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Requirement of a reference measurement system for the tissue factor-induced coagulation time and the international normalized ratio.

van den Besselaar AMHP, van Rijn CJJ, Hubbard AR, Kitchen S, Tripodi A, Cobbaert CM.

Clin Chem Lab Med. 2018 Dec 4. pii: /j/cclm.ahead-of-print/cclm-2018-1194/cclm-2018-1194.xml. doi: 10.1515/cclm-2018-1194. [Epub ahead of print] No abstract available.


Urinary TIMP-2 predicts the presence and duration of delayed graft function in donation after circulatory death kidney transplant recipients.

Bank JR, Ruhaak R, Soonawala D, Mayboroda O, Romijn FP, van Kooten C, Cobbaert CM, de Fijter JW.

Transplantation. 2018 Oct 8. doi: 10.1097/TP.0000000000002472. [Epub ahead of print]


Apolipoproteins A1, B, and apoB/apoA1 ratio are associated with first ST-segment elevation myocardial infarction but not with recurrent events during long-term follow-up.

Bodde MC, Hermans MPJ, Jukema JW, Schalij MJ, Lijfering WM, Rosendaal FR, Romijn FPHTM, Ruhaak LR, van der Laarse A, Cobbaert CM.

Clin Res Cardiol. 2018 Oct 8. doi: 10.1007/s00392-018-1381-5. [Epub ahead of print]


MS-based proteomics: a metrological sound and robust alternative for apolipoprotein E phenotyping in a multiplexed test.

Ruhaak LR, Smit NPM, Suchiman HED, Pieterse MM, Romijn FPHTM, Beekman M, Cobbaert CM.

Clin Chem Lab Med. 2018 Sep 21. pii: /j/cclm.ahead-of-print/cclm-2018-0782/cclm-2018-0782.xml. doi: 10.1515/cclm-2018-0782. [Epub ahead of print] No abstract available.


NUMBER: standardized reference intervals in the Netherlands using a 'big data' approach.

den Elzen WPJ, Brouwer N, Thelen MH, Le Cessie S, Haagen IA, Cobbaert CM.

Clin Chem Lab Med. 2018 Dec 19;57(1):42-56. doi: 10.1515/cclm-2018-0462.


Proteoform Analysis to Fulfill Unmet Clinical Needs and Reach Global Standardization of Protein Measurands in Clinical Chemistry Proteomics.

van der Burgt YEM, Cobbaert CM.

Clin Lab Med. 2018 Sep;38(3):487-497. doi: 10.1016/j.cll.2018.05.001. Epub 2018 Jul 20. Review.


The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data.

Wopereis DM, Du Puy RS, van Heemst D, Walsh JP, Bremner A, Bakker SJL, Bauer DC, Cappola AR, Ceresini G, Degryse J, Dullaart RPF, Feller M, Ferrucci L, Floriani C, Franco OH, Iacoviello M, Iervasi G, Imaizumi M, Jukema JW, Khaw KT, Luben RN, Molinaro S, Nauck M, Patel KV, Peeters RP, Psaty BM, Razvi S, Schindhelm RK, van Schoor NM, Stott DJ, Vaes B, Vanderpump MPJ, Völzke H, Westendorp RGJ, Rodondi N, Cobbaert CM, Gussekloo J, den Elzen WPJ; Thyroid Studies Collaboration.

J Clin Endocrinol Metab. 2018 Oct 1;103(10):3658-3667. doi: 10.1210/jc.2018-00481.


Comparability of Lipoprotein Particle Number Concentrations Across ES-DMA, NMR, LC-MS/MS, Immunonephelometry, and VAP: In Search of a Candidate Reference Measurement Procedure for apoB and non-HDL-P Standardization.

Delatour V, Clouet-Foraison N, Gaie-Levrel F, Marcovina SM, Hoofnagle AN, Kuklenyik Z, Caulfield MP, Otvos JD, Krauss RM, Kulkarni KR, Contois JH, Remaley AT, Vesper HW, Cobbaert CM, Gillery P.

Clin Chem. 2018 Oct;64(10):1485-1495. doi: 10.1373/clinchem.2018.288746. Epub 2018 Aug 7.


Sex differences in body fat distribution are related to sex differences in serum leptin and adiponectin.

Christen T, Trompet S, Noordam R, van Klinken JB, van Dijk KW, Lamb HJ, Cobbaert CM, den Heijer M, Jazet IM, Jukema JW, Rosendaal FR, de Mutsert R.

