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Items: 1 to 50 of 155

1.

Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma.

Rose AM, Spender LC, Stephen C, Mitchell A, Rickaby W, Bray S, Evans AT, Dayal J, Purdie KJ, Harwood CA, Proby CM, Leigh IM, Coates PJ, Inman GJ.

Oncotarget. 2018 Feb 22;9(18):14552-14566. doi: 10.18632/oncotarget.24545. eCollection 2018 Mar 6.

2.

p63 isoforms in triple-negative breast cancer: ΔNp63 associates with the basal phenotype whereas TAp63 associates with androgen receptor, lack of BRCA mutation, PTEN and improved survival.

Coates PJ, Nenutil R, Holcakova J, Nekulova M, Podhorec J, Svoboda M, Vojtesek B.

Virchows Arch. 2018 Mar;472(3):351-359. doi: 10.1007/s00428-018-2324-2. Epub 2018 Feb 27.

PMID:
29484502
3.

Searching for New Targets and Treatments in the Battle Against Squamous Cell Carcinoma of the Head and Neck, with Specific Focus on Tumours of the Tongue.

Sgaramella N, Gu X, Boldrup L, Coates PJ, Fahraeus R, Califano L, Tartaro G, Colella G, Spaak LN, Strom A, Wilms T, Muzio LL, Orabona GD, Santagata M, Loljung L, Rossiello R, Danielsson K, Strindlund K, Lillqvist S, Nylander K.

Curr Top Med Chem. 2018;18(3):214-218. doi: 10.2174/1568026618666180116121624. Review.

PMID:
29345578
4.

No evidence for the presence of Epstein-Barr virus in squamous cell carcinoma of the mobile tongue.

Wilms T, Khan G, Coates PJ, Sgaramella N, Fåhraeus R, Hassani A, Philip PS, Norberg Spaak L, Califano L, Colella G, Olofsson K, Loizou C, Franco R, Nylander K.

PLoS One. 2017 Sep 19;12(9):e0184201. doi: 10.1371/journal.pone.0184201. eCollection 2017.

5.

[Application of PLA Method for Detection of p53/p63/p73 Complexes in Situ in Tumour Cells and Tumour Tissue].

Hrabal V, Nekulová M, Nenutil R, Holčaková J, Coates PJ, Vojtěšek B.

Klin Onkol. 2017 Spring;30(Supplementum1):159-162. Czech.

PMID:
28471195
6.

Patients with high c-MYC-expressing squamous cell carcinomas of the tongue show better survival than those with low- and medium-expressing tumours.

Strindlund K, Troiano G, Sgaramella N, Coates PJ, Gu X, Boldrup L, Califano L, Fahraeus R, Muzio LL, Ardito F, Colella G, Tartaro G, Franco R, Norberg-Spaak L, Saadat M, Nylander K.

J Oral Pathol Med. 2017 Nov;46(10):967-971. doi: 10.1111/jop.12579. Epub 2017 May 9.

PMID:
28393404
7.

ΔNp63 activates EGFR signaling to induce loss of adhesion in triple-negative basal-like breast cancer cells.

Holcakova J, Nekulova M, Orzol P, Nenutil R, Podhorec J, Svoboda M, Dvorakova P, Pjechova M, Hernychova L, Vojtesek B, Coates PJ.

Breast Cancer Res Treat. 2017 Jun;163(3):475-484. doi: 10.1007/s10549-017-4216-6. Epub 2017 Mar 27.

PMID:
28349272
8.

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.

MacLeod AK, Acosta-Jimenez L, Coates PJ, McMahon M, Carey FA, Honda T, Hayes JD, Henderson CJ, Wolf CR.

Br J Cancer. 2017 Aug 22;117(5):e1. doi: 10.1038/bjc.2017.80. Epub 2017 Mar 21.

9.

Gene expression changes in tumor free tongue tissue adjacent to tongue squamous cell carcinoma.

Boldrup L, Gu X, Coates PJ, Norberg-Spaak L, Fahraeus R, Laurell G, Wilms T, Nylander K.

Oncotarget. 2017 Mar 21;8(12):19389-19402. doi: 10.18632/oncotarget.14288.

10.

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.

MacLeod AK, Acosta-Jimenez L, Coates PJ, McMahon M, Carey FA, Honda T, Henderson CJ, Wolf CR.

Br J Cancer. 2016 Dec 6;115(12):1530-1539. doi: 10.1038/bjc.2016.363. Epub 2016 Nov 8. Erratum in: Br J Cancer. 2017 Aug 22;117(5):e1.

11.

ΔNp63α expression induces loss of cell adhesion in triple-negative breast cancer cells.

Nekulova M, Holcakova J, Gu X, Hrabal V, Galtsidis S, Orzol P, Liu Y, Logotheti S, Zoumpourlis V, Nylander K, Coates PJ, Vojtesek B.

