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Items: 1 to 50 of 138

1.

Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics.

Borsari C, Jiménez-Antón MD, Eick J, Bifeld E, Torrado JJ, Olías-Molero AI, Corral MJ, Santarem N, Baptista C, Severi L, Gul S, Wolf M, Kuzikov M, Ellinger B, Reinshagen J, Witt G, Linciano P, Tait A, Costantino L, Luciani R, Tejera Nevado P, Zander-Dinse D, Franco CH, Ferrari S, Moraes CB, Cordeiro-da-Silva A, Ponterini G, Clos J, Alunda JM, Costi MP.

Eur J Med Chem. 2019 Sep 5;183:111676. doi: 10.1016/j.ejmech.2019.111676. [Epub ahead of print]

PMID:
31542713
2.

Gene Replacement by Homologous Recombination.

Zirpel H, Clos J.

Methods Mol Biol. 2019;1971:169-188. doi: 10.1007/978-1-4939-9210-2_8.

PMID:
30980303
3.

Cosmid Library Construction and Functional Cloning.

Clos J, Zander-Dinse D.

Methods Mol Biol. 2019;1971:123-140. doi: 10.1007/978-1-4939-9210-2_6.

PMID:
30980301
4.

Leishmania donovani 90 kD Heat Shock Protein - Impact of Phosphosites on Parasite Fitness, Infectivity and Casein Kinase Affinity.

Hombach-Barrigah A, Bartsch K, Smirlis D, Rosenqvist H, MacDonald A, Dingli F, Loew D, Späth GF, Rachidi N, Wiese M, Clos J.

Sci Rep. 2019 Mar 25;9(1):5074. doi: 10.1038/s41598-019-41640-0.

5.

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform.

Moraes CB, Witt G, Kuzikov M, Ellinger B, Calogeropoulou T, Prousis KC, Mangani S, Di Pisa F, Landi G, Iacono LD, Pozzi C, Freitas-Junior LH, Dos Santos Pascoalino B, Bertolacini CP, Behrens B, Keminer O, Leu J, Wolf M, Reinshagen J, Cordeiro-da-Silva A, Santarem N, Venturelli A, Wrigley S, Karunakaran D, Kebede B, Pöhner I, Müller W, Panecka-Hofman J, Wade RC, Fenske M, Clos J, Alunda JM, Corral MJ, Uliassi E, Bolognesi ML, Linciano P, Quotadamo A, Ferrari S, Santucci M, Borsari C, Costi MP, Gul S.

SLAS Discov. 2019 Mar;24(3):346-361. doi: 10.1177/2472555218823171.

6.

Ribosome Profiling Reveals HSP90 Inhibitor Effects on Stage-Specific Protein Synthesis in Leishmania donovani.

Bifeld E, Lorenzen S, Bartsch K, Vasquez JJ, Siegel TN, Clos J.

mSystems. 2018 Nov 20;3(6). pii: e00214-18. doi: 10.1128/mSystems.00214-18. eCollection 2018 Nov-Dec.

7.

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani.

Corpas-Lopez V, Moniz S, Thomas M, Wall RJ, Torrie LS, Zander-Dinse D, Tinti M, Brand S, Stojanovski L, Manthri S, Hallyburton I, Zuccotto F, Wyatt PG, De Rycker M, Horn D, Ferguson MAJ, Clos J, Read KD, Fairlamb AH, Gilbert IH, Wyllie S.

ACS Infect Dis. 2019 Jan 11;5(1):111-122. doi: 10.1021/acsinfecdis.8b00226. Epub 2018 Nov 12.

8.

Molecular Preadaptation to Antimony Resistance in Leishmania donovani on the Indian Subcontinent.

Dumetz F, Cuypers B, Imamura H, Zander D, D'Haenens E, Maes I, Domagalska MA, Clos J, Dujardin JC, De Muylder G.

mSphere. 2018 Apr 18;3(2). pii: e00548-17. doi: 10.1128/mSphere.00548-17. Print 2018 Apr 25.

