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Items: 1 to 50 of 152

1.

Intracellular metabolism and potential cardiotoxicity of a β-D-2'-C-methyl-2,6-diaminopurine ribonucleoside phosphoramidate that inhibits hepatitis C virus replication.

Tao S, Zhou L, Zhang H, Zhou S, Amiralaei S, Shelton J, Ehteshami M, Jiang Y, Amblard F, Coats SJ, Schinazi RF.

Nucleosides Nucleotides Nucleic Acids. 2019 Oct 9:1-21. doi: 10.1080/15257770.2019.1671594. [Epub ahead of print]

PMID:
31595843
2.

The distinct immune-stimulatory capacities of Porphyromonas gingivalis strains 381 and ATCC 33277 are determined by the fimB allele and gingipain activity.

Coats SR, Kantrong N, To TT, Jain S, Genco CA, McLean JS, Darveau RP.

Infect Immun. 2019 Sep 30. pii: IAI.00319-19. doi: 10.1128/IAI.00319-19. [Epub ahead of print]

PMID:
31570556
3.

Contributions of charcoal, tobacco, and syrup to the toxicity and particle distribution of waterpipe tobacco smoke.

Bernd K, DeGrood D, Stadtler H, Coats S, Carmack D, Mailig R, Lidsky S, Hauser C.

Toxicol Lett. 2019 Oct 1;313:60-65. doi: 10.1016/j.toxlet.2019.06.003. Epub 2019 Jun 18.

PMID:
31226396
4.

A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy.

Li JY, Perry SR, Muniz-Medina V, Wang X, Wetzel LK, Rebelatto MC, Masson Hinrichs MJ, Bezabeh BZ, Fleming RL, Dimasi N, Feng H, Toader D, Yuan AQ, Xu L, Lin J, Gao C, Wu H, Dixit R, Osbourn JK, Coats SR.

Cancer Cell. 2019 Jun 10;35(6):948-949. doi: 10.1016/j.ccell.2019.05.010. No abstract available.

PMID:
31185215
5.

Antibody-Drug Conjugates: Future Directions in Clinical and Translational Strategies to Improve the Therapeutic Index.

Coats S, Williams M, Kebble B, Dixit R, Tseng L, Yao NS, Tice DA, Soria JC.

Clin Cancer Res. 2019 Sep 15;25(18):5441-5448. doi: 10.1158/1078-0432.CCR-19-0272. Epub 2019 Apr 12. Review.

PMID:
30979742
6.

Sleep and Alertness in a Duty-Hour Flexibility Trial in Internal Medicine.

Basner M, Asch DA, Shea JA, Bellini LM, Carlin M, Ecker AJ, Malone SK, Desai SV, Sternberg AL, Tonascia J, Shade DM, Katz JT, Bates DW, Even-Shoshan O, Silber JH, Small DS, Volpp KG, Mott CG, Coats S, Mollicone DJ, Dinges DF; iCOMPARE Research Group.

N Engl J Med. 2019 Mar 7;380(10):915-923. doi: 10.1056/NEJMoa1810641.

7.

Identification of PGN_1123 as the Gene Encoding Lipid A Deacylase, an Enzyme Required for Toll-Like Receptor 4 Evasion, in Porphyromonas gingivalis.

Jain S, Chang AM, Singh M, McLean JS, Coats SR, Kramer RW, Darveau RP.

J Bacteriol. 2019 May 8;201(11). pii: e00683-18. doi: 10.1128/JB.00683-18. Print 2019 Jun 1.

PMID:
30782639
8.

Synthesis and anti-HCV activity of β-d-2'-deoxy-2'-α-chloro-2'-β-fluoro and β-d-2'-deoxy-2'-α-bromo-2'-β-fluoro nucleosides and their phosphoramidate prodrugs.

Ovadia R, Khalil A, Li H, De Schutter C, Mengshetti S, Zhou S, Bassit L, Coats SJ, Amblard F, Schinazi RF.

Bioorg Med Chem. 2019 Feb 15;27(4):664-676. doi: 10.1016/j.bmc.2019.01.005. Epub 2019 Jan 9.

PMID:
30655167
9.

Discovery of a Series of 2'-α-Fluoro,2'-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus.

