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Fasting glucagon concentrations are associated with longitudinal decline of β-cell function in non-diabetic humans.

Adams JD, Dalla Man C, Laurenti MC, Andrade MDH, Cobelli C, Rizza RA, Bailey KR, Vella A.

Metabolism. 2020 Feb 8;105:154175. doi: 10.1016/j.metabol.2020.154175. [Epub ahead of print]


Metabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study.

Galderisi A, Tricò D, Dalla Man C, Santoro N, Pierpont B, Groop L, Cobelli C, Caprio S.

J Clin Endocrinol Metab. 2020 Feb 1;105(2). pii: dgz207. doi: 10.1210/clinem/dgz207.


Dual glucagon-like peptide-1 receptor/glucagon receptor agonist SAR425899 improves beta-cell function in type 2 diabetes.

Visentin R, Schiavon M, Göbel B, Riz M, Cobelli C, Klabunde T, Dalla Man C.

Diabetes Obes Metab. 2019 Dec 5. doi: 10.1111/dom.13939. [Epub ahead of print]


In Silico Trials of an Open-Source Android-Based Artificial Pancreas: A New Paradigm to Test Safety and Efficacy of Do-It-Yourself Systems.

Toffanin C, Kozak M, Sumnik Z, Cobelli C, Petruzelkova L.

Diabetes Technol Ther. 2020 Feb;22(2):112-120. doi: 10.1089/dia.2019.0375. Epub 2019 Dec 17.


Hypoglycemia Prevention via Personalized Glucose-Insulin Models Identified in Free-Living Conditions.

Toffanin C, Aiello EM, Cobelli C, Magni L.

J Diabetes Sci Technol. 2019 Nov;13(6):1008-1016. doi: 10.1177/1932296819880864. Epub 2019 Oct 23.


What do healthcare professionals need to turn risk models for type 2 diabetes into usable computerized clinical decision support systems? Lessons learned from the MOSAIC project.

Fico G, Hernanzez L, Cancela J, Dagliati A, Sacchi L, Martinez-Millana A, Posada J, Manero L, Verdú J, Facchinetti A, Ottaviano M, Zarkogianni K, Nikita K, Groop L, Gabriel-Sanchez R, Chiovato L, Traver V, Merino-Torres JF, Cobelli C, Bellazzi R, Arredondo MT.

BMC Med Inform Decis Mak. 2019 Aug 16;19(1):163. doi: 10.1186/s12911-019-0887-8.


Inducing remission of Type 2 diabetes in the Caribbean: findings from a mixed methods feasibility study of a low-calorie liquid diet-based intervention in Barbados.

Bynoe K, Unwin N, Taylor C, Murphy MM, Bartholomew L, Greenidge A, Abed M, Jeyaseelan S, Cobelli C, Dalla Man C, Taylor R.

Diabet Med. 2019 Jul 31. doi: 10.1111/dme.14096. [Epub ahead of print]


A novel natural tracer method to measure complex carbohydrate metabolism.

Basu R, Schiavon M, Petterson XM, Hinshaw L, Slama M, Carter R, Man CD, Cobelli C, Basu A.

Am J Physiol Endocrinol Metab. 2019 Sep 1;317(3):E483-E493. doi: 10.1152/ajpendo.00133.2019. Epub 2019 Jul 2.


Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range.

Battelino T, Danne T, Bergenstal RM, Amiel SA, Beck R, Biester T, Bosi E, Buckingham BA, Cefalu WT, Close KL, Cobelli C, Dassau E, DeVries JH, Donaghue KC, Dovc K, Doyle FJ 3rd, Garg S, Grunberger G, Heller S, Heinemann L, Hirsch IB, Hovorka R, Jia W, Kordonouri O, Kovatchev B, Kowalski A, Laffel L, Levine B, Mayorov A, Mathieu C, Murphy HR, Nimri R, Nørgaard K, Parkin CG, Renard E, Rodbard D, Saboo B, Schatz D, Stoner K, Urakami T, Weinzimer SA, Phillip M.

Diabetes Care. 2019 Aug;42(8):1593-1603. doi: 10.2337/dci19-0028. Epub 2019 Jun 8. Review.


Modeling Subcutaneous Absorption of Long-Acting Insulin Glargine in Type 1 Diabetes.

Schiavon M, Visentin R, Giegerich C, Klabunde T, Cobelli C, Dalla Man C.

