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Items: 1 to 50 of 75

1.

Using hyperpolarised NMR and DFT to rationalise the unexpected hydrogenation of quinazoline to 3,4-dihydroquinazoline.

Richards JE, Hooper AJJ, Bayfield OW, Cockett MCR, Dear GJ, Holmes AJ, John RO, Mewis RE, Pridmore N, Roberts AD, Whitwood AC, Duckett SB.

Chem Commun (Camb). 2018 Sep 11;54(73):10375-10378. doi: 10.1039/c8cc04826f.

2.

Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 H-cyclopenta[ a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176).

Regueiro-Ren A, Swidorski JJ, Liu Z, Chen Y, Sin N, Sit SY, Chen J, Venables BL, Zhu J, Nowicka-Sans B, Protack T, Lin Z, Terry B, Samanta H, Zhang S, Li Z, Easter J, Beno BR, Arora V, Huang XS, Rahematpura S, Parker DD, Haskell R, Santone KS, Cockett MI, Krystal M, Meanwell NA, Jenkins S, Hanumegowda U, Dicker IB.

J Med Chem. 2018 Aug 23;61(16):7289-7313. doi: 10.1021/acs.jmedchem.8b00854. Epub 2018 Aug 1.

PMID:
30067361
3.

A Novel gp41-Binding Adnectin with Potent Anti-HIV Activity Is Highly Synergistic when Linked to a CD4-Binding Adnectin.

Wensel D, Sun Y, Davis J, Li Z, Zhang S, McDonagh T, Fabrizio D, Cockett M, Krystal M.

J Virol. 2018 Jun 29;92(14). pii: e00421-18. doi: 10.1128/JVI.00421-18. Print 2018 Jul 15.

4.

Safety and efficacy of anti-PD-L1 therapy in the woodchuck model of HBV infection.

Balsitis S, Gali V, Mason PJ, Chaniewski S, Levine SM, Wichroski MJ, Feulner M, Song Y, Granaldi K, Loy JK, Thompson CM, Lesniak JA, Brockus C, Kishnani N, Menne S, Cockett MI, Iyer R, Mason SW, Tenney DJ.

PLoS One. 2018 Feb 14;13(2):e0190058. doi: 10.1371/journal.pone.0190058. eCollection 2018.

5.

Discovery and Characterization of a Novel CD4-Binding Adnectin with Potent Anti-HIV Activity.

Wensel D, Sun Y, Li Z, Zhang S, Picarillo C, McDonagh T, Fabrizio D, Cockett M, Krystal M, Davis J.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00508-17. doi: 10.1128/AAC.00508-17. Print 2017 Aug.

6.

Functionalized triazines as potent HCV entry inhibitors.

Mull ES, Sun LQ, Zhao Q, Eggers B, Pokornowski K, Zhai G, Rajamani R, Jenkins S, Kramer M, Wang YK, Fang H, Tenney D, Baldick CJ, Cockett MI, Meanwell NA, Scola PM.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):1089-1093. doi: 10.1016/j.bmcl.2016.12.038. Epub 2016 Dec 18.

PMID:
28089701
7.

Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors.

Lin Z, Cantone J, Lu H, Nowicka-Sans B, Protack T, Yuan T, Yang H, Liu Z, Drexler D, Regueiro-Ren A, Meanwell NA, Cockett M, Krystal M, Lataillade M, Dicker IB.

PLoS Pathog. 2016 Nov 28;12(11):e1005990. doi: 10.1371/journal.ppat.1005990. eCollection 2016 Nov.

8.

Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing.

Sun LQ, Mull E, Zheng B, D'Andrea S, Zhao Q, Wang AX, Sin N, Venables BL, Sit SY, Chen Y, Chen J, Cocuzza A, Bilder DM, Mathur A, Rampulla R, Chen BC, Palani T, Ganesan S, Arunachalam PN, Falk P, Levine S, Chen C, Friborg J, Yu F, Hernandez D, Sheaffer AK, Knipe JO, Han YH, Schartman R, Donoso M, Mosure K, Sinz MW, Zvyaga T, Rajamani R, Kish K, Tredup J, Klei HE, Gao Q, Ng A, Mueller L, Grasela DM, Adams S, Loy J, Levesque PC, Sun H, Shi H, Sun L, Warner W, Li D, Zhu J, Wang YK, Fang H, Cockett MI, Meanwell NA, McPhee F, Scola PM.

J Med Chem. 2016 Sep 8;59(17):8042-60. doi: 10.1021/acs.jmedchem.6b00821. Epub 2016 Aug 26.

