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Items: 42

1.

Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort.

Zhang WZ, Rice MC, Hoffman KL, Oromendia C, Barjaktarevic I, Wells JM, Hastie AT, Labaki WW, Cooper CB, Comellas AP, Criner GJ, Krishnan JA, Paine Iii R, Hansel NN, Bowler RP, Barr RG, Peters SP, Woodruff PG, Curtis JL, Han MK, Ballman KV, Martinez FJ, Choi AM, Nakahira K, Cloonan SM, Choi ME.

JCI Insight. 2020 Jan 2. pii: 133984. doi: 10.1172/jci.insight.133984. [Epub ahead of print]

2.

Alveolar Macrophage Immunometabolism and Lung Function Impairment in Smoking and Chronic Obstructive Pulmonary Disease.

O'Beirne SL, Kikkers SA, Oromendia C, Salit J, Rostmai MR, Ballman KV, Kaner RJ, Crystal RG, Cloonan SM.

Am J Respir Crit Care Med. 2019 Nov 21. doi: 10.1164/rccm.201908-1683LE. [Epub ahead of print] No abstract available.

PMID:
31751151
3.

To "Fe"ed or Not to "Fe"ed: Iron Depletion Exacerbates Emphysema Development in Murine Smoke Model.

Zhang WZ, Cloonan SM.

Am J Respir Cell Mol Biol. 2019 Nov 19. doi: 10.1165/rcmb.2019-0376ED. [Epub ahead of print] No abstract available.

PMID:
31743655
4.

Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease.

Aghapour M, Remels AHV, Pouwels SD, Bruder D, Hiemstra PS, Cloonan SM, Heijink IH.

Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318(1):L149-L164. doi: 10.1152/ajplung.00329.2019. Epub 2019 Nov 6.

PMID:
31693390
5.

Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis.

Chung KP, Hsu CL, Fan LC, Huang Z, Bhatia D, Chen YJ, Hisata S, Cho SJ, Nakahira K, Imamura M, Choi ME, Yu CJ, Cloonan SM, Choi AMK.

Nat Commun. 2019 Jul 29;10(1):3390. doi: 10.1038/s41467-019-11327-1.

6.

ToF-SIMS mediated analysis of human lung tissue reveals increased iron deposition in COPD (GOLD IV) patients.

Najafinobar N, Venkatesan S, von Sydow L, Klarqvist M, Olsson H, Zhou XH, Cloonan SM, Malmberg P.

Sci Rep. 2019 Jul 11;9(1):10060. doi: 10.1038/s41598-019-46471-7.

7.

Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity.

Plataki M, Fan L, Sanchez E, Huang Z, Torres LK, Imamura M, Zhu Y, Cohen DE, Cloonan SM, Choi AM.

JCI Insight. 2019 Jul 9;5. pii: 127823. doi: 10.1172/jci.insight.127823.

8.

Do sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis.

Faner R, Morrow JD, Casas-Recasens S, Cloonan SM, Noell G, López-Giraldo A, Tal-Singer R, Miller BE, Silverman EK, Agustí A, Hersh CP.

Respir Res. 2019 Jan 8;20(1):5. doi: 10.1186/s12931-018-0965-y.

9.

Mitochondrial Iron in Human Health and Disease.

Ward DM, Cloonan SM.

Annu Rev Physiol. 2019 Feb 10;81:453-482. doi: 10.1146/annurev-physiol-020518-114742. Epub 2018 Nov 28.

PMID:
30485761
10.

Beclin-1 regulates cigarette smoke-induced kidney injury in a murine model of chronic obstructive pulmonary disease.

Pabón MA, Patino E, Bhatia D, Rojas-Quintero J, Ma KC, Finkelsztein EJ, Osorio JC, Malick F, Polverino F, Owen CA, Ryter SW, Choi AM, Cloonan SM, Choi ME.

JCI Insight. 2018 Sep 20;3(18). pii: 99592. doi: 10.1172/jci.insight.99592. eCollection 2018 Sep 20.

11.

Smoking-induced iron dysregulation in the lung.

Zhang WZ, Butler JJ, Cloonan SM.

Free Radic Biol Med. 2019 Mar;133:238-247. doi: 10.1016/j.freeradbiomed.2018.07.024. Epub 2018 Jul 31. Review.

PMID:
30075191
12.

Circulating RIPK3 levels are associated with mortality and organ failure during critical illness.

Ma KC, Schenck EJ, Siempos II, Cloonan SM, Finkelsztein EJ, Pabon MA, Oromendia C, Ballman KV, Baron RM, Fredenburgh LE, Higuera A, Lee JY, Chung CR, Jeon K, Yang JH, Howrylak JA, Huh JW, Suh GY, Choi AM.

JCI Insight. 2018 Jul 12;3(13). pii: 99692. doi: 10.1172/jci.insight.99692.

13.

Autophagy and inflammation in chronic respiratory disease.

Racanelli AC, Kikkers SA, Choi AMK, Cloonan SM.

