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Items: 45


Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. "Alive, with good vision and no comorbidity".

Munier FL, Beck-Popovic M, Chantada GL, Cobrinik D, Kivelä TT, Lohmann D, Maeder P, Moll AC, Carcaboso AM, Moulin A, Schaiquevich P, Bergin C, Dyson PJ, Houghton S, Puccinelli F, Vial Y, Gaillard MC, Stathopoulos C.

Prog Retin Eye Res. 2019 Jun 5:100764. doi: 10.1016/j.preteyeres.2019.05.005. [Epub ahead of print] Review.


A novel thyroid hormone receptor isoform, TRβ2-46, promotes SKP2 expression and retinoblastoma cell proliferation.

Li Z, Qi DL, Singh HP, Zou Y, Shen B, Cobrinik D.

J Biol Chem. 2019 Feb 22;294(8):2961-2969. doi: 10.1074/jbc.AC118.006041. Epub 2019 Jan 14.


Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors.

Singh HP, Wang S, Stachelek K, Lee S, Reid MW, Thornton ME, Craft CM, Grubbs BH, Cobrinik D.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9391-E9400. doi: 10.1073/pnas.1808903115. Epub 2018 Sep 13.


Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma.

Berry JL, Xu L, Kooi I, Murphree AL, Prabakar RK, Reid M, Stachelek K, Le BHA, Welter L, Reiser BJ, Chévez-Barrios P, Jubran R, Lee TC, Kim JW, Kuhn P, Cobrinik D, Hicks J.

Mol Cancer Res. 2018 Nov;16(11):1701-1712. doi: 10.1158/1541-7786.MCR-18-0369. Epub 2018 Jul 30.


Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma-Reply.

Berry JL, Cobrinik D, Hicks J.

JAMA Ophthalmol. 2018 May 1;136(5):598. doi: 10.1001/jamaophthalmol.2018.0395. No abstract available.


Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma.

Berry JL, Xu L, Murphree AL, Krishnan S, Stachelek K, Zolfaghari E, McGovern K, Lee TC, Carlsson A, Kuhn P, Kim JW, Cobrinik D, Hicks J.

JAMA Ophthalmol. 2017 Nov 1;135(11):1221-1230. doi: 10.1001/jamaophthalmol.2017.4097.


SKP2 Activation by Thyroid Hormone Receptor β2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells.

Xu XL, Li Z, Liu A, Fan X, Hu DN, Qi DL, Chitty DW, Jia R, Qui J, Wang JQ, Sharaf J, Zou J, Weiss R, Huang H, Joseph WJ, Ng L, Rosen R, Shen B, Reid MW, Forrest D, Abramson DH, Singer S, Cobrinik D, Jhanwar SC.

Cancer Res. 2017 Dec 15;77(24):6838-6850. doi: 10.1158/0008-5472.CAN-16-3299. Epub 2017 Sep 28.


Structural and Functional Characterization of Human Stem-Cell-Derived Retinal Organoids by Live Imaging.

Browne AW, Arnesano C, Harutyunyan N, Khuu T, Martinez JC, Pollack HA, Koos DS, Lee TC, Fraser SE, Moats RA, Aparicio JG, Cobrinik D.

Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3311-3318. doi: 10.1167/iovs.16-20796. Review.


MDM2 but not MDM4 promotes retinoblastoma cell proliferation through p53-independent regulation of MYCN translation.

Qi DL, Cobrinik D.

Oncogene. 2017 Mar 30;36(13):1760-1769. doi: 10.1038/onc.2016.350. Epub 2016 Oct 17.


Detection and Intraretinal Localization of an 'Invisible' Retinoblastoma Using Optical Coherence Tomography.

Berry JL, Cobrinik D, Kim JW.

Ocul Oncol Pathol. 2016 Apr;2(3):148-52. doi: 10.1159/000442167. Epub 2015 Nov 27.


