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Items: 33


Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.

Pryor R, Norvaisas P, Marinos G, Best L, Thingholm LB, Quintaneiro LM, De Haes W, Esser D, Waschina S, Lujan C, Smith RL, Scott TA, Martinez-Martinez D, Woodward O, Bryson K, Laudes M, Lieb W, Houtkooper RH, Franke A, Temmerman L, Bjedov I, Cochemé HM, Kaleta C, Cabreiro F.

Cell. 2019 Sep 5;178(6):1299-1312.e29. doi: 10.1016/j.cell.2019.08.003. Epub 2019 Aug 29.


Myostatin-like proteins regulate synaptic function and neuronal morphology.

Augustin H, McGourty K, Steinert JR, Cochemé HM, Adcott J, Cabecinha M, Vincent A, Halff EF, Kittler JT, Boucrot E, Partridge L.

Development. 2017 Jul 1;144(13):2445-2455. doi: 10.1242/dev.152975. Epub 2017 May 22.


Click-PEGylation - A mobility shift approach to assess the redox state of cysteines in candidate proteins.

van Leeuwen LAG, Hinchy EC, Murphy MP, Robb EL, Cochemé HM.

Free Radic Biol Med. 2017 Jul;108:374-382. doi: 10.1016/j.freeradbiomed.2017.03.037. Epub 2017 Mar 31.


Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.

Kerr F, Sofola-Adesakin O, Ivanov DK, Gatliff J, Gomez Perez-Nievas B, Bertrand HC, Martinez P, Callard R, Snoeren I, Cochemé HM, Adcott J, Khericha M, Castillo-Quan JI, Wells G, Noble W, Thornton J, Partridge L.

PLoS Genet. 2017 Mar 2;13(3):e1006593. doi: 10.1371/journal.pgen.1006593. eCollection 2017 Mar.


Oxidative stress and life histories: unresolved issues and current needs.

Speakman JR, Blount JD, Bronikowski AM, Buffenstein R, Isaksson C, Kirkwood TB, Monaghan P, Ozanne SE, Beaulieu M, Briga M, Carr SK, Christensen LL, Cochemé HM, Cram DL, Dantzer B, Harper JM, Jurk D, King A, Noguera JC, Salin K, Sild E, Simons MJ, Smith S, Stier A, Tobler M, Vitikainen E, Peaker M, Selman C.

Ecol Evol. 2015 Nov 17;5(24):5745-57. doi: 10.1002/ece3.1790. eCollection 2015 Dec.


Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry.

Logan A, Pell VR, Shaffer KJ, Evans C, Stanley NJ, Robb EL, Prime TA, Chouchani ET, Cochemé HM, Fearnley IM, Vidoni S, James AM, Porteous CM, Partridge L, Krieg T, Smith RA, Murphy MP.

Cell Metab. 2016 Feb 9;23(2):379-85. doi: 10.1016/j.cmet.2015.11.014. Epub 2015 Dec 17.


Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants.

Jameson VJ, Cochemé HM, Logan A, Hanton LR, Smith RA, Murphy MP.

Tetrahedron. 2015 Nov 4;71(44):8444-8453.


Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster.

Menger KE, James AM, Cochemé HM, Harbour ME, Chouchani ET, Ding S, Fearnley IM, Partridge L, Murphy MP.

Cell Rep. 2015 Nov 10;13(6):1285. doi: 10.1016/j.celrep.2015.10.048. Epub 2015 Nov 10. No abstract available.


Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat.

Robb EL, Gawel JM, Aksentijević D, Cochemé HM, Stewart TS, Shchepinova MM, Qiang H, Prime TA, Bright TP, James AM, Shattock MJ, Senn HM, Hartley RC, Murphy MP.

Free Radic Biol Med. 2015 Dec;89:883-94. doi: 10.1016/j.freeradbiomed.2015.08.021. Epub 2015 Oct 8.


Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster.

Menger KE, James AM, Cochemé HM, Harbour ME, Chouchani ET, Ding S, Fearnley IM, Partridge L, Murphy MP.

Cell Rep. 2015 Jun 30;11(12):1856-65. doi: 10.1016/j.celrep.2015.05.033. Epub 2015 Jun 18. Erratum in: Cell Rep. 2015 Nov 10;13(6):1285.


Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction.

Kinghorn KJ, Castillo-Quan JI, Bartolome F, Angelova PR, Li L, Pope S, Cochemé HM, Khan S, Asghari S, Bhatia KP, Hardy J, Abramov AY, Partridge L.

Brain. 2015 Jul;138(Pt 7):1801-16. doi: 10.1093/brain/awv132. Epub 2015 May 22.


Using exomarkers to assess mitochondrial reactive species in vivo.

Logan A, Cochemé HM, Li Pun PB, Apostolova N, Smith RA, Larsen L, Larsen DS, James AM, Fearnley IM, Rogatti S, Prime TA, Finichiu PG, Dare A, Chouchani ET, Pell VR, Methner C, Quin C, McQuaker SJ, Krieg T, Hartley RC, Murphy MP.

Biochim Biophys Acta. 2014 Feb;1840(2):923-30. doi: 10.1016/j.bbagen.2013.05.026. Epub 2013 May 30. Review.


Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I.

Chouchani ET, Methner C, Nadtochiy SM, Logan A, Pell VR, Ding S, James AM, Cochemé HM, Reinhold J, Lilley KS, Partridge L, Fearnley IM, Robinson AJ, Hartley RC, Smith RA, Krieg T, Brookes PS, Murphy MP.

Nat Med. 2013 Jun;19(6):753-9. doi: 10.1038/nm.3212. Epub 2013 May 26.


Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D.

Cell. 2013 Mar 28;153(1):228-39. doi: 10.1016/j.cell.2013.02.035.


A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic.

Kelso GF, Maroz A, Cochemé HM, Logan A, Prime TA, Peskin AV, Winterbourn CC, James AM, Ross MF, Brooker S, Porteous CM, Anderson RF, Murphy MP, Smith RA.

Chem Biol. 2012 Oct 26;19(10):1237-46. doi: 10.1016/j.chembiol.2012.08.005.


Mitochondrial pharmacology.

Smith RA, Hartley RC, Cochemé HM, Murphy MP.

Trends Pharmacol Sci. 2012 Jun;33(6):341-52. doi: 10.1016/ Epub 2012 Apr 18. Review.


Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila.

Cochemé HM, Logan A, Prime TA, Abakumova I, Quin C, McQuaker SJ, Patel JV, Fearnley IM, James AM, Porteous CM, Smith RA, Hartley RC, Partridge L, Murphy MP.

Nat Protoc. 2012 Apr 19;7(5):946-58. doi: 10.1038/nprot.2012.035.


Mitochondrial redox signalling at a glance.

Collins Y, Chouchani ET, James AM, Menger KE, Cochemé HM, Murphy MP.

J Cell Sci. 2012 Feb 15;125(Pt 4):801-6. doi: 10.1242/jcs.098475. No abstract available. Erratum in: J Cell Sci. 2012 Apr 1;125(Pt 7):1837.


Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling.

Alic N, Andrews TD, Giannakou ME, Papatheodorou I, Slack C, Hoddinott MP, Cochemé HM, Schuster EF, Thornton JM, Partridge L.

Mol Syst Biol. 2011 Jun 21;7:502. doi: 10.1038/msb.2011.36.


Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix.

Cochemé HM, Quin C, McQuaker SJ, Cabreiro F, Logan A, Prime TA, Abakumova I, Patel JV, Fearnley IM, James AM, Porteous CM, Smith RA, Saeed S, Carré JE, Singer M, Gems D, Hartley RC, Partridge L, Murphy MP.

