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Items: 1 to 50 of 68

1.

Insertional mutagenesis using the Sleeping Beauty transposon system identifies drivers of erythroleukemia in mice.

Loeb KR, Hughes BT, Fissel BM, Osteen NJ, Knoblaugh SE, Grim JE, Drury LJ, Sarver A, Dupuy AJ, Clurman BE.

Sci Rep. 2019 Apr 2;9(1):5488. doi: 10.1038/s41598-019-41805-x.

2.

Merkel cell polyomavirus Tumor antigens expressed in Merkel cell carcinoma function independently of the ubiquitin ligases Fbw7 and β-TrCP.

Dye KN, Welcker M, Clurman BE, Roman A, Galloway DA.

PLoS Pathog. 2019 Jan 28;15(1):e1007543. doi: 10.1371/journal.ppat.1007543. eCollection 2019 Jan.

3.

Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism.

Davis RJ, Gönen M, Margineantu DH, Handeli S, Swanger J, Hoellerbauer P, Paddison PJ, Gu H, Raftery D, Grim JE, Hockenbery DM, Margolin AA, Clurman BE.

Proc Natl Acad Sci U S A. 2018 May 22;115(21):5462-5467. doi: 10.1073/pnas.1718338115. Epub 2018 May 7.

4.

RAD54 N-terminal domain is a DNA sensor that couples ATP hydrolysis with branch migration of Holliday junctions.

Goyal N, Rossi MJ, Mazina OM, Chi Y, Moritz RL, Clurman BE, Mazin AV.

Nat Commun. 2018 Jan 2;9(1):34. doi: 10.1038/s41467-017-02497-x.

5.

The miR-106a~363Xpcl1 miRNA cluster induces murine T cell lymphoma despite transcriptional activation of the p27Kip1 cell cycle inhibitor.

Kuppers DA, Schmitt TM, Hwang HC, Samraj L, Clurman BE, Fero ML.

Oncotarget. 2017 Apr 7;8(31):50680-50691. doi: 10.18632/oncotarget.16932. eCollection 2017 Aug 1.

6.

DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing.

Calses PC, Dhillon KK, Tucker N, Chi Y, Huang JW, Kawasumi M, Nghiem P, Wang Y, Clurman BE, Jacquemont C, Gafken PR, Sugasawa K, Saijo M, Taniguchi T.

Cell Rep. 2017 Apr 4;19(1):162-174. doi: 10.1016/j.celrep.2017.03.021.

7.

The PP2A-B56 Phosphatase Opposes Cyclin E Autocatalytic Degradation via Site-Specific Dephosphorylation.

Davis RJ, Swanger J, Hughes BT, Clurman BE.

Mol Cell Biol. 2017 Mar 31;37(8). pii: e00657-16. doi: 10.1128/MCB.00657-16. Print 2017 Apr 15.

8.

Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells.

Toledo CM, Ding Y, Hoellerbauer P, Davis RJ, Basom R, Girard EJ, Lee E, Corrin P, Hart T, Bolouri H, Davison J, Zhang Q, Hardcastle J, Aronow BJ, Plaisier CL, Baliga NS, Moffat J, Lin Q, Li XN, Nam DH, Lee J, Pollard SM, Zhu J, Delrow JJ, Clurman BE, Olson JM, Paddison PJ.

Cell Rep. 2015 Dec 22;13(11):2425-2439. doi: 10.1016/j.celrep.2015.11.021. Epub 2015 Dec 7.

9.

NUP50 is necessary for the survival of primordial germ cells in mouse embryos.

Park E, Lee B, Clurman BE, Lee K.

Reproduction. 2016 Jan;151(1):51-8. doi: 10.1530/REP-14-0649. Epub 2015 Oct 29.

PMID:
26515778
10.

Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy.

Zhao H, Faltermeier CM, Mendelsohn L, Porter PL, Clurman BE, Roberts JM.

Oncotarget. 2014 Dec 30;5(24):12704-14.

11.

Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.

Davis RJ, Welcker M, Clurman BE.

Cancer Cell. 2014 Oct 13;26(4):455-64. doi: 10.1016/j.ccell.2014.09.013. Review.

12.

Oncoprotein ubiquitylation: dimers, degrons, and degradation.

Welcker M, Clurman BE.

Cell Cycle. 2014;13(12):1829-30. doi: 10.4161/cc.29325. Epub 2014 May 27. No abstract available.

13.

Fbw7 dimerization determines the specificity and robustness of substrate degradation.

Welcker M, Larimore EA, Swanger J, Bengoechea-Alonso MT, Grim JE, Ericsson J, Zheng N, Clurman BE.

Genes Dev. 2013 Dec 1;27(23):2531-6. doi: 10.1101/gad.229195.113.

14.

Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions.

Sancho R, Blake SM, Tendeng C, Clurman BE, Lewis J, Behrens A.