9.

MAPK1 of Leishmania donovani interacts and phosphorylates HSP70 and HSP90 subunits of foldosome complex.

Kaur P, Garg M, Hombach-Barrigah A, Clos J, Goyal N.

Sci Rep. 2017 Aug 31;7(1):10202. doi: 10.1038/s41598-017-09725-w.

10.

Synthetic analogs of an Entamoeba histolytica glycolipid designed to combat intracellular Leishmania infection.

Choy SL, Bernin H, Aiba T, Bifeld E, Lender SC, Mühlenpfordt M, Noll J, Eick J, Marggraff C, Niss H, Roldán NG, Tanaka S, Kitamura M, Fukase K, Clos J, Tannich E, Fujimoto Y, Lotter H.

Sci Rep. 2017 Aug 25;7(1):9472. doi: 10.1038/s41598-017-09894-8.

11.

Characterization of the Protein Tyrosine Phosphatase LmPRL-1 Secreted by Leishmania major via the Exosome Pathway.

Leitherer S, Clos J, Liebler-Tenorio EM, Schleicher U, Bogdan C, Soulat D.

Infect Immun. 2017 Jul 19;85(8). pii: e00084-17. doi: 10.1128/IAI.00084-17. Print 2017 Aug.

12.

Hsp90 inhibitors radicicol and geldanamycin have opposing effects on Leishmania Aha1-dependent proliferation.

Bartsch K, Hombach-Barrigah A, Clos J.

Cell Stress Chaperones. 2017 Sep;22(5):729-742. doi: 10.1007/s12192-017-0800-2. Epub 2017 Apr 28.

13.

Leishmania donovani chaperonin 10 regulates parasite internalization and intracellular survival in human macrophages.

Colineau L, Clos J, Moon KM, Foster LJ, Reiner NE.

Med Microbiol Immunol. 2017 Jun;206(3):235-257. doi: 10.1007/s00430-017-0500-7. Epub 2017 Mar 11.

PMID:
28283754
14.

Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds.

Borsari C, Santarem N, Torrado J, Olías AI, Corral MJ, Baptista C, Gul S, Wolf M, Kuzikov M, Ellinger B, Witt G, Gribbon P, Reinshagen J, Linciano P, Tait A, Costantino L, Freitas-Junior LH, Moraes CB, Bruno Dos Santos P, Alcântara LM, Franco CH, Bertolacini CD, Fontana V, Tejera Nevado P, Clos J, Alunda JM, Cordeiro-da-Silva A, Ferrari S, Costi MP.

Eur J Med Chem. 2017 Jan 27;126:1129-1135. doi: 10.1016/j.ejmech.2016.12.017. Epub 2016 Dec 9.

PMID:
28064141
15.

Phenotypic Characterization of a Leishmania donovani Cyclophilin 40 Null Mutant.

Yau WL, Lambertz U, Colineau L, Pescher P, MacDonald A, Zander D, Retzlaff S, Eick J, Reiner NE, Clos J, Späth GF.

J Eukaryot Microbiol. 2016 Nov;63(6):823-833. doi: 10.1111/jeu.12329. Epub 2016 Jun 16.

PMID:
27216143
16.

Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.

Borsari C, Luciani R, Pozzi C, Poehner I, Henrich S, Trande M, Cordeiro-da-Silva A, Santarem N, Baptista C, Tait A, Di Pisa F, Dello Iacono L, Landi G, Gul S, Wolf M, Kuzikov M, Ellinger B, Reinshagen J, Witt G, Gribbon P, Kohler M, Keminer O, Behrens B, Costantino L, Tejera Nevado P, Bifeld E, Eick J, Clos J, Torrado J, Jiménez-Antón MD, Corral MJ, Alunda JM, Pellati F, Wade RC, Ferrari S, Mangani S, Costi MP.

J Med Chem. 2016 Aug 25;59(16):7598-616. doi: 10.1021/acs.jmedchem.6b00698. Epub 2016 Aug 5.

PMID:
27411733
17.