BMC Cancer. 2016 Oct 10;16(1):782.

12.

Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites.

Gu X, Boldrup L, Coates PJ, Fahraeus R, Nylander E, Loizou C, Olofsson K, Norberg-Spaak L, Gärskog O, Nylander K.

Sci Rep. 2016 Aug 30;6:32579. doi: 10.1038/srep32579.

13.

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma.

Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D, Coates PJ, McHugh A, Pourreyron C, Dayal JH, Larsson J, Weidlich S, Spender LC, Sapkota GP, Purdie KJ, Proby CM, Harwood CA, Leigh IM, Clevers H, Barker N, Karlsson S, Pritchard C, Marais R, Chelala C, South AP, Sansom OJ, Inman GJ.

Nat Commun. 2016 Aug 25;7:12493. doi: 10.1038/ncomms12493.

14.

High expression of podoplanin in squamous cell carcinoma of the tongue occurs predominantly in patients ≤40 years but does not correlate with tumour spread.

Sgaramella N, Lindell Jonsson E, Boldrup L, Califano L, Coates PJ, Tartaro G, Lo Muzio L, Fåhraeus R, Colella G, Dell'Aversana Orabona G, Loljung L, Santagata M, Rossiello R, Wilms T, Danielsson K, Laurell G, Nylander K.

J Pathol Clin Res. 2015 Oct 9;2(1):3-8. doi: 10.1002/cjp2.28. eCollection 2016 Jan.

15.

Erratum to: ΔNp63 regulates cell proliferation, differentiation, adhesion, and migration in the BL2 subtype of basal-like breast cancer.

Orzol P, Nekulova M, Holcakova J, Muller P, Vojtesek B, Coates PJ.

Tumour Biol. 2016 Jun;37(6):8469. No abstract available.

PMID:
27113740
16.

ΔNp63 regulates cell proliferation, differentiation, adhesion, and migration in the BL2 subtype of basal-like breast cancer.

Orzol P, Nekulova M, Holcakova J, Muller P, Votesek B, Coates PJ.

Tumour Biol. 2016 Aug;37(8):10133-40. doi: 10.1007/s13277-016-4880-x. Epub 2016 Jan 29. Erratum in: Tumour Biol. 2016 Jun;37(6):8469.

PMID:
26825981
17.

AGR2 oncoprotein inhibits p38 MAPK and p53 activation through a DUSP10-mediated regulatory pathway.

Hrstka R, Bouchalova P, Michalova E, Matoulkova E, Muller P, Coates PJ, Vojtesek B.

Mol Oncol. 2016 May;10(5):652-62. doi: 10.1016/j.molonc.2015.12.003. Epub 2015 Dec 17.

18.

Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis.

Grant NJ, Coates PJ, Woods YL, Bray SE, Morrice NA, Hastie CJ, Lamont DJ, Carey FA, Sutherland C.

BMC Cancer. 2015 Nov 10;15:885. doi: 10.1186/s12885-015-1691-1.

19.

Expression of p16 in squamous cell carcinoma of the mobile tongue is independent of HPV infection despite presence of the HPV-receptor syndecan-1.

Sgaramella N, Coates PJ, Strindlund K, Loljung L, Colella G, Laurell G, Rossiello R, Muzio LL, Loizou C, Tartaro G, Olofsson K, Danielsson K, Fåhraeus R, Nylander K.

Br J Cancer. 2015 Jul 14;113(2):321-6. doi: 10.1038/bjc.2015.207. Epub 2015 Jun 9.

20.

Downregulation of miRNA-424: a sign of field cancerisation in clinically normal tongue adjacent to squamous cell carcinoma.

Boldrup L, Coates PJ, Laurell G, Wilms T, Fahraeus R, Nylander K.

Br J Cancer. 2015 May 26;112(11):1760-5. doi: 10.1038/bjc.2015.150. Epub 2015 May 12.

21.

Correlation between Reversal of DNA Methylation and Clinical Symptoms in Psoriatic Epidermis Following Narrow-Band UVB Phototherapy.

Gu X, Nylander E, Coates PJ, Fahraeus R, Nylander K.

J Invest Dermatol. 2015 Aug;135(8):2077-2083. doi: 10.1038/jid.2015.128. Epub 2015 Apr 1.

22.

The diverse oncogenic and tumour suppressor roles of p63 and p73 in cancer: a review by cancer site.

Orzol P, Holcakova J, Nekulova M, Nenutil R, Vojtesek B, Coates PJ.

Histol Histopathol. 2015 May;30(5):503-21. doi: 10.14670/HH-30.503. Epub 2014 Dec 16. Review.

PMID:
25510918
23.

The effect of 222-nm UVC phototesting on healthy volunteer skin: a pilot study.

