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Items: 16


A Randomized, Placebo-Controlled, Respiratory Syncytial Virus Human Challenge Study of the Antiviral Efficacy, Safety, and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein.

DeVincenzo J, Tait D, Efthimiou J, Mori J, Kim YI, Thomas E, Wilson L, Harland R, Mathews N, Cockerill S, Powell K, Littler E.

Antimicrob Agents Chemother. 2020 Jan 27;64(2). pii: e01884-19. doi: 10.1128/AAC.01884-19. Print 2020 Jan 27.


Remasking of Candida albicans β-Glucan in Response to Environmental pH Is Regulated by Quorum Sensing.

Cottier F, Sherrington S, Cockerill S, Del Olmo Toledo V, Kissane S, Tournu H, Orsini L, Palmer GE, Pérez JC, Hall RA.

mBio. 2019 Oct 15;10(5). pii: e02347-19. doi: 10.1128/mBio.02347-19.


Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration.

Duffy SM, Cruse G, Cockerill SL, Brightling CE, Bradding P.

Eur J Immunol. 2008 Sep;38(9):2548-56. doi: 10.1002/eji.200738106.


Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity.

Angell R, Aston NM, Bamborough P, Buckton JB, Cockerill S, deBoeck SJ, Edwards CD, Holmes DS, Jones KL, Laine DI, Patel S, Smee PA, Smith KJ, Somers DO, Walker AL.

Bioorg Med Chem Lett. 2008 Aug 1;18(15):4428-32. doi: 10.1016/j.bmcl.2008.06.048. Epub 2008 Jun 18.


Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes.

Angell RM, Angell TD, Bamborough P, Bamford MJ, Chung CW, Cockerill SG, Flack SS, Jones KL, Laine DI, Longstaff T, Ludbrook S, Pearson R, Smith KJ, Smee PA, Somers DO, Walker AL.

Bioorg Med Chem Lett. 2008 Aug 1;18(15):4433-7. doi: 10.1016/j.bmcl.2008.06.028. Epub 2008 Jun 12.


Are biofuels sustainable? The EU perspective.

Cockerill S, Martin C.

Biotechnol Biofuels. 2008 May 1;1(1):9. doi: 10.1186/1754-6834-1-9. No abstract available.


IgE alone promotes human lung mast cell survival through the autocrine production of IL-6.

Cruse G, Cockerill S, Bradding P.

BMC Immunol. 2008 Jan 23;9:2. doi: 10.1186/1471-2172-9-2.


Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode.

Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19.


Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR.

Angell RM, Angell TD, Bamborough P, Brown D, Brown M, Buckton JB, Cockerill SG, Edwards CD, Jones KL, Longstaff T, Smee PA, Smith KJ, Somers DO, Walker AL, Willson M.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):324-8. Epub 2007 Oct 17.


Modulation of hERG potassium currents in HEK-293 cells by protein kinase C. Evidence for direct phosphorylation of pore forming subunits.

Cockerill SL, Tobin AB, Torrecilla I, Willars GB, Standen NB, Mitcheson JS.

J Physiol. 2007 Jun 1;581(Pt 2):479-93. Epub 2007 Mar 15.


Direct block of human ether-a-go-go-related gene potassium channels by caffeine.

Cockerill SL, Mitcheson JS.

J Pharmacol Exp Ther. 2006 Feb;316(2):860-8. Epub 2005 Oct 14.


Synthesis and SAR of potent EGFR/erbB2 dual inhibitors.

Zhang YM, Cockerill S, Guntrip SB, Rusnak D, Smith K, Vanderwall D, Wood E, Lackey K.

Bioorg Med Chem Lett. 2004 Jan 5;14(1):111-4.


The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer.

Rusnak DW, Affleck K, Cockerill SG, Stubberfield C, Harris R, Page M, Smith KJ, Guntrip SB, Carter MC, Shaw RJ, Jowett A, Stables J, Topley P, Wood ER, Brignola PS, Kadwell SH, Reep BR, Mullin RJ, Alligood KJ, Keith BR, Crosby RM, Murray DM, Knight WB, Gilmer TM, Lackey K.

Cancer Res. 2001 Oct 1;61(19):7196-203.


Synthesis of N-alkyl substituted indolocarbazoles as potent inhibitors of human cytomegalovirus replication.

Slater MJ, Baxter R, Bonser RW, Cockerill S, Gohil K, Parry N, Robinson E, Randall R, Yeates C, Snowden W, Walters A.

Bioorg Med Chem Lett. 2001 Aug 6;11(15):1993-5.


Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2.

Cockerill S, Stubberfield C, Stables J, Carter M, Guntrip S, Smith K, McKeown S, Shaw R, Topley P, Thomsen L, Affleck K, Jowett A, Hayes D, Willson M, Woollard P, Spalding D.

Bioorg Med Chem Lett. 2001 Jun 4;11(11):1401-5.


Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication.

Slater MJ, Cockerill S, Baxter R, Bonser RW, Gohil K, Gowrie C, Robinson JE, Littler E, Parry N, Randall R, Snowden W.

Bioorg Med Chem. 1999 Jun;7(6):1067-74.


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