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Items: 1 to 50 of 243

1.

WNK pathways in cancer signaling networks.

Gallolu Kankanamalage S, Karra AS, Cobb MH.

Cell Commun Signal. 2018 Nov 3;16(1):72. doi: 10.1186/s12964-018-0287-1. Review.

2.

Chromomycin A2 potently inhibits glucose-stimulated insulin secretion from pancreatic β cells.

Kalwat MA, Hwang IH, Macho J, Grzemska MG, Yang JZ, McGlynn K, MacMillan JB, Cobb MH.

J Gen Physiol. 2018 Oct 23. pii: jgp.201812177. doi: 10.1085/jgp.201812177. [Epub ahead of print]

PMID:
30352794
3.

Pulling a MAST1 on Cisplatin Resistance.

Jaykumar AB, Karra AS, Cobb MH.

Cancer Cell. 2018 Aug 13;34(2):183-185. doi: 10.1016/j.ccell.2018.07.010.

PMID:
30107173
4.

OSR1 regulates a subset of inward rectifier potassium channels via a binding motif variant.

Taylor CA 4th, An SW, Kankanamalage SG, Stippec S, Earnest S, Trivedi AT, Yang JZ, Mirzaei H, Huang CL, Cobb MH.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3840-3845. doi: 10.1073/pnas.1802339115. Epub 2018 Mar 26.

5.

Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization.

Thorne CA, Chen IW, Sanman LE, Cobb MH, Wu LF, Altschuler SJ.

Dev Cell. 2018 Mar 12;44(5):624-633.e4. doi: 10.1016/j.devcel.2018.01.024. Epub 2018 Mar 1.

PMID:
29503158
6.

The Epithelial Sodium Channel (αENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors.

He M, Liu S, Gallolu Kankanamalage S, Borromeo MD, Girard L, Gazdar AF, Minna JD, Johnson JE, Cobb MH.

Transl Oncol. 2018 Apr;11(2):292-299. doi: 10.1016/j.tranon.2018.01.004. Epub 2018 Feb 2.

7.

Correction to Insulin Promoter-Driven Gaussia Luciferase-Based Insulin Secretion Biosensor Assay for Discovery of β-Cell Glucose-Sensing Pathways.

Kalwat MA, Wichaidit C, Nava Garcia AY, McCoy MK, McGlynn K, Hwang IH, MacMillan JB, Posner BA, Cobb MH.

ACS Sens. 2017 Feb 24;2(2):316. doi: 10.1021/acssensors.7b00012. Epub 2017 Jan 24. No abstract available.

PMID:
28723136
8.

Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.

Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, Jin K, Nguyen DM, Sands LR, Marchetti F, Abreu MT, Cobb MH, Capobianco AJ, Lee E, Robbins DJ.

Sci Signal. 2017 Jun 27;10(485). pii: eaak9916. doi: 10.1126/scisignal.aak9916.

9.

Assaying Protein Kinase Activity with Radiolabeled ATP.

Karra AS, Stippec S, Cobb MH.

J Vis Exp. 2017 May 26;(123). doi: 10.3791/55504.

10.

Mechanisms of the amplifying pathway of insulin secretion in the β cell.

Kalwat MA, Cobb MH.

Pharmacol Ther. 2017 Nov;179:17-30. doi: 10.1016/j.pharmthera.2017.05.003. Epub 2017 May 18. Review.

PMID:
28527919
11.

WNK1 is an unexpected autophagy inhibitor.

Gallolu Kankanamalage S, Lee AY, Wichaidit C, Lorente-Rodriguez A, Shah AM, Stippec S, Whitehurst AW, Cobb MH.

Autophagy. 2017 May 4;13(5):969-970. doi: 10.1080/15548627.2017.1286431. Epub 2017 Feb 15. Review.

12.

Sucralose activates an ERK1/2-ribosomal protein S6 signaling axis.

Guerra ML, Kalwat MA, McGlynn K, Cobb MH.

FEBS Open Bio. 2017 Jan 18;7(2):174-186. doi: 10.1002/2211-5463.12172. eCollection 2017 Feb.

13.