Mengshetti S, Zhou L, Sari O, De Schutter C, Zhang H, Cho JH, Tao S, Bassit LC, Verma K, Domaoal RA, Ehteshami M, Jiang Y, Ovadia R, Kasthuri M, Ollinger Russell O, McBrayer T, Whitaker T, Pattassery J, Pascual ML, Uher L, Lin BY, Lee S, Amblard F, Coats SJ, Schinazi RF.

J Med Chem. 2019 Feb 28;62(4):1859-1874. doi: 10.1021/acs.jmedchem.8b01300. Epub 2019 Feb 7.

PMID:
30653317
10.

Exacerbation of the 2013-2016 Pan-Caribbean Drought by Anthropogenic Warming.

Herrera DA, Ault TR, Fasullo JT, Coats SJ, Carrillo CM, Cook BI, Williams AP.

Geophys Res Lett. 2018 Oct 16;45(19):10619-10626. doi: 10.1029/2018GL079408. Epub 2018 Oct 7.

11.

Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer.

Cho S, Zammarchi F, Williams DG, Havenith CEG, Monks NR, Tyrer P, D'Hooge F, Fleming R, Vashisht K, Dimasi N, Bertelli F, Corbett S, Adams L, Reinert HW, Dissanayake S, Britten CE, King W, Dacosta K, Tammali R, Schifferli K, Strout P, Korade M 3rd, Masson Hinrichs MJ, Chivers S, Corey E, Liu H, Kim S, Bander NH, Howard PW, Hartley JA, Coats S, Tice DA, Herbst R, van Berkel PH.

Mol Cancer Ther. 2018 Oct;17(10):2176-2186. doi: 10.1158/1535-7163.MCT-17-0982. Epub 2018 Jul 31.

12.

Synthesis of (2S)-2-Chloro-2-fluororibolactone via Stereoselective Electrophilic Fluorination.

De Schutter C, Sari O, Coats SJ, Amblard F, Schinazi RF.

J Org Chem. 2017 Dec 15;82(24):13171-13178. doi: 10.1021/acs.joc.7b02245. Epub 2017 Dec 4.

PMID:
29140703
13.

Synthesis and anti-HCV activity of a series of β-d-2'-deoxy-2'-dibromo nucleosides and their corresponding phosphoramidate prodrugs.

Chen Z, Cox BD, Garnier-Amblard EC, McBrayer TR, Coats SJ, Schinazi RF, Amblard F.

Bioorg Med Chem Lett. 2017 Dec 1;27(23):5296-5299. doi: 10.1016/j.bmcl.2017.10.024. Epub 2017 Oct 12.

14.

Precipitation, temperature, and teleconnection signals across the combined North American, Monsoon Asia, and Old World Drought Atlases.

Baek SH, Smerdon JE, Coats S, Williams AP, Cook BI, Cook ER, Seager R.

J Clim. 2017 Sep;30(18):7141-7155. doi: 10.1175/JCLI-D-16-0766.1. Epub 2017 Aug 8.

15.

Use of the Psychomotor Vigilance Test in Fitness for Work Assessments.

Lerman S, Mollicone D, Coats S.

J Occup Environ Med. 2017 Aug;59(8):716-720. doi: 10.1097/JOM.0000000000001065.

PMID:
28692008
16.

2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.

Zhou S, Mahmoud S, Liu P, Zhou L, Ehteshami M, Bassit L, Tao S, Domaoal RA, Sari O, Schutter C, Amiralaei S, Khalil A, Ollinger Russell O, McBrayer T, Whitaker T, Abou-Taleb N, Amblard F, Coats SJ, Schinazi RF.

J Med Chem. 2017 Jul 13;60(13):5424-5437. doi: 10.1021/acs.jmedchem.7b00067. Epub 2017 Jun 26.

PMID:
28595015
17.

Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase.

Ehteshami M, Zhou L, Amiralaei S, Shelton JR, Cho JH, Zhang H, Li H, Lu X, Ozturk T, Stanton R, Amblard F, McBrayer TR, Coats SJ, Schinazi RF.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00492-17. doi: 10.1128/AAC.00492-17. Print 2017 Aug.

18.

Synthesis and antiviral evaluation of 2',2',3',3'-tetrafluoro nucleoside analogs.

Sari O, Bassit L, Gavegnano C, McBrayer TR, McCormick L, Cox B, Coats SJ, Amblard F, Schinazi RF.

