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Automated urinalysis combining physicochemical analysis, on-board centrifugation, and digital imaging in one system: A multicenter performance evaluation of the cobas 6500 urine work area.

Cobbaert CM, Arslan F, Caballé Martín I, Serra AA, Picó-Plana E, Sánchez-Margalet V, Carmona-Fernández A, Burden J, Ziegler A, Bechel W.

Pract Lab Med. 2019 Sep 19;17:e00139. doi: 10.1016/j.plabm.2019.e00139. eCollection 2019 Nov.


Perioperative proADM-change is associated with the development of acute respiratory distress syndrome in critically ill cardiac surgery patients: a prospective cohort study.

van Paassen J, van Dissel JT, Hiemstra PS, Zwaginga JJ, Cobbaert CM, Juffermans NP, de Wilde RB, Stijnen T, de Jonge E, Klautz RJ, Arbous MS.

Biomark Med. 2019 Sep;13(13):1081-1091. doi: 10.2217/bmm-2019-0028. Epub 2019 Sep 23.


Predictors of 90-Day Restart of Renal Replacement Therapy after Discontinuation of Continuous Renal Replacement Therapy, a Prospective Multicenter Study.

Stads S, Kant KM, de Jong MFC, de Ruijter W, Cobbaert CM, Betjes MGH, Gommers D, Oudemans-van Straaten HM.

Blood Purif. 2019;48(3):243-252. doi: 10.1159/000501387. Epub 2019 Jul 22.


Fast 0/1-h algorithm for detection of NSTEMI: are current high-sensitivity cardiac troponin assays fit for purpose? An EQA-based evaluation.

van der Hagen EAE, Cobbaert CM, Meijer R, Thelen MHM.

Clin Chem Lab Med. 2019 Nov 26;57(12):1999-2007. doi: 10.1515/cclm-2019-0253.


Interchangeability of sodium and chloride measurements by indirect and direct ISE assays: Stakeholders, take responsibility!

den Elzen WP, Cobbaert CM, Arbous MS, Elzo Kraemer CV, Schoe A, de Jonge E, Schenk PW.

Pract Lab Med. 2019 Jun 13;16:e00126. doi: 10.1016/j.plabm.2019.e00126. eCollection 2019 Aug. No abstract available.


Kidney Injury Biomarkers in an Academic Hospital Setting: Where Are We Now?

van Duijl TT, Ruhaak LR, de Fijter JW, Cobbaert CM.

Clin Biochem Rev. 2019 May;40(2):79-97. doi: 10.33176/AACB-18-00017. Review.


Urinary Tissue Inhibitor of Metalloproteinases-2 and Insulin-Like Growth Factor-Binding Protein 7 Do Not Correlate With Disease Severity in ADPKD Patients.

Dekker SEI, Ruhaak LR, Romijn FPHTM, Meijer E, Cobbaert CM, de Fijter JW, Soonawala D; DIPAK Consortium.

Kidney Int Rep. 2019 Mar 22;4(6):833-841. doi: 10.1016/j.ekir.2019.03.011. eCollection 2019 Jun.


Non-lytic antibiotic treatment in community-acquired pneumococcal pneumonia does not attenuate inflammation: the PRISTINE trial.

Groeneveld GH, van der Reyden TJ, Joosten SA, Bootsma HJ, Cobbaert CM, de Vries JJC, Kuijper EJ, van Dissel JT.

J Antimicrob Chemother. 2019 Aug 1;74(8):2385-2393. doi: 10.1093/jac/dkz207.


Predictors of short-term successful discontinuation of continuous renal replacement therapy: results from a prospective multicentre study.

Stads S, Kant KM, de Jong MFC, de Ruijter W, Cobbaert CM, Betjes MGH, Gommers D, Oudemans-van Straaten HM.

BMC Nephrol. 2019 Apr 15;20(1):129. doi: 10.1186/s12882-019-1327-9.


Setting clinical performance specifications to develop and evaluate biomarkers for clinical use.

Lord SJ, St John A, Bossuyt PM, Sandberg S, Monaghan PJ, O'Kane M, Cobbaert CM, Röddiger R, Lennartz L, Gelfi C, Horvath AR; Test Evaluation Working Group of the European Federation of Clinical Chemistry and Laboratory Medicine.

