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Thyroid hormone effects on glucose disposal in patients with insulin receptor mutations.

Kushchayeva YS, Startzell M, Cochran E, Auh S, Sekizkardes H, Soldin SJ, Kushchayev SV, Dieckmann W, Skarulis M, Abdul Sater Z, Brychta RJ, Cypess AM, Lin TC, Lightbourne M, Millo C, Brown RJ.

J Clin Endocrinol Metab. 2019 Oct 7. pii: dgz079. doi: 10.1210/clinem/dgz079. [Epub ahead of print]


Intravascular Papillary Endothelial Hyperplasia of the Pineal Region: A Case Report and Review of the Literature.

Retzlaff AA, Arispe K, Cochran EJ, Zwagerman NT.

World Neurosurg. 2019 Sep 13. pii: S1878-8750(19)32452-0. doi: 10.1016/j.wneu.2019.09.022. [Epub ahead of print]


Comorbidities and Survival in Patients With Lipodystrophy: An International Chart Review Study.

Akinci B, Oral EA, Neidert A, Rus D, Cheng WY, Thompson-Leduc P, Cheung HC, Bradt P, Foss de Freitas MC, Montenegro RM, Fernandes VO, Cochran E, Brown RJ.

J Clin Endocrinol Metab. 2019 Nov 1;104(11):5120-5135. doi: 10.1210/jc.2018-02730.


Thin Biobased Transparent UV-Blocking Coating Enabled by Nanoparticle Self-Assembly.

Olson E, Li Y, Lin FY, Miller A, Liu F, Tsyrenova A, Palm D, Curtzwiler GW, Vorst KL, Cochran E, Jiang S.

ACS Appl Mater Interfaces. 2019 Jul 10;11(27):24552-24559. doi: 10.1021/acsami.9b05383. Epub 2019 Jun 27.


Efficacy of Metreleptin Treatment in Familial Partial Lipodystrophy Due to PPARG vs LMNA Pathogenic Variants.

Sekizkardes H, Cochran E, Malandrino N, Garg A, Brown RJ.

J Clin Endocrinol Metab. 2019 Aug 1;104(8):3068-3076. doi: 10.1210/jc.2018-02787.


Cerebral Trypanosomiasis in an Immunocompromised Patient: Case Report and Review of the Literature.

Kaushal M, Shabani S, Cochran EJ, Samra H, Zwagerman NT.

World Neurosurg. 2019 Sep;129:225-231. doi: 10.1016/j.wneu.2019.05.260. Epub 2019 Jun 7.


Effects of metreleptin on proteinuria in patients with lipodystrophy.

Lee HL, Waldman MA, Auh S, Balow JE, Cochran EK, Gorden P, Brown RJ.

J Clin Endocrinol Metab. 2019 Apr 16. pii: jc.2019-00200. doi: 10.1210/jc.2019-00200. [Epub ahead of print]


Primary Papillary Thyroid Cancer of a Thyroglossal Duct Cyst.

Liaw J, Cochran E, Wilson MN.

Ear Nose Throat J. 2019 Mar;98(3):136-138. doi: 10.1177/0145561319825555. Epub 2019 Feb 5.


M281, an anti-FcRn antibody, inhibits IgG transfer in a human ex vivo placental perfusion model.

Roy S, Nanovskaya T, Patrikeeva S, Cochran E, Parge V, Guess J, Schaeck J, Choudhury A, Ahmed M, Ling LE.

Am J Obstet Gynecol. 2019 May;220(5):498.e1-498.e9. doi: 10.1016/j.ajog.2019.02.058. Epub 2019 Mar 5.


Visceral fat does not contribute to metabolic disease in lipodystrophy.

Malandrino N, Reynolds JC, Brychta RJ, Chen KY, Auh S, Gharib AM, Startzell M, Cochran EK, Brown RJ.

Obes Sci Pract. 2019 Jan 24;5(1):75-82. doi: 10.1002/osp4.319. eCollection 2019 Feb.


Long-term effectiveness and safety of metreleptin in the treatment of patients with partial lipodystrophy.

Oral EA, Gorden P, Cochran E, Araújo-Vilar D, Savage DB, Long A, Fine G, Salinardi T, Brown RJ.

Endocrine. 2019 Jun;64(3):500-511. doi: 10.1007/s12020-019-01862-8. Epub 2019 Feb 25.


The Limits of Earthquake Early Warning Accuracy and Best Alerting Strategy.

Minson SE, Baltay AS, Cochran ES, Hanks TC, Page MT, McBride SK, Milner KR, Meier MA.

Sci Rep. 2019 Feb 21;9(1):2478. doi: 10.1038/s41598-019-39384-y.


Thyroid Abnormalities in Patients With Extreme Insulin Resistance Syndromes.