Chemoattractant concentration-dependent tuning of ERK signaling dynamics in migrating neutrophils.

Zhang ER, Liu S, Wu LF, Altschuler SJ, Cobb MH.

Sci Signal. 2016 Dec 13;9(458):ra122.

14.

Multistep regulation of autophagy by WNK1.

Gallolu Kankanamalage S, Lee AY, Wichaidit C, Lorente-Rodriguez A, Shah AM, Stippec S, Whitehurst AW, Cobb MH.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14342-14347. Epub 2016 Nov 28.

15.

Insulin promoter-driven Gaussia luciferase-based insulin secretion biosensor assay for discovery of β-cell glucose-sensing pathways.

Kalwat MA, Wichaidit C, Nava Garcia AY, McCoy MK, McGlynn K, Hwang IH, MacMillan JB, Posner BA, Cobb MH.

ACS Sens. 2016 Oct 28;1(10):1208-1212. Epub 2016 Oct 12.

16.

Amino Acids Regulate mTORC1 by an Obligate Two-step Mechanism.

Dyachok J, Earnest S, Iturraran EN, Cobb MH, Ross EM.

J Biol Chem. 2016 Oct 21;291(43):22414-22426. Epub 2016 Sep 1.

17.

Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II.

Barry DM, Koo Y, Norden PR, Wylie LA, Xu K, Wichaidit C, Azizoglu DB, Zheng Y, Cobb MH, Davis GE, Cleaver O.

Circ Res. 2016 Sep 16;119(7):810-26. doi: 10.1161/CIRCRESAHA.116.309094. Epub 2016 Aug 2.

18.

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs.

Borromeo MD, Savage TK, Kollipara RK, He M, Augustyn A, Osborne JK, Girard L, Minna JD, Gazdar AF, Cobb MH, Johnson JE.

Cell Rep. 2016 Aug 2;16(5):1259-1272. doi: 10.1016/j.celrep.2016.06.081. Epub 2016 Jul 21.

19.

Hypertension: the missing WNKs.

Dbouk HA, Huang CL, Cobb MH.

Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F16-27. doi: 10.1152/ajprenal.00358.2015. Epub 2016 Mar 23. Review.

20.

Phosphorylation or Mutation of the ERK2 Activation Loop Alters Oligonucleotide Binding.

McReynolds AC, Karra AS, Li Y, Lopez ED, Turjanski AG, Dioum E, Lorenz K, Zaganjor E, Stippec S, McGlynn K, Earnest S, Cobb MH.

Biochemistry. 2016 Mar 29;55(12):1909-17. doi: 10.1021/acs.biochem.6b00096. Epub 2016 Mar 16.

21.

Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?

Bunn PA Jr, Minna JD, Augustyn A, Gazdar AF, Ouadah Y, Krasnow MA, Berns A, Brambilla E, Rekhtman N, Massion PP, Niederst M, Peifer M, Yokota J, Govindan R, Poirier JT, Byers LA, Wynes MW, McFadden DG, MacPherson D, Hann CL, Farago AF, Dive C, Teicher BA, Peacock CD, Johnson JE, Cobb MH, Wendel HG, Spigel D, Sage J, Yang P, Pietanza MC, Krug LM, Heymach J, Ujhazy P, Zhou C, Goto K, Dowlati A, Christensen CL, Park K, Einhorn LH, Edelman MJ, Giaccone G, Gerber DE, Salgia R, Owonikoko T, Malik S, Karachaliou N, Gandara DR, Slotman BJ, Blackhall F, Goss G, Thomas R, Rudin CM, Hirsch FR.

J Thorac Oncol. 2016 Apr;11(4):453-74. doi: 10.1016/j.jtho.2016.01.012. Epub 2016 Jan 30. Review. No abstract available.

22.

Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells.

Kalwat MA, Huang Z, Wichaidit C, McGlynn K, Earnest S, Savoia C, Dioum EM, Schneider JW, Hutchison MR, Cobb MH.

ACS Chem Biol. 2016 Apr 15;11(4):1128-36. doi: 10.1021/acschembio.5b00993. Epub 2016 Feb 10.