Tetrahedron Lett. 2017 Feb 15;58(7):642-644. doi: 10.1016/j.tetlet.2017.01.006. Epub 2017 Jan 4.

19.

Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors.

Boucle S, Lu X, Bassit L, Ozturk T, Russell OO, Amblard F, Coats SJ, Schinazi RF.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):904-910. doi: 10.1016/j.bmcl.2017.01.010. Epub 2017 Jan 6.

20.

A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties.

Nyborg AC, Ward C, Zacco A, Chacko B, Grinberg L, Geoghegan JC, Bean R, Wendeler M, Bartnik F, O'Connor E, Gruia F, Iyer V, Feng H, Roy V, Berge M, Miner JN, Wilson DM, Zhou D, Nicholson S, Wilker C, Wu CY, Wilson S, Jermutus L, Wu H, Owen DA, Osbourn J, Coats S, Baca M.

PLoS One. 2016 Dec 21;11(12):e0167935. doi: 10.1371/journal.pone.0167935. eCollection 2016.

21.

Synthesis and antiviral evaluation of fluorinated acyclo-nucleosides and their phosphoramidates.

Mahmoud S, Li H, McBrayer TR, Bassit L, Hammad SF, Coats SJ, Amblard F, Schinazi RF.

Nucleosides Nucleotides Nucleic Acids. 2017 Jan 2;36(1):66-82. doi: 10.1080/15257770.2016.1218023. Epub 2016 Oct 19.

PMID:
27759481
22.

Internal ocean-atmosphere variability drives megadroughts in Western North America.

Coats S, Smerdon JE, Cook BI, Seager R, Cook ER, Anchukaitis KJ.

Geophys Res Lett. 2016 Sep 28;43(18):9886-9894. doi: 10.1002/2016GL070105. Epub 2016 Sep 14.

23.

Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094.

Ehteshami M, Tao S, Ozturk T, Zhou L, Cho JH, Zhang H, Amiralaei S, Shelton JR, Lu X, Khalil A, Domaoal RA, Stanton RA, Suesserman JE, Lin B, Lee SS, Amblard F, Whitaker T, Coats SJ, Schinazi RF.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4659-69. doi: 10.1128/AAC.00318-16. Print 2016 Aug.

24.

Cardiolipins Act as a Selective Barrier to Toll-Like Receptor 4 Activation in the Intestine.

Coats SR, Hashim A, Paramonov NA, To TT, Curtis MA, Darveau RP.

Appl Environ Microbiol. 2016 Jun 30;82(14):4264-78. doi: 10.1128/AEM.00463-16. Print 2016 Jul 15.

25.

Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV Replication.

Zhou L, Zhang H, Tao S, Ehteshami M, Cho JH, McBrayer TR, Tharnish P, Whitaker T, Amblard F, Coats SJ, Schinazi RF.

ACS Med Chem Lett. 2015 Nov 23;7(1):17-22. doi: 10.1021/acsmedchemlett.5b00402. eCollection 2016 Jan 14.

26.

A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy.

Li JY, Perry SR, Muniz-Medina V, Wang X, Wetzel LK, Rebelatto MC, Hinrichs MJ, Bezabeh BZ, Fleming RL, Dimasi N, Feng H, Toader D, Yuan AQ, Xu L, Lin J, Gao C, Wu H, Dixit R, Osbourn JK, Coats SR.

Cancer Cell. 2016 Jan 11;29(1):117-29. doi: 10.1016/j.ccell.2015.12.008. Erratum in: Cancer Cell. 2019 Jun 10;35(6):948-949.

27.

Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors.

Boucle S, Tao S, Amblard F, Stanton RA, Nettles JH, Li C, McBrayer TR, Whitaker T, Coats SJ, Schinazi RF.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3711-5. doi: 10.1016/j.bmcl.2015.06.031. Epub 2015 Jun 15.

28.

Synthesis of carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases.

Cho JH, Coats SJ, Schinazi RF.

Tetrahedron Lett. 2015 Jun 3;56(23):3587-3590.

29.

Development of an antibody that neutralizes soluble IgE and eliminates IgE expressing B cells.

Nyborg AC, Zacco A, Ettinger R, Jack Borrok M, Zhu J, Martin T, Woods R, Kiefer C, Bowen MA, Suzanne Cohen E, Herbst R, Wu H, Coats S.