Woods JA, Evans A, Forbes PD, Coates PJ, Gardner J, Valentine RM, Ibbotson SH, Ferguson J, Fricker C, Moseley H.

Photodermatol Photoimmunol Photomed. 2015 May;31(3):159-66. doi: 10.1111/phpp.12156. Epub 2015 Jan 15.

PMID:
25495690
24.

Predictive gene signatures: molecular markers distinguishing colon adenomatous polyp and carcinoma.

Drew JE, Farquharson AJ, Mayer CD, Vase HF, Coates PJ, Steele RJ, Carey FA.

PLoS One. 2014 Nov 25;9(11):e113071. doi: 10.1371/journal.pone.0113071. eCollection 2014.

25.

Viruses and disease: emerging concepts for prevention, diagnosis and treatment.

Herrington CS, Coates PJ, Duprex WP.

J Pathol. 2015 Jan;235(2):149-52. doi: 10.1002/path.4476.

PMID:
25366544
26.

Oxidation reduction is a key process for successful treatment of psoriasis by narrow-band UVB phototherapy.

Gu X, Nylander E, Coates PJ, Nylander K.

Acta Derm Venereol. 2015 Feb;95(2):140-6. doi: 10.2340/00015555-1905.

27.

Mutant p53 accumulation in human breast cancer is not an intrinsic property or dependent on structural or functional disruption but is regulated by exogenous stress and receptor status.

Bouchalova P, Nenutil R, Muller P, Hrstka R, Appleyard MV, Murray K, Jordan LB, Purdie CA, Quinlan P, Thompson AM, Vojtesek B, Coates PJ.

J Pathol. 2014 Jul;233(3):238-46. doi: 10.1002/path.4356. Epub 2014 May 21.

PMID:
24687952
28.

Genes involved in epithelial differentiation and development are differentially expressed in oral and genital lichen planus epithelium compared to normal epithelium.

Danielsson K, Coates PJ, Ebrahimi M, Nylander E, Wahlin YB, Nylander K.

Acta Derm Venereol. 2014 Sep;94(5):526-30. doi: 10.2340/00015555-1803.

29.

Lack of correlation of stem cell markers in breast cancer stem cells.

Liu Y, Nenutil R, Appleyard MV, Murray K, Boylan M, Thompson AM, Coates PJ.

Br J Cancer. 2014 Apr 15;110(8):2063-71. doi: 10.1038/bjc.2014.105. Epub 2014 Feb 27.

30.

Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue.

Rentoft M, Coates PJ, Loljung L, Wilms T, Laurell G, Nylander K.

Tumour Biol. 2014 May;35(5):4191-8. doi: 10.1007/s13277-013-1549-6. Epub 2014 Jan 7.

31.

Responses to ionizing radiation mediated by inflammatory mechanisms.

Mukherjee D, Coates PJ, Lorimore SA, Wright EG.

J Pathol. 2014 Feb;232(3):289-99. doi: 10.1002/path.4299. Review.

PMID:
24254983
32.

p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia.

Groves MJ, Johnson CE, James J, Prescott AR, Cunningham J, Haydock S, Pepper C, Fegan C, Pirrie L, Westwood NJ, Coates PJ, Ganley IG, Tauro S.

Br J Cancer. 2013 Oct 29;109(9):2434-44. doi: 10.1038/bjc.2013.601. Epub 2013 Oct 3.

33.

Three-year experience of prophylactic placement of inferior vena cava filters in women with gynecological cancer.

Babu SB, Khan AM, Coates PJ.

Int J Gen Med. 2013 Aug 13;6:671-4. doi: 10.2147/IJGM.S44191. eCollection 2013.

34.

Characterization of specific p63 and p63-N-terminal isoform antibodies and their application for immunohistochemistry.

Nekulova M, Holcakova J, Nenutil R, Stratmann R, Bouchalova P, Müller P, Mouková L, Coates PJ, Vojtesek B.

Virchows Arch. 2013 Sep;463(3):415-25. doi: 10.1007/s00428-013-1459-4. Epub 2013 Jul 26.

PMID:
23887585
35.

High expression of p63 is correlated to poor prognosis in squamous cell carcinoma of the tongue.

Loljung L, Coates PJ, Nekulova M, Laurell G, Wahlgren M, Wilms T, Widlöf M, Hansel A, Nylander K.

J Oral Pathol Med. 2014 Jan;43(1):14-9. doi: 10.1111/jop.12074. Epub 2013 Apr 23.

PMID:
23607508
36.

The influence of p53 functions on radiation-induced inflammatory bystander-type signaling in murine bone marrow.

Lorimore SA, Rastogi S, Mukherjee D, Coates PJ, Wright EG.

Radiat Res. 2013 Apr;179(4):406-15. doi: 10.1667/RR3158.2.

