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Comprehensive model for X-ray-induced damage in protein crystallography.

Close DM, Bernhard WA.

J Synchrotron Radiat. 2019 Jul 1;26(Pt 4):945-957. doi: 10.1107/S1600577519005083. Epub 2019 May 24.


Familial Immune Thrombocytopenia Associated With a Novel Variant in IKZF1.

Sriaroon P, Chang Y, Ujhazi B, Csomos K, Joshi HR, Zhou Q, Close DW, Walter JE, Kumánovics A.

Front Pediatr. 2019 Apr 24;7:139. doi: 10.3389/fped.2019.00139. eCollection 2019.


Confirmation of Selected Synergistic Cancer Drug Combinations Identified in an HTS Campaign and Exploration of Drug Efflux Transporter Contributions to the Mode of Synergy.

Kochanek SJ, Close DA, Wang AX, Shun T, Empey PE, Eiseman JL, Johnston PA.

SLAS Discov. 2019 Jul;24(6):653-668. doi: 10.1177/2472555219844566. Epub 2019 Apr 30.


Improving Estrogenic Compound Screening Efficiency by Using Self-Modulating, Continuously Bioluminescent Human Cell Bioreporters Expressing a Synthetic Luciferase.

Xu T, Kirkpatrick A, Toperzer J, Ripp S, Close D.

Toxicol Sci. 2019 Apr 1;168(2):551-560. doi: 10.1093/toxsci/kfz004.


Implementation of the NCI-60 Human Tumor Cell Line Panel to Screen 2260 Cancer Drug Combinations to Generate >3 Million Data Points Used to Populate a Large Matrix of Anti-Neoplastic Agent Combinations (ALMANAC) Database.

Close DA, Wang AX, Kochanek SJ, Shun T, Eiseman JL, Johnston PA.

SLAS Discov. 2019 Mar;24(3):242-263. doi: 10.1177/2472555218812429. Epub 2018 Nov 30.


Pharmacodynamic biomarkers and differential effects of TNF- and GM-CSF-targeting biologics in rheumatoid arthritis.

Guo X, Wang S, Godwood A, Close D, Ryan PC, Roskos LK, White WI.

Int J Rheum Dis. 2019 Apr;22(4):646-653. doi: 10.1111/1756-185X.13395. Epub 2018 Oct 24.


High-Content Screening Campaign to Identify Compounds That Inhibit or Disrupt Androgen Receptor-Transcriptional Intermediary Factor 2 Protein-Protein Interactions for the Treatment of Prostate Cancer.

Fancher AT, Hua Y, Camarco DP, Close DA, Strock CJ, Johnston PA.

Assay Drug Dev Technol. 2018 Aug/Sep;16(6):297-319. doi: 10.1089/adt.2018.858. Epub 2018 Aug 15.


Mavrilimumab, a Fully Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Monoclonal Antibody: Long-Term Safety and Efficacy in Patients With Rheumatoid Arthritis.

Burmester GR, McInnes IB, Kremer JM, Miranda P, Vencovský J, Godwood A, Albulescu M, Michaels MA, Guo X, Close D, Weinblatt M.

Arthritis Rheumatol. 2018 May;70(5):679-689. doi: 10.1002/art.40420. Epub 2018 Mar 31.


Calculation of Standard Reduction Potentials of Amino Acid Radicals and the Effects of Water and Incorporation into Peptides.

Close DM, Wardman P.

J Phys Chem A. 2018 Jan 11;122(1):439-445. doi: 10.1021/acs.jpca.7b10766. Epub 2017 Dec 26.


High-Content Screening Comparison of Cancer Drug Accumulation and Distribution in Two-Dimensional and Three-Dimensional Culture Models of Head and Neck Cancer.

Shan F, Close DA, Camarco DP, Johnston PA.

Assay Drug Dev Technol. 2018 Jan;16(1):27-50. doi: 10.1089/adt.2017.812. Epub 2017 Dec 7.


A rapid and reagent-free bioassay for the detection of dioxin-like compounds and other aryl hydrocarbon receptor (AhR) agonists using autobioluminescent yeast.

Xu T, Young A, Marr E, Sayler G, Ripp S, Close D.

Anal Bioanal Chem. 2018 Feb;410(4):1247-1256. doi: 10.1007/s00216-017-0780-1. Epub 2017 Dec 6.


Co-Cultured Continuously Bioluminescent Human Cells as Bioreporters for the Detection of Prodrug Therapeutic Impact Pre- and Post-Metabolism.

Xu T, Conway M, Frank A, Ripp S, Sayler G, Close D.

