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Items: 1 to 50 of 102

1.

Underdosing of Benzodiazepines in Patients With Status Epilepticus Enrolled in Established Status Epilepticus Treatment Trial.

Sathe AG, Tillman H, Coles LD, Elm JJ, Silbergleit R, Chamberlain J, Kapur J, Cock HR, Fountain NB, Shinnar S, Lowenstein DH, Conwit RA, Bleck TP, Cloyd JC.

Acad Emerg Med. 2019 Aug;26(8):940-943. doi: 10.1111/acem.13811. Epub 2019 Jul 18. No abstract available.

PMID:
31161706
2.

Intranasal Coadministration of a Diazepam Prodrug with a Converting Enzyme Results in Rapid Absorption of Diazepam in Rats.

Rautiola D, Maglalang PD, Cheryala N, Nelson KM, Georg GI, Fine JM, Svitak AL, Faltesek KA, Hanson LR, Mishra U, Coles LD, Cloyd JC, Siegel RA.

J Pharmacol Exp Ther. 2019 Sep;370(3):796-805. doi: 10.1124/jpet.118.255943. Epub 2019 Mar 5.

PMID:
30837282
3.

Conversion of a soluble diazepam prodrug to supersaturated diazepam for rapid intranasal delivery: Kinetics and stability.

Rautiola D, Cloyd JC, Siegel RA.

J Control Release. 2018 Nov 10;289:1-9. doi: 10.1016/j.jconrel.2018.09.013. Epub 2018 Sep 15.

PMID:
30227158
4.

Rescue therapies for seizure emergencies: New modes of administration.

Maglalang PD, Rautiola D, Siegel RA, Fine JM, Hanson LR, Coles LD, Cloyd JC.

Epilepsia. 2018 Oct;59 Suppl 2:207-215. doi: 10.1111/epi.14479. Epub 2018 Aug 29.

5.

Repeated-Dose Oral N-Acetylcysteine in Parkinson's Disease: Pharmacokinetics and Effect on Brain Glutathione and Oxidative Stress.

Coles LD, Tuite PJ, Öz G, Mishra UR, Kartha RV, Sullivan KM, Cloyd JC, Terpstra M.

J Clin Pharmacol. 2018 Feb;58(2):158-167. doi: 10.1002/jcph.1008. Epub 2017 Sep 22.

6.

Intravenous Topiramate: Pharmacokinetics in Dogs with Naturally Occurring Epilepsy.

Vuu I, Coles LD, Maglalang P, Leppik IE, Worrell G, Crepeau D, Mishra U, Cloyd JC, Patterson EE.

Front Vet Sci. 2016 Dec 5;3:107. eCollection 2016.

7.

A Randomized Dose Escalation Study of Intravenous Baclofen in Healthy Volunteers: Clinical Tolerance and Pharmacokinetics.

Schmitz NS, Krach LE, Coles LD, Mishra U, Agarwal SK, Cloyd JC, Kriel RL.

PM R. 2017 Aug;9(8):743-750. doi: 10.1016/j.pmrj.2016.11.002. Epub 2016 Nov 17.

PMID:
27867020
8.

Deconstructing tolerance with clobazam: Post hoc analyses from an open-label extension study.

Gidal BE, Wechsler RT, Sankar R, Montouris GD, White HS, Cloyd JC, Kane MC, Peng G, Tworek DM, Shen V, Isojarvi J.

Neurology. 2016 Oct 25;87(17):1806-1812. Epub 2016 Sep 28.

9.

A hierarchical Bayesian approach for combining pharmacokinetic/pharmacodynamic modeling and Phase IIa trial design in orphan drugs: Treating adrenoleukodystrophy with Lorenzo's oil.

Basu C, Ahmed MA, Kartha RV, Brundage RC, Raymond GV, Cloyd JC, Carlin BP.

J Biopharm Stat. 2016;26(6):1025-1039. Epub 2016 Aug 22.

10.

A review of intranasal formulations for the treatment of seizure emergencies.

Kapoor M, Cloyd JC, Siegel RA.

J Control Release. 2016 Sep 10;237:147-59. doi: 10.1016/j.jconrel.2016.07.001. Epub 2016 Jul 7. Review.

PMID:
27397490
11.

Chirally Pure Prodrugs and Their Converting Enzymes Lead to High Supersaturation and Rapid Transcellular Permeation of Benzodiazepines.

Kapoor M, Cheryala N, Rautiola D, Georg GI, Cloyd JC, Siegel RA.

J Pharm Sci. 2016 Aug;105(8):2365-71. doi: 10.1016/j.xphs.2016.05.011. Epub 2016 Jun 22.