Cell Metab. 2011 Mar 2;13(3):340-50. doi: 10.1016/j.cmet.2011.02.003.


Complementation of coenzyme Q-deficient yeast by coenzyme Q analogues requires the isoprenoid side chain.

James AM, Cochemé HM, Murai M, Miyoshi H, Murphy MP.

FEBS J. 2010 May;277(9):2067-82. doi: 10.1111/j.1742-4658.2010.07622.x. Epub 2010 Mar 22.


Can antioxidants be effective therapeutics?

Cochemé HM, Murphy MP.

Curr Opin Investig Drugs. 2010 Apr;11(4):426-31.


Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice.

Rodriguez-Cuenca S, Cochemé HM, Logan A, Abakumova I, Prime TA, Rose C, Vidal-Puig A, Smith AC, Rubinsztein DC, Fearnley IM, Jones BA, Pope S, Heales SJ, Lam BY, Neogi SG, McFarlane I, James AM, Smith RA, Murphy MP.

Free Radic Biol Med. 2010 Jan 1;48(1):161-72. doi: 10.1016/j.freeradbiomed.2009.10.039. Epub 2009 Oct 23.


Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy.

Graham D, Huynh NN, Hamilton CA, Beattie E, Smith RA, Cochemé HM, Murphy MP, Dominiczak AF.

Hypertension. 2009 Aug;54(2):322-8. doi: 10.1161/HYPERTENSIONAHA.109.130351. Epub 2009 Jul 6.


Chapter 22 The uptake and interactions of the redox cycler paraquat with mitochondria.

Cochemé HM, Murphy MP.

Methods Enzymol. 2009;456:395-417. doi: 10.1016/S0076-6879(08)04422-4.


Mitochondria-targeted antioxidants in the treatment of disease.

Smith RA, Adlam VJ, Blaikie FH, Manas AR, Porteous CM, James AM, Ross MF, Logan A, Cochemé HM, Trnka J, Prime TA, Abakumova I, Jones BA, Filipovska A, Murphy MP.

Ann N Y Acad Sci. 2008 Dec;1147:105-11. doi: 10.1196/annals.1427.003. Review.


Complex I is the major site of mitochondrial superoxide production by paraquat.

Cochemé HM, Murphy MP.

J Biol Chem. 2008 Jan 25;283(4):1786-98. Epub 2007 Nov 26.


Mitochondrial targeting of quinones: therapeutic implications.

Cochemé HM, Kelso GF, James AM, Ross MF, Trnka J, Mahendiran T, Asin-Cayuela J, Blaikie FH, Manas AR, Porteous CM, Adlam VJ, Smith RA, Murphy MP.

Mitochondrion. 2007 Jun;7 Suppl:S94-102. Epub 2007 Mar 16. Review.


Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing.

James AM, Cochemé HM, Murphy MP.

Mech Ageing Dev. 2005 Sep;126(9):982-6. Review.


Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology.

Ross MF, Kelso GF, Blaikie FH, James AM, Cochemé HM, Filipovska A, Da Ros T, Hurd TR, Smith RA, Murphy MP.

Biochemistry (Mosc). 2005 Feb;70(2):222-30. Review.


Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences.

Smith RA, Kelso GF, Blaikie FH, Porteous CM, Ledgerwood EC, Hughes G, James AM, Ross MF, Asin-Cayuela J, Cochemé HM, Filipovska A, Murphy MP.

Biochem Soc Trans. 2003 Dec;31(Pt 6):1295-9.


Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone.

Murphy MP, Echtay KS, Blaikie FH, Asin-Cayuela J, Cocheme HM, Green K, Buckingham JA, Taylor ER, Hurrell F, Hughes G, Miwa S, Cooper CE, Svistunenko DA, Smith RA, Brand MD.

J Biol Chem. 2003 Dec 5;278(49):48534-45. Epub 2003 Sep 12.

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