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Necuparanib, a multi-targeting heparan sulfate mimetic, targets tumor and stromal compartments in pancreatic cancer.

MacDonald A, Priess M, Curran J, Guess J, Farutin V, Oosterom I, Chu CL, Cochran E, Zhang L, Getchell K, Lolkema M, Schultes BC, Krause S.

Mol Cancer Ther. 2018 Nov 6. pii: molcanther.0417.2018. doi: 10.1158/1535-7163.MCT-18-0417. [Epub ahead of print]


Combined Immunosuppressive Therapy Induces Remission in Patients With Severe Type B Insulin Resistance: A Prospective Cohort Study.

Klubo-Gwiezdzinska J, Lange M, Cochran E, Semple RK, Gewert C, Brown RJ, Gorden P.

Diabetes Care. 2018 Nov;41(11):2353-2360. doi: 10.2337/dc18-0884. Epub 2018 Sep 10.


To catch a quake.

Cochran ES.

Nat Commun. 2018 Jul 3;9(1):2508. doi: 10.1038/s41467-018-04790-9.


The limits of earthquake early warning: Timeliness of ground motion estimates.

Minson SE, Meier MA, Baltay AS, Hanks TC, Cochran ES.

Sci Adv. 2018 Mar 21;4(3):eaaq0504. doi: 10.1126/sciadv.aaq0504. eCollection 2018 Mar.


Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy.

Brown RJ, Valencia A, Startzell M, Cochran E, Walter PJ, Garraffo HM, Cai H, Gharib AM, Ouwerkerk R, Courville AB, Bernstein S, Brychta RJ, Chen KY, Walter M, Auh S, Gorden P.

J Clin Invest. 2018 Aug 1;128(8):3504-3516. doi: 10.1172/JCI95476. Epub 2018 Jul 16.


Long-term effectiveness and safety of metreleptin in the treatment of patients with generalized lipodystrophy.

Brown RJ, Oral EA, Cochran E, Araújo-Vilar D, Savage DB, Long A, Fine G, Salinardi T, Gorden P.

Endocrine. 2018 Jun;60(3):479-489. doi: 10.1007/s12020-018-1589-1. Epub 2018 Apr 12.


Acid ceramidase and its inhibitors: a de novo drug target and a new class of drugs for killing glioblastoma cancer stem cells with high efficiency.

Doan NB, Alhajala H, Al-Gizawiy MM, Mueller WM, Rand SD, Connelly JM, Cochran EJ, Chitambar CR, Clark P, Kuo J, Schmainda KM, Mirza SP.

Oncotarget. 2017 Nov 7;8(68):112662-112674. doi: 10.18632/oncotarget.22637. eCollection 2017 Dec 22.


A Novel Generalized Lipodystrophy-Associated Progeroid Syndrome Due to Recurrent Heterozygous LMNA p.T10I Mutation.

Hussain I, Patni N, Ueda M, Sorkina E, Valerio CM, Cochran E, Brown RJ, Peeden J, Tikhonovich Y, Tiulpakov A, Stender SRS, Klouda E, Tayeh MK, Innis JW, Meyer A, Lal P, Godoy-Matos AF, Teles MG, Adams-Huet B, Rader DJ, Hegele RA, Oral EA, Garg A.

J Clin Endocrinol Metab. 2018 Mar 1;103(3):1005-1014. doi: 10.1210/jc.2017-02078.


Spatial discrimination of glioblastoma and treatment effect with histologically-validated perfusion and diffusion magnetic resonance imaging metrics.

Prah MA, Al-Gizawiy MM, Mueller WM, Cochran EJ, Hoffmann RG, Connelly JM, Schmainda KM.

J Neurooncol. 2018 Jan;136(1):13-21. doi: 10.1007/s11060-017-2617-3. Epub 2017 Sep 12.


Metreleptin therapy lowers plasma angiopoietin-like protein 3 in patients with generalized lipodystrophy.

Muniyappa R, Abel BS, Asthana A, Walter MF, Cochran EK, Remaley AT, Skarulis MC, Gorden P, Brown RJ.

J Clin Lipidol. 2017 Mar - Apr;11(2):543-550. doi: 10.1016/j.jacl.2017.02.002. Epub 2017 Feb 24.


Effects of Metreleptin in Pediatric Patients With Lipodystrophy.

Brown RJ, Meehan CA, Cochran E, Rother KI, Kleiner DE, Walter M, Gorden P.

J Clin Endocrinol Metab. 2017 May 1;102(5):1511-1519. doi: 10.1210/jc.2016-3628.


Amorphous Mixed-Metal Oxide Thin Films from Aqueous Solution Precursors with Near-Atomic Smoothness.