Peptides. 2018 Sep;107:25-31. doi: 10.1016/j.peptides.2018.07.008. Epub 2018 Aug 1.


Practical guide for identifying unmet clinical needs for biomarkers.

Monaghan PJ, Robinson S, Rajdl D, Bossuyt PMM, Sandberg S, St John A, O'Kane M, Lennartz L, Röddiger R, Lord SJ, Cobbaert CM, Horvath AR.

EJIFCC. 2018 Jul 11;29(2):129-137. eCollection 2018 Jul.


Detecting molecular forms of antithrombin by LC-MRM-MS: defining the measurands.

Ruhaak LR, Romijn FPHTM, Smit NPM, van der Laarse A, Pieterse MM, de Maat MPM, Haas FJLM, Kluft C, Amiral J, Meijer P, Cobbaert CM.

Clin Chem Lab Med. 2018 Sep 25;56(10):1704-1714. doi: 10.1515/cclm-2017-1111. No abstract available.


Interference of glucose and total protein on Jaffe based creatinine methods: mind the covolume - reply.

den Elzen WPJ, Cobbaert CM, Weykamp C.

Clin Chem Lab Med. 2018 Jul 26;56(8):e190. doi: 10.1515/cclm-2018-0269. No abstract available.


Use of Automated Urine Microscopy Analysis in Clinical Diagnosis of Urinary Tract Infection: Defining an Optimal Diagnostic Score in an Academic Medical Center Population.

Foudraine DE, Bauer MP, Russcher A, Kusters E, Cobbaert CM, van der Beek MT, Stalenhoef JE.

J Clin Microbiol. 2018 May 25;56(6). pii: e02030-17. doi: 10.1128/JCM.02030-17. Print 2018 Jun.


Glucose and total protein: unacceptable interference on Jaffe creatinine assays in patients.

den Elzen WPJ, Cobbaert CM, Klein Gunnewiek JMT, Bakkeren DL, van Berkel M, Frasa MAM, Herpers RLJM, Kuypers AWHM, Ramakers C, Roelofsen-de Beer RJAC, van der Vuurst H, Weykamp C.

Clin Chem Lab Med. 2018 Jul 26;56(8):e185-e187. doi: 10.1515/cclm-2017-1170. No abstract available.


Robust and Accurate 2-Year Performance of a Quantitative Mass Spectrometry-Based Apolipoprotein Test in a Clinical Chemistry Laboratory.

Ruhaak LR, Smit NPM, Romijn FPHTM, Pieterse MM, van der Laarse A, van der Burgt YEM, Cobbaert CM.

Clin Chem. 2018 Apr;64(4):747-749. doi: 10.1373/clinchem.2017.285098. Epub 2018 Jan 29. No abstract available.


The quest for equivalence of test results: the pilgrimage of the Dutch Calibration 2.000 program for metrological traceability.

Jansen RTP, Cobbaert CM, Weykamp C, Thelen M.

Clin Chem Lab Med. 2018 Sep 25;56(10):1673-1684. doi: 10.1515/cclm-2017-0796. Review. No abstract available.


Low levels of apolipoprotein-CII in normotriglyceridemic patients with very premature coronary artery disease: Observations from the MISSION! Intervention study.

Hermans MPJ, Bodde MC, Jukema JW, Schalij MJ, van der Laarse A, Cobbaert CM.

J Clin Lipidol. 2017 Nov - Dec;11(6):1407-1414. doi: 10.1016/j.jacl.2017.08.002. Epub 2017 Aug 8.


Short-term cooling increases serum triglycerides and small high-density lipoprotein levels in humans.

Hoeke G, Nahon KJ, Bakker LEH, Norkauer SSC, Dinnes DLM, Kockx M, Lichtenstein L, Drettwan D, Reifel-Miller A, Coskun T, Pagel P, Romijn FPHTM, Cobbaert CM, Jazet IM, Martinez LO, Kritharides L, Berbée JFP, Boon MR, Rensen PCN.

J Clin Lipidol. 2017 Jul - Aug;11(4):920-928.e2. doi: 10.1016/j.jacl.2017.04.117. Epub 2017 May 3.


Disease stage and plasma levels of cytokines in Huntington's disease: A 2-year follow-up study.