Sensors (Basel). 2017 Dec 6;17(12). pii: E2827. doi: 10.3390/s17122827.


The Generation of Three-Dimensional Head and Neck Cancer Models for Drug Discovery in 384-Well Ultra-Low Attachment Microplates.

Close DA, Camarco DP, Shan F, Kochanek SJ, Johnston PA.

Methods Mol Biol. 2018;1683:355-369. doi: 10.1007/978-1-4939-7357-6_20. Erratum in: Methods Mol Biol. 2018;1683:E1.


Blockade of GM-CSF pathway induced sustained suppression of myeloid and T cell activities in rheumatoid arthritis.

Guo X, Higgs BW, Bay-Jensen AC, Wu Y, Karsdal MA, Kuziora M, Godwood A, Close D, Ryan PC, Roskos LK, White WI.

Rheumatology (Oxford). 2018 Jan 1;57(1):175-184. doi: 10.1093/rheumatology/kex383.


A Randomized Phase IIb Study of Mavrilimumab and Golimumab in Rheumatoid Arthritis.

Weinblatt ME, McInnes IB, Kremer JM, Miranda P, Vencovsky J, Guo X, White WI, Ryan PC, Godwood A, Albulescu M, Close D, Burmester GR.

Arthritis Rheumatol. 2018 Jan;70(1):49-59. doi: 10.1002/art.40323.


Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines.

Sen M, Johnston PA, Pollock NI, DeGrave K, Joyce SC, Freilino ML, Hua Y, Camarco DP, Close DA, Huryn DM, Wipf P, Grandis JR.

J Chem Biol. 2017 May 11;10(3):129-141. doi: 10.1007/s12154-017-0169-9. eCollection 2017 Jul.


Predicting Pulmonary Function from Phone Sensors.

Cheng Q, Juen J, Bellam S, Fulara N, Close D, Silverstein JC, Schatz B.

Telemed J E Health. 2017 Nov;23(11):913-919. doi: 10.1089/tmj.2017.0008. Epub 2017 Mar 16.


Classification Models for Pulmonary Function using Motion Analysis from Phone Sensors.

Cheng Q, Juen J, Bellam S, Fulara N, Close D, Silverstein JC, Schatz B.

AMIA Annu Symp Proc. 2017 Feb 10;2016:401-410. eCollection 2016.


A randomised phase IIb study of mavrilimumab, a novel GM-CSF receptor alpha monoclonal antibody, in the treatment of rheumatoid arthritis.

Burmester GR, McInnes IB, Kremer J, Miranda P, Korkosz M, Vencovsky J, Rubbert-Roth A, Mysler E, Sleeman MA, Godwood A, Sinibaldi D, Guo X, White WI, Wang B, Wu CY, Ryan PC, Close D, Weinblatt ME; EARTH EXPLORER 1 study investigators.

Ann Rheum Dis. 2017 Jun;76(6):1020-1030. doi: 10.1136/annrheumdis-2016-210624. Epub 2017 Feb 17.


Draft Genome Sequence of Cryptococcus terricola JCM 24523, an Oleaginous Yeast Capable of Expressing Exogenous DNA.

Close D, Ojumu J, Zhang G.

Genome Announc. 2016 Nov 3;4(6). pii: e01238-16. doi: 10.1128/genomeA.01238-16.


Draft Genome Sequence of the Oleaginous Yeast Cryptococcus curvatus ATCC 20509.

Close D, Ojumu J.

Genome Announc. 2016 Nov 3;4(6). pii: e01235-16. doi: 10.1128/genomeA.01235-16.


Corrigendum to "Evolution and Characterization of a New Reversibly Photoswitching Chromogenic Protein, Dathail" [J. Mol. Biol., 428, (2016), 1776-89].

Langan PS, Close DW, Coates L, Rocha RC, Ghosh K, Kiss C, Waldo G, Freyer J, Kovalevsky A, Bradbury ARM.

J Mol Biol. 2016 Oct 9;428(20):4244. doi: 10.1016/j.jmb.2016.08.024. Epub 2016 Sep 11. No abstract available.


Estimated disease incidence of RAG1/2 mutations: A case report and querying the Exome Aggregation Consortium.

Kumánovics A, Lee YN, Close DW, Coonrod EM, Ujhazi B, Chen K, MacArthur DG, Krivan G, Notarangelo LD, Walter JE.

J Allergy Clin Immunol. 2017 Feb;139(2):690-692.e3. doi: 10.1016/j.jaci.2016.07.027. Epub 2016 Sep 5. No abstract available.


Reconfiguring the AR-TIF2 Protein-Protein Interaction HCS Assay in Prostate Cancer Cells and Characterizing the Hits from a LOPAC Screen.