PLoS Biol. 2013;11(6):e1001586. doi: 10.1371/journal.pbio.1001586. Epub 2013 Jun 11.

15.

Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation.

Hughes BT, Sidorova J, Swanger J, Monnat RJ Jr, Clurman BE.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):8954-9. doi: 10.1073/pnas.1302927110. Epub 2013 May 13.

16.

Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins.

Pierce NW, Lee JE, Liu X, Sweredoski MJ, Graham RL, Larimore EA, Rome M, Zheng N, Clurman BE, Hess S, Shan SO, Deshaies RJ.

Cell. 2013 Mar 28;153(1):206-15. doi: 10.1016/j.cell.2013.02.024. Epub 2013 Feb 28.

17.

The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.

Davis MA, Larimore EA, Fissel BM, Swanger J, Taatjes DJ, Clurman BE.

Genes Dev. 2013 Jan 15;27(2):151-6. doi: 10.1101/gad.207720.112. Epub 2013 Jan 15.

18.

Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase.

Hizli AA, Chi Y, Swanger J, Carter JH, Liao Y, Welcker M, Ryazanov AG, Clurman BE.

Mol Cell Biol. 2013 Feb;33(3):596-604. doi: 10.1128/MCB.01270-12. Epub 2012 Nov 26.

19.

Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer.

Grim JE, Knoblaugh SE, Guthrie KA, Hagar A, Swanger J, Hespelt J, Delrow JJ, Small T, Grady WM, Nakayama KI, Clurman BE.

Mol Cell Biol. 2012 Jun;32(11):2160-7. doi: 10.1128/MCB.00305-12. Epub 2012 Apr 2.

20.

Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis.

Sengupta T, Abraham G, Xu Y, Clurman BE, Minella AC.

Mol Cell Biol. 2011 Sep;31(18):3885-95. doi: 10.1128/MCB.05089-11. Epub 2011 Jul 11.

21.
22.

Effect of Xpcl1 activation and p27(Kip1) loss on gene expression in murine lymphoma.

Kuppers DA, Hwang HC, Jackson AL, Linsley PS, Clurman BE, Fero ML.

PLoS One. 2011 Mar 11;6(3):e14758. doi: 10.1371/journal.pone.0014758.

23.

Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3.

Welcker M, Larimore EA, Frappier L, Clurman BE.

Mol Cell Biol. 2011 Mar;31(6):1214-24. doi: 10.1128/MCB.01347-10. Epub 2011 Jan 10.

24.

Mass spectrometry-based identification of protein kinase substrates utilizing engineered kinases and thiophosphate labeling.

Chi Y, Clurman BE.

Curr Protoc Chem Biol. 2010 Dec 1;2(4):219-34. doi: 10.1002/9780470559277.ch100151.

PMID:
23839977
25.

Identification of CDK2 substrates in human cell lysates.

Chi Y, Welcker M, Hizli AA, Posakony JJ, Aebersold R, Clurman BE.

Genome Biol. 2008 Oct 13;9(10):R149. doi: 10.1186/gb-2008-9-10-r149.

26.

Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase.

Grim JE, Gustafson MP, Hirata RK, Hagar AC, Swanger J, Welcker M, Hwang HC, Ericsson J, Russell DW, Clurman BE.

J Cell Biol. 2008 Jun 16;181(6):913-20. doi: 10.1083/jcb.200802076.

27.

Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo.

Minella AC, Loeb KR, Knecht A, Welcker M, Varnum-Finney BJ, Bernstein ID, Roberts JM, Clurman BE.

Genes Dev. 2008 Jun 15;22(12):1677-89. doi: 10.1101/gad.1650208.

28.

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.

Welcker M, Clurman BE.

Nat Rev Cancer. 2008 Feb;8(2):83-93. Review.

PMID:
18094723
29.

A mechanism misregulating p27 in tumors discovered in a functional genomic screen.

Garrett-Engele CM, Tasch MA, Hwang HC, Fero ML, Perlmutter RM, Clurman BE, Roberts JM.

PLoS Genet. 2007 Dec;3(12):e219.

30.

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors.

O'Neil J, Grim J, Strack P, Rao S, Tibbitts D, Winter C, Hardwick J, Welcker M, Meijerink JP, Pieters R, Draetta G, Sears R, Clurman BE, Look AT.

J Exp Med. 2007 Aug 6;204(8):1813-24. Epub 2007 Jul 23.

31.

Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype.

Besson A, Hwang HC, Cicero S, Donovan SL, Gurian-West M, Johnson D, Clurman BE, Dyer MA, Roberts JM.

Genes Dev. 2007 Jul 15;21(14):1731-46. Epub 2007 Jul 12.

32.

Analysis of gene expression, copy number and palindrome formation with a Dt40 enriched cDNA microarray.