Bouwens JA, van Duijn E, Cobbaert CM, Roos RAC, van der Mast RC, Giltay EJ.

Mov Disord. 2017 Jul;32(7):1103-1104. doi: 10.1002/mds.26950. Epub 2017 May 29. No abstract available.


Effect of Anthelmintic Treatment on Insulin Resistance: A Cluster-Randomized, Placebo-Controlled Trial in Indonesia.

Tahapary DL, de Ruiter K, Martin I, Brienen EAT, van Lieshout L, Cobbaert CM, Soewondo P, Djuardi Y, Wiria AE, Houwing-Duistermaat JJ, Sartono E, Smit JWA, Yazdanbakhsh M, Supali T.

Clin Infect Dis. 2017 Sep 1;65(5):764-771. doi: 10.1093/cid/cix416.


Fibrinogen determination according to Clauss: commutability assessment of International and commercial standards and quality control samples.

van den Besselaar AMHP, van Rijn CJJ, Cobbaert CM, Reijnierse GLA, Hollestelle MJ, Niessen RWLM, Hudig F.

Clin Chem Lab Med. 2017 Oct 26;55(11):1761-1769. doi: 10.1515/cclm-2016-1088.


Expressing analytical performance from multi-sample evaluation in laboratory EQA.

Thelen MHM, Jansen RTP, Weykamp CW, Steigstra H, Meijer R, Cobbaert CM.

Clin Chem Lab Med. 2017 Aug 28;55(10):1509-1516. doi: 10.1515/cclm-2016-0970.


Plasma Cytokine Levels in Relation to Neuropsychiatric Symptoms and Cognitive Dysfunction in Huntington's disease.

Bouwens JA, van Duijn E, Cobbaert CM, Roos RA, van der Mast RC, Giltay EJ.

J Huntingtons Dis. 2016 Dec 15;5(4):369-377.


Familial Longevity Is Not Associated with Major Differences in the Hypothalamic-Pituitary-Gonadal Axis in Healthy Middle-Aged Men.

van der Spoel E, Roelfsema F, Jansen SW, Akintola AA, Ballieux BE, Cobbaert CM, Blauw GJ, Slagboom PE, Westendorp RG, Pijl H, van Heemst D.

Front Endocrinol (Lausanne). 2016 Nov 9;7:143. eCollection 2016.


Prospective applications of ultrahigh resolution proteomics in clinical mass spectrometry.

Ruhaak LR, van der Burgt YE, Cobbaert CM.

Expert Rev Proteomics. 2016 Dec;13(12):1063-1071. Epub 2016 Nov 7. Review.


Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity.

van der Spoel E, Jansen SW, Akintola AA, Ballieux BE, Cobbaert CM, Slagboom PE, Blauw GJ, Westendorp RGJ, Pijl H, Roelfsema F, van Heemst D.

Aging Cell. 2016 Dec;15(6):1126-1131. doi: 10.1111/acel.12519. Epub 2016 Sep 7.


How to define reference intervals to rule in healthy individuals for clinical trials?

den Elzen WP, van Gerven J, Schenk PW, Uit Den Boogaard A, Kroon R, Klaassen E, Ballieux BE, Cobbaert CM.

Clin Chem Lab Med. 2017 Mar 1;55(3):e59-e61. doi: 10.1515/cclm-2016-0307. No abstract available.


Biomarker development targeting unmet clinical needs.

Monaghan PJ, Lord SJ, St John A, Sandberg S, Cobbaert CM, Lennartz L, Verhagen-Kamerbeek WD, Ebert C, Bossuyt PM, Horvath AR; Test Evaluation Working Group of the European Federation of Clinical Chemistry and Laboratory Medicine.

Clin Chim Acta. 2016 Sep 1;460:211-9. doi: 10.1016/j.cca.2016.06.037. Epub 2016 Jun 30.


Keeping Ebola out of the lab: a practical solution on how to analyze Ebola associated blood anomalies.

van den Wijngaard JP, Bakker JA, Gillis JM, Ballieux BE, de Vries JJ, Schenk PW, Cobbaert CM.

Clin Chem Lab Med. 2016 Nov 1;54(11):e353-e357. doi: 10.1515/cclm-2015-1225. No abstract available.


Automated Multiplex LC-MS/MS Assay for Quantifying Serum Apolipoproteins A-I, B, C-I, C-II, C-III, and E with Qualitative Apolipoprotein E Phenotyping.

van den Broek I, Romijn FP, Nouta J, van der Laarse A, Drijfhout JW, Smit NP, van der Burgt YE, Cobbaert CM.