Autophagy. 2018;14(2):221-232. doi: 10.1080/15548627.2017.1389823. Epub 2018 Feb 8. Review.

14.

In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions.

Burstein SR, Valsecchi F, Kawamata H, Bourens M, Zeng R, Zuberi A, Milner TA, Cloonan SM, Lutz C, Barrientos A, Manfredi G.

Hum Mol Genet. 2018 Jan 1;27(1):160-177. doi: 10.1093/hmg/ddx397.

15.

Circulating Mitochondrial DNA as a Mechanism-based, Prognostic Biomarker for Idiopathic Pulmonary Fibrosis.

Cloonan SM.

Am J Respir Crit Care Med. 2017 Dec 15;196(12):1502-1504. doi: 10.1164/rccm.201708-1593ED. No abstract available.

16.

The "Iron"-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease.

Cloonan SM, Mumby S, Adcock IM, Choi AMK, Chung KF, Quinlan GJ.

Am J Respir Crit Care Med. 2017 Nov 1;196(9):1103-1112. doi: 10.1164/rccm.201702-0311PP. No abstract available.

17.

Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue.

Morrow JD, Zhou X, Lao T, Jiang Z, DeMeo DL, Cho MH, Qiu W, Cloonan S, Pinto-Plata V, Celli B, Marchetti N, Criner GJ, Bueno R, Washko GR, Glass K, Quackenbush J, Choi AM, Silverman EK, Hersh CP.

Sci Rep. 2017 Mar 13;7:44232. doi: 10.1038/srep44232.

18.

Autophagy: Friend or Foe in Lung Disease?

Mizumura K, Cloonan S, Choi ME, Hashimoto S, Nakahira K, Ryter SW, Choi AM.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S40-7. doi: 10.1513/AnnalsATS.201507-450MG. Review.

19.

Mitochondria in lung disease.

Cloonan SM, Choi AM.

J Clin Invest. 2016 Mar 1;126(3):809-20. doi: 10.1172/JCI81113. Epub 2016 Mar 1. Review.

20.

Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.

Cloonan SM, Glass K, Laucho-Contreras ME, Bhashyam AR, Cervo M, Pabón MA, Konrad C, Polverino F, Siempos II, Perez E, Mizumura K, Ghosh MC, Parameswaran H, Williams NC, Rooney KT, Chen ZH, Goldklang MP, Yuan GC, Moore SC, Demeo DL, Rouault TA, D'Armiento JM, Schon EA, Manfredi G, Quackenbush J, Mahmood A, Silverman EK, Owen CA, Choi AM.

Nat Med. 2016 Feb;22(2):163-74. doi: 10.1038/nm.4021. Epub 2016 Jan 11.

21.

Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells.

Cloonan SM, Elmes RB, Erby M, Bright SA, Poynton FE, Nolan DE, Quinn SJ, Gunnlaugsson T, Williams DC.

J Med Chem. 2015 Jun 11;58(11):4494-505. doi: 10.1021/acs.jmedchem.5b00451. Epub 2015 May 27.

PMID:
25961430
22.

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD.

Mizumura K, Cloonan SM, Nakahira K, Bhashyam AR, Cervo M, Kitada T, Glass K, Owen CA, Mahmood A, Washko GR, Hashimoto S, Ryter SW, Choi AM.

J Clin Invest. 2014 Sep;124(9):3987-4003. doi: 10.1172/JCI74985. Epub 2014 Aug 1.

23.

"Ciliophagy": The consumption of cilia components by autophagy.

Cloonan SM, Lam HC, Ryter SW, Choi AM.

Autophagy. 2014 Mar;10(3):532-4. doi: 10.4161/auto.27641. Epub 2014 Jan 7. Review.

24.

Synthesis and antiproliferative action of a novel series of maprotiline analogues.

McNamara YM, Bright SA, Byrne AJ, Cloonan SM, McCabe T, Williams DC, Meegan MJ.

Eur J Med Chem. 2014 Jan;71:333-53. doi: 10.1016/j.ejmech.2013.10.076. Epub 2013 Nov 9.

PMID:
24333581
25.

Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction.

Lam HC, Cloonan SM, Bhashyam AR, Haspel JA, Singh A, Sathirapongsasuti JF, Cervo M, Yao H, Chung AL, Mizumura K, An CH, Shan B, Franks JM, Haley KJ, Owen CA, Tesfaigzi Y, Washko GR, Quackenbush J, Silverman EK, Rahman I, Kim HP, Mahmood A, Biswal SS, Ryter SW, Choi AM.

J Clin Invest. 2013 Dec;123(12):5212-30. doi: 10.1172/JCI69636. Epub 2013 Nov 8.

26.

Autophagy: a crucial moderator of redox balance, inflammation, and apoptosis in lung disease.

Nakahira K, Cloonan SM, Mizumura K, Choi AM, Ryter SW.

Antioxid Redox Signal. 2014 Jan 20;20(3):474-94. doi: 10.1089/ars.2013.5373. Epub 2013 Sep 26. Review.