IEEE Trans Biomed Eng. 2020 Feb;67(2):624-631. doi: 10.1109/TBME.2019.2919250. Epub 2019 May 28.


Letter to the Editor: "Defects in GLP-1 Response to an Oral Challenge Do Not Play a Significant Role in the Pathogenesis of Prediabetes".

Smushkin G, Sathananthan A, Man CD, Camilleri M, Cobelli C, Rizza RA, Vella A.

J Clin Endocrinol Metab. 2019 Nov 1;104(11):5106-5107. doi: 10.1210/jc.2019-00904. No abstract available.


Continuous Glucose Monitoring Linked to an Artificial Intelligence Risk Index: Early Footprints of Intraventricular Hemorrhage in Preterm Neonates.

Galderisi A, Zammataro L, Losiouk E, Lanzola G, Kraemer K, Facchinetti A, Galeazzo B, Favero V, Baraldi E, Cobelli C, Trevisanuto D, Steil GM.

Diabetes Technol Ther. 2019 Mar;21(3):146-153. doi: 10.1089/dia.2018.0383.


Assessment of pulsatile insulin secretion derived from peripheral plasma C-peptide concentrations by nonparametric stochastic deconvolution.

Laurenti MC, Vella A, Varghese RT, Andrews JC, Sharma A, Kittah NE, Rizza RA, Matveyenko A, De Nicolao G, Cobelli C, Dalla Man C.

Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E687-E694. doi: 10.1152/ajpendo.00519.2018. Epub 2019 Feb 26.


Incorporating Long-Acting Insulin Glargine into the UVA/ Padova Type 1 Diabetes Simulator for In Silico Testing of MDI Therapies.

Visentin R, Schiavon M, Giegerich C, Klabunde T, Dalla Man C, Cobelli C.

IEEE Trans Biomed Eng. 2019 Feb 6. doi: 10.1109/TBME.2019.2897851. [Epub ahead of print]


The International Diabetes Closed-Loop Study: Testing Artificial Pancreas Component Interoperability.

Anderson SM, Dassau E, Raghinaru D, Lum J, Brown SA, Pinsker JE, Church MM, Levy C, Lam D, Kudva YC, Buckingham B, Forlenza GP, Wadwa RP, Laffel L, Doyle FJ 3rd, DeVries JH, Renard E, Cobelli C, Boscari F, Del Favero S, Kovatchev BP.

Diabetes Technol Ther. 2019 Feb;21(2):73-80. doi: 10.1089/dia.2018.0308. Epub 2019 Jan 16.


Increased Rates of Meal Absorption Do Not Explain Elevated 1-Hour Glucose in Subjects With Normal Glucose Tolerance.

Adams JD, Treiber G, Hurtado MD, Laurenti MC, Dalla Man C, Cobelli C, Rizza RA, Vella A.

J Endocr Soc. 2018 Nov 21;3(1):135-145. doi: 10.1210/js.2018-00222. eCollection 2019 Jan 1. Erratum in: J Endocr Soc. 2019 Jan 11;3(3):516.


Contribution of endogenous glucagon-like peptide-1 to changes in glucose metabolism and islet function in people with type 2 diabetes four weeks after Roux-en-Y gastric bypass (RYGB).

Shah M, Laurenti MC, Dalla Man C, Ma J, Cobelli C, Rizza RA, Vella A.

Metabolism. 2019 Apr;93:10-17. doi: 10.1016/j.metabol.2018.12.005. Epub 2018 Dec 23.


Long-acting Insulin in Diabetes Therapy: In Silico Clinical Trials with the UVA/Padova Type 1 Diabetes Simulator.

Visentin R, Schiavon M, Giegerich C, Klabunde T, Man CD, Cobelli C.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:4905-4908. doi: 10.1109/EMBC.2018.8513234.


Intranasal oxytocin fails to acutely improve glucose metabolism in obese men.

Brede S, Fehr S, Dalla-Man C, Cobelli C, Lehnert H, Hallschmid M, Klement J.

Diabetes Obes Metab. 2019 Feb;21(2):424-428. doi: 10.1111/dom.13527. Epub 2018 Oct 3.


Mixed Meal and Intravenous L-Arginine Tests Both Stimulate Incretin Release Across Glucose Tolerance in Man: Lack of Correlation with β Cell Function.