Cell Mol Immunol. 2016 May;13(3):391-400. doi: 10.1038/cmi.2015.19. Epub 2015 Mar 23.

30.

β-D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms.

Zhou L, Zhang HW, Tao S, Bassit L, Whitaker T, McBrayer TR, Ehteshami M, Amiralaei S, Pradere U, Cho JH, Amblard F, Bobeck D, Detorio M, Coats SJ, Schinazi RF.

J Med Chem. 2015 Apr 23;58(8):3445-58. doi: 10.1021/jm501874e. Epub 2015 Apr 7.

PMID:
25849312
31.

Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy.

Zhang MY, Churpek JE, Keel SB, Walsh T, Lee MK, Loeb KR, Gulsuner S, Pritchard CC, Sanchez-Bonilla M, Delrow JJ, Basom RS, Forouhar M, Gyurkocza B, Schwartz BS, Neistadt B, Marquez R, Mariani CJ, Coats SA, Hofmann I, Lindsley RC, Williams DA, Abkowitz JL, Horwitz MS, King MC, Godley LA, Shimamura A.

Nat Genet. 2015 Feb;47(2):180-5. doi: 10.1038/ng.3177. Epub 2015 Jan 12.

32.

CEA/CD3 bispecific antibody MEDI-565/AMG 211 activation of T cells and subsequent killing of human tumors is independent of mutations commonly found in colorectal adenocarcinomas.

Oberst MD, Fuhrmann S, Mulgrew K, Amann M, Cheng L, Lutterbuese P, Richman L, Coats S, Baeuerle PA, Hammond SA.

MAbs. 2014;6(6):1571-84. doi: 10.4161/19420862.2014.975660.

33.

Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs.

Cho JH, Bondana L, Detorio MA, Montero C, Bassit LC, Amblard F, Coats SJ, Schinazi RF.

Bioorg Med Chem. 2014 Dec 1;22(23):6665-6671. doi: 10.1016/j.bmc.2014.10.003. Epub 2014 Oct 13.

34.

Asymmetric binding to NS5A by daclatasvir (BMS-790052) and analogs suggests two novel modes of HCV inhibition.

Nettles JH, Stanton RA, Broyde J, Amblard F, Zhang H, Zhou L, Shi J, McBrayer TR, Whitaker T, Coats SJ, Kohler JJ, Schinazi RF.

J Med Chem. 2014 Dec 11;57(23):10031-43. doi: 10.1021/jm501291c. Epub 2014 Nov 3.

35.

Synthesis of nucleoside phosphate and phosphonate prodrugs.

Pradere U, Garnier-Amblard EC, Coats SJ, Amblard F, Schinazi RF.

Chem Rev. 2014 Sep 24;114(18):9154-218. doi: 10.1021/cr5002035. Epub 2014 Aug 21. Review. No abstract available.

36.

Distinct lipid a moieties contribute to pathogen-induced site-specific vascular inflammation.

Slocum C, Coats SR, Hua N, Kramer C, Papadopoulos G, Weinberg EO, Gudino CV, Hamilton JA, Darveau RP, Genco CA.

PLoS Pathog. 2014 Jul 10;10(7):e1004215. doi: 10.1371/journal.ppat.1004215. eCollection 2014 Jul.

37.

9th annual European Antibody Congress, November 11-13, 2013, Geneva, Switzerland.

Reichert JM, Beck A, Lugovskoy AA, Wurch T, Coats S, Brezski RJ.

MAbs. 2014 Mar-Apr;6(2):309-26. doi: 10.4161/mabs.27903. Epub 2014 Jan 17.

PMID:
24492298
38.

Chutes and ladders in hepatitis C nucleoside drug development.

Coats SJ, Garnier-Amblard EC, Amblard F, Ehteshami M, Amiralaei S, Zhang H, Zhou L, Boucle SR, Lu X, Bondada L, Shelton JR, Li H, Liu P, Li C, Cho JH, Chavre SN, Zhou S, Mathew J, Schinazi RF.

Antiviral Res. 2014 Feb;102:119-47. doi: 10.1016/j.antiviral.2013.11.008. Epub 2013 Nov 23. Review.

39.

Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors.