27.

Mitochondria: sensors and mediators of innate immune receptor signaling.

Cloonan SM, Choi AM.

Curr Opin Microbiol. 2013 Jun;16(3):327-38. doi: 10.1016/j.mib.2013.05.005. Epub 2013 Jun 8. Review.

28.

Autophagy: a critical regulator of cellular metabolism and homeostasis.

Ryter SW, Cloonan SM, Choi AM.

Mol Cells. 2013 Jul;36(1):7-16. doi: 10.1007/s10059-013-0140-8. Epub 2013 May 24. Review.

29.

The emerging importance of autophagy in pulmonary diseases.

Mizumura K, Cloonan SM, Haspel JA, Choi AMK.

Chest. 2012 Nov;142(5):1289-1299. doi: 10.1378/chest.12-0809. Review.

30.

Therapeutic potential of heme oxygenase-1/carbon monoxide in lung disease.

Constantin M, Choi AJ, Cloonan SM, Ryter SW.

Int J Hypertens. 2012;2012:859235. doi: 10.1155/2012/859235. Epub 2012 Feb 1.

31.

Self-assembly of hybrid organic-inorganic polyoxovanadates: functionalised mixed-valent clusters and molecular cages.

Breen JM, Clérac R, Zhang L, Cloonan SM, Kennedy E, Feeney M, McCabe T, Williams DC, Schmitt W.

Dalton Trans. 2012 Mar 14;41(10):2918-26. doi: 10.1039/c2dt11153e. Epub 2012 Jan 23.

PMID:
22266646
32.

Mitochondria: commanders of innate immunity and disease?

Cloonan SM, Choi AM.

Curr Opin Immunol. 2012 Feb;24(1):32-40. doi: 10.1016/j.coi.2011.11.001. Epub 2011 Dec 3. Review.

PMID:
22138315
33.

Luminescent ruthenium(II) polypyridyl functionalized gold nanoparticles; their DNA binding abilities and application as cellular imaging agents.

Elmes RB, Orange KN, Cloonan SM, Williams DC, Gunnlaugsson T.

J Am Chem Soc. 2011 Oct 12;133(40):15862-5. doi: 10.1021/ja2061159. Epub 2011 Sep 20.

PMID:
21923121
34.

Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents.

McNamara YM, Cloonan SM, Knox AJ, Keating JJ, Butler SG, Peters GH, Meegan MJ, Williams DC.

Bioorg Med Chem. 2011 Feb 1;19(3):1328-48. doi: 10.1016/j.bmc.2010.11.054. Epub 2010 Dec 7.

PMID:
21227702
35.

Quaternarized pdppz: synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation.

Elmes RB, Erby M, Cloonan SM, Quinn SJ, Williams DC, Gunnlaugsson T.

Chem Commun (Camb). 2011 Jan 14;47(2):686-8. doi: 10.1039/c0cc04303f. Epub 2010 Nov 22.

PMID:
21103542
36.

Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells.

Nathwani SM, Cloonan SM, Stronach M, Campiani G, Lawler M, Williams DC, Zisterer DM.

Oncol Rep. 2010 Dec;24(6):1499-507.

PMID:
21042745
37.

The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma.

Cloonan SM, Williams DC.

Int J Cancer. 2011 Apr 1;128(7):1712-23. doi: 10.1002/ijc.25477. Epub 2010 May 25.

38.

Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulfur substituted alpha-alkylthioamphetamines.

Cloonan SM, Keating JJ, Corrigan D, O'Brien JE, Kavanagh PV, Williams DC, Meegan MJ.

Bioorg Med Chem. 2010 Jun 1;18(11):4009-31. doi: 10.1016/j.bmc.2010.04.022. Epub 2010 Apr 13.

PMID:
20466553
39.
40.

Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents.

Cloonan SM, Keating JJ, Butler SG, Knox AJ, Jørgensen AM, Peters GH, Rai D, Corrigan D, Lloyd DG, Williams DC, Meegan MJ.

Eur J Med Chem. 2009 Dec;44(12):4862-88. doi: 10.1016/j.ejmech.2009.07.027. Epub 2009 Aug 6.

PMID:
19717215
41.

Synthesis, structural characterisation and biological evaluation of fluorinated analogues of resveratrol.

Moran BW, Anderson FP, Devery A, Cloonan S, Butler WE, Varughese S, Draper SM, Kenny PT.

Bioorg Med Chem. 2009 Jul 1;17(13):4510-22. doi: 10.1016/j.bmc.2009.05.007. Epub 2009 May 8.

PMID:
19481462
42.

Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines.

Mulligan JM, Greene LM, Cloonan S, Mc Gee MM, Onnis V, Campiani G, Fattorusso C, Lawler M, Williams DC, Zisterer DM.

Mol Pharmacol. 2006 Jul;70(1):60-70. Epub 2006 Mar 29.

PMID:
16571652

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