Ruetten H, Gebauer M, Raymond RH, Calle RA, Cobelli C, Ghosh A, Robertson RP, Shankar SS, Staten MA, Stefanovski D, Vella A, Wright K, Fryburg DA; Foundation for the NIH Biomarkers Consortium Beta Cell Project Team.

Metab Syndr Relat Disord. 2018 Oct;16(8):406-415. doi: 10.1089/met.2018.0022. Epub 2018 Aug 17. Erratum in: Metab Syndr Relat Disord. 2019 Mar;17(2):128.


Transcranial direct current stimulation combined with cognitive training for the treatment of Parkinson Disease: A randomized, placebo-controlled study.

Manenti R, Cotelli MS, Cobelli C, Gobbi E, Brambilla M, Rusich D, Alberici A, Padovani A, Borroni B, Cotelli M.

Brain Stimul. 2018 Nov - Dec;11(6):1251-1262. doi: 10.1016/j.brs.2018.07.046. Epub 2018 Jul 18.


Outpatient versus inpatient mixed meal tolerance and arginine stimulation testing yields comparable measures of variability for assessment of beta cell function.

Shankar SS, Lee DS, Raymond RH, Calle RA, Cobelli C, Ghosh A, Robertson RP, Ruetten H, Staten MA, Stefanovski D, Vella A, Whitaker S, Fryburg DA; Foundation for the NIH Biomarkers Consortium Beta Cell Project Team.

Contemp Clin Trials Commun. 2018 Mar 29;10:94-99. doi: 10.1016/j.conctc.2018.03.009. eCollection 2018 Jun.


Modeling Subcutaneous Absorption of Fast-Acting Insulin in Type 1 Diabetes.

Schiavon M, Dalla Man C, Cobelli C.

IEEE Trans Biomed Eng. 2018 Sep;65(9):2079-2086. doi: 10.1109/TBME.2017.2784101. Epub 2017 Dec 15.


A novel triple-tracer approach to assess postprandial protein turnover.

Moran A, Toffolo G, Schiavon M, Vella A, Klaus K, Cobelli C, Nair KS.

Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E469-E477. doi: 10.1152/ajpendo.00012.2018. Epub 2018 Jun 5.


Differential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans.

Qian J, Dalla Man C, Morris CJ, Cobelli C, Scheer FAJL.

Diabetes Obes Metab. 2018 Oct;20(10):2481-2485. doi: 10.1111/dom.13391. Epub 2018 Jul 2.


Procedural Pain during Insertion of a Continuous Glucose Monitoring Device in Preterm Infants.

Galderisi A, Lago P, Steil GM, Ghirardo M, Cobelli C, Baraldi E, Trevisanuto D.

J Pediatr. 2018 Sep;200:261-264.e1. doi: 10.1016/j.jpeds.2018.03.040. Epub 2018 May 31.


Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes.

Konopka AR, Esponda RR, Robinson MM, Johnson ML, Carter RE, Schiavon M, Cobelli C, Wondisford FE, Lanza IR, Nair KS.

Cell Rep. 2018 May 22;23(8):2532. doi: 10.1016/j.celrep.2018.05.027. No abstract available.


Impaired insulin signaling in unaffected siblings and patients with first-episode psychosis.

Chouinard VA, Henderson DC, Dalla Man C, Valeri L, Gray BE, Ryan KP, Cypess AM, Cobelli C, Cohen BM, Öngür D.

Mol Psychiatry. 2019 Oct;24(10):1513-1522. doi: 10.1038/s41380-018-0045-1. Epub 2018 Mar 9.


The UVA/Padova Type 1 Diabetes Simulator Goes From Single Meal to Single Day.

Visentin R, Campos-Náñez E, Schiavon M, Lv D, Vettoretti M, Breton M, Kovatchev BP, Dalla Man C, Cobelli C.

J Diabetes Sci Technol. 2018 Mar;12(2):273-281. doi: 10.1177/1932296818757747. Epub 2018 Feb 16.


Prospective evaluation of insulin and incretin dynamics in obese adults with and without diabetes for 2 years after Roux-en-Y gastric bypass.

Purnell JQ, Johnson GS, Wahed AS, Dalla Man C, Piccinini F, Cobelli C, Prigeon RL, Goodpaster BH, Kelley DE, Staten MA, Foster-Schubert KE, Cummings DE, Flum DR, Courcoulas AP, Havel PJ, Wolfe BM.

Diabetologia. 2018 May;61(5):1142-1154. doi: 10.1007/s00125-018-4553-y. Epub 2018 Feb 10.