Kushchayeva YS, Kushchayev SV, Startzell M, Cochran E, Auh S, Dai Y, Lightbourne M, Skarulis M, Brown RJ.

J Clin Endocrinol Metab. 2019 Jun 1;104(6):2216-2228. doi: 10.1210/jc.2018-02289.


Self-assembly of Janus Dumbbell Nanocrystals and Their Enhanced Surface Plasmon Resonance.

Liu F, Goyal S, Forrester M, Ma T, Miller K, Mansoorieh Y, Henjum J, Zhou L, Cochran E, Jiang S.

Nano Lett. 2019 Mar 13;19(3):1587-1594. doi: 10.1021/acs.nanolett.8b04464. Epub 2018 Dec 31.


Necuparanib, A Multitargeting Heparan Sulfate Mimetic, Targets Tumor and Stromal Compartments in Pancreatic Cancer.

MacDonald A, Priess M, Curran J, Guess J, Farutin V, Oosterom I, Chu CL, Cochran E, Zhang L, Getchell K, Lolkema M, Schultes BC, Krause S.

Mol Cancer Ther. 2019 Feb;18(2):245-256. doi: 10.1158/1535-7163.MCT-18-0417. Epub 2018 Nov 6.


Combined Immunosuppressive Therapy Induces Remission in Patients With Severe Type B Insulin Resistance: A Prospective Cohort Study.

Klubo-Gwiezdzinska J, Lange M, Cochran E, Semple RK, Gewert C, Brown RJ, Gorden P.

Diabetes Care. 2018 Nov;41(11):2353-2360. doi: 10.2337/dc18-0884. Epub 2018 Sep 10.


To catch a quake.

Cochran ES.

Nat Commun. 2018 Jul 3;9(1):2508. doi: 10.1038/s41467-018-04790-9.


The limits of earthquake early warning: Timeliness of ground motion estimates.

Minson SE, Meier MA, Baltay AS, Hanks TC, Cochran ES.

Sci Adv. 2018 Mar 21;4(3):eaaq0504. doi: 10.1126/sciadv.aaq0504. eCollection 2018 Mar.


Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy.

Brown RJ, Valencia A, Startzell M, Cochran E, Walter PJ, Garraffo HM, Cai H, Gharib AM, Ouwerkerk R, Courville AB, Bernstein S, Brychta RJ, Chen KY, Walter M, Auh S, Gorden P.

J Clin Invest. 2018 Aug 1;128(8):3504-3516. doi: 10.1172/JCI95476. Epub 2018 Jul 16.


Long-term effectiveness and safety of metreleptin in the treatment of patients with generalized lipodystrophy.

Brown RJ, Oral EA, Cochran E, Araújo-Vilar D, Savage DB, Long A, Fine G, Salinardi T, Gorden P.

Endocrine. 2018 Jun;60(3):479-489. doi: 10.1007/s12020-018-1589-1. Epub 2018 Apr 12.


Acid ceramidase and its inhibitors: a de novo drug target and a new class of drugs for killing glioblastoma cancer stem cells with high efficiency.

Doan NB, Alhajala H, Al-Gizawiy MM, Mueller WM, Rand SD, Connelly JM, Cochran EJ, Chitambar CR, Clark P, Kuo J, Schmainda KM, Mirza SP.

Oncotarget. 2017 Nov 7;8(68):112662-112674. doi: 10.18632/oncotarget.22637. eCollection 2017 Dec 22.


A Novel Generalized Lipodystrophy-Associated Progeroid Syndrome Due to Recurrent Heterozygous LMNA p.T10I Mutation.

Hussain I, Patni N, Ueda M, Sorkina E, Valerio CM, Cochran E, Brown RJ, Peeden J, Tikhonovich Y, Tiulpakov A, Stender SRS, Klouda E, Tayeh MK, Innis JW, Meyer A, Lal P, Godoy-Matos AF, Teles MG, Adams-Huet B, Rader DJ, Hegele RA, Oral EA, Garg A.

J Clin Endocrinol Metab. 2018 Mar 1;103(3):1005-1014. doi: 10.1210/jc.2017-02078.


Spatial discrimination of glioblastoma and treatment effect with histologically-validated perfusion and diffusion magnetic resonance imaging metrics.

Prah MA, Al-Gizawiy MM, Mueller WM, Cochran EJ, Hoffmann RG, Connelly JM, Schmainda KM.

J Neurooncol. 2018 Jan;136(1):13-21. doi: 10.1007/s11060-017-2617-3. Epub 2017 Sep 12.


Metreleptin therapy lowers plasma angiopoietin-like protein 3 in patients with generalized lipodystrophy.

Muniyappa R, Abel BS, Asthana A, Walter MF, Cochran EK, Remaley AT, Skarulis MC, Gorden P, Brown RJ.

J Clin Lipidol. 2017 Mar - Apr;11(2):543-550. doi: 10.1016/j.jacl.2017.02.002. Epub 2017 Feb 24.


