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A Novel Role for Triglyceride Metabolism in Foxp3 Expression.

Howie D, Ten Bokum A, Cobbold SP, Yu Z, Kessler BM, Waldmann H.

Front Immunol. 2019 Aug 13;10:1860. doi: 10.3389/fimmu.2019.01860. eCollection 2019.


CD4+ T Cell Fate Decisions Are Stochastic, Precede Cell Division, Depend on GITR Co-Stimulation, and Are Associated With Uropodium Development.

Cobbold SP, Adams E, Howie D, Waldmann H.

Front Immunol. 2018 Jun 18;9:1381. doi: 10.3389/fimmu.2018.01381. eCollection 2018.


The Role of Lipid Metabolism in T Lymphocyte Differentiation and Survival.

Howie D, Ten Bokum A, Necula AS, Cobbold SP, Waldmann H.

Front Immunol. 2018 Jan 12;8:1949. doi: 10.3389/fimmu.2017.01949. eCollection 2017. Review.


Foxp3 drives oxidative phosphorylation and protection from lipotoxicity.

Howie D, Cobbold SP, Adams E, Ten Bokum A, Necula AS, Zhang W, Huang H, Roberts DJ, Thomas B, Hester SS, Vaux DJ, Betz AG, Waldmann H.

JCI Insight. 2017 Feb 9;2(3):e89160. doi: 10.1172/jci.insight.89160.


Induced Foxp3(+) T Cells Colonizing Tolerated Allografts Exhibit the Hypomethylation Pattern Typical of Mature Regulatory T Cells.

Hilbrands R, Chen Y, Kendal AR, Adams E, Cobbold SP, Waldmann H, Howie D.

Front Immunol. 2016 Apr 11;7:124. doi: 10.3389/fimmu.2016.00124. eCollection 2016.


The mTOR pathway and integrating immune regulation.

Cobbold SP.

Immunology. 2013 Dec;140(4):391-8. doi: 10.1111/imm.12162. Review.


Regulatory cells and transplantation tolerance.

Cobbold SP, Waldmann H.

Cold Spring Harb Perspect Med. 2013 Jun 1;3(6). pii: a015545. doi: 10.1101/cshperspect.a015545. Review.


CD73 and adenosine generation in the creation of regulatory microenvironments.

Regateiro FS, Cobbold SP, Waldmann H.

Clin Exp Immunol. 2013 Jan;171(1):1-7. doi: 10.1111/j.1365-2249.2012.04623.x. Review.


Translating Tolerogenic Therapies to the Clinic - Where Do We Stand and What are the Barriers?

Cobbold SP, Li XC.

Front Immunol. 2012 Oct 12;3:317. doi: 10.3389/fimmu.2012.00317. eCollection 2012. No abstract available.


Foxp3 expression is required for the induction of therapeutic tissue tolerance.

Regateiro FS, Chen Y, Kendal AR, Hilbrands R, Adams E, Cobbold SP, Ma J, Andersen KG, Betz AG, Zhang M, Madhiwalla S, Roberts B, Waldmann H, Nolan KF, Howie D.

J Immunol. 2012 Oct 15;189(8):3947-56. doi: 10.4049/jimmunol.1200449. Epub 2012 Sep 17.


Th17 cells induce a distinct graft rejection response that does not require IL-17A.

Agorogiannis EI, Regateiro FS, Howie D, Waldmann H, Cobbold SP.

Am J Transplant. 2012 Apr;12(4):835-45. doi: 10.1111/j.1600-6143.2011.03971.x. Epub 2012 Mar 5.


Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance.

Kendal AR, Chen Y, Regateiro FS, Ma J, Adams E, Cobbold SP, Hori S, Waldmann H.

J Exp Med. 2011 Sep 26;208(10):2043-53. doi: 10.1084/jem.20110767. Epub 2011 Aug 29.


TGF-β in transplantation tolerance.

Regateiro FS, Howie D, Cobbold SP, Waldmann H.

Curr Opin Immunol. 2011 Oct;23(5):660-9. doi: 10.1016/j.coi.2011.07.003. Epub 2011 Aug 10. Review.


Generation of anti-inflammatory adenosine by leukocytes is regulated by TGF-β.

Regateiro FS, Howie D, Nolan KF, Agorogiannis EI, Greaves DR, Cobbold SP, Waldmann H.

Eur J Immunol. 2011 Oct;41(10):2955-65. doi: 10.1002/eji.201141512. Epub 2011 Sep 6.


Biomarkers of transplantation tolerance: more hopeful than helpful?

Cobbold SP, Adams E, Waldmann H.