HAPT2D: high accuracy of prediction of T2D with a model combining basic and advanced data depending on availability.

Di Camillo B, Hakaste L, Sambo F, Gabriel R, Kravic J, Isomaa B, Tuomilehto J, Alonso M, Longato E, Facchinetti A, Groop LC, Cobelli C, Tuomi T.

Eur J Endocrinol. 2018 Apr;178(4):331-341. doi: 10.1530/EJE-17-0921. Epub 2018 Jan 25.


Yet Another Glucose Variability Index: Time for a Paradigm Change?

Cobelli C, Facchinetti A.

Diabetes Technol Ther. 2018 Jan;20(1):1-3. doi: 10.1089/dia.2017.0397. No abstract available.


Strengthening of Existing Episodic Memories Through Non-invasive Stimulation of Prefrontal Cortex in Older Adults with Subjective Memory Complaints.

Manenti R, Sandrini M, Gobbi E, Cobelli C, Brambilla M, Binetti G, Cotelli M.

Front Aging Neurosci. 2017 Dec 5;9:401. doi: 10.3389/fnagi.2017.00401. eCollection 2017.


International Consensus on Use of Continuous Glucose Monitoring.

Danne T, Nimri R, Battelino T, Bergenstal RM, Close KL, DeVries JH, Garg S, Heinemann L, Hirsch I, Amiel SA, Beck R, Bosi E, Buckingham B, Cobelli C, Dassau E, Doyle FJ 3rd, Heller S, Hovorka R, Jia W, Jones T, Kordonouri O, Kovatchev B, Kowalski A, Laffel L, Maahs D, Murphy HR, Nørgaard K, Parkin CG, Renard E, Saboo B, Scharf M, Tamborlane WV, Weinzimer SA, Phillip M.

Diabetes Care. 2017 Dec;40(12):1631-1640. doi: 10.2337/dc17-1600. Review.


Impaired Insulin Action Is Associated With Increased Glucagon Concentrations in Nondiabetic Humans.

Sharma A, Varghese RT, Shah M, Man CD, Cobelli C, Rizza RA, Bailey KR, Vella A.

J Clin Endocrinol Metab. 2018 Jan 1;103(1):314-319. doi: 10.1210/jc.2017-01197.


Twelve-Week 24/7 Ambulatory Artificial Pancreas With Weekly Adaptation of Insulin Delivery Settings: Effect on Hemoglobin A1c and Hypoglycemia.

Dassau E, Pinsker JE, Kudva YC, Brown SA, Gondhalekar R, Dalla Man C, Patek S, Schiavon M, Dadlani V, Dasanayake I, Church MM, Carter RE, Bevier WC, Huyett LM, Hughes J, Anderson S, Lv D, Schertz E, Emory E, McCrady-Spitzer SK, Jean T, Bradley PK, Hinshaw L, Laguna Sanz AJ, Basu A, Kovatchev B, Cobelli C, Doyle FJ 3rd.

Diabetes Care. 2017 Dec;40(12):1719-1726. doi: 10.2337/dc17-1188. Epub 2017 Oct 13.


A methodological framework for detecting ulcers' risk in diabetic foot subjects by combining gait analysis, a new musculoskeletal foot model and a foot finite element model.

Scarton A, Guiotto A, Malaquias T, Spolaor F, Sinigaglia G, Cobelli C, Jonkers I, Sawacha Z.

Gait Posture. 2018 Feb;60:279-285. doi: 10.1016/j.gaitpost.2017.08.036. Epub 2017 Sep 1.


Continuous Glucose Monitoring in Very Preterm Infants: A Randomized Controlled Trial.

Galderisi A, Facchinetti A, Steil GM, Ortiz-Rubio P, Cavallin F, Tamborlane WV, Baraldi E, Cobelli C, Trevisanuto D.

Pediatrics. 2017 Oct;140(4). pii: e20171162. doi: 10.1542/peds.2017-1162. Epub 2017 Sep 15.


Validation of plantar pressure simulations using finite and discrete element modelling in healthy and diabetic subjects.

Aerts W, Scarton A, De Groote F, Guiotto A, Sawacha Z, Cobelli C, Vander Sloten J, Jonkers I.

Comput Methods Biomech Biomed Engin. 2017 Oct;20(13):1442-1452. doi: 10.1080/10255842.2017.1372428. Epub 2017 Sep 12.