Effects of Metreleptin in Pediatric Patients With Lipodystrophy.

Brown RJ, Meehan CA, Cochran E, Rother KI, Kleiner DE, Walter M, Gorden P.

J Clin Endocrinol Metab. 2017 May 1;102(5):1511-1519. doi: 10.1210/jc.2016-3628.


Amorphous Mixed-Metal Oxide Thin Films from Aqueous Solution Precursors with Near-Atomic Smoothness.

Kast MG, Cochran EA, Enman LJ, Mitchson G, Ditto J, Siefe C, Plassmeyer PN, Greenaway AL, Johnson DC, Page CJ, Boettcher SW.

J Am Chem Soc. 2016 Dec 28;138(51):16800-16808. doi: 10.1021/jacs.6b11084. Epub 2016 Dec 16.


Type B Insulin Resistance Masquerading as Ovarian Hyperthecosis.

Brown RJ, Joseph J, Cochran E, Gewert C, Semple R, Gorden P.

J Clin Endocrinol Metab. 2017 Jun 1;102(6):1789-1791. doi: 10.1210/jc.2016-3674.


Magnetic Resonance Imaging-Based Radiomic Profiles Predict Patient Prognosis in Newly Diagnosed Glioblastoma Before Therapy.

McGarry SD, Hurrell SL, Kaczmarowski AL, Cochran EJ, Connelly J, Rand SD, Schmainda KM, LaViolette PS.

Tomography. 2016 Sep;2(3):223-228.


Spinal osteoblastic meningioma with hematopoiesis: radiologic-pathologic correlation and review of the literature.

Cochran EJ, Schlauderaff A, Rand SD, Eckardt GW, Kurpad S.

Ann Diagn Pathol. 2016 Oct;24:30-4. doi: 10.1016/j.anndiagpath.2016.07.002. Epub 2016 Aug 2. Review.


Progressing Bevacizumab-Induced Diffusion Restriction Is Associated with Coagulative Necrosis Surrounded by Viable Tumor and Decreased Overall Survival in Patients with Recurrent Glioblastoma.

Nguyen HS, Milbach N, Hurrell SL, Cochran E, Connelly J, Bovi JA, Schultz CJ, Mueller WM, Rand SD, Schmainda KM, LaViolette PS.

AJNR Am J Neuroradiol. 2016 Dec;37(12):2201-2208. Epub 2016 Aug 4.


Metastatic Small Cell Carcinoma of the Lung: An Unusual Cause of Acute Fulminant Hepatic Failure.

Maglantay R, Qin J, Lanjewar S, Wieczorek R, Saad H, Cochran E, Harper A, Al-Ajam M, Goozner B, Blumenthal D, Pincus MR.

Fed Pract. 2016 Aug;33(Suppl 5):30S-34S.


Gel Point Suppression in RAFT Polymerization of Pure Acrylic Cross-Linker Derived from Soybean Oil.

Yan M, Huang Y, Lu M, Lin FY, Hernández NB, Cochran EW.

Biomacromolecules. 2016 Aug 8;17(8):2701-9. doi: 10.1021/acs.biomac.6b00745. Epub 2016 Jul 13.


Metastatic Scirrhous Breast Carcinoma to Orbit Causing Enophthalmos.

Orr CK, Cochran E, Shinder R.

Ophthalmology. 2016 Jul;123(7):1529. doi: 10.1016/j.ophtha.2016.04.012. No abstract available.


Management of Diabetic Ketoacidosis in Severe Insulin Resistance.

Robinson C, Cochran E, Gorden P, Brown RJ.

Diabetes Care. 2016 Aug;39(8):e116-8. doi: 10.2337/dc16-0635. Epub 2016 Jun 6. No abstract available.


Hidradenoma Papilliferum With Oncocytic Metaplasia: A Histopathological and Immunohistochemical Study.

Elbendary A, Cochran E, Xie Q, Kabigting F, Pereira L, Elston DM, Heilman E.

Am J Dermatopathol. 2016 Jun;38(6):444-7. doi: 10.1097/DAD.0000000000000599.


Combining Metabolic Engineering and Electrocatalysis: Application to the Production of Polyamides from Sugar.

Suastegui M, Matthiesen JE, Carraher JM, Hernandez N, Rodriguez Quiroz N, Okerlund A, Cochran EW, Shao Z, Tessonnier JP.

Angew Chem Int Ed Engl. 2016 Feb 12;55(7):2368-73. doi: 10.1002/anie.201509653. Epub 2016 Jan 14.


Immunogenicity associated with metreleptin treatment in patients with obesity or lipodystrophy.

Chan JL, Koda J, Heilig JS, Cochran EK, Gorden P, Oral EA, Brown RJ.