A Telomeric Cluster of Antimony Resistance Genes on Chromosome 34 of Leishmania infantum.

Tejera Nevado P, Bifeld E, Höhn K, Clos J.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5262-75. doi: 10.1128/AAC.00544-16. Print 2016 Sep.

18.

A versatile qPCR assay to quantify trypanosomatidic infections of host cells and tissues.

Bifeld E, Tejera Nevado P, Bartsch J, Eick J, Clos J.

Med Microbiol Immunol. 2016 Oct;205(5):449-58. doi: 10.1007/s00430-016-0460-3. Epub 2016 Jun 9.

PMID:
27283847
19.

Joining forces: first application of a rapamycin-induced dimerizable Cre system for conditional null mutant analysis in Leishmania.

Späth GF, Clos J.

Mol Microbiol. 2016 Jun;100(6):923-7. doi: 10.1111/mmi.13374. Epub 2016 Apr 20.

20.

Co-circulation of a novel phlebovirus and Massilia virus in sandflies, Portugal.

Amaro F, Zé-Zé L, Alves MJ, Börstler J, Clos J, Lorenzen S, Becker SC, Schmidt-Chanasit J, Cadar D.

Virol J. 2015 Oct 24;12:174. doi: 10.1186/s12985-015-0407-0.

21.

The genetics of Leishmania virulence.

Bifeld E, Clos J.

Med Microbiol Immunol. 2015 Dec;204(6):619-34. doi: 10.1007/s00430-015-0422-1. Epub 2015 Jun 6. Review.

PMID:
26047933
22.

Leishmania donovani P23 protects parasites against HSP90 inhibitor-mediated growth arrest.

Hombach A, Ommen G, Sattler V, Clos J.

Cell Stress Chaperones. 2015 Jul;20(4):673-85. doi: 10.1007/s12192-015-0595-y. Epub 2015 May 7.

23.

Geographical sequence variation in the Leishmania major virulence factor P46.

Bifeld E, Chrobak M, Zander D, Schleicher U, Schönian G, Clos J.

Infect Genet Evol. 2015 Mar;30:195-205. doi: 10.1016/j.meegid.2014.12.029. Epub 2014 Dec 31.

24.

A small heat shock protein is essential for thermotolerance and intracellular survival of Leishmania donovani.

Hombach A, Ommen G, MacDonald A, Clos J.

J Cell Sci. 2014 Nov 1;127(Pt 21):4762-73. doi: 10.1242/jcs.157297. Epub 2014 Sep 1.

25.

The Leishmania donovani chaperone cyclophilin 40 is essential for intracellular infection independent of its stage-specific phosphorylation status.

Yau WL, Pescher P, MacDonald A, Hem S, Zander D, Retzlaff S, Blisnick T, Rotureau B, Rosenqvist H, Wiese M, Bastin P, Clos J, Späth GF.

Mol Microbiol. 2014 Jul;93(1):80-97. doi: 10.1111/mmi.12639. Epub 2014 May 23.

26.

No stress--Hsp90 and signal transduction in Leishmania.

Hombach A, Clos J.

Parasitology. 2014 Aug;141(9):1156-66. doi: 10.1017/S0031182013002151. Epub 2014 Apr 4.

PMID:
24703183
27.

Leishmania infantum EndoG is an endo/exo-nuclease essential for parasite survival.

Rico E, Oliva C, Gutierrez KJ, Alzate JF, Genes CM, Moreno D, Casanova E, Gigante A, Pérez-Pérez MJ, Camarasa MJ, Clos J, Gago F, Jiménez-Ruiz A.

PLoS One. 2014 Feb 26;9(2):e89526. doi: 10.1371/journal.pone.0089526. eCollection 2014.

28.

A novel marker, ARM58, confers antimony resistance to Leishmania spp.

Nühs A, Schäfer C, Zander D, Trübe L, Tejera Nevado P, Schmidt S, Arevalo J, Adaui V, Maes L, Dujardin JC, Clos J.