Neiman PE, Burnside J, Elsaesser K, Hwang H, Clurman BE, Kimmel R, Delrow J.

Subcell Biochem. 2006;40:245-56. Review.

PMID:
17623909
33.

Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome.

Chen X, Barton LF, Chi Y, Clurman BE, Roberts JM.

Mol Cell. 2007 Jun 22;26(6):843-52.

34.

Hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute myeloid leukemia arising from myelodysplastic syndrome: similar outcomes in patients with de novo disease and disease following prior therapy or antecedent hematologic disorders.

Chang C, Storer BE, Scott BL, Bryant EM, Shulman HM, Flowers ME, Sandmaier BM, Witherspoon RP, Nash RA, Sanders JE, Bedalov A, Hansen JA, Clurman BE, Storb R, Appelbaum FR, Deeg HJ.

Blood. 2007 Aug 15;110(4):1379-87. Epub 2007 May 8.

35.

p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability.

Minella AC, Grim JE, Welcker M, Clurman BE.

Oncogene. 2007 Oct 18;26(48):6948-53. Epub 2007 May 7.

PMID:
17486057
36.

Fbw7/hCDC4 dimerization regulates its substrate interactions.

Welcker M, Clurman BE.

Cell Div. 2007 Feb 13;2:7.

37.

Kinase-independent function of cyclin E.

Geng Y, Lee YM, Welcker M, Swanger J, Zagozdzon A, Winer JD, Roberts JM, Kaldis P, Clurman BE, Sicinski P.

Mol Cell. 2007 Jan 12;25(1):127-39.

38.

Regulation of cell proliferation in a stratified culture system of epithelial cells from prostate tissue.

Gustafson MP, Xu C, Grim JE, Clurman BE, Knudsen BS.

Cell Tissue Res. 2006 Aug;325(2):263-76. Epub 2006 Mar 24.

PMID:
16557385
39.

Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins.

Gustafson MP, Welcker M, Hwang HC, Clurman BE.

Biochem Biophys Res Commun. 2005 Dec 23;338(3):1359-67. Epub 2005 Oct 25.

PMID:
16263084
40.

Mechanisms of tumor suppression by the SCF(Fbw7).

Minella AC, Clurman BE.

Cell Cycle. 2005 Oct;4(10):1356-9. Epub 2005 Oct 27. Review.

PMID:
16131838
41.

A mouse model for cyclin E-dependent genetic instability and tumorigenesis.

Loeb KR, Kostner H, Firpo E, Norwood T, D Tsuchiya K, Clurman BE, Roberts JM.

Cancer Cell. 2005 Jul;8(1):35-47.

42.

Ras activity regulates cyclin E degradation by the Fbw7 pathway.

Minella AC, Welcker M, Clurman BE.

Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9649-54. Epub 2005 Jun 24.

43.

Cyclin E in normal and neoplastic cell cycles.

Hwang HC, Clurman BE.

Oncogene. 2005 Apr 18;24(17):2776-86. Review.

PMID:
15838514
44.

The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4.

Welcker M, Clurman BE.

J Biol Chem. 2005 Mar 4;280(9):7654-8. Epub 2004 Dec 20.

45.

Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma.

Thomas DM, Johnson SA, Sims NA, Trivett MK, Slavin JL, Rubin BP, Waring P, McArthur GA, Walkley CR, Holloway AJ, Diyagama D, Grim JE, Clurman BE, Bowtell DD, Lee JS, Gutierrez GM, Piscopo DM, Carty SA, Hinds PW.

J Cell Biol. 2004 Dec 6;167(5):925-34.

46.

N-acetylation and ubiquitin-independent proteasomal degradation of p21(Cip1).

Chen X, Chi Y, Bloecher A, Aebersold R, Clurman BE, Roberts JM.

Mol Cell. 2004 Dec 3;16(5):839-47.

47.

A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size.

Welcker M, Orian A, Grim JE, Eisenman RN, Clurman BE.

Curr Biol. 2004 Oct 26;14(20):1852-7. Erratum in: Curr Biol. 2005 Dec;15(24):2285. Grim, Jonathan A [corrected to Grim, Jonathan E].

48.

Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression.

Noseda M, Chang L, McLean G, Grim JE, Clurman BE, Smith LL, Karsan A.

Mol Cell Biol. 2004 Oct;24(20):8813-22.

49.

Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase.

Ye X, Nalepa G, Welcker M, Kessler BM, Spooner E, Qin J, Elledge SJ, Clurman BE, Harper JW.

J Biol Chem. 2004 Nov 26;279(48):50110-9. Epub 2004 Sep 13.

50.

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation.

Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN, Clurman BE.

Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9085-90. Epub 2004 May 18. Erratum in: Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):504. Grim, Jonathan A [corrected to Grim, Jonathan E].

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