Clin Endocrinol (Oxf). 2016 Jul;85(1):137-49. doi: 10.1111/cen.12980. Epub 2016 Feb 2.


Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy.

Meehan CA, Cochran E, Kassai A, Brown RJ, Gorden P.

Expert Rev Clin Pharmacol. 2016;9(1):59-68. doi: 10.1586/17512433.2016.1096772. Epub 2015 Oct 14. Review.


Mild Caloric Restriction Decreases Insulin Requirements in Patients With Type 2 Diabetes and Severe Insulin Resistance.

Meehan CA, Cochran E, Mattingly M, Gorden P, Brown RJ.

Medicine (Baltimore). 2015 Jul;94(30):e1160. doi: 10.1097/MD.0000000000001160.


Prehospital use of plasma in traumatic hemorrhage (The PUPTH Trial): study protocol for a randomised controlled trial.

Reynolds PS, Michael MJ, Cochran ED, Wegelin JA, Spiess BD.

Trials. 2015 Jul 30;16:321. doi: 10.1186/s13063-015-0844-5.


Stability and bonding of new superalkali phosphide species.

Cochran E, Muller G, Meloni G.

Dalton Trans. 2015 Sep 7;44(33):14753-62. doi: 10.1039/c5dt02277k.


Lymphoma in acquired generalized lipodystrophy.

Brown RJ, Chan JL, Jaffe ES, Cochran E, DePaoli AM, Gautier JF, Goujard C, Vigouroux C, Gorden P.

Leuk Lymphoma. 2016;57(1):45-50. doi: 10.3109/10428194.2015.1040015. Epub 2015 May 12.


An ovarian pregnancy in a patient with a history of bilateral salpingectomies: a rare case.

Khandaker S, Chitkara P, Cochran E, Cutler J.

Case Rep Obstet Gynecol. 2015;2015:740376. doi: 10.1155/2015/740376. Epub 2015 Mar 17.


Partial and generalized lipodystrophy: comparison of baseline characteristics and response to metreleptin.

Diker-Cohen T, Cochran E, Gorden P, Brown RJ.

J Clin Endocrinol Metab. 2015 May;100(5):1802-10. doi: 10.1210/jc.2014-4491. Epub 2015 Mar 3.


Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity.

Washburn N, Schwab I, Ortiz D, Bhatnagar N, Lansing JC, Medeiros A, Tyler S, Mekala D, Cochran E, Sarvaiya H, Garofalo K, Meccariello R, Meador JW 3rd, Rutitzky L, Schultes BC, Ling L, Avery W, Nimmerjahn F, Manning AM, Kaundinya GV, Bosques CJ.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1297-306. doi: 10.1073/pnas.1422481112. Epub 2015 Mar 2. Erratum in: Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4339.


Insulin Receptor and the Kidney: Nephrocalcinosis in Patients with Recessive INSR Mutations.

Simpkin A, Cochran E, Cameron F, Dattani M, de Bock M, Dunger DB, Forsander G, Guran T, Harris J, Isaac I, Hussain K, Kleta R, Peters C, Tasic V, Williams R, Yap Kok Peng F, O''Rahilly S, Gorden P, Semple RK, Bockenhauer D.

Nephron Physiol. 2014;128(3-4):55-61. doi: 10.1159/000366225. Epub 2014 Oct 24.


Extradural chondroma presenting as lumbar mass with compressive neuropathy.

Pace J, Lozen AM, Wang MC, Cochran EJ.

J Craniovertebr Junction Spine. 2014 Jul;5(3):131-3. doi: 10.4103/0974-8237.142308.


Bone mineral content in patients with congenital generalized lipodystrophy is unaffected by metreleptin replacement therapy.

Christensen JD, Lungu AO, Cochran E, Collins MT, Gafni RI, Reynolds JC, Rother KI, Gorden P, Brown RJ.

J Clin Endocrinol Metab. 2014 Aug;99(8):E1493-500. doi: 10.1210/jc.2014-1353. Epub 2014 Jul 29.


Precise ex vivo histological validation of heightened cellularity and diffusion-restricted necrosis in regions of dark apparent diffusion coefficient in 7 cases of high-grade glioma.

LaViolette PS, Mickevicius NJ, Cochran EJ, Rand SD, Connelly J, Bovi JA, Malkin MG, Mueller WM, Schmainda KM.

Neuro Oncol. 2014 Dec;16(12):1599-606. doi: 10.1093/neuonc/nou142. Epub 2014 Jul 24.


Lipid regulation in lipodystrophy versus the obesity-associated metabolic syndrome: the dissociation of HDL-C and triglycerides.

Joseph J, Shamburek RD, Cochran EK, Gorden P, Brown RJ.

J Clin Endocrinol Metab. 2014 Sep;99(9):E1676-80. doi: 10.1210/jc.2014-1878. Epub 2014 Jun 13.

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