Ann Clin Biochem. 2019 Sep;56(5):527-535. doi: 10.1177/0004563219842265. Epub 2019 Apr 16. No abstract available.


Apolipoprotein profiling as a personalized approach to the diagnosis and treatment of dyslipidaemia.

Renee Ruhaak L, van der Laarse A, Cobbaert CM.

Ann Clin Biochem. 2019 May;56(3):338-356. doi: 10.1177/0004563219827620. Epub 2019 Mar 19.


Accuracy assessment of consecutive test strip lots for whole blood INR point-of-care instruments: clarifying the role of frozen plasma pools.

van den Besselaar AMHP, Abdoel CF, van Rijn CJJ, van der Meer FJM, Cobbaert CM.

Clin Chem Lab Med. 2019 Aug 27;57(9):1349-1357. doi: 10.1515/cclm-2018-1054.


Plasma LDL-Cholesterol Level at Admission is Independently Associated with Infarct Size in Patients with ST-Segment Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention.

Bodde MC, Hermans MPJ, Wolterbeek R, Cobbaert CM, van der Laarse A, Schalij MJ, Jukema JW.

Cardiol Ther. 2019 Jun;8(1):55-67. doi: 10.1007/s40119-019-0126-5. Epub 2019 Feb 13.


Growth Differentiation Factor-15 Levels at Admission Provide Incremental Prognostic Information on All-Cause Long-term Mortality in ST-Segment Elevation Myocardial Infarction Patients Treated with Primary Percutaneous Coronary Intervention.

Bodde MC, Hermans MPJ, van der Laarse A, Mertens B, Romijn FPHTM, Schalij MJ, Cobbaert CM, Jukema JW.

Cardiol Ther. 2019 Jun;8(1):29-41. doi: 10.1007/s40119-019-0127-4. Epub 2019 Jan 30.


Requirement of a reference measurement system for the tissue factor-induced coagulation time and the international normalized ratio.

van den Besselaar AMHP, van Rijn CJJ, Hubbard AR, Kitchen S, Tripodi A, Cobbaert CM.

Clin Chem Lab Med. 2019 Jun 26;57(7):e169-e172. doi: 10.1515/cclm-2018-1194. No abstract available.


Urinary TIMP-2 Predicts the Presence and Duration of Delayed Graft Function in Donation After Circulatory Death Kidney Transplant Recipients.

Bank JR, Ruhaak R, Soonawala D, Mayboroda O, Romijn FP, van Kooten C, Cobbaert CM, de Fijter JW.

Transplantation. 2019 May;103(5):1014-1023. doi: 10.1097/TP.0000000000002472.


Apolipoproteins A1, B, and apoB/apoA1 ratio are associated with first ST-segment elevation myocardial infarction but not with recurrent events during long-term follow-up.

Bodde MC, Hermans MPJ, Jukema JW, Schalij MJ, Lijfering WM, Rosendaal FR, Romijn FPHTM, Ruhaak LR, van der Laarse A, Cobbaert CM.

Clin Res Cardiol. 2019 May;108(5):520-538. doi: 10.1007/s00392-018-1381-5. Epub 2018 Oct 8.


MS-based proteomics: a metrological sound and robust alternative for apolipoprotein E phenotyping in a multiplexed test.

Ruhaak LR, Smit NPM, Suchiman HED, Pieterse MM, Romijn FPHTM, Beekman M, Cobbaert CM.

Clin Chem Lab Med. 2019 Apr 24;57(5):e102-e104. doi: 10.1515/cclm-2018-0782. No abstract available.


NUMBER: standardized reference intervals in the Netherlands using a 'big data' approach.

den Elzen WPJ, Brouwer N, Thelen MH, Le Cessie S, Haagen IA, Cobbaert CM.

Clin Chem Lab Med. 2018 Dec 19;57(1):42-56. doi: 10.1515/cclm-2018-0462.


Proteoform Analysis to Fulfill Unmet Clinical Needs and Reach Global Standardization of Protein Measurands in Clinical Chemistry Proteomics.

van der Burgt YEM, Cobbaert CM.

Clin Lab Med. 2018 Sep;38(3):487-497. doi: 10.1016/j.cll.2018.05.001. Epub 2018 Jul 20. Review.


The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data.