Type-1 Diabetes Patient Decision Simulator for In Silico Testing Safety and Effectiveness of Insulin Treatments.

Vettoretti M, Facchinetti A, Sparacino G, Cobelli C.

IEEE Trans Biomed Eng. 2018 Jun;65(6):1281-1290. doi: 10.1109/TBME.2017.2746340. Epub 2017 Aug 29.


Performance of individually measured vs population-based C-peptide kinetics to assess β-cell function in the presence and absence of acute insulin resistance.

Varghese RT, Dalla Man C, Laurenti MC, Piccinini F, Sharma A, Shah M, Bailey KR, Rizza RA, Cobelli C, Vella A.

Diabetes Obes Metab. 2018 Mar;20(3):549-555. doi: 10.1111/dom.13106. Epub 2017 Sep 27.


Comparison of lower limb muscle strength between diabetic neuropathic and healthy subjects using OpenSim.

Scarton A, Jonkers I, Guiotto A, Spolaor F, Guarneri G, Avogaro A, Cobelli C, Sawacha Z.

Gait Posture. 2017 Oct;58:194-200. doi: 10.1016/j.gaitpost.2017.07.117. Epub 2017 Jul 31.


Overnight Closed-Loop Control Improves Glycemic Control in a Multicenter Study of Adults With Type 1 Diabetes.

Brown SA, Breton MD, Anderson SM, Kollar L, Keith-Hynes P, Levy CJ, Lam DW, Levister C, Baysal N, Kudva YC, Basu A, Dadlani V, Hinshaw L, McCrady-Spitzer S, Bruttomesso D, Visentin R, Galasso S, Del Favero S, Leal Y, Boscari F, Avogaro A, Cobelli C, Kovatchev BP.

J Clin Endocrinol Metab. 2017 Oct 1;102(10):3674-3682. doi: 10.1210/jc.2017-00556.


Exploring the Frequency Domain of Continuous Glucose Monitoring Signals to Improve Characterization of Glucose Variability and of Diabetic Profiles.

Fico G, Hernández L, Cancela J, Isabel MM, Facchinetti A, Fabris C, Gabriel R, Cobelli C, Arredondo Waldmeyer MT.

J Diabetes Sci Technol. 2017 Jul;11(4):773-779. doi: 10.1177/1932296816685717. Epub 2017 Jan 9.


The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing β-Cell Function and Hepatic Insulin Sensitivity.

Cropano C, Santoro N, Groop L, Dalla Man C, Cobelli C, Galderisi A, Kursawe R, Pierpont B, Goffredo M, Caprio S.

Diabetes Care. 2017 Aug;40(8):1082-1089. doi: 10.2337/dc17-0290. Epub 2017 Jun 13.


Diabetes and Prediabetes Classification Using Glycemic Variability Indices From Continuous Glucose Monitoring Data.

Acciaroli G, Sparacino G, Hakaste L, Facchinetti A, Di Nunzio GM, Palombit A, Tuomi T, Gabriel R, Aranda J, Vega S, Cobelli C.

J Diabetes Sci Technol. 2018 Jan;12(1):105-113. doi: 10.1177/1932296817710478. Epub 2017 Jun 1.


Glucose metabolism during rotational shift-work in healthcare workers.

Sharma A, Laurenti MC, Dalla Man C, Varghese RT, Cobelli C, Rizza RA, Matveyenko A, Vella A.

Diabetologia. 2017 Aug;60(8):1483-1490. doi: 10.1007/s00125-017-4317-0. Epub 2017 May 27.


Reduction of Blood Glucose Measurements to Calibrate Subcutaneous Glucose Sensors: A Bayesian Multiday Framework.

Acciaroli G, Vettoretti M, Facchinetti A, Sparacino G, Cobelli C.

IEEE Trans Biomed Eng. 2018 Mar;65(3):587-595. doi: 10.1109/TBME.2017.2706974. Epub 2017 May 23.


Accuracy of a CGM Sensor in Pediatric Subjects With Type 1 Diabetes. Comparison of Three Insertion Sites: Arm, Abdomen, and Gluteus.

Faccioli S, Del Favero S, Visentin R, Bonfanti R, Iafusco D, Rabbone I, Marigliano M, Schiaffini R, Bruttomesso D, Cobelli C; PedArPan Study Group.

J Diabetes Sci Technol. 2017 Nov;11(6):1147-1154. doi: 10.1177/1932296817706377. Epub 2017 May 9.

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