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Items: 40


Modulation by Sigma-1 Receptor of Morphine Analgesia and Tolerance: Nociceptive Pain, Tactile Allodynia and Grip Strength Deficits During Joint Inflammation.

Montilla-García Á, Tejada MÁ, Ruiz-Cantero MC, Bravo-Caparrós I, Yeste S, Zamanillo D, Cobos EJ.

Front Pharmacol. 2019 Feb 22;10:136. doi: 10.3389/fphar.2019.00136. eCollection 2019.


Modality-specific peripheral antinociceptive effects of μ-opioid agonists on heat and mechanical stimuli: Contribution of sigma-1 receptors.

Montilla-García Á, Perazzoli G, Tejada MÁ, González-Cano R, Sánchez-Fernández C, Cobos EJ, Baeyens JM.

Neuropharmacology. 2018 Jun;135:328-342. doi: 10.1016/j.neuropharm.2018.03.025. Epub 2018 Mar 24.


Targeting immune-driven opioid analgesia by sigma-1 receptors: Opening the door to novel perspectives for the analgesic use of sigma-1 antagonists.

Tejada MÁ, Montilla-García Á, González-Cano R, Bravo-Caparrós I, Ruiz-Cantero MC, Nieto FR, Cobos EJ.

Pharmacol Res. 2018 May;131:224-230. doi: 10.1016/j.phrs.2018.02.008. Epub 2018 Feb 15. Review.


Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling.

Cobos EJ, Nickerson CA, Gao F, Chandran V, Bravo-Caparrós I, González-Cano R, Riva P, Andrews NA, Latremoliere A, Seehus CR, Perazzoli G, Nieto FR, Joller N, Painter MW, Ma CHE, Omura T, Chesler EJ, Geschwind DH, Coppola G, Rangachari M, Woolf CJ, Costigan M.

Cell Rep. 2018 Jan 30;22(5):1301-1312. doi: 10.1016/j.celrep.2018.01.006.


(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties.

Amata E, Rescifina A, Prezzavento O, Arena E, Dichiara M, Pittalà V, Montilla-García Á, Punzo F, Merino P, Cobos EJ, Marrazzo A.

J Med Chem. 2018 Jan 11;61(1):372-384. doi: 10.1021/acs.jmedchem.7b01584. Epub 2017 Dec 20.


Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia.

Montilla-García Á, Tejada MÁ, Perazzoli G, Entrena JM, Portillo-Salido E, Fernández-Segura E, Cañizares FJ, Cobos EJ.

Neuropharmacology. 2017 Oct;125:231-242. doi: 10.1016/j.neuropharm.2017.07.029. Epub 2017 Jul 29.


Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice.

Tejada MA, Montilla-García A, Cronin SJ, Cikes D, Sánchez-Fernández C, González-Cano R, Ruiz-Cantero MC, Penninger JM, Vela JM, Baeyens JM, Cobos EJ.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8396-8401. doi: 10.1073/pnas.1620068114. Epub 2017 Jul 17.


Sigma-1 Receptor Antagonists: A New Class of Neuromodulatory Analgesics.

Sánchez-Fernández C, Entrena JM, Baeyens JM, Cobos EJ.

Adv Exp Med Biol. 2017;964:109-132. doi: 10.1007/978-3-319-50174-1_9. Review.


Mild Social Stress in Mice Produces Opioid-Mediated Analgesia in Visceral but Not Somatic Pain States.

Pitcher MH, Gonzalez-Cano R, Vincent K, Lehmann M, Cobos EJ, Coderre TJ, Baeyens JM, Cervero F.

J Pain. 2017 Jun;18(6):716-725. doi: 10.1016/j.jpain.2017.02.422. Epub 2017 Feb 20.


Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin.

Entrena JM, Sánchez-Fernández C, Nieto FR, González-Cano R, Yeste S, Cobos EJ, Baeyens JM.

Sci Rep. 2016 Nov 25;6:37835. doi: 10.1038/srep37835.


(+)-and (-)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects.

Prezzavento O, Arena E, Sánchez-Fernández C, Turnaturi R, Parenti C, Marrazzo A, Catalano R, Amata E, Pasquinucci L, Cobos EJ.

Eur J Med Chem. 2017 Jan 5;125:603-610. doi: 10.1016/j.ejmech.2016.09.077. Epub 2016 Sep 26.


Use of Very-Low-Dose Methadone and Haloperidol for Pain Control in Palliative Care Patients: Are the Sigma-1 Receptors Involved?

Cobos EJ, Baeyens JM.

J Palliat Med. 2015 Aug;18(8):660. doi: 10.1089/jpm.2015.0147. Epub 2015 Jun 18. No abstract available.