PMID:
27342435
12.

Intravenous and Intramuscular Formulations of Antiseizure Drugs in the Treatment of Epilepsy.

Patel SI, Birnbaum AK, Cloyd JC, Leppik IE.

CNS Drugs. 2015 Dec;29(12):1009-22. doi: 10.1007/s40263-015-0289-0. Review.

PMID:
26603741
13.

Pharmacokinetic-Pharmacodynamic Modeling of Intravenous and Oral Topiramate and Its Effect on the Symbol-Digit Modalities Test in Adult Healthy Volunteers.

Lim CN, Birnbaum AK, Brundage RC, Leppik IE, Cloyd JC, Clark A, Marino SE.

J Clin Pharmacol. 2016 Jun;56(6):714-22. doi: 10.1002/jcph.646. Epub 2015 Dec 21.

14.

Water-soluble benzodiazepine prodrug/enzyme combinations for intranasal rescue therapies.

Siegel RA, Kapoor M, Cheryala N, Georg GI, Cloyd JC.

Epilepsy Behav. 2015 Aug;49:347-50. doi: 10.1016/j.yebeh.2015.05.004. Epub 2015 Jun 24.

PMID:
26115606
15.

Intravenous Administration of Stable-Labeled N-Acetylcysteine Demonstrates an Indirect Mechanism for Boosting Glutathione and Improving Redox Status.

Zhou J, Coles LD, Kartha RV, Nash N, Mishra U, Lund TC, Cloyd JC.

J Pharm Sci. 2015 Aug;104(8):2619-26. doi: 10.1002/jps.24482. Epub 2015 Jun 5.

PMID:
26052837
16.

Canine status epilepticus treated with fosphenytoin: A proof of principle study.

Patterson EE, Leppik IE, Coles LD, Podell M, Vite CH, Bush W, Cloyd JC.

Epilepsia. 2015 Jun;56(6):882-7. doi: 10.1111/epi.12994. Epub 2015 May 7.

17.

Use of IV fosphenytoin pharmacokinetics to determine the loading dose for a clinical trial of canine status epilepticus.

Coles LD, Leppik IE, Patterson EE, Rivers Z, Mishra U, Cloyd JC.

Epilepsia. 2015 Jun;56(6):888-94. doi: 10.1111/epi.12961. Epub 2015 May 7.

18.

Development of benzodiazepines for out-of-hospital management of seizure emergencies.

Agarwal SK, Cloyd JC.

Neurol Clin Pract. 2015 Feb;5(1):80-85. doi: 10.1212/CPJ.0000000000000099.

19.

Pharmacokinetic-pharmacodynamic modelling of intravenous and oral topiramate and its effect on phonemic fluency in adult healthy volunteers.

Ahmed GF, Marino SE, Brundage RC, Pakhomov SV, Leppik IE, Cloyd JC, Clark A, Birnbaum AK.

Br J Clin Pharmacol. 2015 May;79(5):820-30. doi: 10.1111/bcp.12556.

20.

A pilot study assessing pharmacokinetics and tolerability of oral and intravenous baclofen in healthy adult volunteers.

Agarwal SK, Kriel RL, Cloyd JC, Coles LD, Scherkenbach LA, Tobin MH, Krach LE.

J Child Neurol. 2015 Jan;30(1):37-41. doi: 10.1177/0883073814535504. Epub 2014 Jul 14.

PMID:
25028414
21.

USL255 extended-release topiramate: dose-proportional pharmacokinetics and tolerability in healthy volunteers.

Clark AM, Halvorsen MB, Braun TL, Johnson KM, Cloyd JC.

Epilepsia. 2014 Jul;55(7):1069-76. doi: 10.1111/epi.12654. Epub 2014 May 23.

22.

Pharmacokinetics and pharmacodynamics of intravenous baclofen in dogs: a preliminary study.

Scherkenbach LA, Coles LD, Patterson EE, Cloyd JC, Krach LE, Kriel RL.

J Pharm Pharmacol. 2014 Jul;66(7):935-42. doi: 10.1111/jphp.12221. Epub 2014 Feb 13.

PMID:
24697865
23.

Feasibility study of a caregiver seizure alert system in canine epilepsy.

Coles LD, Patterson EE, Sheffield WD, Mavoori J, Higgins J, Michael B, Leyde K, Cloyd JC, Litt B, Vite C, Worrell GA.

Epilepsy Res. 2013 Oct;106(3):456-60. doi: 10.1016/j.eplepsyres.2013.06.007. Epub 2013 Aug 18.

24.

N-Acetylcysteine boosts brain and blood glutathione in Gaucher and Parkinson diseases.