A Rapid and Sensitive Next-Generation Sequencing Method to Detect RB1 Mutations Improves Care for Retinoblastoma Patients and Their Families.

Li WL, Buckley J, Sanchez-Lara PA, Maglinte DT, Viduetsky L, Tatarinova TV, Aparicio JG, Kim JW, Au M, Ostrow D, Lee TC, O'Gorman M, Judkins A, Cobrinik D, Triche TJ.

J Mol Diagn. 2016 Jul;18(4):480-93. doi: 10.1016/j.jmoldx.2016.02.006. Epub 2016 May 4.


Retinoblastoma Progression.

Cobrinik D.

EBioMedicine. 2015 Jul 17;2(7):623-4. doi: 10.1016/j.ebiom.2015.07.023. eCollection 2015 Jul. No abstract available.



Dimaras H, Corson TW, Cobrinik D, White A, Zhao J, Munier FL, Abramson DH, Shields CL, Chantada GL, Njuguna F, Gallie BL.

Nat Rev Dis Primers. 2015 Aug 27;1:15021. doi: 10.1038/nrdp.2015.21. Review.


Rb suppresses human cone-precursor-derived retinoblastoma tumours.

Xu XL, Singh HP, Wang L, Qi DL, Poulos BK, Abramson DH, Jhanwar SC, Cobrinik D.

Nature. 2014 Oct 16;514(7522):385-8. doi: 10.1038/nature13813. Epub 2014 Sep 24.


Recurrent pre-existing and acquired DNA copy number alterations, including focal TERT gains, in neuroblastoma central nervous system metastases.

Cobrinik D, Ostrovnaya I, Hassimi M, Tickoo SK, Cheung IY, Cheung NK.

Genes Chromosomes Cancer. 2013 Dec;52(12):1150-66. doi: 10.1002/gcc.22110. Epub 2013 Oct 10.


Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF.

Xing F, Persaud Y, Pratilas CA, Taylor BS, Janakiraman M, She QB, Gallardo H, Liu C, Merghoub T, Hefter B, Dolgalev I, Viale A, Heguy A, De Stanchina E, Cobrinik D, Bollag G, Wolchok J, Houghton A, Solit DB.

Oncogene. 2012 Jan 26;31(4):446-57. doi: 10.1038/onc.2011.250. Epub 2011 Jul 4.


Critical role of the Rb family in myoblast survival and fusion.

Ciavarra G, Ho AT, Cobrinik D, Zacksenhaus E.

PLoS One. 2011 Mar 10;6(3):e17682. doi: 10.1371/journal.pone.0017682.


Tumor-associated retinal astrocytes promote retinoblastoma cell proliferation through production of IGFBP-5.

Xu XL, Lee TC, Offor N, Cheng C, Liu A, Fang Y, Jhanwar SC, Abramson DH, Cobrinik D.

Am J Pathol. 2010 Jul;177(1):424-35. doi: 10.2353/ajpath.2010.090512. Epub 2010 May 27.


Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice.

Wang H, Bauzon F, Ji P, Xu X, Sun D, Locker J, Sellers RS, Nakayama K, Nakayama KI, Cobrinik D, Zhu L.

Nat Genet. 2010 Jan;42(1):83-8. doi: 10.1038/ng.498. Epub 2009 Dec 6.


Retinoblastoma has properties of a cone precursor tumor and depends upon cone-specific MDM2 signaling.

Xu XL, Fang Y, Lee TC, Forrest D, Gregory-Evans C, Almeida D, Liu A, Jhanwar SC, Abramson DH, Cobrinik D.

Cell. 2009 Jun 12;137(6):1018-31. doi: 10.1016/j.cell.2009.03.051.


The retinoblastoma protein and its homolog p130 regulate the G1/S transition in pancreatic beta-cells.

Harb G, Vasavada RC, Cobrinik D, Stewart AF.