Kast MG, Cochran EA, Enman LJ, Mitchson G, Ditto J, Siefe C, Plassmeyer PN, Greenaway AL, Johnson DC, Page CJ, Boettcher SW.

J Am Chem Soc. 2016 Dec 28;138(51):16800-16808. doi: 10.1021/jacs.6b11084. Epub 2016 Dec 16.


Type B Insulin Resistance Masquerading as Ovarian Hyperthecosis.

Brown RJ, Joseph J, Cochran E, Gewert C, Semple R, Gorden P.

J Clin Endocrinol Metab. 2017 Jun 1;102(6):1789-1791. doi: 10.1210/jc.2016-3674.


Magnetic Resonance Imaging-Based Radiomic Profiles Predict Patient Prognosis in Newly Diagnosed Glioblastoma Before Therapy.

McGarry SD, Hurrell SL, Kaczmarowski AL, Cochran EJ, Connelly J, Rand SD, Schmainda KM, LaViolette PS.

Tomography. 2016 Sep;2(3):223-228.


Spinal osteoblastic meningioma with hematopoiesis: radiologic-pathologic correlation and review of the literature.

Cochran EJ, Schlauderaff A, Rand SD, Eckardt GW, Kurpad S.

Ann Diagn Pathol. 2016 Oct;24:30-4. doi: 10.1016/j.anndiagpath.2016.07.002. Epub 2016 Aug 2. Review.


Progressing Bevacizumab-Induced Diffusion Restriction Is Associated with Coagulative Necrosis Surrounded by Viable Tumor and Decreased Overall Survival in Patients with Recurrent Glioblastoma.

Nguyen HS, Milbach N, Hurrell SL, Cochran E, Connelly J, Bovi JA, Schultz CJ, Mueller WM, Rand SD, Schmainda KM, LaViolette PS.

AJNR Am J Neuroradiol. 2016 Dec;37(12):2201-2208. Epub 2016 Aug 4.


Gel Point Suppression in RAFT Polymerization of Pure Acrylic Cross-Linker Derived from Soybean Oil.

Yan M, Huang Y, Lu M, Lin FY, Hernández NB, Cochran EW.

Biomacromolecules. 2016 Aug 8;17(8):2701-9. doi: 10.1021/acs.biomac.6b00745. Epub 2016 Jul 13.


Metastatic Scirrhous Breast Carcinoma to Orbit Causing Enophthalmos.

Orr CK, Cochran E, Shinder R.

Ophthalmology. 2016 Jul;123(7):1529. doi: 10.1016/j.ophtha.2016.04.012. No abstract available.


Management of Diabetic Ketoacidosis in Severe Insulin Resistance.

Robinson C, Cochran E, Gorden P, Brown RJ.

Diabetes Care. 2016 Aug;39(8):e116-8. doi: 10.2337/dc16-0635. Epub 2016 Jun 6. No abstract available.


Hidradenoma Papilliferum With Oncocytic Metaplasia: A Histopathological and Immunohistochemical Study.

Elbendary A, Cochran E, Xie Q, Kabigting F, Pereira L, Elston DM, Heilman E.

Am J Dermatopathol. 2016 Jun;38(6):444-7. doi: 10.1097/DAD.0000000000000599.


Combining Metabolic Engineering and Electrocatalysis: Application to the Production of Polyamides from Sugar.

Suastegui M, Matthiesen JE, Carraher JM, Hernandez N, Rodriguez Quiroz N, Okerlund A, Cochran EW, Shao Z, Tessonnier JP.

Angew Chem Int Ed Engl. 2016 Feb 12;55(7):2368-73. doi: 10.1002/anie.201509653. Epub 2016 Jan 14.


Immunogenicity associated with metreleptin treatment in patients with obesity or lipodystrophy.

Chan JL, Koda J, Heilig JS, Cochran EK, Gorden P, Oral EA, Brown RJ.

Clin Endocrinol (Oxf). 2016 Jul;85(1):137-49. doi: 10.1111/cen.12980. Epub 2016 Feb 2.


Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy.

Meehan CA, Cochran E, Kassai A, Brown RJ, Gorden P.

Expert Rev Clin Pharmacol. 2016;9(1):59-68. doi: 10.1586/17512433.2016.1096772. Epub 2015 Oct 14. Review.


Mild Caloric Restriction Decreases Insulin Requirements in Patients With Type 2 Diabetes and Severe Insulin Resistance.

Meehan CA, Cochran E, Mattingly M, Gorden P, Brown RJ.

Medicine (Baltimore). 2015 Jul;94(30):e1160. doi: 10.1097/MD.0000000000001160.


Prehospital use of plasma in traumatic hemorrhage (The PUPTH Trial): study protocol for a randomised controlled trial.