Clin Chem. 2016 Jan;62(1):188-97. doi: 10.1373/clinchem.2015.246702. Epub 2015 Nov 19.


Interlaboratory Collaboration for Optimized Screening for Urinary Tract Infection.

Russcher A, Kusters E, Wolterbeek R, Kuijper EJ, Cobbaert CM, van der Beek MT.

J Clin Microbiol. 2016 Jan;54(1):93-8. doi: 10.1128/JCM.01943-15. Epub 2015 Oct 21.


A multicenter comparison of whole blood vitamin B6 assays.

van Zelst BD, de Beer RJ, Neele M, Kos S, Kema IP, Tegelaers FP, Cobbaert CM, Weykamp CW, de Jonge R.

Clin Chem Lab Med. 2016 Apr;54(4):609-16. doi: 10.1515/cclm-2015-0385.


Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals.

Akintola AA, Noordam R, Jansen SW, de Craen AJ, Ballieux BE, Cobbaert CM, Mooijaart SP, Pijl H, Westendorp RG, van Heemst D.

PLoS One. 2015 Oct 7;10(10):e0139973. doi: 10.1371/journal.pone.0139973. eCollection 2015.


Serum Cardiac Troponin-I is Superior to Troponin-T as a Marker for Left Ventricular Dysfunction in Clinically Stable Patients with End-Stage Renal Disease.

Buiten MS, de Bie MK, Rotmans JI, Dekker FW, van Buren M, Rabelink TJ, Cobbaert CM, Schalij MJ, van der Laarse A, Jukema JW.

PLoS One. 2015 Aug 3;10(8):e0134245. doi: 10.1371/journal.pone.0134245. eCollection 2015.


Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship.

Jansen SW, Roelfsema F, van der Spoel E, Akintola AA, Postmus I, Ballieux BE, Slagboom PE, Cobbaert CM, van der Grond J, Westendorp RG, Pijl H, van Heemst D.

J Clin Endocrinol Metab. 2015 Oct;100(10):3806-13. doi: 10.1210/jc.2015-2624. Epub 2015 Jul 31.


Characterization of the Hypothalamic-Pituitary-Adrenal-Axis in Familial Longevity under Resting Conditions.

Jansen SW, Roelfsema F, Akintola AA, Oei NY, Cobbaert CM, Ballieux BE, van der Grond J, Westendorp RG, Pijl H, van Heemst D.

PLoS One. 2015 Jul 20;10(7):e0133119. doi: 10.1371/journal.pone.0133119. eCollection 2015.


Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism.

Jansen SW, Akintola AA, Roelfsema F, van der Spoel E, Cobbaert CM, Ballieux BE, Egri P, Kvarta-Papp Z, Gereben B, Fekete C, Slagboom PE, van der Grond J, Demeneix BA, Pijl H, Westendorp RG, van Heemst D.

Sci Rep. 2015 Jun 19;5:11525. doi: 10.1038/srep11525.


Setting analytical performance specifications based on outcome studies - is it possible?

Horvath AR, Bossuyt PM, Sandberg S, John AS, Monaghan PJ, Verhagen-Kamerbeek WD, Lennartz L, Cobbaert CM, Ebert C, Lord SJ; Test Evaluation Working Group of the European Federation of Clinical Chemistry and Laboratory Medicine.

Clin Chem Lab Med. 2015 May;53(6):841-8. doi: 10.1515/cclm-2015-0214. Review.


Stem and progenitor cell therapy for pulmonary arterial hypertension: effects on the right ventricle (2013 Grover Conference Series).

van der Laarse A, Cobbaert CM, Umar S.

Pulm Circ. 2015 Mar;5(1):73-80. doi: 10.1086/679701. Review.


Quantification of serum apolipoproteins A-I and B-100 in clinical samples using an automated SISCAPA-MALDI-TOF-MS workflow.

van den Broek I, Nouta J, Razavi M, Yip R, Bladergroen MR, Romijn FP, Smit NP, Drews O, Paape R, Suckau D, Deelder AM, van der Burgt YE, Pearson TW, Anderson NL, Cobbaert CM.

Methods. 2015 Jun 15;81:74-85. doi: 10.1016/j.ymeth.2015.03.001. Epub 2015 Mar 9.