Wopereis DM, Du Puy RS, van Heemst D, Walsh JP, Bremner A, Bakker SJL, Bauer DC, Cappola AR, Ceresini G, Degryse J, Dullaart RPF, Feller M, Ferrucci L, Floriani C, Franco OH, Iacoviello M, Iervasi G, Imaizumi M, Jukema JW, Khaw KT, Luben RN, Molinaro S, Nauck M, Patel KV, Peeters RP, Psaty BM, Razvi S, Schindhelm RK, van Schoor NM, Stott DJ, Vaes B, Vanderpump MPJ, Völzke H, Westendorp RGJ, Rodondi N, Cobbaert CM, Gussekloo J, den Elzen WPJ; Thyroid Studies Collaboration.

J Clin Endocrinol Metab. 2018 Oct 1;103(10):3658-3667. doi: 10.1210/jc.2018-00481.


Comparability of Lipoprotein Particle Number Concentrations Across ES-DMA, NMR, LC-MS/MS, Immunonephelometry, and VAP: In Search of a Candidate Reference Measurement Procedure for apoB and non-HDL-P Standardization.

Delatour V, Clouet-Foraison N, Gaie-Levrel F, Marcovina SM, Hoofnagle AN, Kuklenyik Z, Caulfield MP, Otvos JD, Krauss RM, Kulkarni KR, Contois JH, Remaley AT, Vesper HW, Cobbaert CM, Gillery P.

Clin Chem. 2018 Oct;64(10):1485-1495. doi: 10.1373/clinchem.2018.288746. Epub 2018 Aug 7.


Sex differences in body fat distribution are related to sex differences in serum leptin and adiponectin.

Christen T, Trompet S, Noordam R, van Klinken JB, van Dijk KW, Lamb HJ, Cobbaert CM, den Heijer M, Jazet IM, Jukema JW, Rosendaal FR, de Mutsert R.

Peptides. 2018 Sep;107:25-31. doi: 10.1016/j.peptides.2018.07.008. Epub 2018 Aug 1.


Practical guide for identifying unmet clinical needs for biomarkers.

Monaghan PJ, Robinson S, Rajdl D, Bossuyt PMM, Sandberg S, St John A, O'Kane M, Lennartz L, Röddiger R, Lord SJ, Cobbaert CM, Horvath AR.

EJIFCC. 2018 Jul 11;29(2):129-137. eCollection 2018 Jul.


Detecting molecular forms of antithrombin by LC-MRM-MS: defining the measurands.

Ruhaak LR, Romijn FPHTM, Smit NPM, van der Laarse A, Pieterse MM, de Maat MPM, Haas FJLM, Kluft C, Amiral J, Meijer P, Cobbaert CM.

Clin Chem Lab Med. 2018 Sep 25;56(10):1704-1714. doi: 10.1515/cclm-2017-1111. No abstract available.


Interference of glucose and total protein on Jaffe based creatinine methods: mind the covolume - reply.

den Elzen WPJ, Cobbaert CM, Weykamp C.

Clin Chem Lab Med. 2018 Jul 26;56(8):e190. doi: 10.1515/cclm-2018-0269. No abstract available.


Use of Automated Urine Microscopy Analysis in Clinical Diagnosis of Urinary Tract Infection: Defining an Optimal Diagnostic Score in an Academic Medical Center Population.

Foudraine DE, Bauer MP, Russcher A, Kusters E, Cobbaert CM, van der Beek MT, Stalenhoef JE.

J Clin Microbiol. 2018 May 25;56(6). pii: e02030-17. doi: 10.1128/JCM.02030-17. Print 2018 Jun.


Glucose and total protein: unacceptable interference on Jaffe creatinine assays in patients.

den Elzen WPJ, Cobbaert CM, Klein Gunnewiek JMT, Bakkeren DL, van Berkel M, Frasa MAM, Herpers RLJM, Kuypers AWHM, Ramakers C, Roelofsen-de Beer RJAC, van der Vuurst H, Weykamp C.

Clin Chem Lab Med. 2018 Jul 26;56(8):e185-e187. doi: 10.1515/cclm-2017-1170. No abstract available.


Robust and Accurate 2-Year Performance of a Quantitative Mass Spectrometry-Based Apolipoprotein Test in a Clinical Chemistry Laboratory.

Ruhaak LR, Smit NPM, Romijn FPHTM, Pieterse MM, van der Laarse A, van der Burgt YEM, Cobbaert CM.