Reynolds PS, Michael MJ, Cochran ED, Wegelin JA, Spiess BD.

Trials. 2015 Jul 30;16:321. doi: 10.1186/s13063-015-0844-5.


Stability and bonding of new superalkali phosphide species.

Cochran E, Muller G, Meloni G.

Dalton Trans. 2015 Sep 7;44(33):14753-62. doi: 10.1039/c5dt02277k.


Lymphoma in acquired generalized lipodystrophy.

Brown RJ, Chan JL, Jaffe ES, Cochran E, DePaoli AM, Gautier JF, Goujard C, Vigouroux C, Gorden P.

Leuk Lymphoma. 2016;57(1):45-50. doi: 10.3109/10428194.2015.1040015. Epub 2015 May 12.


An ovarian pregnancy in a patient with a history of bilateral salpingectomies: a rare case.

Khandaker S, Chitkara P, Cochran E, Cutler J.

Case Rep Obstet Gynecol. 2015;2015:740376. doi: 10.1155/2015/740376. Epub 2015 Mar 17.


Partial and generalized lipodystrophy: comparison of baseline characteristics and response to metreleptin.

Diker-Cohen T, Cochran E, Gorden P, Brown RJ.

J Clin Endocrinol Metab. 2015 May;100(5):1802-10. doi: 10.1210/jc.2014-4491. Epub 2015 Mar 3.


Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity.

Washburn N, Schwab I, Ortiz D, Bhatnagar N, Lansing JC, Medeiros A, Tyler S, Mekala D, Cochran E, Sarvaiya H, Garofalo K, Meccariello R, Meador JW 3rd, Rutitzky L, Schultes BC, Ling L, Avery W, Nimmerjahn F, Manning AM, Kaundinya GV, Bosques CJ.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1297-306. doi: 10.1073/pnas.1422481112. Epub 2015 Mar 2. Erratum in: Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4339.


Insulin Receptor and the Kidney: Nephrocalcinosis in Patients with Recessive INSR Mutations.

Simpkin A, Cochran E, Cameron F, Dattani M, de Bock M, Dunger DB, Forsander G, Guran T, Harris J, Isaac I, Hussain K, Kleta R, Peters C, Tasic V, Williams R, Yap Kok Peng F, O''Rahilly S, Gorden P, Semple RK, Bockenhauer D.

Nephron Physiol. 2014;128(3-4):55-61. doi: 10.1159/000366225. Epub 2014 Oct 24.


Extradural chondroma presenting as lumbar mass with compressive neuropathy.

Pace J, Lozen AM, Wang MC, Cochran EJ.

J Craniovertebr Junction Spine. 2014 Jul;5(3):131-3. doi: 10.4103/0974-8237.142308.


Bone mineral content in patients with congenital generalized lipodystrophy is unaffected by metreleptin replacement therapy.

Christensen JD, Lungu AO, Cochran E, Collins MT, Gafni RI, Reynolds JC, Rother KI, Gorden P, Brown RJ.

J Clin Endocrinol Metab. 2014 Aug;99(8):E1493-500. doi: 10.1210/jc.2014-1353. Epub 2014 Jul 29.


Precise ex vivo histological validation of heightened cellularity and diffusion-restricted necrosis in regions of dark apparent diffusion coefficient in 7 cases of high-grade glioma.

LaViolette PS, Mickevicius NJ, Cochran EJ, Rand SD, Connelly J, Bovi JA, Malkin MG, Mueller WM, Schmainda KM.

Neuro Oncol. 2014 Dec;16(12):1599-606. doi: 10.1093/neuonc/nou142. Epub 2014 Jul 24.


Lipid regulation in lipodystrophy versus the obesity-associated metabolic syndrome: the dissociation of HDL-C and triglycerides.

Joseph J, Shamburek RD, Cochran EK, Gorden P, Brown RJ.

J Clin Endocrinol Metab. 2014 Sep;99(9):E1676-80. doi: 10.1210/jc.2014-1878. Epub 2014 Jun 13.


Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease.

Payne F, Lim K, Girousse A, Brown RJ, Kory N, Robbins A, Xue Y, Sleigh A, Cochran E, Adams C, Dev Borman A, Russel-Jones D, Gorden P, Semple RK, Saudek V, O'Rahilly S, Walther TC, Barroso I, Savage DB.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8901-6. doi: 10.1073/pnas.1408523111. Epub 2014 Jun 2.


Hypervalence in monoxides and dioxides of superalkali clusters.

Cochran E, Meloni G.

J Chem Phys. 2014 May 28;140(20):204319. doi: 10.1063/1.4879658.


Comprehensive characterization of glioblastoma tumor tissues for biomarker identification using mass spectrometry-based label-free quantitative proteomics.

