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Items: 1 to 50 of 63

1.

Generation of a fully erythromycin-sensitive strain of Clostridioides difficile using a novel CRISPR-Cas9 genome editing system.

Ingle P, Groothuis D, Rowe P, Huang H, Cockayne A, Kuehne SA, Jiang W, Gu Y, Humphreys CM, Minton NP.

Sci Rep. 2019 May 31;9(1):8123. doi: 10.1038/s41598-019-44458-y.

2.

Antibiotic Spider Silk: Site-Specific Functionalization of Recombinant Spider Silk Using "Click" Chemistry.

Harvey D, Bardelang P, Goodacre SL, Cockayne A, Thomas NR.

Adv Mater. 2017 Mar;29(10). doi: 10.1002/adma.201604245. Epub 2016 Dec 28.

PMID:
28028885
3.

What's a SNP between friends: The influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives.

Collery MM, Kuehne SA, McBride SM, Kelly ML, Monot M, Cockayne A, Dupuy B, Minton NP.

Virulence. 2017 Aug 18;8(6):767-781. doi: 10.1080/21505594.2016.1237333. Epub 2016 Sep 21.

4.

Improving the reproducibility of the NAP1/B1/027 epidemic strain R20291 in the hamster model of infection.

Kelly ML, Ng YK, Cartman ST, Collery MM, Cockayne A, Minton NP.

Anaerobe. 2016 Jun;39:51-3. doi: 10.1016/j.anaerobe.2016.02.011. Epub 2016 Mar 2.

5.

Development of a heptaplex PCR assay for identification of Staphylococcus aureus and CoNS with simultaneous detection of virulence and antibiotic resistance genes.

Okolie CE, Wooldridge KG, Turner DP, Cockayne A, James R.

BMC Microbiol. 2015 Aug 5;15:157. doi: 10.1186/s12866-015-0490-9.

6.

Pathogenesis of Clostridium difficile Infection and Its Potential Role in Inflammatory Bowel Disease.

Monaghan TM, Cockayne A, Mahida YR.

Inflamm Bowel Dis. 2015 Aug;21(8):1957-66. doi: 10.1097/MIB.0000000000000461. Review.

PMID:
26199993
7.
8.

Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors.

Murray EJ, Crowley RC, Truman A, Clarke SR, Cottam JA, Jadhav GP, Steele VR, O'Shea P, Lindholm C, Cockayne A, Chhabra SR, Chan WC, Williams P.

J Med Chem. 2014 Mar 27;57(6):2813-9. doi: 10.1021/jm500215s. Epub 2014 Mar 13.

9.

Engineering of the LukS-PV and LukF-PV subunits of Staphylococcus aureus Panton-Valentine leukocidin for diagnostic and therapeutic applications.

Okolie CE, Cockayne A, Penfold C, James R.

BMC Biotechnol. 2013 Nov 19;13:103. doi: 10.1186/1472-6750-13-103.

10.

Importance of toxin A, toxin B, and CDT in virulence of an epidemic Clostridium difficile strain.

Kuehne SA, Collery MM, Kelly ML, Cartman ST, Cockayne A, Minton NP.

J Infect Dis. 2014 Jan 1;209(1):83-6. doi: 10.1093/infdis/jit426. Epub 2013 Aug 9.

11.

Combinatorial discovery of polymers resistant to bacterial attachment.

Hook AL, Chang CY, Yang J, Luckett J, Cockayne A, Atkinson S, Mei Y, Bayston R, Irvine DJ, Langer R, Anderson DG, Williams P, Davies MC, Alexander MR.

Nat Biotechnol. 2012 Sep;30(9):868-875. doi: 10.1038/nbt.2316. Erratum in: Nat Biotechnol. 2014 Jun;32(6):592.

12.

Comparison of the regulation, metabolic functions, and roles in virulence of the glyceraldehyde-3-phosphate dehydrogenase homologues gapA and gapB in Staphylococcus aureus.

Purves J, Cockayne A, Moody PC, Morrissey JA.

Infect Immun. 2010 Dec;78(12):5223-32. doi: 10.1128/IAI.00762-10. Epub 2010 Sep 27.

13.

The role of toxin A and toxin B in Clostridium difficile infection.

Kuehne SA, Cartman ST, Heap JT, Kelly ML, Cockayne A, Minton NP.

Nature. 2010 Oct 7;467(7316):711-3. doi: 10.1038/nature09397. Epub 2010 Sep 15.

14.

Fur is required for the activation of virulence gene expression through the induction of the sae regulatory system in Staphylococcus aureus.

Johnson M, Sengupta M, Purves J, Tarrant E, Williams PH, Cockayne A, Muthaiyan A, Stephenson R, Ledala N, Wilkinson BJ, Jayaswal RK, Morrissey JA.

