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Items: 1 to 50 of 57


Oxidative metabolism alterations in the emotional brain of anxiety-prone rats.

McCoy CR, Sabbagh MN, Huaman JP, Pickrell AM, Clinton SM.

Prog Neuropsychopharmacol Biol Psychiatry. 2019 Dec 20;95:109706. doi: 10.1016/j.pnpbp.2019.109706. Epub 2019 Jul 19.


Rats bred for high anxiety exhibit distinct fear-related coping behavior, hippocampal physiology, and synaptic plasticity-related gene expression.

Widman AJ, Cohen JL, McCoy CR, Unroe KA, Glover ME, Khan AU, Bredemann T, McMahon LL, Clinton SM.

Hippocampus. 2019 Oct;29(10):939-956. doi: 10.1002/hipo.23092. Epub 2019 Apr 17.


Altered DNA Methylation in the Developing Brains of Rats Genetically Prone to High versus Low Anxiety.

McCoy CR, Glover ME, Flynn LT, Simmons RK, Cohen JL, Ptacek T, Lefkowitz EJ, Jackson NL, Akil H, Wu X, Clinton SM.

J Neurosci. 2019 Apr 17;39(16):3144-3158. doi: 10.1523/JNEUROSCI.1157-15.2019. Epub 2019 Jan 25.


Perinatal exposure to the SSRI paroxetine alters the methylome landscape of the developing dentate gyrus.

Glover ME, McCoy CR, Shupe EA, Unroe KA, Jackson NL, Clinton SM.

Eur J Neurosci. 2019 Jul;50(2):1843-1870. doi: 10.1111/ejn.14315. Epub 2019 Jan 28.


Distinct effects of early-life experience and trait aggression on cardiovascular reactivity and recovery.

Rana S, Pugh PC, Wyss JM, Clinton SM, Kerman IA.

Physiol Behav. 2019 Feb 1;199:375-385. doi: 10.1016/j.physbeh.2018.12.005. Epub 2018 Dec 4.


A paternal methyl donor depleted diet leads to increased anxiety- and depression-like behavior in adult rat offspring.

McCoy CR, Jackson NL, Brewer RL, Moughnyeh MM, Smith DL Jr, Clinton SM.

Biosci Rep. 2018 Jul 6;38(4). pii: BSR20180730. doi: 10.1042/BSR20180730. Print 2018 Aug 31.


Potential impacts of hypoxia and a warming ocean on oyster microbiomes.

Khan B, Clinton SM, Hamp TJ, Oliver JD, Ringwood AH.

Mar Environ Res. 2018 Aug;139:27-34. doi: 10.1016/j.marenvres.2018.04.018. Epub 2018 May 2. No abstract available.


Promoting professional identity, motivation, and persistence: Benefits of an informal mentoring program for female undergraduate students.

Hernandez PR, Bloodhart B, Barnes RT, Adams AS, Clinton SM, Pollack I, Godfrey E, Burt M, Fischer EV.

PLoS One. 2017 Nov 1;12(11):e0187531. doi: 10.1371/journal.pone.0187531. eCollection 2017.


Amygdalar expression of the microRNA miR-101a and its target Ezh2 contribute to rodent anxiety-like behaviour.

Cohen JL, Jackson NL, Ballestas ME, Webb WM, Lubin FD, Clinton SM.

Eur J Neurosci. 2017 Oct;46(7):2241-2252. doi: 10.1111/ejn.13624. Epub 2017 Jul 6.


Genetic predisposition to high anxiety- and depression-like behavior coincides with diminished DNA methylation in the adult rat amygdala.

McCoy CR, Jackson NL, Day J, Clinton SM.

Behav Brain Res. 2017 Mar 1;320:165-178. doi: 10.1016/j.bbr.2016.12.008. Epub 2016 Dec 11.


Characterizing the Effects of Stormwater Mitigation on Nutrient Export and Stream Concentrations.