PMID:
27564532
9.

Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.

Regueiro-Ren A, Liu Z, Chen Y, Sin N, Sit SY, Swidorski JJ, Chen J, Venables BL, Zhu J, Nowicka-Sans B, Protack T, Lin Z, Terry B, Samanta H, Zhang S, Li Z, Beno BR, Huang XS, Rahematpura S, Parker DD, Haskell R, Jenkins S, Santone KS, Cockett MI, Krystal M, Meanwell NA, Hanumegowda U, Dicker IB.

ACS Med Chem Lett. 2016 Apr 22;7(6):568-72. doi: 10.1021/acsmedchemlett.6b00010. eCollection 2016 Jun 9.

10.

Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.

Nowicka-Sans B, Protack T, Lin Z, Li Z, Zhang S, Sun Y, Samanta H, Terry B, Liu Z, Chen Y, Sin N, Sit SY, Swidorski JJ, Chen J, Venables BL, Healy M, Meanwell NA, Cockett M, Hanumegowda U, Regueiro-Ren A, Krystal M, Dicker IB.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):3956-69. doi: 10.1128/AAC.02560-15. Print 2016 Jul.

11.

The Human Vaccines Project: A roadmap for cancer vaccine development.

Romero P, Banchereau J, Bhardwaj N, Cockett M, Disis ML, Dranoff G, Gilboa E, Hammond SA, Hershberg R, Korman AJ, Kvistborg P, Melief C, Mellman I, Palucka AK, Redchenko I, Robins H, Sallusto F, Schenkelberg T, Schoenberger S, Sosman J, Türeci Ö, Van den Eynde B, Koff W, Coukos G.

Sci Transl Med. 2016 Apr 13;8(334):334ps9. doi: 10.1126/scitranslmed.aaf0685. Review.

PMID:
27075624
12.

Synergistic Activity of Combined NS5A Inhibitors.

O'Boyle DR 2nd, Nower PT, Gao M, Fridell R, Wang C, Hewawasam P, Lopez O, Tu Y, Meanwell NA, Belema M, Roberts SB, Cockett M, Sun JH.

Antimicrob Agents Chemother. 2015 Dec 28;60(3):1573-83. doi: 10.1128/AAC.02639-15.

13.

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A.

Sun JH, O'Boyle DR 2nd, Fridell RA, Langley DR, Wang C, Roberts SB, Nower P, Johnson BM, Moulin F, Nophsker MJ, Wang YK, Liu M, Rigat K, Tu Y, Hewawasam P, Kadow J, Meanwell NA, Cockett M, Lemm JA, Kramer M, Belema M, Gao M.

Nature. 2015 Nov 12;527(7577):245-8. doi: 10.1038/nature15711. Epub 2015 Nov 4.

PMID:
26536115
14.

Lethality of PAK3 and SGK2 shRNAs to human papillomavirus positive cervical cancer cells is independent of PAK3 and SGK2 knockdown.

Zhou N, Ding B, Agler M, Cockett M, McPhee F.

PLoS One. 2015 Jan 23;10(1):e0117357. doi: 10.1371/journal.pone.0117357. eCollection 2015.

15.

Strategies for the hyperpolarization of acetonitrile and related ligands by SABRE.

Mewis RE, Green RA, Cockett MC, Cowley MJ, Duckett SB, Green GG, John RO, Rayner PJ, Williamson DC.

J Phys Chem B. 2015 Jan 29;119(4):1416-24. doi: 10.1021/jp511492q. Epub 2015 Jan 13.

16.

Hydrogen-bonding in the pyrimidine···NH₃ van der Waals complex: experiment and theory.

Gosling MP, Cockett MC.

Phys Chem Chem Phys. 2014 Jul 21;16(27):14195-205. doi: 10.1039/c4cp01472c. Epub 2014 Jun 9.

PMID:
24910315
17.

Detection of unusual reaction intermediates during the conversion of W(N2)2(dppe)2 to W(H)4(dppe)2 and of H2O into H2.

Eguillor B, Caldwell PJ, Cockett MC, Duckett SB, John RO, Lynam JM, Sleigh CJ, Wilson I.

J Am Chem Soc. 2012 Nov 7;134(44):18257-65. doi: 10.1021/ja302202q. Epub 2012 Oct 26.

PMID:
23072491
18.

High-throughput screening and rapid inhibitor triage using an infectious chimeric Hepatitis C virus.