Int J Med Microbiol. 2011 Jan;301(1):44-52. doi: 10.1016/j.ijmm.2010.05.003. Epub 2010 Aug 12.

15.

The emergence of 'hypervirulence' in Clostridium difficile.

Cartman ST, Heap JT, Kuehne SA, Cockayne A, Minton NP.

Int J Med Microbiol. 2010 Aug;300(6):387-95. doi: 10.1016/j.ijmm.2010.04.008. Epub 2010 May 23. Review.

PMID:
20547099
16.

Iron-regulated biofilm formation in Staphylococcus aureus Newman requires ica and the secreted protein Emp.

Johnson M, Cockayne A, Morrissey JA.

Infect Immun. 2008 Apr;76(4):1756-65. doi: 10.1128/IAI.01635-07. Epub 2008 Feb 11.

17.

Control of bacterial aggregation by thermoresponsive glycopolymers.

Pasparakis G, Cockayne A, Alexander C.

J Am Chem Soc. 2007 Sep 12;129(36):11014-5. Epub 2007 Aug 16. No abstract available.

PMID:
17696543
18.

Crystal structure of the heme-IsdC complex, the central conduit of the Isd iron/heme uptake system in Staphylococcus aureus.

Sharp KH, Schneider S, Cockayne A, Paoli M.

J Biol Chem. 2007 Apr 6;282(14):10625-31. Epub 2007 Feb 7.

19.

N-acylhomoserine lactones antagonize virulence gene expression and quorum sensing in Staphylococcus aureus.

Qazi S, Middleton B, Muharram SH, Cockayne A, Hill P, O'Shea P, Chhabra SR, Cámara M, Williams P.

Infect Immun. 2006 Feb;74(2):910-9.

20.
21.
22.

The staphylococcal ferritins are differentially regulated in response to iron and manganese and via PerR and Fur.

Morrissey JA, Cockayne A, Brummell K, Williams P.

Infect Immun. 2004 Feb;72(2):972-9.

23.

Synthesis and deformylation of Staphylococcus aureus delta-toxin are linked to tricarboxylic acid cycle activity.

Somerville GA, Cockayne A, Dürr M, Peschel A, Otto M, Musser JM.

J Bacteriol. 2003 Nov;185(22):6686-94.

24.

Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system.

Scott RJ, Lian LY, Muharram SH, Cockayne A, Wood SJ, Bycroft BW, Williams P, Chan WC.

Bioorg Med Chem Lett. 2003 Aug 4;13(15):2449-53.

PMID:
12852941
25.

NapA protects Helicobacter pylori from oxidative stress damage, and its production is influenced by the ferric uptake regulator.

Cooksley C, Jenks PJ, Green A, Cockayne A, Logan RP, Hardie KR.

J Med Microbiol. 2003 Jun;52(Pt 6):461-9.

PMID:
12748264
26.

Conservation, surface exposure, and in vivo expression of the Frp family of iron-regulated cell wall proteins in Staphylococcus aureus.

Morrissey JA, Cockayne A, Hammacott J, Bishop K, Denman-Johnson A, Hill PJ, Williams P.

Infect Immun. 2002 May;70(5):2399-407.

27.

agr expression precedes escape of internalized Staphylococcus aureus from the host endosome.

Qazi SN, Counil E, Morrissey J, Rees CE, Cockayne A, Winzer K, Chan WC, Williams P, Hill PJ.

Infect Immun. 2001 Nov;69(11):7074-82.

28.

Structure, activity and evolution of the group I thiolactone peptide quorum-sensing system of Staphylococcus aureus.

MDowell P, Affas Z, Reynolds C, Holden MT, Wood SJ, Saint S, Cockayne A, Hill PJ, Dodd CE, Bycroft BW, Chan WC, Williams P.

Mol Microbiol. 2001 Jul;41(2):503-12.

29.

Molecular cloning and analysis of a putative siderophore ABC transporter from Staphylococcus aureus.

Morrissey JA, Cockayne A, Hill PJ, Williams P.

Infect Immun. 2000 Nov;68(11):6281-8.

30.

Mastic gum kills Helicobacter pylori.

Huwez FU, Thirlwell D, Cockayne A, Ala'Aldeen DA.

N Engl J Med. 1998 Dec 24;339(26):1946. No abstract available.

PMID:
9874617
31.

Safety and efficacy of rabeprazole in combination with four antibiotic regimens for the eradication of Helicobacter pylori in patients with chronic gastritis with or without peptic ulceration.

Stack WA, Knifton A, Thirlwell D, Cockayne A, Jenkins D, Hawkey CJ, Atherton JC.

Am J Gastroenterol. 1998 Oct;93(10):1909-13.

PMID:
9772054
32.

SirR, a novel iron-dependent repressor in Staphylococcus epidermidis.

Hill PJ, Cockayne A, Landers P, Morrissey JA, Sims CM, Williams P.

Infect Immun. 1998 Sep;66(9):4123-9.