Holmay MJ, Terpstra M, Coles LD, Mishra U, Ahlskog M, Öz G, Cloyd JC, Tuite PJ.

Clin Neuropharmacol. 2013 Jul-Aug;36(4):103-6. doi: 10.1097/WNF.0b013e31829ae713.

25.

Intravenous topiramate: safety and pharmacokinetics following a single dose in patients with epilepsy or migraines taking oral topiramate.

Clark AM, Kriel RL, Leppik IE, White JR, Henry TR, Brundage RC, Cloyd JC.

Epilepsia. 2013 Jun;54(6):1106-11. doi: 10.1111/epi.12165. Epub 2013 Apr 15.

26.

A pilot study assessing the bioavailability and pharmacokinetics of diazepam after intranasal and intravenous administration in healthy volunteers.

Agarwal SK, Kriel RL, Brundage RC, Ivaturi VD, Cloyd JC.

Epilepsy Res. 2013 Aug;105(3):362-7. doi: 10.1016/j.eplepsyres.2013.02.018. Epub 2013 Apr 2.

PMID:
23561287
27.

Intravenous topiramate: comparison of pharmacokinetics and safety with the oral formulation in healthy volunteers.

Clark AM, Kriel RL, Leppik IE, Marino SE, Mishra U, Brundage RC, Cloyd JC.

Epilepsia. 2013 Jun;54(6):1099-105. doi: 10.1111/epi.12134. Epub 2013 Mar 18.

28.

Population pharmacokinetics of unbound and total drug concentrations following intravenously administered carbamazepine in elderly and younger adult patients with epilepsy.

Ahmed GF, Brundage RC, Marino SE, Cloyd JC, Leppik IE, Pennell PB, Ramsay RE, Birnbaum AK.

J Clin Pharmacol. 2013 Mar;53(3):276-84. doi: 10.1002/jcph.8. Epub 2013 Feb 13.

29.

Plasma topiramate concentrations resulting from doses associated with neuroprotection against white matter injury and stroke in two strains of rat pups.

Clark AM, Mondick JT, Cloyd JC, Zuppa AF, Raol YH, Clancy RR.

Pediatr Res. 2013 Mar;73(3):317-24. doi: 10.1038/pr.2012.194. Epub 2012 Dec 19.

PMID:
23254278
30.

Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy.

Puranik YG, Birnbaum AK, Marino SE, Ahmed G, Cloyd JC, Remmel RP, Leppik IE, Lamba JK.

Pharmacogenomics. 2013 Jan;14(1):35-45. doi: 10.2217/pgs.12.180.

31.

Interaction of N-acetylcysteine and cysteine in human plasma.

Radtke KK, Coles LD, Mishra U, Orchard PJ, Holmay M, Cloyd JC.

J Pharm Sci. 2012 Dec;101(12):4653-9. doi: 10.1002/jps.23325. Epub 2012 Sep 27.

PMID:
23018672
32.

The role of academic institutions in the development of drugs for rare and neglected diseases.

Coles LD, Cloyd JC.

Clin Pharmacol Ther. 2012 Aug;92(2):193-202. doi: 10.1038/clpt.2012.83. Epub 2012 Jul 4. Review.

PMID:
22760003
33.

Steady-state carbamazepine pharmacokinetics following oral and stable-labeled intravenous administration in epilepsy patients: effects of race and sex.

Marino SE, Birnbaum AK, Leppik IE, Conway JM, Musib LC, Brundage RC, Ramsay RE, Pennell PB, White JR, Gross CR, Rarick JO, Mishra U, Cloyd JC.

Clin Pharmacol Ther. 2012 Mar;91(3):483-8. doi: 10.1038/clpt.2011.251. Epub 2012 Jan 25.

34.

A sensitive capillary GC-MS method for analysis of topiramate from plasma obtained from single-dose studies.

Conway JM, Birnbaum AK, Marino SE, Cloyd JC, Remmel RP.

Biomed Chromatogr. 2012 Sep;26(9):1071-6. doi: 10.1002/bmc.1749. Epub 2012 Jan 4.

35.

Canine status epilepticus: a translational platform for human therapeutic trials.

Leppik IE, Patterson EN, Coles LD, Craft EM, Cloyd JC.

Epilepsia. 2011 Oct;52 Suppl 8:31-4. doi: 10.1111/j.1528-1167.2011.03231.x.

36.

Clinical tolerance and toxicity of intravenous baclofen: a pilot study in a canine model.

Krach LE, Kriel RL, Patterson EE, Scherkenbach LA, Coles LD, Cloyd JC.