Sigma-1 receptor and inflammatory pain.

Gris G, Cobos EJ, Zamanillo D, Portillo-Salido E.

Inflamm Res. 2015 Jun;64(6):377-81. doi: 10.1007/s00011-015-0819-8. Epub 2015 Apr 23. Review.


The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene.

Luna-Sánchez M, Díaz-Casado E, Barca E, Tejada MÁ, Montilla-García Á, Cobos EJ, Escames G, Acuña-Castroviejo D, Quinzii CM, López LC.

EMBO Mol Med. 2015 May;7(5):670-87. doi: 10.15252/emmm.201404632.


Correction: Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity.

Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman G, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf C.

Elife. 2015 Feb 6;4:e06720. doi: 10.7554/eLife.06720. No abstract available.


Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity.

Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman GS, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf CJ.

Elife. 2014 Dec 19;3. doi: 10.7554/eLife.04660. Erratum in: Elife. 2015;4:e06720.


Diminished Schwann cell repair responses underlie age-associated impaired axonal regeneration.

Painter MW, Brosius Lutz A, Cheng YC, Latremoliere A, Duong K, Miller CM, Posada S, Cobos EJ, Zhang AX, Wagers AJ, Havton LA, Barres B, Omura T, Woolf CJ.

Neuron. 2014 Jul 16;83(2):331-343. doi: 10.1016/j.neuron.2014.06.016.


Sigma-1 receptor inhibition reverses acute inflammatory hyperalgesia in mice: role of peripheral sigma-1 receptors.

Tejada MA, Montilla-García A, Sánchez-Fernández C, Entrena JM, Perazzoli G, Baeyens JM, Cobos EJ.

Psychopharmacology (Berl). 2014 Oct;231(19):3855-69. doi: 10.1007/s00213-014-3524-3. Epub 2014 Mar 18.


"Bedside-to-Bench" Behavioral Outcomes in Animal Models of Pain: Beyond the Evaluation of Reflexes.

Cobos EJ, Portillo-Salido E.

Curr Neuropharmacol. 2013 Dec;11(6):560-91. doi: 10.2174/1570159X113119990041.


Modulation of peripheral μ-opioid analgesia by σ1 receptors.

Sánchez-Fernández C, Montilla-García Á, González-Cano R, Nieto FR, Romero L, Artacho-Cordón A, Montes R, Fernández-Pastor B, Merlos M, Baeyens JM, Entrena JM, Cobos EJ.

J Pharmacol Exp Ther. 2014 Jan;348(1):32-45. doi: 10.1124/jpet.113.208272. Epub 2013 Oct 23.


Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block.

Brenneis C, Kistner K, Puopolo M, Jo S, Roberson D, Sisignano M, Segal D, Cobos EJ, Wainger BJ, Labocha S, Ferreirós N, von Hehn C, Tran J, Geisslinger G, Reeh PW, Bean BP, Woolf CJ.

Br J Pharmacol. 2014 Jan;171(2):438-51. doi: 10.1111/bph.12466.


Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea.

Nieto FR, Cobos EJ, Entrena JM, Parra A, García-Granados A, Baeyens JM.

J Nat Prod. 2013 Apr 26;76(4):737-40. doi: 10.1021/np300783a. Epub 2013 Mar 29.


Potentiation of morphine-induced mechanical antinociception by σ₁ receptor inhibition: role of peripheral σ₁ receptors.

Sánchez-Fernández C, Nieto FR, González-Cano R, Artacho-Cordón A, Romero L, Montilla-García Á, Zamanillo D, Baeyens JM, Entrena JM, Cobos EJ.

Neuropharmacology. 2013 Jul;70:348-58. doi: 10.1016/j.neuropharm.2013.03.002. Epub 2013 Mar 21.


Phenotyping the function of TRPV1-expressing sensory neurons by targeted axonal silencing.

Brenneis C, Kistner K, Puopolo M, Segal D, Roberson D, Sisignano M, Labocha S, Ferreirós N, Strominger A, Cobos EJ, Ghasemlou N, Geisslinger G, Reeh PW, Bean BP, Woolf CJ.

J Neurosci. 2013 Jan 2;33(1):315-26. doi: 10.1523/JNEUROSCI.2804-12.2013.


Role of sigma-1 receptors in paclitaxel-induced neuropathic pain in mice.

Nieto FR, Cendán CM, Sánchez-Fernández C, Cobos EJ, Entrena JM, Tejada MA, Zamanillo D, Vela JM, Baeyens JM.