33.

Molecular cloning of a 32-kilodalton lipoprotein component of a novel iron-regulated Staphylococcus epidermidis ABC transporter.

Cockayne A, Hill PJ, Powell NB, Bishop K, Sims C, Williams P.

Infect Immun. 1998 Aug;66(8):3767-74.

34.

A novel flow cytometric assay for quantitating adherence of Helicobacter pylori to gastric epithelial cells.

Logan RP, Robins A, Turner GA, Cockayne A, Borriello SP, Hawkey CJ.

J Immunol Methods. 1998 Apr 1;213(1):19-30.

PMID:
9671122
35.

The Staphylococcus aureus and Staphylococcus epidermidis transferrin-binding proteins are expressed in vivo during infection.

Modun BJ, Cockayne A, Finch R, Williams P.

Microbiology. 1998 Apr;144 ( Pt 4):1005-12.

PMID:
9579074
36.

Clarification of the link between polyunsaturated fatty acids and Helicobacter pylori-associated duodenal ulcer disease: a dietary intervention study.

Duggan AE, Atherton JC, Cockayne A, Balsitis M, Evison S, Hale T, Hawkey CJ, Spiller RC.

Br J Nutr. 1997 Oct;78(4):515-22.

PMID:
9389880
38.

Teicoplanin resistance in Staphylococcus haemolyticus, developing during treatment.

Cunningham R, Gurnell M, Bayston R, Cockayne A, Shelton A.

J Antimicrob Chemother. 1997 Mar;39(3):438-9. No abstract available.

PMID:
9096201
39.

Clinical and molecular aspects of the pathogenesis of Staphylococcus aureus bone and joint infections.

Cunningham R, Cockayne A, Humphreys H.

J Med Microbiol. 1996 Mar;44(3):157-64. Review.

PMID:
8636931
40.

Detection of the intragastric sites at which Helicobacter pylori evades treatment with amoxycillin and cimetidine.

Atherton JC, Cockayne A, Balsitis M, Kirk GE, Hawkey CJ, Spiller RC.

Gut. 1995 May;36(5):670-4.

42.

Investigation of microbial growth in vivo: evaluation of a novel in vivo chamber implant system.

Arbuthnott JP, Arbuthnott ER, Arbuthnott AD, Pike WJ, Cockayne A.

FEMS Microbiol Lett. 1992 Dec 15;100(1-3):75-9.

PMID:
1478484
43.

Cell envelope proteins of Staphylococcus epidermidis grown in vivo in a peritoneal chamber implant.

Modun B, Williams P, Pike WJ, Cockayne A, Arbuthnott JP, Finch R, Denyer SP.

Infect Immun. 1992 Jun;60(6):2551-3.

44.

Antigen-binding diversity of human hybridoma autoantibodies derived from splenocytes of patients with SLE.

Ravirajan CT, Kalsi J, Wiloch HW, Barakat S, Tuaillon N, Irvine W, Cockayne A, Harris A, Williams DG, Williams W, et al.

Lupus. 1992 May;1(3):157-65.

PMID:
1301976
45.

Staphylococcal enterotoxins and the immune system.

Wood AC, Todd I, Cockayne A, Arbuthnott JP.

FEMS Microbiol Immunol. 1991 Jun;3(3):121-33. Review. No abstract available.

PMID:
1878257
46.

Development and design of a novel in vivo chamber implant for the analysis of microbial virulence and assessment of antimicrobial therapy.

Pike WJ, Cockayne A, Webster CA, Slack RC, Shelton AP, Arbuthnott JP.

Microb Pathog. 1991 Jun;10(6):443-50.

PMID:
1795621
47.

Identification of flagellar and associated polypeptides of Helicobacter (formerly Campylobacter) pylori.

Luke CJ, Kubiak E, Cockayne A, Elliott TS, Penn CW.

FEMS Microbiol Lett. 1990 Sep 1;59(1-2):225-30.

PMID:
2276611
48.

A new attempt to distinguish serologically the subspecies of Treponema pallidum causing syphilis and yaws.

Noordhoek GT, Cockayne A, Schouls LM, Meloen RH, Stolz E, van Embden JD.

J Clin Microbiol. 1990 Jul;28(7):1600-7. Erratum in: J Clin Microbiol 1990 Dec;28(12):2853.

49.

Stable expression of foreign antigens from the chromosome of Salmonella typhimurium vaccine strains.

Strugnell RA, Maskell D, Fairweather N, Pickard D, Cockayne A, Penn C, Dougan G.

Gene. 1990 Mar 30;88(1):57-63.

PMID:
2187747
50.

Immune response to Treponema pertenue and Treponema pallidum Nichols in patients with yaws.

Martin PM, Cockayne A, Georges AJ, Penn CW.

Res Microbiol. 1990 Feb;141(2):181-6.

PMID:
1693218

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