Immunotherapy Resistance by Inflammation-Induced Dedifferentiation.

Mehta A, Kim YJ, Robert L, Tsoi J, Comin-Anduix B, Berent-Maoz B, Cochran AJ, Economou JS, Tumeh PC, Puig-Saus C, Ribas A.

Cancer Discov. 2018 Aug;8(8):935-943. doi: 10.1158/2159-8290.CD-17-1178. Epub 2018 Jun 13.


High response rate to PD-1 blockade in desmoplastic melanomas.

Eroglu Z, Zaretsky JM, Hu-Lieskovan S, Kim DW, Algazi A, Johnson DB, Liniker E, Ben Kong, Munhoz R, Rapisuwon S, Gherardini PF, Chmielowski B, Wang X, Shintaku IP, Wei C, Sosman JA, Joseph RW, Postow MA, Carlino MS, Hwu WJ, Scolyer RA, Messina J, Cochran AJ, Long GV, Ribas A.

Nature. 2018 Jan 18;553(7688):347-350. doi: 10.1038/nature25187. Epub 2018 Jan 10.


Regarding complications following completion lymphadenectomy.

Faries MB, Cochran AJ, Thompson JF.

Eur J Surg Oncol. 2017 Dec;43(12):2374-2375. doi: 10.1016/j.ejso.2017.09.024. Epub 2017 Nov 2. No abstract available.


Melanoma Sentinel-Node Metastasis.

Faries MB, Cochran AJ, Thompson JF.

N Engl J Med. 2017 Aug 31;377(9):892. doi: 10.1056/NEJMc1708918. No abstract available.


Impact of Time Between Diagnosis and SLNB on Outcomes in Cutaneous Melanoma.

Nelson DW, Stern S, Elashoff DE, Elashoff R, Thompson JF, Mozzillo N, Nieweg OE, Hoekstra HJ, Cochran AJ, Faries MB.

J Am Coll Surg. 2017 Aug;225(2):302-311. doi: 10.1016/j.jamcollsurg.2017.05.013. Epub 2017 Jun 28.


Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma.

Faries MB, Thompson JF, Cochran AJ, Andtbacka RH, Mozzillo N, Zager JS, Jahkola T, Bowles TL, Testori A, Beitsch PD, Hoekstra HJ, Moncrieff M, Ingvar C, Wouters MWJM, Sabel MS, Levine EA, Agnese D, Henderson M, Dummer R, Rossi CR, Neves RI, Trocha SD, Wright F, Byrd DR, Matter M, Hsueh E, MacKenzie-Ross A, Johnson DB, Terheyden P, Berger AC, Huston TL, Wayne JD, Smithers BM, Neuman HB, Schneebaum S, Gershenwald JE, Ariyan CE, Desai DC, Jacobs L, McMasters KM, Gesierich A, Hersey P, Bines SD, Kane JM, Barth RJ, McKinnon G, Farma JM, Schultz E, Vidal-Sicart S, Hoefer RA, Lewis JM, Scheri R, Kelley MC, Nieweg OE, Noyes RD, Hoon DSB, Wang HJ, Elashoff DA, Elashoff RM.

N Engl J Med. 2017 Jun 8;376(23):2211-2222. doi: 10.1056/NEJMoa1613210.


Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors.

Escuin-Ordinas H, Li S, Xie MW, Sun L, Hugo W, Huang RR, Jiao J, de-Faria FM, Realegeno S, Krystofinski P, Azhdam A, Komenan SM, Atefi M, Comin-Anduix B, Pellegrini M, Cochran AJ, Modlin RL, Herschman HR, Lo RS, McBride WH, Segura T, Ribas A.

Nat Commun. 2016 Aug 1;7:12348. doi: 10.1038/ncomms12348.


Restarting antidepressant treatment following early discontinuation--a primary care database study.

Burton C, Cochran AJ, Cameron IM.

Fam Pract. 2015 Oct;32(5):520-4. doi: 10.1093/fampra/cmv063. Epub 2015 Aug 5.


Identification, clinical significance, and management of very small melanoma metastases in sentinel lymph nodes.

Cochran AJ.

Ann Surg Oncol. 2015 Sep;22(9):2812-4. doi: 10.1245/s10434-015-4625-x. Epub 2015 May 27. No abstract available.


β-Alanine Supplementation Does Not Augment the Skeletal Muscle Adaptive Response to 6 Weeks of Sprint Interval Training.