Int J Parasitol Drugs Drug Resist. 2013 Dec 6;4(1):37-47. doi: 10.1016/j.ijpddr.2013.11.004. eCollection 2014 Apr.

29.

Reduced antimony accumulation in ARM58-overexpressing Leishmania infantum.

Schäfer C, Tejera Nevado P, Zander D, Clos J.

Antimicrob Agents Chemother. 2014;58(3):1565-74. doi: 10.1128/AAC.01881-13. Epub 2013 Dec 23.

30.

The loss of virulence of histone H1 overexpressing Leishmania donovani parasites is directly associated with a reduction of HSP83 rate of translation.

Alexandratos A, Clos J, Samiotaki M, Efstathiou A, Panayotou G, Soteriadou K, Smirlis D.

Mol Microbiol. 2013 Jun;88(5):1015-31. doi: 10.1111/mmi.12240. Epub 2013 May 7.

31.

The Hsp90-Sti1 interaction is critical for Leishmania donovani proliferation in both life cycle stages.

Hombach A, Ommen G, Chrobak M, Clos J.

Cell Microbiol. 2013 Apr;15(4):585-600. doi: 10.1111/cmi.12057. Epub 2012 Nov 20.

32.

Rapid identification of Leishmania spp. in formalin-fixed, paraffin-embedded tissue samples by fluorescence in situ hybridization.

Frickmann H, Alnamar Y, Essig A, Clos J, Racz P, Barth TF, Hagen RM, Fischer M, Poppert S.

Trop Med Int Health. 2012 Sep;17(9):1117-26. doi: 10.1111/j.1365-3156.2012.03024.x. Epub 2012 Jul 9.

33.

Secreted virulence factors and immune evasion in visceral leishmaniasis.

Lambertz U, Silverman JM, Nandan D, McMaster WR, Clos J, Foster LJ, Reiner NE.

J Leukoc Biol. 2012 Jun;91(6):887-99. doi: 10.1189/jlb.0611326. Epub 2012 Mar 21. Review.

PMID:
22442494
34.

Leishmania donovani HslV does not interact stably with HslU proteins.

Chrobak M, Förster S, Meisel S, Pfefferkorn R, Förster F, Clos J.

Int J Parasitol. 2012 Apr;42(4):329-39. doi: 10.1016/j.ijpara.2012.01.008. Epub 2012 Feb 21.

PMID:
22370310
35.

Leishmania exosomes modulate innate and adaptive immune responses through effects on monocytes and dendritic cells.

Silverman JM, Clos J, Horakova E, Wang AY, Wiesgigl M, Kelly I, Lynn MA, McMaster WR, Foster LJ, Levings MK, Reiner NE.

J Immunol. 2010 Nov 1;185(9):5011-22. doi: 10.4049/jimmunol.1000541. Epub 2010 Sep 29.

36.

Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage.

Morales MA, Watanabe R, Dacher M, Chafey P, Osorio y Fortéa J, Scott DA, Beverley SM, Ommen G, Clos J, Hem S, Lenormand P, Rousselle JC, Namane A, Späth GF.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8381-6. doi: 10.1073/pnas.0914768107. Epub 2010 Apr 19.

37.

Overexpression of a single Leishmania major gene enhances parasite infectivity in vivo and in vitro.

Reiling L, Chrobak M, Schmetz C, Clos J.

Mol Microbiol. 2010 Jun 1;76(5):1175-90. doi: 10.1111/j.1365-2958.2010.07130.x. Epub 2010 Mar 25.

38.

LmxMPK4, an essential mitogen-activated protein kinase of Leishmania mexicana is phosphorylated and activated by the STE7-like protein kinase LmxMKK5.

John von Freyend S, Rosenqvist H, Fink A, Melzer IM, Clos J, Jensen ON, Wiese M.

Int J Parasitol. 2010 Jul;40(8):969-78. doi: 10.1016/j.ijpara.2010.02.004. Epub 2010 Feb 21.

PMID:
20178803
39.

An exosome-based secretion pathway is responsible for protein export from Leishmania and communication with macrophages.