Front Immunol. 2011 Apr 6;2:9. doi: 10.3389/fimmu.2011.00009. eCollection 2011.


Rejecting minors--it's all in the presentation.

Cobbold SP.

Transplantation. 2011 Jan 27;91(2):152-3. doi: 10.1097/TP.0b013e318201ac7b. No abstract available.


mTOR signalling and metabolic regulation of T cell differentiation.

Peter C, Waldmann H, Cobbold SP.

Curr Opin Immunol. 2010 Oct;22(5):655-61. doi: 10.1016/j.coi.2010.08.010. Epub 2010 Sep 15. Review.


A role for regulatory T cells in acceptance of ESC-derived tissues transplanted across an major histocompatibility complex barrier.

Lui KO, Boyd AS, Cobbold SP, Waldmann H, Fairchild PJ.

Stem Cells. 2010 Oct;28(10):1905-14. doi: 10.1002/stem.506.


Connecting the mechanisms of T-cell regulation: dendritic cells as the missing link.

Cobbold SP, Adams E, Nolan KF, Regateiro FS, Waldmann H.

Immunol Rev. 2010 Jul;236:203-18. doi: 10.1111/j.1600-065X.2010.00913.x. Review.


Tolerogenicity is not an absolute property of a dendritic cell.

Farquhar CA, Paterson AM, Cobbold SP, Garcia Rueda H, Fairchild PJ, Yates SF, Adams E, Saunders NJ, Waldmann H, Nolan KF.

Eur J Immunol. 2010 Jun;40(6):1728-37. doi: 10.1002/eji.200939974.


Combining regulation with suppression and aiming for tolerance.

Cobbold SP.

Transplantation. 2010 Apr 27;89(8):909-10. doi: 10.1097/TP.0b013e3181d3ca03. No abstract available.


MS4A4B is a GITR-associated membrane adapter, expressed by regulatory T cells, which modulates T cell activation.

Howie D, Nolan KF, Daley S, Butterfield E, Adams E, Garcia-Rueda H, Thompson C, Saunders NJ, Cobbold SP, Tone Y, Tone M, Waldmann H.

J Immunol. 2009 Oct 1;183(7):4197-204. doi: 10.4049/jimmunol.0901070. Epub 2009 Sep 14.


Infectious tolerance via the consumption of essential amino acids and mTOR signaling.

Cobbold SP, Adams E, Farquhar CA, Nolan KF, Howie D, Lui KO, Fairchild PJ, Mellor AL, Ron D, Waldmann H.

Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12055-60. doi: 10.1073/pnas.0903919106. Epub 2009 Jun 30.


Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression.

Campbell JD, Buckland KF, McMillan SJ, Kearley J, Oldfield WL, Stern LJ, Grönlund H, van Hage M, Reynolds CJ, Boyton RJ, Cobbold SP, Kay AB, Altmann DM, Lloyd CM, Larché M.

J Exp Med. 2009 Jul 6;206(7):1535-47. doi: 10.1084/jem.20082901. Epub 2009 Jun 15.


Future therapeutics for the induction of peripheral immune tolerance in autoimmune disease and organ transplantation.

Cobbold SP.

Immunotherapy. 2009 May;1(3):447-60. doi: 10.2217/imt.09.9. Review.


CD8+ T-Cell depletion and rapamycin synergize with combined coreceptor/stimulation blockade to induce robust limb allograft tolerance in mice.

Li Z, Benghiat FS, Charbonnier LM, Kubjak C, Rivas MN, Cobbold SP, Waldmann H, De Wilde V, Petein M, Schuind F, Goldman M, Le Moine A.

Am J Transplant. 2008 Dec;8(12):2527-36. doi: 10.1111/j.1600-6143.2008.02419.x. Epub 2008 Oct 6.


Fc-disabled anti-mouse CD40L antibodies retain efficacy in promoting transplantation tolerance.

Daley SR, Cobbold SP, Waldmann H.

Am J Transplant. 2008 Nov;8(11):2265-71. doi: 10.1111/j.1600-6143.2008.02382.x. Epub 2008 Sep 8.


Regulatory T cells and transplantation tolerance.

Cobbold SP.

J Nephrol. 2008 Jul-Aug;21(4):485-96. Review.


Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance.

Robertson NJ, Brook FA, Gardner RL, Cobbold SP, Waldmann H, Fairchild PJ.

Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20920-5. Epub 2007 Dec 18.


SAGE analysis of cell types involved in tolerance induction.

Nolan KF, Cobbold SP, Waldmann H.

Methods Mol Biol. 2007;380:225-51. Review.


A key role for TGF-beta signaling to T cells in the long-term acceptance of allografts.