Wichroski MJ, Fang J, Eggers BJ, Rose RE, Mazzucco CE, Pokornowski KA, Baldick CJ, Anthony MN, Dowling CJ, Barber LE, Leet JE, Beno BR, Gerritz SW, Agler ML, Cockett MI, Tenney DJ.

PLoS One. 2012;7(8):e42609. doi: 10.1371/journal.pone.0042609. Epub 2012 Aug 6.

19.

Isomer selective IR-UV depletion spectroscopy of 4-fluorotoluene-NH3: evidence for π-proton-acceptor and linear hydrogen-bonded complexes.

Cockett MC, Miyazaki M, Tanabe K, Fujii M.

Phys Chem Chem Phys. 2011 Sep 14;13(34):15633-8. doi: 10.1039/c1cp21545k. Epub 2011 Aug 1.

PMID:
21804978
20.

Iridium N-heterocyclic carbene complexes as efficient catalysts for magnetization transfer from para-hydrogen.

Cowley MJ, Adams RW, Atkinson KD, Cockett MC, Duckett SB, Green GG, Lohman JA, Kerssebaum R, Kilgour D, Mewis RE.

J Am Chem Soc. 2011 Apr 27;133(16):6134-7. doi: 10.1021/ja200299u. Epub 2011 Apr 6.

22.

A novel small molecule inhibitor of hepatitis C virus entry.

Baldick CJ, Wichroski MJ, Pendri A, Walsh AW, Fang J, Mazzucco CE, Pokornowski KA, Rose RE, Eggers BJ, Hsu M, Zhai W, Zhai G, Gerritz SW, Poss MA, Meanwell NA, Cockett MI, Tenney DJ.

PLoS Pathog. 2010 Sep 2;6(9):e1001086. doi: 10.1371/journal.ppat.1001086.

23.

The role of the methyl group in stabilising the weak N-H...pi hydrogen bond in the 4-fluorotoluene-ammonia complex.

Gosling MP, Pugliesi I, Cockett MC.

Phys Chem Chem Phys. 2010 Jan 7;12(1):132-42. doi: 10.1039/b916815j. Epub 2009 Nov 6.

PMID:
20024452
24.

Transcriptional profiling of the dose response: a more powerful approach for characterizing drug activities.

Ji RR, de Silva H, Jin Y, Bruccoleri RE, Cao J, He A, Huang W, Kayne PS, Neuhaus IM, Ott KH, Penhallow B, Cockett MI, Neubauer MG, Siemers NO, Ross-Macdonald P.

PLoS Comput Biol. 2009 Sep;5(9):e1000512. doi: 10.1371/journal.pcbi.1000512. Epub 2009 Sep 18.

25.

An excited state ab initio and multidimensional Franck-Condon analysis of the A (1)B2 <-- X (1)A1 band system of fluorobenzene.

Pugliesi I, Tonge NM, Cockett MC.

J Chem Phys. 2008 Sep 14;129(10):104303. doi: 10.1063/1.2970092.

PMID:
19044909
26.

CRIB (NGF delivery) Cyto Therapeutics Inc.

Cockett MI.

IDrugs. 1998 Jul;1(3):362-7.

PMID:
18465562
27.

An examination of structural characteristics of phenylacetylene by vibronic and rovibronic simulations of ab initio data.

Pugliesi I, Tonge NM, Hornsby KE, Cockett MC, Watkins MJ.

Phys Chem Chem Phys. 2007 Oct 28;9(40):5436-45. Epub 2007 Aug 20.

PMID:
17925970
28.
29.

Chemical genetics reveals an RGS/G-protein role in the action of a compound.

Fitzgerald K, Tertyshnikova S, Moore L, Bjerke L, Burley B, Cao J, Carroll P, Choy R, Doberstein S, Dubaquie Y, Franke Y, Kopczynski J, Korswagen H, Krystek SR, Lodge NJ, Plasterk R, Starrett J, Stouch T, Thalody G, Wayne H, van der Linden A, Zhang Y, Walker SG, Cockett M, Wardwell-Swanson J, Ross-Macdonald P, Kindt RM.

PLoS Genet. 2006 Apr;2(4):e57. Epub 2006 Apr 21.

30.

Photoelectron spectroscopy without photoelectrons: twenty years of ZEKE spectroscopy.

Cockett MC.

Chem Soc Rev. 2005 Nov;34(11):935-48. Epub 2005 Sep 5. Review.

PMID:
16239995
31.

Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors.