Cochran AJ, Percival ME, Thompson S, Gillen JB, MacInnis MJ, Potter MA, Tarnopolsky MA, Gibala MJ.

Int J Sport Nutr Exerc Metab. 2015 Dec;25(6):541-9. doi: 10.1123/ijsnem.2015-0046. Epub 2015 May 22.


Manipulating Carbohydrate Availability Between Twice-Daily Sessions of High-Intensity Interval Training Over 2 Weeks Improves Time-Trial Performance.

Cochran AJ, Myslik F, MacInnis MJ, Percival ME, Bishop D, Tarnopolsky MA, Gibala MJ.

Int J Sport Nutr Exerc Metab. 2015 Oct;25(5):463-70. doi: 10.1123/ijsnem.2014-0263. Epub 2015 Mar 26.


Keratoacanthoma and squamous cell carcinoma are distinct from a molecular perspective.

Ra SH, Su A, Li X, Zhou J, Cochran AJ, Kulkarni RP, Binder SW.

Mod Pathol. 2015 Jun;28(6):799-806. doi: 10.1038/modpathol.2015.5. Epub 2015 Feb 13.


Is sentinel node susceptibility to metastases related to nodal immune modulation?

Cochran AJ, Huang RR, Su A, Itakura E, Wen DR.

Cancer J. 2015 Jan-Feb;21(1):39-46. doi: 10.1097/PPO.0000000000000094. Review.


MSLT-I-response of clinical trial investigators.

Faries MB, Cochran AJ, Thompson JF.

Nat Rev Clin Oncol. 2014 Nov;11(11). doi: 10.1038/nrclinonc.2014.65-c1. Epub 2014 Oct 14. No abstract available.


Sentinel lymph node biopsy for melanoma: a plea to let the data be heard.

Thompson JF, Faries MB, Cochran AJ.

Ann Surg Oncol. 2014 Oct;21(11):3362-4. doi: 10.1245/s10434-014-3967-0. Epub 2014 Aug 8. No abstract available.


Sentinel-node biopsy in melanoma.

Thompson JF, Cochran AJ, Faries MB.

N Engl J Med. 2014 May 29;370(22):2149-50. doi: 10.1056/NEJMc1402989. No abstract available.


Should patients being considered for surgical management in melanoma centers have their histology reviewed by specialized pathologists?

Cochran AJ.

Ann Surg Oncol. 2014 Jul;21(7):2124-6. doi: 10.1245/s10434-014-3694-6. Epub 2014 Apr 14. No abstract available.


Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma.

Chodon T, Comin-Anduix B, Chmielowski B, Koya RC, Wu Z, Auerbach M, Ng C, Avramis E, Seja E, Villanueva A, McCannel TA, Ishiyama A, Czernin J, Radu CG, Wang X, Gjertson DW, Cochran AJ, Cornetta K, Wong DJ, Kaplan-Lefko P, Hamid O, Samlowski W, Cohen PA, Daniels GA, Mukherji B, Yang L, Zack JA, Kohn DB, Heath JR, Glaspy JA, Witte ON, Baltimore D, Economou JS, Ribas A.

Clin Cancer Res. 2014 May 1;20(9):2457-65. doi: 10.1158/1078-0432.CCR-13-3017. Epub 2014 Mar 14.


A randomized, double-blind, placebo-controlled phase II clinical trial of lovastatin for various endpoints of melanoma pathobiology.

Linden KG, Leachman SA, Zager JS, Jakowatz JG, Viner JL, McLaren CE, Barr RJ, Carpenter PM, Chen WP, Elmets CA, Tangrea JA, Lim SJ, Cochran AJ, Meyskens FL Jr.

Cancer Prev Res (Phila). 2014 May;7(5):496-504. doi: 10.1158/1940-6207.CAPR-13-0189. Epub 2014 Mar 10.


CTLA4 blockade broadens the peripheral T-cell receptor repertoire.

Robert L, Tsoi J, Wang X, Emerson R, Homet B, Chodon T, Mok S, Huang RR, Cochran AJ, Comin-Anduix B, Koya RC, Graeber TG, Robins H, Ribas A.

Clin Cancer Res. 2014 May 1;20(9):2424-32. doi: 10.1158/1078-0432.CCR-13-2648. Epub 2014 Feb 28. Erratum in: Clin Cancer Res. 2015 Jul 15;21(14):3359.


Intermittent and continuous high-intensity exercise training induce similar acute but different chronic muscle adaptations.