PMID:
23578188
37.

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.

MacCallum SF, Groves MJ, James J, Murray K, Appleyard V, Prescott AR, Drbal AA, Nicolaou A, Cunningham J, Haydock S, Ganley IG, Westwood NJ, Coates PJ, Lain S, Tauro S.

Sci Rep. 2013;3:1275. doi: 10.1038/srep01275.

38.

In brief: cell senescence.

Coates PJ.

J Pathol. 2013 Jul;230(3):239-40. doi: 10.1002/path.4182.

PMID:
23424093
39.

Interactions of apoptotic cells with macrophages in radiation-induced bystander signaling.

Rastogi S, Boylan M, Wright EG, Coates PJ.

Radiat Res. 2013 Feb;179(2):135-45. doi: 10.1667/RR2969.1. Epub 2012 Dec 13.

PMID:
23237586
40.

Subsite-based alterations in miR-21, miR-125b, and miR-203 in squamous cell carcinoma of the oral cavity and correlation to important target proteins.

Boldrup L, Coates PJ, Wahlgren M, Laurell G, Nylander K.

J Carcinog. 2012;11:18. doi: 10.4103/1477-3163.104007. Epub 2012 Nov 28.

41.

Autoantibodies and decreased expression of the transcription factor ELF-3 together with increased chemokine pathways support an autoimmune phenotype and altered differentiation in lichen planus located in oral mucosa.

Danielsson K, Boldrup L, Rentoft M, Coates PJ, Ebrahimi M, Nylander E, Wahlin YB, Nylander K.

J Eur Acad Dermatol Venereol. 2013 Nov;27(11):1410-6. doi: 10.1111/jdv.12027. Epub 2012 Nov 8.

PMID:
23134363
42.

Radiation-induced bone marrow apoptosis, inflammatory bystander-type signaling and tissue cytotoxicity.

Mukherjee D, Coates PJ, Rastogi S, Lorimore SA, Wright EG.

Int J Radiat Biol. 2013 Mar;89(3):139-46. doi: 10.3109/09553002.2013.741280. Epub 2012 Nov 6.

PMID:
23078404
43.

The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage.

Nicol SM, Bray SE, Black HD, Lorimore SA, Wright EG, Lane DP, Meek DW, Coates PJ, Fuller-Pace FV.

Oncogene. 2013 Jul 18;32(29):3461-9. doi: 10.1038/onc.2012.426. Epub 2012 Sep 17.

44.

Heterogeneity of p53-pathway Protein Expression in Chemosensitive Chronic Lymphocytic Leukemia: A Pilot Study.

Groves MJ, Maccallum SF, Boylan MT, Haydock S, Cunningham J, Gelly K, Gowans D, Kerr R, Coates PJ, Tauro S.

J Cancer. 2012;3:354-61. doi: 10.7150/jca.4813. Epub 2012 Aug 24.

45.

C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances.

Muller P, Ruckova E, Halada P, Coates PJ, Hrstka R, Lane DP, Vojtesek B.

Oncogene. 2013 Jun 20;32(25):3101-10. doi: 10.1038/onc.2012.314. Epub 2012 Jul 23.

PMID:
22824801
46.

Transcriptional profiling of formalin fixed paraffin embedded tissue: pitfalls and recommendations for identifying biologically relevant changes.

Rentoft M, Coates PJ, Laurell G, Nylander K.

PLoS One. 2012;7(4):e35276. doi: 10.1371/journal.pone.0035276. Epub 2012 Apr 17.

47.

In vivo interactions between ionizing radiation, inflammation and chemical carcinogens identified by increased DNA damage responses.

McAllister KA, Lorimore SA, Wright EG, Coates PJ.

Radiat Res. 2012 May;177(5):584-93. Epub 2012 Mar 30.

PMID:
22463680
48.

Phenformin as prophylaxis and therapy in breast cancer xenografts.

Appleyard MV, Murray KE, Coates PJ, Wullschleger S, Bray SE, Kernohan NM, Fleming S, Alessi DR, Thompson AM.

Br J Cancer. 2012 Mar 13;106(6):1117-22. doi: 10.1038/bjc.2012.56. Epub 2012 Feb 23.

49.

Bystander-type effects mediated by long-lived inflammatory signaling in irradiated bone marrow.

Rastogi S, Coates PJ, Lorimore SA, Wright EG.

Radiat Res. 2012 Mar;177(3):244-50. Epub 2011 Dec 9.

PMID:
22149991
50.

The in vivo expression of radiation-induced chromosomal instability has an inflammatory mechanism.

Mukherjee D, Coates PJ, Lorimore SA, Wright EG.

Radiat Res. 2012 Jan;177(1):18-24. Epub 2011 Nov 3.

PMID:
22050452

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