Bell CD, McMillan SK, Clinton SM, Jefferson AJ.

Environ Manage. 2017 Apr;59(4):604-618. doi: 10.1007/s00267-016-0801-4. Epub 2016 Dec 8.


Differential stress induced c-Fos expression and identification of region-specific miRNA-mRNA networks in the dorsal raphe and amygdala of high-responder/low-responder rats.

Cohen JL, Ata AE, Jackson NL, Rahn EJ, Ramaker RC, Cooper S, Kerman IA, Clinton SM.

Behav Brain Res. 2017 Feb 15;319:110-123. doi: 10.1016/j.bbr.2016.11.015. Epub 2016 Nov 16.


Neonatal maternal separation stress elicits lasting DNA methylation changes in the hippocampus of stress-reactive Wistar Kyoto rats.

McCoy CR, Rana S, Stringfellow SA, Day JJ, Wyss JM, Clinton SM, Kerman IA.

Eur J Neurosci. 2016 Nov;44(10):2829-2845. doi: 10.1111/ejn.13404. Epub 2016 Oct 16.


Independent effects of early-life experience and trait aggression on cardiovascular function.

Rana S, Pugh PC, Katz E, Stringfellow SA, Lin CP, Wyss JM, Stauss HM, White CR, Clinton SM, Kerman IA.

Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R272-86. doi: 10.1152/ajpregu.00505.2015. Epub 2016 Jun 8.


Of rodents and humans: A comparative review of the neurobehavioral effects of early life SSRI exposure in preclinical and clinical research.

Glover ME, Clinton SM.

Int J Dev Neurosci. 2016 Jun;51:50-72. doi: 10.1016/j.ijdevneu.2016.04.008. Epub 2016 May 7. Review.


Genetic background and epigenetic modifications in the core of the nucleus accumbens predict addiction-like behavior in a rat model.

Flagel SB, Chaudhury S, Waselus M, Kelly R, Sewani S, Clinton SM, Thompson RC, Watson SJ Jr, Akil H.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):E2861-70. doi: 10.1073/pnas.1520491113. Epub 2016 Apr 25.


Altered metabolic activity in the developing brain of rats predisposed to high versus low depression-like behavior.

McCoy CR, Golf SR, Melendez-Ferro M, Perez-Costas E, Glover ME, Jackson NL, Stringfellow SA, Pugh PC, Fant AD, Clinton SM.

Neuroscience. 2016 Jun 2;324:469-484. doi: 10.1016/j.neuroscience.2016.03.014. Epub 2016 Mar 12.


Protective effects of chronic mild stress during adolescence in the low-novelty responder rat.

Rana S, Nam H, Glover ME, Akil H, Watson SJ, Clinton SM, Kerman IA.

Stress. 2016;19(1):133-8. doi: 10.3109/10253890.2015.1108304. Epub 2015 Nov 20.


Maternal Style Selectively Shapes Amygdalar Development and Social Behavior in Rats Genetically Prone to High Anxiety.

Cohen JL, Glover ME, Pugh PC, Fant AD, Simmons RK, Akil H, Kerman IA, Clinton SM.

Dev Neurosci. 2015;37(3):203-14. doi: 10.1159/000374108. Epub 2015 Mar 17.


Inborn stress reactivity shapes adult behavioral consequences of early-life maternal separation stress.

Rana S, Pugh PC, Jackson N, Clinton SM, Kerman IA.

Neurosci Lett. 2015 Jan 1;584:146-50. doi: 10.1016/j.neulet.2014.10.011. Epub 2014 Oct 16.


Early-life exposure to the SSRI paroxetine exacerbates depression-like behavior in anxiety/depression-prone rats.

Glover ME, Pugh PC, Jackson NL, Cohen JL, Fant AD, Akil H, Clinton SM.

Neuroscience. 2015 Jan 22;284:775-97. doi: 10.1016/j.neuroscience.2014.10.044. Epub 2014 Nov 4.