Application of a point of care creatinine device for trend monitoring in kidney transplant patients: fit for purpose?

van Lint CL, van der Boog PJ, Romijn FP, Schenk PW, van Dijk S, Rövekamp TJ, Kessler A, Siekmann L, Rabelink TJ, Cobbaert CM.

Clin Chem Lab Med. 2015 Sep 1;53(10):1547-56. doi: 10.1515/cclm-2014-0932.


Hypothalamic-pituitary-adrenal axis functioning in Huntington's disease and its association with depressive symptoms and suicidality.

Hubers AA, van der Mast RC, Pereira AM, Roos RA, Veen LJ, Cobbaert CM, van Duijn E, Giltay EJ.

J Neuroendocrinol. 2015 Mar;27(3):234-44. doi: 10.1111/jne.12255.


Quantifying protein measurands by peptide measurements: where do errors arise?

van den Broek I, Romijn FP, Smit NP, van der Laarse A, Drijfhout JW, van der Burgt YE, Cobbaert CM.

J Proteome Res. 2015 Feb 6;14(2):928-42. doi: 10.1021/pr5011179. Epub 2015 Jan 6.


Metrological traceability in mass spectrometry-based targeted protein quantitation: a proof-of-principle study for serum apolipoproteins A-I and B100.

Smit NP, Romijn FP, van den Broek I, Drijfhout JW, Haex M, van der Laarse A, van der Burgt YE, Cobbaert CM.

J Proteomics. 2014 Sep 23;109:143-61. doi: 10.1016/j.jprot.2014.06.015. Epub 2014 Jun 25.


Acute-phase proteins in relation to neuropsychiatric symptoms and use of psychotropic medication in Huntington's disease.

Bouwens JA, Hubers AA, van Duijn E, Cobbaert CM, Roos RA, van der Mast RC, Giltay EJ.

Eur Neuropsychopharmacol. 2014 Aug;24(8):1248-56. doi: 10.1016/j.euroneuro.2014.05.004. Epub 2014 May 20.


A comparative study of conventional versus new, magnesium-poor Vacutainer® Sodium Citrate blood collection tubes for determination of prothrombin time and INR.

van den Besselaar AM, van Vlodrop IJ, Berendes PB, Cobbaert CM.

Thromb Res. 2014 Jul;134(1):187-91. doi: 10.1016/j.thromres.2014.04.016. Epub 2014 Apr 26.


Cardiospecific sevoflurane treatment quenches inflammation but does not attenuate myocardial cell damage markers: a proof-of-concept study in patients undergoing mitral valve repair.

Kortekaas KA, van der Baan A, Aarts LP, Palmen M, Cobbaert CM, Verhagen JC, Engbers FH, Klautz RJ, Lindeman JH.

Br J Anaesth. 2014 Jun;112(6):1005-14. doi: 10.1093/bja/aet588. Epub 2014 Mar 3.


Confounding factors in the relation between high sensitivity cardiac troponin T levels in serum and infarct size of patients with first ST-elevation myocardial infarction.

Cobbaert CM, Bootsma M, Boden H, Ahmed TA, Hoogslag GE, Romijn FP, Ballieux BE, Wolterbeek R, Hermens WT, Schalij MJ, van der Laarse A.

Int J Cardiol. 2014 Mar 1;172(1):e3-5. doi: 10.1016/j.ijcard.2013.12.141. Epub 2014 Jan 4. No abstract available.


Evaluation of interspecimen trypsin digestion efficiency prior to multiple reaction monitoring-based absolute protein quantification with native protein calibrators.

van den Broek I, Smit NP, Romijn FP, van der Laarse A, Deelder AM, van der Burgt YE, Cobbaert CM.

J Proteome Res. 2013 Dec 6;12(12):5760-74. doi: 10.1021/pr400763d. Epub 2013 Nov 13.


From biomarkers to medical tests: the changing landscape of test evaluation.

Horvath AR, Lord SJ, StJohn A, Sandberg S, Cobbaert CM, Lorenz S, Monaghan PJ, Verhagen-Kamerbeek WD, Ebert C, Bossuyt PM; Test Evaluation Working Group of the European Federation of Clinical Chemistry Laboratory Medicine.

Clin Chim Acta. 2014 Jan 1;427:49-57. doi: 10.1016/j.cca.2013.09.018. Epub 2013 Sep 27.


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