Clin Chem. 2018 Apr;64(4):747-749. doi: 10.1373/clinchem.2017.285098. Epub 2018 Jan 29. No abstract available.


The quest for equivalence of test results: the pilgrimage of the Dutch Calibration 2.000 program for metrological traceability.

Jansen RTP, Cobbaert CM, Weykamp C, Thelen M.

Clin Chem Lab Med. 2018 Sep 25;56(10):1673-1684. doi: 10.1515/cclm-2017-0796. Review. No abstract available.


Low levels of apolipoprotein-CII in normotriglyceridemic patients with very premature coronary artery disease: Observations from the MISSION! Intervention study.

Hermans MPJ, Bodde MC, Jukema JW, Schalij MJ, van der Laarse A, Cobbaert CM.

J Clin Lipidol. 2017 Nov - Dec;11(6):1407-1414. doi: 10.1016/j.jacl.2017.08.002. Epub 2017 Aug 8.


Short-term cooling increases serum triglycerides and small high-density lipoprotein levels in humans.

Hoeke G, Nahon KJ, Bakker LEH, Norkauer SSC, Dinnes DLM, Kockx M, Lichtenstein L, Drettwan D, Reifel-Miller A, Coskun T, Pagel P, Romijn FPHTM, Cobbaert CM, Jazet IM, Martinez LO, Kritharides L, Berbée JFP, Boon MR, Rensen PCN.

J Clin Lipidol. 2017 Jul - Aug;11(4):920-928.e2. doi: 10.1016/j.jacl.2017.04.117. Epub 2017 May 3.


Disease stage and plasma levels of cytokines in Huntington's disease: A 2-year follow-up study.

Bouwens JA, van Duijn E, Cobbaert CM, Roos RAC, van der Mast RC, Giltay EJ.

Mov Disord. 2017 Jul;32(7):1103-1104. doi: 10.1002/mds.26950. Epub 2017 May 29. No abstract available.


Effect of Anthelmintic Treatment on Insulin Resistance: A Cluster-Randomized, Placebo-Controlled Trial in Indonesia.

Tahapary DL, de Ruiter K, Martin I, Brienen EAT, van Lieshout L, Cobbaert CM, Soewondo P, Djuardi Y, Wiria AE, Houwing-Duistermaat JJ, Sartono E, Smit JWA, Yazdanbakhsh M, Supali T.

Clin Infect Dis. 2017 Sep 1;65(5):764-771. doi: 10.1093/cid/cix416.


Fibrinogen determination according to Clauss: commutability assessment of International and commercial standards and quality control samples.

van den Besselaar AMHP, van Rijn CJJ, Cobbaert CM, Reijnierse GLA, Hollestelle MJ, Niessen RWLM, Hudig F.

Clin Chem Lab Med. 2017 Oct 26;55(11):1761-1769. doi: 10.1515/cclm-2016-1088.


Expressing analytical performance from multi-sample evaluation in laboratory EQA.

Thelen MHM, Jansen RTP, Weykamp CW, Steigstra H, Meijer R, Cobbaert CM.

Clin Chem Lab Med. 2017 Aug 28;55(10):1509-1516. doi: 10.1515/cclm-2016-0970.


Plasma Cytokine Levels in Relation to Neuropsychiatric Symptoms and Cognitive Dysfunction in Huntington's disease.

Bouwens JA, van Duijn E, Cobbaert CM, Roos RA, van der Mast RC, Giltay EJ.

J Huntingtons Dis. 2016 Dec 15;5(4):369-377.


Familial Longevity Is Not Associated with Major Differences in the Hypothalamic-Pituitary-Gonadal Axis in Healthy Middle-Aged Men.

van der Spoel E, Roelfsema F, Jansen SW, Akintola AA, Ballieux BE, Cobbaert CM, Blauw GJ, Slagboom PE, Westendorp RG, Pijl H, van Heemst D.

Front Endocrinol (Lausanne). 2016 Nov 9;7:143. eCollection 2016.


Prospective applications of ultrahigh resolution proteomics in clinical mass spectrometry.

Ruhaak LR, van der Burgt YE, Cobbaert CM.

Expert Rev Proteomics. 2016 Dec;13(12):1063-1071. Epub 2016 Nov 7. Review.


Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity.

van der Spoel E, Jansen SW, Akintola AA, Ballieux BE, Cobbaert CM, Slagboom PE, Blauw GJ, Westendorp RGJ, Pijl H, Roelfsema F, van Heemst D.