Cochran AJ, Percival ME, Tricarico S, Little JP, Cermak N, Gillen JB, Tarnopolsky MA, Gibala MJ.

Exp Physiol. 2014 May 1;99(5):782-91. doi: 10.1113/expphysiol.2013.077453. Epub 2014 Feb 14.


Age as a predictor of sentinel node metastasis among patients with localized melanoma: an inverse correlation of melanoma mortality and incidence of sentinel node metastasis among young and old patients.

Balch CM, Thompson JF, Gershenwald JE, Soong SJ, Ding S, McMasters KM, Coit DG, Eggermont AM, Gimotty PA, Johnson TM, Kirkwood JM, Leong SP, Ross MI, Byrd DR, Cochran AJ, Mihm MC Jr, Morton DL, Atkins MB, Flaherty KT, Sondak VK.

Ann Surg Oncol. 2014 Apr;21(4):1075-81. doi: 10.1245/s10434-013-3464-x. Epub 2014 Feb 15.


Final trial report of sentinel-node biopsy versus nodal observation in melanoma.

Morton DL, Thompson JF, Cochran AJ, Mozzillo N, Nieweg OE, Roses DF, Hoekstra HJ, Karakousis CP, Puleo CA, Coventry BJ, Kashani-Sabet M, Smithers BM, Paul E, Kraybill WG, McKinnon JG, Wang HJ, Elashoff R, Faries MB; MSLT Group.

N Engl J Med. 2014 Feb 13;370(7):599-609. doi: 10.1056/NEJMoa1310460.


COX-2 inhibition prevents the appearance of cutaneous squamous cell carcinomas accelerated by BRAF inhibitors.

Escuin-Ordinas H, Atefi M, Fu Y, Cass A, Ng C, Huang RR, Yashar S, Comin-Anduix B, Avramis E, Cochran AJ, Marais R, Lo RS, Graeber TG, Herschman HR, Ribas A.

Mol Oncol. 2014 Mar;8(2):250-60. doi: 10.1016/j.molonc.2013.11.005. Epub 2013 Dec 1.


Age as a prognostic factor in patients with localized melanoma and regional metastases.

Balch CM, Soong SJ, Gershenwald JE, Thompson JF, Coit DG, Atkins MB, Ding S, Cochran AJ, Eggermont AM, Flaherty KT, Gimotty PA, Johnson TM, Kirkwood JM, Leong SP, McMasters KM, Mihm MC Jr, Morton DL, Ross MI, Sondak VK.

Ann Surg Oncol. 2013 Nov;20(12):3961-8. doi: 10.1245/s10434-013-3100-9. Epub 2013 Jul 10.


Multifunctional T-cell analyses to study response and progression in adoptive cell transfer immunotherapy.

Ma C, Cheung AF, Chodon T, Koya RC, Wu Z, Ng C, Avramis E, Cochran AJ, Witte ON, Baltimore D, Chmielowski B, Economou JS, Comin-Anduix B, Ribas A, Heath JR.

Cancer Discov. 2013 Apr;3(4):418-29. doi: 10.1158/2159-8290.CD-12-0383. Epub 2013 Mar 21.


Reduced carbohydrate availability enhances exercise-induced p53 signaling in human skeletal muscle: implications for mitochondrial biogenesis.

Bartlett JD, Louhelainen J, Iqbal Z, Cochran AJ, Gibala MJ, Gregson W, Close GL, Drust B, Morton JP.

Am J Physiol Regul Integr Comp Physiol. 2013 Mar 15;304(6):R450-8. doi: 10.1152/ajpregu.00498.2012. Epub 2013 Jan 30.


Pilot study on "pericytic mimicry" and potential embryonic/stem cell properties of angiotropic melanoma cells interacting with the abluminal vascular surface.

Lugassy C, Wadehra M, Li X, Corselli M, Akhavan D, Binder SW, Péault B, Cochran AJ, Mischel PS, Kleinman HK, Barnhill RL.

Cancer Microenviron. 2013 Apr;6(1):19-29. doi: 10.1007/s12307-012-0128-5. Epub 2012 Dec 29.


Metastasectomy for distant metastatic melanoma: analysis of data from the first Multicenter Selective Lymphadenectomy Trial (MSLT-I).

Howard JH, Thompson JF, Mozzillo N, Nieweg OE, Hoekstra HJ, Roses DF, Sondak VK, Reintgen DS, Kashani-Sabet M, Karakousis CP, Coventry BJ, Kraybill WG, Smithers BM, Elashoff R, Stern SL, Cochran AJ, Faries MB, Morton DL.