Daley SR, Ma J, Adams E, Cobbold SP, Waldmann H.

J Immunol. 2007 Sep 15;179(6):3648-54.


Induction of regulatory T cells and dominant tolerance by dendritic cells incapable of full activation.

Yates SF, Paterson AM, Nolan KF, Cobbold SP, Saunders NJ, Waldmann H, Fairchild PJ.

J Immunol. 2007 Jul 15;179(2):967-76.


A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein.

Senis YA, Tomlinson MG, García A, Dumon S, Heath VL, Herbert J, Cobbold SP, Spalton JC, Ayman S, Antrobus R, Zitzmann N, Bicknell R, Frampton J, Authi KS, Martin A, Wakelam MJ, Watson SP.

Mol Cell Proteomics. 2007 Mar;6(3):548-64. Epub 2006 Dec 23.


Immune privilege induced by regulatory T cells in transplantation tolerance.

Cobbold SP, Adams E, Graca L, Daley S, Yates S, Paterson A, Robertson NJ, Nolan KF, Fairchild PJ, Waldmann H.

Immunol Rev. 2006 Oct;213:239-55. Review.


Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning.

Graca L, Daley S, Fairchild PJ, Cobbold SP, Waldmann H.

BMC Immunol. 2006 Apr 25;7:9.


T cell tolerance induced by therapeutic antibodies.

Cobbold SP.

Philos Trans R Soc Lond B Biol Sci. 2005 Sep 29;360(1461):1695-705. Review.


Introduction: immunoregulation: harnessing T cell biology for therapeutic benefit.

Metcalfe SM, Calne RY, Cobbold SP.

Philos Trans R Soc Lond B Biol Sci. 2005 Sep 29;360(1461):1641-3. No abstract available.


Dominant tolerance: activation thresholds for peripheral generation of regulatory T cells.

Graca L, Chen TC, Le Moine A, Cobbold SP, Howie D, Waldmann H.

Trends Immunol. 2005 Mar;26(3):130-5. Review. No abstract available.


New trends in immunosuppression.

Cobbold SP.

Int Immunopharmacol. 2005 Jan;5(1):1-5.


Induction of immunological tolerance/hyporesponsiveness in baboons with a nondepleting CD4 antibody.

Winsor-Hines D, Merrill C, O'Mahony M, Rao PE, Cobbold SP, Waldmann H, Ringler DJ, Ponath PD.

J Immunol. 2004 Oct 1;173(7):4715-23.


Donor-specific transplantation tolerance: the paradoxical behavior of CD4+CD25+ T cells.

Graca L, Le Moine A, Lin CY, Fairchild PJ, Cobbold SP, Waldmann H.

Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10122-6. Epub 2004 Jun 24.


Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants.

Cobbold SP, Castejon R, Adams E, Zelenika D, Graca L, Humm S, Waldmann H.

J Immunol. 2004 May 15;172(10):6003-10.


Generation of anergic and regulatory T cells following prolonged exposure to a harmless antigen.

Chen TC, Cobbold SP, Fairchild PJ, Waldmann H.

J Immunol. 2004 May 15;172(10):5900-7.


IL-10-conditioned dendritic cells, decommissioned for recruitment of adaptive immunity, elicit innate inflammatory gene products in response to danger signals.

Nolan KF, Strong V, Soler D, Fairchild PJ, Cobbold SP, Croxton R, Gonzalo JA, Rubio A, Wells M, Waldmann H.

J Immunol. 2004 Feb 15;172(4):2201-9.


Antibody-induced transplantation tolerance: the role of dominant regulation.

Graca L, Le Moine A, Cobbold SP, Waldmann H.

Immunol Res. 2003;28(3):181-91. Review.


Serial analysis of gene expression provides new insights into regulatory T cells.

Cobbold SP, Adams E, Graca L, Waldmann H.

Semin Immunol. 2003 Aug;15(4):209-14. Review.


Regulatory T cells and dendritic cells in transplantation tolerance: molecular markers and mechanisms.

Cobbold SP, Nolan KF, Graca L, Castejon R, Le Moine A, Frewin M, Humm S, Adams E, Thompson S, Zelenika D, Paterson A, Yates S, Fairchild PJ, Waldmann H.

Immunol Rev. 2003 Dec;196:109-24. Review.


Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells.

Tone M, Tone Y, Adams E, Yates SF, Frewin MR, Cobbold SP, Waldmann H.

Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15059-64. Epub 2003 Nov 7.


Dominant transplantation tolerance. Opinion.

Graca L, Le Moine A, Cobbold SP, Waldmann H.

Curr Opin Immunol. 2003 Oct;15(5):499-506. Review.


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