Bondada L, Rondla R, Pradere U, Liu P, Li C, Bobeck D, McBrayer T, Tharnish P, Courcambeck J, Halfon P, Whitaker T, Amblard F, Coats SJ, Schinazi RF.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6325-30. doi: 10.1016/j.bmcl.2013.09.068. Epub 2013 Sep 30.

40.

Adenosine Dioxolane Nucleoside Phosphoramidates as Antiviral Agents for Human Immunodeficiency and Hepatitis B Viruses.

Bondada L, Detorio M, Bassit L, Tao S, Montero CM, Singletary TM, Zhang H, Zhou L, Cho JH, Coats SJ, Schinazi RF.

ACS Med Chem Lett. 2013 Aug 8;4(8):747-751.

41.

Acute and subacute changes in neural activation during the recovery from sport-related concussion.

Hammeke TA, McCrea M, Coats SM, Verber MD, Durgerian S, Flora K, Olsen GS, Leo PD, Gennarelli TA, Rao SM.

J Int Neuropsychol Soc. 2013 Sep;19(8):863-72. doi: 10.1017/S1355617713000702. Epub 2013 Jul 8.

PMID:
23829951
42.

Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors.

Zhou L, Amblard F, Zhang H, McBrayer TR, Detorio MA, Whitaker T, Coats SJ, Schinazi RF.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3385-8. doi: 10.1016/j.bmcl.2013.03.077. Epub 2013 Mar 29.

43.

Synthesis and evaluation of non-dimeric HCV NS5A inhibitors.

Amblard F, Zhang H, Zhou L, Shi J, Bobeck DR, Nettles JH, Chavre S, McBrayer TR, Tharnish P, Whitaker T, Coats SJ, Schinazi RF.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2031-4. doi: 10.1016/j.bmcl.2013.02.023. Epub 2013 Feb 13.

44.

A novel class of lipoprotein lipase-sensitive molecules mediates Toll-like receptor 2 activation by Porphyromonas gingivalis.

Jain S, Coats SR, Chang AM, Darveau RP.

Infect Immun. 2013 Apr;81(4):1277-86. doi: 10.1128/IAI.01036-12. Epub 2013 Feb 4.

45.

Synthesis of cyclopentanyl carbocyclic 5-fluorocytosine ((-)-5-fluorocarbodine) using a facially selective hydrogenation approach.

Cho JH, Amblard F, Coats SJ, Schinazi RF.

J Org Chem. 2013 Jan 18;78(2):723-7. doi: 10.1021/jo302038d. Epub 2012 Dec 26.

46.

Scaleable processes for the synthesis of (-)-β-D-2,6-diaminopurine dioxolane (Amdoxovir, DAPD) and (-)-β-D-2-aminopurine dioxolane (APD).

Zhou L, Coats SJ, Zhang H, Junxing S, Bobeck DR, Schinazi RF.

Tetrahedron. 2012 Jul 22;68(29):5738-5743. Epub 2012 May 16.

47.

Impaired ribosomal subunit association in Shwachman-Diamond syndrome.

Burwick N, Coats SA, Nakamura T, Shimamura A.

Blood. 2012 Dec 20;120(26):5143-52. doi: 10.1182/blood-2012-04-420166. Epub 2012 Oct 31.

48.

Sex differences in relationship regret: the role of perceived mate characteristics.

Coats S, Harrington JT, Beaubouef M, Locke H.

Evol Psychol. 2012 Jul 17;10(3):422-42.

PMID:
22947670
49.

Synthesis of 5'-methylene-phosphonate furanonucleoside prodrugs: application to D-2'-deoxy-2'-α-fluoro-2'-β-C-methyl nucleosides.

Pradere U, Amblard F, Coats SJ, Schinazi RF.

Org Lett. 2012 Sep 7;14(17):4426-9. doi: 10.1021/ol301937v. Epub 2012 Aug 23.

50.

Synthesis and evaluation of novel potent HCV NS5A inhibitors.

Zhang H, Zhou L, Amblard F, Shi J, Bobeck DR, Tao S, McBrayer TR, Tharnish PM, Whitaker T, Coats SJ, Schinazi RF.

Bioorg Med Chem Lett. 2012 Jul 15;22(14):4864-8. doi: 10.1016/j.bmcl.2012.05.039. Epub 2012 May 24.

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