J Pediatr Rehabil Med. 2011;4(2):89-98. doi: 10.3233/PRM-2011-0160.

PMID:
21955965
37.

Excretion of the principal urinary metabolites of phenytoin and absolute oral bioavailability determined by use of a stable isotope in patients with epilepsy.

Aliwarga T, Cloyd JC, Goel V, Brundage RC, Marino SE, Leppik IE, Remmel RP.

Ther Drug Monit. 2011 Feb;33(1):56-63. doi: 10.1097/FTD.0b013e3182081089.

PMID:
21233690
38.

Intramuscular and intravenous levetiracetam in humans: safety and pharmacokinetics.

Leppik IE, Goel V, Rarick J, Nixdorf DR, Cloyd JC.

Epilepsy Res. 2010 Oct;91(2-3):289-92. doi: 10.1016/j.eplepsyres.2010.07.016. Epub 2010 Aug 14.

PMID:
20708904
39.

Canine status epilepticus: Proof of principle studies.

Leppik IE, Patterson E, Hardy B, Cloyd JC.

Epilepsia. 2009 Dec;50 Suppl 12:14-5. doi: 10.1111/j.1528-1167.2009.02362.x. No abstract available.

40.

Characterization of the time course of carbamazepine deinduction by an enzyme turnover model.

Punyawudho B, Cloyd JC, Leppik IE, Ramsay RE, Marino SE, Pennell PB, White JR, Birnbaum AK.

Clin Pharmacokinet. 2009;48(5):313-20. doi: 10.2165/00003088-200948050-00003.

41.

Pharmacokinetics and tolerability of intranasal diazepam and midazolam in healthy adult volunteers.

Ivaturi VD, Riss JR, Kriel RL, Cloyd JC.

Acta Neurol Scand. 2009 Nov;120(5):353-7. doi: 10.1111/j.1600-0404.2009.01170.x. Epub 2009 May 14.

PMID:
19456308
42.

Safety of an IV formulation of carbamazepine.

Conway JM, White JR, Birnbaum AK, Eugene Ramsay R, Pennell PB, Rarick JO, Musib L, Leppik IE, Cloyd JC.

Epilepsy Res. 2009 Apr;84(2-3):242-4. doi: 10.1016/j.eplepsyres.2009.01.013. Epub 2009 Mar 18.

43.

Bioavailability and tolerability of intranasal diazepam in healthy adult volunteers.

Ivaturi VD, Riss JR, Kriel RL, Siegel RA, Cloyd JC.

Epilepsy Res. 2009 Apr;84(2-3):120-6. doi: 10.1016/j.eplepsyres.2009.01.001. Epub 2009 Feb 20.

PMID:
19231138
44.

Treatment of community-onset childhood convulsive status epilepticus.

Kriel RL, Cloyd JC.

Lancet Neurol. 2009 Feb;8(2):133-4; author reply 134-5. doi: 10.1016/S1474-4422(09)70005-5. No abstract available.

PMID:
19161903
45.

Phenytoin half-life and clearance during maintenance therapy in adults and elderly patients with epilepsy.

Ahn JE, Cloyd JC, Brundage RC, Marino SE, Conway JM, Ramsay RE, White JR, Musib LC, Rarick JO, Birnbaum AK, Leppik IE.

Neurology. 2008 Jul 1;71(1):38-43. doi: 10.1212/01.wnl.0000316392.55784.57.

PMID:
18591503
46.

Intramuscular, intravenous and oral levetiracetam in dogs: safety and pharmacokinetics.

Patterson EE, Goel V, Cloyd JC, O'Brien TD, Fisher JE, Dunn AW, Leppik IE.

J Vet Pharmacol Ther. 2008 Jun;31(3):253-8. doi: 10.1111/j.1365-2885.2008.00948.x.

PMID:
18471147
47.

Antiepileptic drugs--best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies.

Patsalos PN, Berry DJ, Bourgeois BF, Cloyd JC, Glauser TA, Johannessen SI, Leppik IE, Tomson T, Perucca E.

Epilepsia. 2008 Jul;49(7):1239-76. doi: 10.1111/j.1528-1167.2008.01561.x.

48.
49.

Factors affecting antiepileptic drug pharmacokinetics in community-dwelling elderly.

Cloyd JC, Marino S, Birnbaum AK.

Int Rev Neurobiol. 2007;81:201-10.

PMID:
17433925
50.

Relative bioavailability, metabolism and tolerability of rectally administered oxcarbazepine suspension.

Clemens PL, Cloyd JC, Kriel RL, Remmel RP.

Clin Drug Investig. 2007;27(4):243-50.

PMID:
17358096

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