Aging Cell. 2016 Dec;15(6):1126-1131. doi: 10.1111/acel.12519. Epub 2016 Sep 7.


How to define reference intervals to rule in healthy individuals for clinical trials?

den Elzen WP, van Gerven J, Schenk PW, Uit Den Boogaard A, Kroon R, Klaassen E, Ballieux BE, Cobbaert CM.

Clin Chem Lab Med. 2017 Mar 1;55(3):e59-e61. doi: 10.1515/cclm-2016-0307. No abstract available.


Biomarker development targeting unmet clinical needs.

Monaghan PJ, Lord SJ, St John A, Sandberg S, Cobbaert CM, Lennartz L, Verhagen-Kamerbeek WD, Ebert C, Bossuyt PM, Horvath AR; Test Evaluation Working Group of the European Federation of Clinical Chemistry and Laboratory Medicine.

Clin Chim Acta. 2016 Sep 1;460:211-9. doi: 10.1016/j.cca.2016.06.037. Epub 2016 Jun 30.


Keeping Ebola out of the lab: a practical solution on how to analyze Ebola associated blood anomalies.

van den Wijngaard JP, Bakker JA, Gillis JM, Ballieux BE, de Vries JJ, Schenk PW, Cobbaert CM.

Clin Chem Lab Med. 2016 Nov 1;54(11):e353-e357. doi: 10.1515/cclm-2015-1225. No abstract available.


Automated Multiplex LC-MS/MS Assay for Quantifying Serum Apolipoproteins A-I, B, C-I, C-II, C-III, and E with Qualitative Apolipoprotein E Phenotyping.

van den Broek I, Romijn FP, Nouta J, van der Laarse A, Drijfhout JW, Smit NP, van der Burgt YE, Cobbaert CM.

Clin Chem. 2016 Jan;62(1):188-97. doi: 10.1373/clinchem.2015.246702. Epub 2015 Nov 19.


Interlaboratory Collaboration for Optimized Screening for Urinary Tract Infection.

Russcher A, Kusters E, Wolterbeek R, Kuijper EJ, Cobbaert CM, van der Beek MT.

J Clin Microbiol. 2016 Jan;54(1):93-8. doi: 10.1128/JCM.01943-15. Epub 2015 Oct 21.


A multicenter comparison of whole blood vitamin B6 assays.

van Zelst BD, de Beer RJ, Neele M, Kos S, Kema IP, Tegelaers FP, Cobbaert CM, Weykamp CW, de Jonge R.

Clin Chem Lab Med. 2016 Apr;54(4):609-16. doi: 10.1515/cclm-2015-0385.


Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals.

Akintola AA, Noordam R, Jansen SW, de Craen AJ, Ballieux BE, Cobbaert CM, Mooijaart SP, Pijl H, Westendorp RG, van Heemst D.

PLoS One. 2015 Oct 7;10(10):e0139973. doi: 10.1371/journal.pone.0139973. eCollection 2015.


Serum Cardiac Troponin-I is Superior to Troponin-T as a Marker for Left Ventricular Dysfunction in Clinically Stable Patients with End-Stage Renal Disease.

Buiten MS, de Bie MK, Rotmans JI, Dekker FW, van Buren M, Rabelink TJ, Cobbaert CM, Schalij MJ, van der Laarse A, Jukema JW.

PLoS One. 2015 Aug 3;10(8):e0134245. doi: 10.1371/journal.pone.0134245. eCollection 2015.


Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship.

Jansen SW, Roelfsema F, van der Spoel E, Akintola AA, Postmus I, Ballieux BE, Slagboom PE, Cobbaert CM, van der Grond J, Westendorp RG, Pijl H, van Heemst D.

J Clin Endocrinol Metab. 2015 Oct;100(10):3806-13. doi: 10.1210/jc.2015-2624. Epub 2015 Jul 31.


Characterization of the Hypothalamic-Pituitary-Adrenal-Axis in Familial Longevity under Resting Conditions.

Jansen SW, Roelfsema F, Akintola AA, Oei NY, Cobbaert CM, Ballieux BE, van der Grond J, Westendorp RG, Pijl H, van Heemst D.

PLoS One. 2015 Jul 20;10(7):e0133119. doi: 10.1371/journal.pone.0133119. eCollection 2015.

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