J Pain. 2012 Nov;13(11):1107-21. doi: 10.1016/j.jpain.2012.08.006. Epub 2012 Oct 12.


5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals.

Sisignano M, Park CK, Angioni C, Zhang DD, von Hehn C, Cobos EJ, Ghasemlou N, Xu ZZ, Kumaran V, Lu R, Grant A, Fischer MJ, Schmidtko A, Reeh P, Ji RR, Woolf CJ, Geisslinger G, Scholich K, Brenneis C.

J Neurosci. 2012 May 2;32(18):6364-72. doi: 10.1523/JNEUROSCI.5793-11.2012.


Tetrodotoxin (TTX) as a therapeutic agent for pain.

Nieto FR, Cobos EJ, Tejada MÁ, Sánchez-Fernández C, González-Cano R, Cendán CM.

Mar Drugs. 2012 Feb;10(2):281-305. doi: 10.3390/md10020281. Epub 2012 Jan 31. Review.


Inflammation-induced decrease in voluntary wheel running in mice: a nonreflexive test for evaluating inflammatory pain and analgesia.

Cobos EJ, Ghasemlou N, Araldi D, Segal D, Duong K, Woolf CJ.

Pain. 2012 Apr;153(4):876-84. doi: 10.1016/j.pain.2012.01.016. Epub 2012 Feb 15.


Sigma-1 receptors do not regulate calcium influx through voltage-dependent calcium channels in mouse brain synaptosomes.

González LG, Sánchez-Fernández C, Cobos EJ, Baeyens JM, del Pozo E.

Eur J Pharmacol. 2012 Feb 29;677(1-3):102-6. doi: 10.1016/j.ejphar.2011.12.029. Epub 2011 Dec 29.


Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice.

Ma CH, Omura T, Cobos EJ, Latrémolière A, Ghasemlou N, Brenner GJ, van Veen E, Barrett L, Sawada T, Gao F, Coppola G, Gertler F, Costigan M, Geschwind D, Woolf CJ.

J Clin Invest. 2011 Nov;121(11):4332-47. doi: 10.1172/JCI58675. Epub 2011 Oct 3.


Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties.

Marrazzo A, Cobos EJ, Parenti C, Aricò G, Marrazzo G, Ronsisvalle S, Pasquinucci L, Prezzavento O, Colabufo NA, Contino M, González LG, Scoto GM, Ronsisvalle G.

J Med Chem. 2011 May 26;54(10):3669-73. doi: 10.1021/jm200144j. Epub 2011 Apr 21.


Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1.

Costigan M, Belfer I, Griffin RS, Dai F, Barrett LB, Coppola G, Wu T, Kiselycznyk C, Poddar M, Lu Y, Diatchenko L, Smith S, Cobos EJ, Zaykin D, Allchorne A, Gershon E, Livneh J, Shen PH, Nikolajsen L, Karppinen J, Männikkö M, Kelempisioti A, Goldman D, Maixner W, Geschwind DH, Max MB, Seltzer Z, Woolf CJ.

Brain. 2010 Sep;133(9):2519-27. doi: 10.1093/brain/awq195. Epub 2010 Aug 18. Erratum in: Brain. 2011 Jul;134(7):2186. Gershon, Edith [added]; Livneh, Jessica [added].


Pharmacology and therapeutic potential of sigma(1) receptor ligands.

Cobos EJ, Entrena JM, Nieto FR, Cendán CM, Del Pozo E.

Curr Neuropharmacol. 2008 Dec;6(4):344-66. doi: 10.2174/157015908787386113.


Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: studies with selective sigma-1 ligands and sigma-1 knockout mice.

Entrena JM, Cobos EJ, Nieto FR, Cendán CM, Gris G, Del Pozo E, Zamanillo D, Baeyens JM.

Pain. 2009 Jun;143(3):252-61. doi: 10.1016/j.pain.2009.03.011. Epub 2009 Apr 17.


Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.

Entrena JM, Cobos EJ, Nieto FR, Cendán CM, Baeyens JM, Del Pozo E.

Psychopharmacology (Berl). 2009 Jul;205(1):21-33. doi: 10.1007/s00213-009-1513-8. Epub 2009 Mar 27.


Potassium channels and pain: present realities and future opportunities.

Ocaña M, Cendán CM, Cobos EJ, Entrena JM, Baeyens JM.

Eur J Pharmacol. 2004 Oct 1;500(1-3):203-19. Review.


Fluorometric evidence for different stoichiometries for the Na+/Mg2+ exchange in Mg-loaded rat thymocytes.

Contreras-Jurado C, González-Martínez MT, Cobos EJ, Soler-Diaz A.

Front Biosci. 2004 May 1;9:1843-8.


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