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Items: 12


An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE).

Clouthier DL, Lien SC, Yang SYC, Nguyen LT, Manem VSK, Gray D, Ryczko M, Razak ARA, Lewin J, Lheureux S, Colombo I, Bedard PL, Cescon D, Spreafico A, Butler MO, Hansen AR, Jang RW, Ghai S, Weinreb I, Sotov V, Gadalla R, Noamani B, Guo M, Elston S, Giesler A, Hakgor S, Jiang H, McGaha T, Brooks DG, Haibe-Kains B, Pugh TJ, Ohashi PS, Siu LL.

J Immunother Cancer. 2019 Mar 13;7(1):72. doi: 10.1186/s40425-019-0541-0.


Landscape of genomic alterations in high-grade serous ovarian cancer from exceptional long- and short-term survivors.

Yang SYC, Lheureux S, Karakasis K, Burnier JV, Bruce JP, Clouthier DL, Danesh A, Quevedo R, Dowar M, Hanna Y, Li T, Lu L, Xu W, Clarke BA, Ohashi PS, Shaw PA, Pugh TJ, Oza AM.

Genome Med. 2018 Oct 31;10(1):81. doi: 10.1186/s13073-018-0590-x.


Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity.

Chang YH, Wang KC, Chu KL, Clouthier DL, Tran AT, Torres Perez MS, Zhou AC, Abdul-Sater AA, Watts TH.

Immunity. 2017 Nov 21;47(5):943-958.e9. doi: 10.1016/j.immuni.2017.10.014. Epub 2017 Nov 14.


Costimulation, a surprising connection for immunotherapy.

Clouthier DL, Ohashi PS.

Science. 2017 Mar 31;355(6332):1373-1374. doi: 10.1126/science.aan1467. No abstract available.


The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease.

Abdul-Sater AA, Edilova MI, Clouthier DL, Mbanwi A, Kremmer E, Watts TH.

Nat Immunol. 2017 Jan;18(1):26-35. doi: 10.1038/ni.3618. Epub 2016 Nov 28.


TNFRs and Control of Chronic LCMV Infection: Implications for Therapy.

Clouthier DL, Watts TH.

Trends Immunol. 2015 Nov;36(11):697-708. doi: 10.1016/ Epub 2015 Oct 17. Review.


Requisite role for Nck adaptors in cardiovascular development, endothelial-to-mesenchymal transition, and directed cell migration.

Clouthier DL, Harris CN, Harris RA, Martin CE, Puri MC, Jones N.

Mol Cell Biol. 2015 May;35(9):1573-87. doi: 10.1128/MCB.00072-15. Epub 2015 Feb 17.


GITR intrinsically sustains early type 1 and late follicular helper CD4 T cell accumulation to control a chronic viral infection.

Clouthier DL, Zhou AC, Wortzman ME, Luft O, Levy GA, Watts TH.

PLoS Pathog. 2015 Jan 15;11(1):e1004517. doi: 10.1371/journal.ppat.1004517. eCollection 2015 Jan.


Cell-specific and context-dependent effects of GITR in cancer, autoimmunity, and infection.

Clouthier DL, Watts TH.

Cytokine Growth Factor Rev. 2014 Apr;25(2):91-106. doi: 10.1016/j.cytogfr.2013.12.003. Epub 2014 Jan 4. Review.


The contextual role of TNFR family members in CD8(+) T-cell control of viral infections.

Wortzman ME, Clouthier DL, McPherson AJ, Lin GH, Watts TH.

Immunol Rev. 2013 Sep;255(1):125-48. doi: 10.1111/imr.12086. Review.


GITR-dependent regulation of 4-1BB expression: implications for T cell memory and anti-4-1BB-induced pathology.

Lin GH, Snell LM, Wortzman ME, Clouthier DL, Watts TH.

J Immunol. 2013 May 1;190(9):4627-39. doi: 10.4049/jimmunol.1201854. Epub 2013 Mar 27.

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