Ann Surg Oncol. 2012 Aug;19(8):2547-55. doi: 10.1245/s10434-012-2398-z. Epub 2012 May 31.


Differential gene expression profiling of primary cutaneous melanoma and sentinel lymph node metastases.

Koh SS, Wei JP, Li X, Huang RR, Doan NB, Scolyer RA, Cochran AJ, Binder SW.

Mod Pathol. 2012 Jun;25(6):828-37. doi: 10.1038/modpathol.2012.32. Epub 2012 Mar 9.


Matched work high-intensity interval and continuous running induce similar increases in PGC-1α mRNA, AMPK, p38, and p53 phosphorylation in human skeletal muscle.

Bartlett JD, Hwa Joo C, Jeong TS, Louhelainen J, Cochran AJ, Gibala MJ, Gregson W, Close GL, Drust B, Morton JP.

J Appl Physiol (1985). 2012 Apr;112(7):1135-43. doi: 10.1152/japplphysiol.01040.2011. Epub 2012 Jan 19.


Muscle time under tension during resistance exercise stimulates differential muscle protein sub-fractional synthetic responses in men.

Burd NA, Andrews RJ, West DW, Little JP, Cochran AJ, Hector AJ, Cashaback JG, Gibala MJ, Potvin JR, Baker SK, Phillips SM.

J Physiol. 2012 Jan 15;590(2):351-62. doi: 10.1113/jphysiol.2011.221200. Epub 2011 Nov 21.


"Stealth" melanoma cells in histology-negative sentinel lymph nodes.

Itakura E, Huang RR, Wen DR, Cochran AJ.

Am J Surg Pathol. 2011 Nov;35(11):1657-65. doi: 10.1097/PAS.0b013e3182322cf7.


Clinically relevant information from sentinel lymph node biopsies of melanoma patients.

Wen DR, Cochran AJ, Huang RR, Itakura E, Binder S.

J Surg Oncol. 2011 Sep;104(4):369-78. doi: 10.1002/jso.21818. Review.


Exome sequencing-based copy-number variation and loss of heterozygosity detection: ExomeCNV.

Sathirapongsasuti JF, Lee H, Horst BA, Brunner G, Cochran AJ, Binder S, Quackenbush J, Nelson SF.

Bioinformatics. 2011 Oct 1;27(19):2648-54. doi: 10.1093/bioinformatics/btr462. Epub 2011 Aug 9.


CTLA4 blockade induces frequent tumor infiltration by activated lymphocytes regardless of clinical responses in humans.

Huang RR, Jalil J, Economou JS, Chmielowski B, Koya RC, Mok S, Sazegar H, Seja E, Villanueva A, Gomez-Navarro J, Glaspy JA, Cochran AJ, Ribas A.

Clin Cancer Res. 2011 Jun 15;17(12):4101-9. doi: 10.1158/1078-0432.CCR-11-0407. Epub 2011 May 10.


Prognostic significance of mitotic rate in localized primary cutaneous melanoma: an analysis of patients in the multi-institutional American Joint Committee on Cancer melanoma staging database.

Thompson JF, Soong SJ, Balch CM, Gershenwald JE, Ding S, Coit DG, Flaherty KT, Gimotty PA, Johnson T, Johnson MM, Leong SP, Ross MI, Byrd DR, Cascinelli N, Cochran AJ, Eggermont AM, McMasters KM, Mihm MC Jr, Morton DL, Sondak VK.

J Clin Oncol. 2011 Jun 1;29(16):2199-205. doi: 10.1200/JCO.2010.31.5812. Epub 2011 Apr 25. Erratum in: J Clin Oncol. 2011 Jul 20;29(21):2949.


Regulating the regulators: the role of transcriptional regulatory proteins in the adaptive response to exercise in human skeletal muscle.

Little JP, Cochran AJ.

J Physiol. 2011 Apr 1;589(Pt 7):1511-2. doi: 10.1113/jphysiol.2011.205401. No abstract available.


IL-10 expression by primary tumor cells correlates with melanoma progression from radial to vertical growth phase and development of metastatic competence.

Itakura E, Huang RR, Wen DR, Paul E, Wünsch PH, Cochran AJ.

Mod Pathol. 2011 Jun;24(6):801-9. doi: 10.1038/modpathol.2011.5. Epub 2011 Feb 11.


Genetic and morphologic features for melanoma classification.