Heroux MS, Chesnik MA, Halligan BD, Al-Gizawiy M, Connelly JM, Mueller WM, Rand SD, Cochran EJ, LaViolette PS, Malkin MG, Schmainda KM, Mirza SP.

Physiol Genomics. 2014 Jul 1;46(13):467-81. doi: 10.1152/physiolgenomics.00034.2014. Epub 2014 May 6.


The battle for the "green" polymer. Different approaches for biopolymer synthesis: bioadvantaged vs. bioreplacement.

Hernández N, Williams RC, Cochran EW.

Org Biomol Chem. 2014 May 14;12(18):2834-49. doi: 10.1039/c3ob42339e. Review.


Effects of leptin replacement therapy on pancreatic β-cell function in patients with lipodystrophy.

Muniyappa R, Brown RJ, Mari A, Joseph J, Warren MA, Cochran EK, Skarulis MC, Gorden P.

Diabetes Care. 2014 Apr;37(4):1101-7. doi: 10.2337/dc13-2040. Epub 2014 Feb 4.


Practice tips and tools for the successful use of U-500 regular human insulin: the diabetes educator is key.

Cochran EK, Valentine V, Samaan KH, Corey IB, Jackson JA.

Diabetes Educ. 2014 Mar-Apr;40(2):153-65. doi: 10.1177/0145721713508822. Epub 2013 Oct 24. Review.


Metreleptin improves blood glucose in patients with insulin receptor mutations.

Brown RJ, Cochran E, Gorden P.

J Clin Endocrinol Metab. 2013 Nov;98(11):E1749-56. doi: 10.1210/jc.2013-2317. Epub 2013 Aug 22.


Silicon detectors for combined MR-PET and MR-SPECT imaging.

Studen A, Chesi E, Cindro V, Clinthorne NH, Cochran E, Grošičar B, Grkovski M, Honscheid K, Kagan H, Lacasta C, Llosa G, Mikuž M, Stankova V, Weilhammer P, Zontar D.

Nucl Instrum Methods Phys Res A. 2013 Feb 21;702:88-90. Epub 2012 Sep 1.


The liver diseases of lipodystrophy: the long-term effect of leptin treatment.

Safar Zadeh E, Lungu AO, Cochran EK, Brown RJ, Ghany MG, Heller T, Kleiner DE, Gorden P.

J Hepatol. 2013 Jul;59(1):131-7. doi: 10.1016/j.jhep.2013.02.007. Epub 2013 Feb 21.


Silicon as an Unconventional Detector in Positron Emission Tomography.

Clinthorne NH, Brzezinski K, Chesi E, Cochran E, Grkovski M, Grošičar B, Honscheid K, Huh S, Kagan H, Lacasta C, Linhart V, Mikuž M, Smith S, Stankova V, Studen A, Weilhammer P, Zontar D.

Nucl Instrum Methods Phys Res A. 2013 Jan 1;699(21):216-220. Epub 2012 May 14.


Syndromic insulin resistance: models for the therapeutic basis of the metabolic syndrome and other targets of insulin resistance.

Gorden P, Zadeh ES, Cochran E, Brown RJ.

Endocr Pract. 2012 Sep-Oct;18(5):763-71. doi: 10.4158/EP12139.RA. Review.


Consequences of stopping and restarting leptin in an adolescent with lipodystrophy.

Kamran F, Rother KI, Cochran E, Safar Zadeh E, Gorden P, Brown RJ.

Horm Res Paediatr. 2012;78(5-6):320-5. doi: 10.1159/000341398. Epub 2012 Sep 4.


Pregnancy in a woman with congenital generalized lipodystrophy: leptin's vital role in reproduction.

Maguire M, Lungu A, Gorden P, Cochran E, Stratton P.

Obstet Gynecol. 2012 Feb;119(2 Pt 2):452-5. doi: 10.1097/AOG.0b013e31822cecf7. Erratum in: Obstet Gynecol. 2013 Jul;122(1):160.


The Clinical Center's blood glucose management service: a story in quality integrated care.

Feigenbaum K, Brooks PG, Chamberlain CE, Cochran E, Adams-McLean A, Malek R, Harlan DM.

Diabetes Educ. 2012 Mar-Apr;38(2):194-206. doi: 10.1177/0145721711430355. Epub 2011 Dec 21.


Insulin resistance is a sufficient basis for hyperandrogenism in lipodystrophic women with polycystic ovarian syndrome.

Lungu AO, Zadeh ES, Goodling A, Cochran E, Gorden P.

J Clin Endocrinol Metab. 2012 Feb;97(2):563-7. doi: 10.1210/jc.2011-1896. Epub 2011 Nov 16.

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