Diabetes. 2009 Aug;58(8):1852-62. doi: 10.2337/db08-0759. Epub 2009 Jun 9. Erratum in: Diabetes. 2009 Oct;58(10):2425.


Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cells.

Cobrinik D, Francis RO, Abramson DH, Lee TC.

Mol Cancer. 2006 Dec 12;5:72.


Cell cycle-specific and cell type-specific expression of Rb in the developing human retina.

Lee TC, Almeida D, Claros N, Abramson DH, Cobrinik D.

Invest Ophthalmol Vis Sci. 2006 Dec;47(12):5590-8.


Small molecule inhibition of HDM2 leads to p53-mediated cell death in retinoblastoma cells.

Elison JR, Cobrinik D, Claros N, Abramson DH, Lee TC.

Arch Ophthalmol. 2006 Sep;124(9):1269-75.


Pocket proteins and cell cycle control.

Cobrinik D.

Oncogene. 2005 Apr 18;24(17):2796-809. Review.


The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytes.

MacLean HE, Guo J, Knight MC, Zhang P, Cobrinik D, Kronenberg HM.

J Clin Invest. 2004 May;113(9):1334-43.


FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest.

Laplantine E, Rossi F, Sahni M, Basilico C, Cobrinik D.

J Cell Biol. 2002 Aug 19;158(4):741-50. Epub 2002 Aug 12.


p107 and p130 Coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development.

Rossi F, MacLean HE, Yuan W, Francis RO, Semenova E, Lin CS, Kronenberg HM, Cobrinik D.

Dev Biol. 2002 Jul 15;247(2):271-85.


Rho regulates p21(CIP1), cyclin D1, and checkpoint control in mammary epithelial cells.

Liberto M, Cobrinik D, Minden A.

Oncogene. 2002 Feb 28;21(10):1590-9.


Complementary and alternative medicine: the role of the cancer center.

Antman K, Benson MC, Chabot J, Cobrinik D, Grann VR, Jacobson JS, Joe AK, Katz AE, Kelly K, Neugut AI, Russo D, Tiersten A, Weinstein IB.

J Clin Oncol. 2001 Sep 15;19(18 Suppl):55S-60S. No abstract available.


Cdk2-dependent phosphorylation and functional inactivation of the pRB-related p130 protein in pRB(-), p16INK4A(+) tumor cells.

Cheng L, Rossi F, Fang W, Mori T, Cobrinik D.

J Biol Chem. 2000 Sep 29;275(39):30317-25.


pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

Hurford RK Jr, Cobrinik D, Lee MH, Dyson N.

Genes Dev. 1997 Jun 1;11(11):1447-63.


Shared role of the pRB-related p130 and p107 proteins in limb development.

Cobrinik D, Lee MH, Hannon G, Mulligan G, Bronson RT, Dyson N, Harlow E, Beach D, Weinberg RA, Jacks T.

Genes Dev. 1996 Jul 1;10(13):1633-44.


Regulatory interactions among E2Fs and cell cycle control proteins.

Cobrinik D.

Curr Top Microbiol Immunol. 1996;208:31-61. Review. No abstract available.


E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.

Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA.

Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2403-7.


Cell cycle-specific association of E2F with the p130 E1A-binding protein.

Cobrinik D, Whyte P, Peeper DS, Jacks T, Weinberg RA.

Genes Dev. 1993 Dec;7(12A):2392-404.


The retinoblastoma protein and the regulation of cell cycling.

Cobrinik D, Dowdy SF, Hinds PW, Mittnacht S, Weinberg RA.

Trends Biochem Sci. 1992 Aug;17(8):312-5. Review.


Properties of avian sarcoma-leukosis virus pp32-related pol-endonucleases produced in Escherichia coli.

Terry R, Soltis DA, Katzman M, Cobrinik D, Leis J, Skalka AM.

J Virol. 1988 Jul;62(7):2358-65.

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