Fancher AT, Hua Y, Camarco DP, Close DA, Strock CJ, Johnston PA.

Assay Drug Dev Technol. 2016 Oct;14(8):453-477. Epub 2016 Sep 8.


An assessment of ectomycorrhizal fungal communities in Tasmanian temperate high-altitude Eucalyptus delegatensis forest reveals a dominance of the Cortinariaceae.

Horton BM, Glen M, Davidson NJ, Ratkowsky DA, Close DC, Wardlaw TJ, Mohammed C.

Mycorrhiza. 2017 Jan;27(1):67-74. doi: 10.1007/s00572-016-0725-0. Epub 2016 Aug 22.


HLA genotyping in the clinical laboratory: comparison of next-generation sequencing methods.

Profaizer T, Lázár-Molnár E, Close DW, Delgado JC, Kumánovics A.

HLA. 2016 Jul;88(1-2):14-24. doi: 10.1111/tan.12850. Epub 2016 Aug 14.


The Expanding Toolbox of In Vivo Bioluminescent Imaging.

Xu T, Close D, Handagama W, Marr E, Sayler G, Ripp S.

Front Oncol. 2016 Jun 23;6:150. doi: 10.3389/fonc.2016.00150. eCollection 2016. Review.


Rapid detection of microbial cell abundance in aquatic systems.

Rocha AM, Yuan Q, Close DM, O'Dell KB, Fortney JL, Wu J, Hazen TC.

Biosens Bioelectron. 2016 Nov 15;85:915-923. doi: 10.1016/j.bios.2016.05.098. Epub 2016 Jun 1.


Calculations of the Energetics of Oxidation of Aqueous Nucleosides and the Effects of Prototropic Equilibria.

Close DM, Wardman P.

J Phys Chem A. 2016 Jun 16;120(23):4043-8. doi: 10.1021/acs.jpca.6b02653. Epub 2016 Jun 6.


Evolution and characterization of a new reversibly photoswitching chromogenic protein, Dathail.

Langan PS, Close DW, Coates L, Rocha RC, Ghosh K, Kiss C, Waldo G, Freyer J, Kovalevsky A, Bradbury AR.

J Mol Biol. 2016 May 8;428(9 Pt A):1776-89. doi: 10.1016/j.jmb.2016.02.029. Epub 2016 Mar 18. Erratum in: J Mol Biol. 2016 Oct 9;428(20):4244.


Projected Scenarios for Coastal First Nations' Fisheries Catch Potential under Climate Change: Management Challenges and Opportunities.

Weatherdon LV, Ota Y, Jones MC, Close DA, Cheung WW.

PLoS One. 2016 Jan 13;11(1):e0145285. doi: 10.1371/journal.pone.0145285. eCollection 2016.


Effect of Biochar on Nutrient Leaching in a Young Apple Orchard.

Hardie MA, Oliver G, Clothier BE, Bound SA, Green SA, Close DC.

J Environ Qual. 2015 Jul;44(4):1273-82. doi: 10.2134/jeq2015.02.0068.


Toxicological challenges to microbial bioethanol production and strategies for improved tolerance.

Akinosho H, Rydzak T, Borole A, Ragauskas A, Close D.

Ecotoxicology. 2015 Dec;24(10):2156-74. doi: 10.1007/s10646-015-1543-4. Epub 2015 Sep 30. Review.


Real-time toxicity and metabolic activity tracking of human cells exposed to Escherichia coli O157:H7 in a mixed consortia.

Xu T, Marr E, Lam H, Ripp S, Sayler G, Close D.

Ecotoxicology. 2015 Dec;24(10):2133-40. doi: 10.1007/s10646-015-1552-3. Epub 2015 Sep 30.


Production of Uniform 3D Microtumors in Hydrogel Microwell Arrays for Measurement of Viability, Morphology, and Signaling Pathway Activation.

Singh M, Close DA, Mukundan S, Johnston PA, Sant S.

Assay Drug Dev Technol. 2015 Nov;13(9):570-83. doi: 10.1089/adt.2015.662. Epub 2015 Aug 14.


Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma.

Van Allen EM, Lui VW, Egloff AM, Goetz EM, Li H, Johnson JT, Duvvuri U, Bauman JE, Stransky N, Zeng Y, Gilbert BR, Pendleton KP, Wang L, Chiosea S, Sougnez C, Wagle N, Zhang F, Du Y, Close D, Johnston PA, McKenna A, Carter SL, Golub TR, Getz G, Mills GB, Garraway LA, Grandis JR.