23.

A Kinase Divided.

Karra AS, Taylor CA 4th, Thorne CA, Cobb MH.

Cancer Cell. 2015 Aug 10;28(2):145-7. doi: 10.1016/j.ccell.2015.07.008.

24.

Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK.

Taylor CA 4th, Juang YC, Earnest S, Sengupta S, Goldsmith EJ, Cobb MH.

Biochemistry. 2015 Aug 18;54(32):5063-71. doi: 10.1021/acs.biochem.5b00593. Epub 2015 Aug 3.

25.

Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells.

Wauson EM, Guerra ML, Dyachok J, McGlynn K, Giles J, Ross EM, Cobb MH.

Mol Endocrinol. 2015 Aug;29(8):1114-22. doi: 10.1210/ME.2014-1181. Epub 2015 Jul 13.

26.

Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.

Dbouk HA, Weil LM, Perera GK, Dellinger MT, Pearson G, Brekken RA, Cobb MH.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):15999-6004. doi: 10.1073/pnas.1419057111. Epub 2014 Oct 31.

27.

ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers.

Augustyn A, Borromeo M, Wang T, Fujimoto J, Shao C, Dospoy PD, Lee V, Tan C, Sullivan JP, Larsen JE, Girard L, Behrens C, Wistuba II, Xie Y, Cobb MH, Gazdar AF, Johnson JE, Minna JD.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14788-93. doi: 10.1073/pnas.1410419111. Epub 2014 Sep 29.

28.

Menin determines K-RAS proliferative outputs in endocrine cells.

Chamberlain CE, Scheel DW, McGlynn K, Kim H, Miyatsuka T, Wang J, Nguyen V, Zhao S, Mavropoulos A, Abraham AG, O'Neill E, Ku GM, Cobb MH, Martin GR, German MS.

J Clin Invest. 2014 Sep;124(9):4093-101. doi: 10.1172/JCI69004. Epub 2014 Aug 18.

29.

ERK5 signaling gets XIAPed: a role for ubiquitin in the disassembly of a MAPK cascade.

Klein AM, Cobb MH.

EMBO J. 2014 Aug 18;33(16):1735-6. doi: 10.15252/embj.201489205. Epub 2014 Jul 10. No abstract available.

30.

Ras transformation uncouples the kinesin-coordinated cellular nutrient response.

Zaganjor E, Weil LM, Gonzales JX, Minna JD, Cobb MH.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10568-73. doi: 10.1073/pnas.1411016111. Epub 2014 Jul 7.

31.

Chloride sensing by WNK1 involves inhibition of autophosphorylation.

Piala AT, Moon TM, Akella R, He H, Cobb MH, Goldsmith EJ.

Sci Signal. 2014 May 6;7(324):ra41. doi: 10.1126/scisignal.2005050.

32.

G protein-coupled receptors and the regulation of autophagy.

Wauson EM, Dbouk HA, Ghosh AB, Cobb MH.

Trends Endocrinol Metab. 2014 May;25(5):274-82. doi: 10.1016/j.tem.2014.03.006. Epub 2014 Apr 18. Review.

33.

NeuroD1 mediates nicotine-induced migration and invasion via regulation of the nicotinic acetylcholine receptor subunits in a subset of neural and neuroendocrine carcinomas.

Osborne JK, Guerra ML, Gonzales JX, McMillan EA, Minna JD, Cobb MH.

Mol Biol Cell. 2014 Jun;25(11):1782-92. doi: 10.1091/mbc.E13-06-0316. Epub 2014 Apr 9.

34.

Muscarinic control of MIN6 pancreatic β cells is enhanced by impaired amino acid signaling.

Guerra ML, Wauson EM, McGlynn K, Cobb MH.

J Biol Chem. 2014 May 16;289(20):14370-9. doi: 10.1074/jbc.M114.565069. Epub 2014 Apr 2.

35.

Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells.

Zaganjor E, Osborne JK, Weil LM, Diaz-Martinez LA, Gonzales JX, Singel SM, Larsen JE, Girard L, Minna JD, Cobb MH.