Silverman JM, Clos J, de'Oliveira CC, Shirvani O, Fang Y, Wang C, Foster LJ, Reiner NE.

J Cell Sci. 2010 Mar 15;123(Pt 6):842-52. doi: 10.1242/jcs.056465. Epub 2010 Feb 16.

40.

Characterization of a subunit of the outer dynein arm docking complex necessary for correct flagellar assembly in Leishmania donovani.

Harder S, Thiel M, Clos J, Bruchhaus I.

PLoS Negl Trop Dis. 2010 Jan 26;4(1):e586. doi: 10.1371/journal.pntd.0000586.

41.

The co-chaperone SGT of Leishmania donovani is essential for the parasite's viability.

Ommen G, Chrobak M, Clos J.

Cell Stress Chaperones. 2010 Jul;15(4):443-55. doi: 10.1007/s12192-009-0160-7. Epub 2009 Dec 2.

42.

Using pay-for-performance to introduce changes in primary healthcare centres in Spain: first year results.

Benavent J, Juan C, Clos J, Sequeira E, Gimferrer N, Vilaseca J.

Qual Prim Care. 2009;17(2):123-31.

PMID:
19416605
43.

Gas-phase intramolecular elimination reaction studies of steviol glycosides in positive electrospray and tandem mass spectrometry.

Upreti M, Clos JF, Somayajula KV, Milanowski DJ, Mocek U, Dubois GE, Prakash I.

Eur J Mass Spectrom (Chichester). 2009;15(1):11-21. doi: 10.1255/ejms.981.

PMID:
19174590
44.

One-step generation of double-allele gene replacement mutants in Leishmania donovani.

Ommen G, Lorenz S, Clos J.

Int J Parasitol. 2009 Apr;39(5):541-6. doi: 10.1016/j.ijpara.2008.10.009. Epub 2008 Nov 8.

PMID:
19028498
45.

Leishmania infantum expresses a mitochondrial nuclease homologous to EndoG that migrates to the nucleus in response to an apoptotic stimulus.

Rico E, Alzate JF, Arias AA, Moreno D, Clos J, Gago F, Moreno I, Domínguez M, Jiménez-Ruiz A.

Mol Biochem Parasitol. 2009 Jan;163(1):28-38. doi: 10.1016/j.molbiopara.2008.09.007. Epub 2008 Oct 2.

PMID:
18940204
46.

Photostability of rebaudioside A and stevioside in beverages.

Clos JF, DuBois GE, Prakash I.

J Agric Food Chem. 2008 Sep 24;56(18):8507-13. doi: 10.1021/jf801343e. Epub 2008 Aug 22.

PMID:
18717571
47.

Development of rebiana, a natural, non-caloric sweetener.

Prakash I, Dubois GE, Clos JF, Wilkens KL, Fosdick LE.

Food Chem Toxicol. 2008 Jul;46 Suppl 7:S75-82. doi: 10.1016/j.fct.2008.05.004. Epub 2008 May 16. Review.

PMID:
18554769
48.

Leishmania major: identification of developmentally regulated proteins in procyclic and metacyclic promastigotes.

Mojtahedi Z, Clos J, Kamali-Sarvestani E.

Exp Parasitol. 2008 Jul;119(3):422-9. doi: 10.1016/j.exppara.2008.04.008. Epub 2008 Apr 14.

PMID:
18486941
49.

Identification of a Leishmania infantum gene mediating resistance to miltefosine and SbIII.

Choudhury K, Zander D, Kube M, Reinhardt R, Clos J.

Int J Parasitol. 2008 Oct;38(12):1411-23. doi: 10.1016/j.ijpara.2008.03.005. Epub 2008 Apr 8.

PMID:
18457839
50.

Spontaneous recovery of pathogenicity by Leishmania major hsp100-/- alters the immune response in mice.

Reiling L, Jacobs T, Kroemer M, Gaworski I, Graefe S, Clos J.

Infect Immun. 2006 Nov;74(11):6027-36.

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