Broekaert SM, Roy R, Okamoto I, van den Oord J, Bauer J, Garbe C, Barnhill RL, Busam KJ, Cochran AJ, Cook MG, Elder DE, McCarthy SW, Mihm MC, Schadendorf D, Scolyer RA, Spatz A, Bastian BC.

Pigment Cell Melanoma Res. 2010 Dec;23(6):763-70. doi: 10.1111/j.1755-148X.2010.00778.x.


The role of lymphatic mapping and sentinel node biopsy in the management of atypical and anomalous melanocytic lesions.

Cochran AJ, Binder S, Morton DL.

J Cutan Pathol. 2010 Apr;37 Suppl 1:54-9. doi: 10.1111/j.1600-0560.2010.01509.x.


Multivariate analysis of prognostic factors among 2,313 patients with stage III melanoma: comparison of nodal micrometastases versus macrometastases.

Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Ding S, Byrd DR, Cascinelli N, Cochran AJ, Coit DG, Eggermont AM, Johnson T, Kirkwood JM, Leong SP, McMasters KM, Mihm MC Jr, Morton DL, Ross MI, Sondak VK.

J Clin Oncol. 2010 May 10;28(14):2452-9. doi: 10.1200/JCO.2009.27.1627. Epub 2010 Apr 5.


Carbohydrate feeding during recovery alters the skeletal muscle metabolic response to repeated sessions of high-intensity interval exercise in humans.

Cochran AJ, Little JP, Tarnopolsky MA, Gibala MJ.

J Appl Physiol (1985). 2010 Mar;108(3):628-36. doi: 10.1152/japplphysiol.00659.2009. Epub 2010 Jan 7.


Final version of 2009 AJCC melanoma staging and classification.

Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, Byrd DR, Buzaid AC, Cochran AJ, Coit DG, Ding S, Eggermont AM, Flaherty KT, Gimotty PA, Kirkwood JM, McMasters KM, Mihm MC Jr, Morton DL, Ross MI, Sober AJ, Sondak VK.

J Clin Oncol. 2009 Dec 20;27(36):6199-206. doi: 10.1200/JCO.2009.23.4799. Epub 2009 Nov 16.


A glimpse of future management of melanoma.

Cochran AJ.

Arch Dermatol. 2009 Oct;145(10):1176-7. doi: 10.1001/archdermatol.2009.230. No abstract available.


Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma.

Ribas A, Comin-Anduix B, Chmielowski B, Jalil J, de la Rocha P, McCannel TA, Ochoa MT, Seja E, Villanueva A, Oseguera DK, Straatsma BR, Cochran AJ, Glaspy JA, Hui L, Marincola FM, Wang E, Economou JS, Gomez-Navarro J.

Clin Cancer Res. 2009 Oct 1;15(19):6267-76. doi: 10.1158/1078-0432.CCR-09-1254. Epub 2009 Sep 29.


The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene.

Shi S, Yoon DY, Hodge-Bell KC, Bebenek IG, Whitekus MJ, Zhang R, Cochran AJ, Huerta-Yepez S, Yim SH, Gonzalez FJ, Jaiswal AK, Hankinson O.

Carcinogenesis. 2009 Nov;30(11):1957-61. doi: 10.1093/carcin/bgp201. Epub 2009 Sep 15.


EANM-EORTC general recommendations for sentinel node diagnostics in melanoma.

Chakera AH, Hesse B, Burak Z, Ballinger JR, Britten A, Caracò C, Cochran AJ, Cook MG, Drzewiecki KT, Essner R, Even-Sapir E, Eggermont AM, Stopar TG, Ingvar C, Mihm MC Jr, McCarthy SW, Mozzillo N, Nieweg OE, Scolyer RA, Starz H, Thompson JF, Trifirò G, Viale G, Vidal-Sicart S, Uren R, Waddington W, Chiti A, Spatz A, Testori A; European Association of Nuclear Medicine-European Organisation for Research and.

Eur J Nucl Med Mol Imaging. 2009 Oct;36(10):1713-42. doi: 10.1007/s00259-009-1228-4.


Interobserver reproducibility of histologic parameters of melanoma deposits in sentinel lymph nodes: implications for management of patients with melanoma.

Murali R, Cochran AJ, Cook MG, Hillman JD, Karim RZ, Moncrieff M, Starz H, Thompson JF, Scolyer RA.

Cancer. 2009 Nov 1;115(21):5026-37. doi: 10.1002/cncr.24298.

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