Oncogene. 2014 Nov 20;33(47):5457-66. doi: 10.1038/onc.2013.486. Epub 2013 Nov 18.

36.

Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.

Sengupta S, Lorente-Rodríguez A, Earnest S, Stippec S, Guo X, Trudgian DC, Mirzaei H, Cobb MH.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18826-31. doi: 10.1073/pnas.1318676110. Epub 2013 Nov 4.

37.

NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition.

Osborne JK, Larsen JE, Gonzales JX, Shames DS, Sato M, Wistuba II, Girard L, Minna JD, Cobb MH.

Oncogenesis. 2013 Aug 19;2:e63. doi: 10.1038/oncsis.2013.24.

38.

Off-target effects of MEK inhibitors.

Wauson EM, Guerra ML, Barylko B, Albanesi JP, Cobb MH.

Biochemistry. 2013 Aug 6;52(31):5164-6. doi: 10.1021/bi4007644. Epub 2013 Jul 22.

39.

Minireview: Nutrient sensing by G protein-coupled receptors.

Wauson EM, Lorente-Rodríguez A, Cobb MH.

Mol Endocrinol. 2013 Aug;27(8):1188-97. doi: 10.1210/me.2013-1100. Epub 2013 Jul 2. Review.

40.

NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM.

Osborne JK, Larsen JE, Shields MD, Gonzales JX, Shames DS, Sato M, Kulkarni A, Wistuba II, Girard L, Minna JD, Cobb MH.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6524-9. doi: 10.1073/pnas.1303932110. Epub 2013 Apr 3.

41.

Chromatin-tethered MAPKs.

Klein AM, Zaganjor E, Cobb MH.

Curr Opin Cell Biol. 2013 Apr;25(2):272-7. doi: 10.1016/j.ceb.2013.01.002. Epub 2013 Feb 20. Review.

42.

Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3.

Wauson EM, Zaganjor E, Cobb MH.

Autophagy. 2013 Mar;9(3):418-9. doi: 10.4161/auto.22911. Epub 2012 Dec 7.

43.

Protein kinase WNK3 regulates the neuronal splicing factor Fox-1.

Lee AY, Chen W, Stippec S, Self J, Yang F, Ding X, Chen S, Juang YC, Cobb MH.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16841-6. doi: 10.1073/pnas.1215406109. Epub 2012 Oct 1.

44.

Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity.

Sengupta S, Tu SW, Wedin K, Earnest S, Stippec S, Luby-Phelps K, Cobb MH.

J Biol Chem. 2012 Nov 2;287(45):37868-79. doi: 10.1074/jbc.M112.398750. Epub 2012 Sep 18.

45.

The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy.

Wauson EM, Zaganjor E, Lee AY, Guerra ML, Ghosh AB, Bookout AL, Chambers CP, Jivan A, McGlynn K, Hutchison MR, Deberardinis RJ, Cobb MH.

Mol Cell. 2012 Sep 28;47(6):851-62. doi: 10.1016/j.molcel.2012.08.001. Epub 2012 Sep 6.

46.

A small molecule differentiation inducer increases insulin production by pancreatic β cells.

Dioum EM, Osborne JK, Goetsch S, Russell J, Schneider JW, Cobb MH.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20713-8. doi: 10.1073/pnas.1118526109. Epub 2011 Dec 5.

47.

Signal control through Raf: in sickness and in health.

Osborne JK, Zaganjor E, Cobb MH.

Cell Res. 2012 Jan;22(1):14-22. doi: 10.1038/cr.2011.193. Epub 2011 Dec 6. Review.

48.

WNK1 is required for mitosis and abscission.

Tu SW, Bugde A, Luby-Phelps K, Cobb MH.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1385-90. doi: 10.1073/pnas.1018567108. Epub 2011 Jan 10.

49.

Exposing contingency plans for kinase networks.

Klein AM, Dioum EM, Cobb MH.

Cell. 2010 Dec 10;143(6):867-9. doi: 10.1016/j.cell.2010.11.046.

50.

Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback.

Duan L, Cobb MH.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22314-9. doi: 10.1073/pnas.1016630108. Epub 2010 Dec 6.

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