Lackner MR, Kindt RM, Carroll PM, Brown K, Cancilla MR, Chen C, de Silva H, Franke Y, Guan B, Heuer T, Hung T, Keegan K, Lee JM, Manne V, O'Brien C, Parry D, Perez-Villar JJ, Reddy RK, Xiao H, Zhan H, Cockett M, Plowman G, Fitzgerald K, Costa M, Ross-Macdonald P.

Cancer Cell. 2005 Apr;7(4):325-36.

33.

Hydrogenic Rydberg states of molecular van der Waals complexes: resolved Rydberg spectroscopy of DABCO-N2.

Cockett MC, Watkins MJ.

Phys Rev Lett. 2004 Jan 30;92(4):043001. Epub 2004 Jan 29.

PMID:
14995368
34.

Technology evaluation: cystic fibrosis therapy, Genzyme.

Cockett MI.

Curr Opin Mol Ther. 1999 Apr;1(2):279-83. Review.

PMID:
11715952
35.

Regional distribution of regulators of G-protein signaling (RGS) 1, 2, 13, 14, 16, and GAIP messenger ribonucleic acids by in situ hybridization in rat brain.

Grafstein-Dunn E, Young KH, Cockett MI, Khawaja XZ.

Brain Res Mol Brain Res. 2001 Mar 31;88(1-2):113-23.

PMID:
11295237
36.

Applied genomics: integration of the technology within pharmaceutical research and development.

Cockett M, Dracopoli N, Sigal E.

Curr Opin Biotechnol. 2000 Dec;11(6):602-9.

PMID:
11102797
37.

RGS7 is palmitoylated and exists as biochemically distinct forms.

Rose JJ, Taylor JB, Shi J, Cockett MI, Jones PG, Hepler JR.

J Neurochem. 2000 Nov;75(5):2103-12.

38.

NMR structure of free RGS4 reveals an induced conformational change upon binding Galpha.

Moy FJ, Chanda PK, Cockett MI, Edris W, Jones PG, Mason K, Semus S, Powers R.

Biochemistry. 2000 Jun 20;39(24):7063-73.

PMID:
10852703
39.

1H, 15N, 13C, and 13CO assignments and secondary structure determination of RGS4.

Moy FJ, Chanda PK, Cockett MI, Edris W, Jones PG, Powers R.

J Biomol NMR. 1999 Dec;15(4):339-40. No abstract available.

PMID:
10685342
40.

Pindolol-insensitive [3H]-5-hydroxytryptamine binding in the rat hypothalamus; identity with 5-hydroxytryptamine7 receptors.

Clemett DA, Kendall DA, Cockett MI, Marsden CA, Fone KC.

Br J Pharmacol. 1999 May;127(1):236-42.

41.

Cloning and expression of the human kv4.3 potassium channel.

Dilks D, Ling HP, Cockett M, Sokol P, Numann R.

J Neurophysiol. 1999 Apr;81(4):1974-7.

42.

Immunohistochemical distribution of RGS7 protein and cellular selectivity in colocalizing with Galphaq proteins in the adult rat brain.

Khawaja XZ, Liang JJ, Saugstad JA, Jones PG, Harnish S, Conn PJ, Cockett MI.

J Neurochem. 1999 Jan;72(1):174-84.

43.

New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates.

Mewshaw RE, Husbands M, Gildersleeve ES, Webb MB, Shi X, Mazandarani H, Cockett MI, Ochalski R, Brennan JA, Abou-Gharbia M, Marquis K, McGaughey GB, Coupet J, Andree TH.

Bioorg Med Chem Lett. 1998 Feb 3;8(3):295-300.

PMID:
9871673
45.

Enhanced neuronal differentiation of NTera-2 cells expressing neuronally restricted beta2 adrenergic receptor.

Fennell M, Khawaja XZ, Cockett MI, Wood A.

Brain Res. 1998 Jul 20;799(2):243-9.

PMID:
9675299
46.
47.

Distribution of heterotrimeric G-protein beta and gamma subunits in the rat brain.

Betty M, Harnish SW, Rhodes KJ, Cockett MI.

Neuroscience. 1998 Jul;85(2):475-86.

PMID:
9622245
48.

Cloning and tissue distribution of the human G protein beta 5 cDNA.

Jones PG, Lombardi SJ, Cockett MI.

Biochim Biophys Acta. 1998 Apr 24;1402(3):288-91.

49.

Parents, parenting, and family breakdown.

Tripp JH, Cockett M.

Arch Dis Child. 1998 Feb;78(2):104-8. No abstract available.

50.

RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells.

Shuey DJ, Betty M, Jones PG, Khawaja XZ, Cockett MI.

J Neurochem. 1998 May;70(5):1964-72.

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