JAMA Oncol. 2015 May;1(2):238-44. doi: 10.1001/jamaoncol.2015.34.


Design and activity of AP endonuclease-1 inhibitors.

Feng Z, Kochanek S, Close D, Wang L, Srinivasan A, Almehizia AA, Iyer P, Xie XQ, Johnston PA, Gold B.

J Chem Biol. 2015 Apr 19;8(3):79-93. doi: 10.1007/s12154-015-0131-7. eCollection 2015 Jul.


X-Ray Crystal Structure and Properties of Phanta, a Weakly Fluorescent Photochromic GFP-Like Protein.

Don Paul C, Traore DA, Olsen S, Devenish RJ, Close DW, Bell TD, Bradbury A, Wilce MC, Prescott M.

PLoS One. 2015 Apr 29;10(4):e0123338. doi: 10.1371/journal.pone.0123338. eCollection 2015.


Yeast strain affects phenolic concentration in Pinot noir wines made by microwave maceration with early pressing.

Carew AL, Close DC, Dambergs RG.

J Appl Microbiol. 2015 Jun;118(6):1385-94. doi: 10.1111/jam.12785. Epub 2015 Mar 26.


Steroid profiling reveals widespread local regulation of glucocorticoid levels during mouse development.

Taves MD, Plumb AW, Sandkam BA, Ma C, Van Der Gugten JG, Holmes DT, Close DA, Abraham N, Soma KK.

Endocrinology. 2015 Feb;156(2):511-22. doi: 10.1210/en.2013-1606. Epub 2014 Nov 18.


Smart device use and burnout among health science educators.

Killion JB, Johnston JN, Gresham J, Gipson M, Vealé BL, Behrens PI, Velasquez B, Jansen L, Woods-Fidelie L, Close DM.

Radiol Technol. 2014 Nov-Dec;86(2):144-54.


Thermal green protein, an extremely stable, nonaggregating fluorescent protein created by structure-guided surface engineering.

Close DW, Paul CD, Langan PS, Wilce MC, Traore DA, Halfmann R, Rocha RC, Waldo GS, Payne RJ, Rucker JB, Prescott M, Bradbury AR.

Proteins. 2015 Jul;83(7):1225-37. doi: 10.1002/prot.24699. Epub 2015 May 8.


A new family of β-helix proteins with similarities to the polysaccharide lyases.

Close DW, D'Angelo S, Bradbury AR.

Acta Crystallogr D Biol Crystallogr. 2014 Oct;70(Pt 10):2583-92. doi: 10.1107/S1399004714015934. Epub 2014 Sep 27.


The emergence of Clostridium thermocellum as a high utility candidate for consolidated bioprocessing applications.

Akinosho H, Yee K, Close D, Ragauskas A.

Front Chem. 2014 Aug 26;2:66. doi: 10.3389/fchem.2014.00066. eCollection 2014. Review.


Detection of organic compounds with whole-cell bioluminescent bioassays.

Xu T, Close D, Smartt A, Ripp S, Sayler G.

Adv Biochem Eng Biotechnol. 2014;144:111-51. doi: 10.1007/978-3-662-43385-0_4. Review.


A putative corticosteroid hormone in Pacific lamprey, Entosphenus tridentatus.

Rai S, Szeitz A, Roberts BW, Christie Q, Didier W, Eom J, Yun SS, Close DA.

Gen Comp Endocrinol. 2015 Feb 1;212:178-84. doi: 10.1016/j.ygcen.2014.06.019. Epub 2014 Jun 24.


Expression of a humanized viral 2A-mediated lux operon efficiently generates autonomous bioluminescence in human cells.

Xu T, Ripp S, Sayler GS, Close DM.

PLoS One. 2014 May 2;9(5):e96347. doi: 10.1371/journal.pone.0096347. eCollection 2014.


Efficacy and safety of mavrilimumab in Japanese subjects with rheumatoid arthritis: findings from a Phase IIa study.

Takeuchi T, Tanaka Y, Close D, Godwood A, Wu CY, Saurigny D.

Mod Rheumatol. 2015 Jan;25(1):21-30. doi: 10.3109/14397595.2014.896448. Epub 2014 Apr 11.


Auranofin is an apoptosis-simulating agent with in vitro and in vivo anti-leishmanial activity.

Sharlow ER, Leimgruber S, Murray S, Lira A, Sciotti RJ, Hickman M, Hudson T, Leed S, Caridha D, Barrios AM, Close D, Grögl M, Lazo JS.

ACS Chem Biol. 2014 Mar 21;9(3):663-72. doi: 10.1021/cb400800q. Epub 2013 Dec 23.


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