006 Sep 6.

47.

Real-time monitoring of the membrane-binding and insertion properties of the cholesterol-dependent cytolysin anthrolysin O from Bacillus anthracis.

Cocklin S, Jost M, Robertson NM, Weeks SD, Weber HW, Young E, Seal S, Zhang C, Mosser E, Loll PJ, Saunders AJ, Rest RF, Chaiken IM.

J Mol Recognit. 2006 Jul-Aug;19(4):354-62.

PMID:
16775845
48.
49.

Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis.

Lamb HK, Ren J, Park A, Johnson C, Leslie K, Cocklin S, Thompson P, Mee C, Cooper A, Stammers DK, Hawkins AR.

Protein Sci. 2004 Dec;13(12):3127-38. Epub 2004 Nov 10.

50.

Crystal structure of the TetR/CamR family repressor Mycobacterium tuberculosis EthR implicated in ethionamide resistance.

Dover LG, Corsino PE, Daniels IR, Cocklin SL, Tatituri V, Besra GS, Fütterer K.

J Mol Biol. 2004 Jul 23;340(5):1095-105.

PMID:
15236969

Supplemental Content

Loading ...
Support Center