Learned helplessness and social avoidance in the Wistar-Kyoto rat.

Nam H, Clinton SM, Jackson NL, Kerman IA.

Front Behav Neurosci. 2014 Apr 1;8:109. doi: 10.3389/fnbeh.2014.00109. eCollection 2014.


O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses.

Taylor EW, Wang K, Nelson AR, Bredemann TM, Fraser KB, Clinton SM, Puckett R, Marchase RB, Chatham JC, McMahon LL.

J Neurosci. 2014 Jan 1;34(1):10-21. doi: 10.1523/JNEUROSCI.4761-12.2014.


High novelty-seeking rats are resilient to negative physiological effects of the early life stress.

Clinton SM, Watson SJ, Akil H.

Stress. 2014 Jan;17(1):97-107. doi: 10.3109/10253890.2013.850670. Epub 2013 Nov 6.


DNA methylation markers in the postnatal developing rat brain.

Simmons RK, Stringfellow SA, Glover ME, Wagle AA, Clinton SM.

Brain Res. 2013 Oct 2;1533:26-36. doi: 10.1016/j.brainres.2013.08.005. Epub 2013 Aug 14.


Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood.

Clinton SM, Glover ME, Maltare A, Laszczyk AM, Mehi SJ, Simmons RK, King GD.

Brain Res. 2013 Aug 21;1527:1-14. doi: 10.1016/j.brainres.2013.06.044. Epub 2013 Jul 6.


Antecedents and consequences of drug abuse in rats selectively bred for high and low response to novelty.

Flagel SB, Waselus M, Clinton SM, Watson SJ, Akil H.

Neuropharmacology. 2014 Jan;76 Pt B:425-36. doi: 10.1016/j.neuropharm.2013.04.033. Epub 2013 Apr 29. Review.


Male rats that differ in novelty exploration demonstrate distinct patterns of sexual behavior.

Cummings JA, Clinton SM, Perry AN, Akil H, Becker JB.

Behav Neurosci. 2013 Feb;127(1):47-58. doi: 10.1037/a0031528.


Neonatal fibroblast growth factor treatment enhances cocaine sensitization.

Clinton SM, Turner CA, Flagel SB, Simpson DN, Watson SJ, Akil H.

Pharmacol Biochem Behav. 2012 Nov;103(1):6-17.


DNA methylation in the developing hippocampus and amygdala of anxiety-prone versus risk-taking rats.

Simmons RK, Howard JL, Simpson DN, Akil H, Clinton SM.

Dev Neurosci. 2012;34(1):58-67. doi: 10.1159/000336641. Epub 2012 May 8.


The melanin-concentrating hormone (MCH) system in an animal model of depression-like behavior.

García-Fuster MJ, Parks GS, Clinton SM, Watson SJ, Akil H, Civelli O.

Eur Neuropsychopharmacol. 2012 Aug;22(8):607-13. doi: 10.1016/j.euroneuro.2011.12.001. Epub 2011 Dec 29.


Pattern of forebrain activation in high novelty-seeking rats following aggressive encounter.

Clinton SM, Kerman IA, Orr HR, Bedrosian TA, Abraham AD, Simpson DN, Watson SJ, Akil H.

Brain Res. 2011 Nov 8;1422:20-31. doi: 10.1016/j.brainres.2011.08.033. Epub 2011 Aug 19.


High novelty-seeking predicts aggression and gene expression differences within defined serotonergic cell groups.

Kerman IA, Clinton SM, Bedrosian TA, Abraham AD, Rosenthal DT, Akil H, Watson SJ.

Brain Res. 2011 Oct 24;1419:34-45. doi: 10.1016/j.brainres.2011.08.038. Epub 2011 Aug 22.


Developmental underpinnings of differences in rodent novelty-seeking and emotional reactivity.

Clinton SM, Stead JD, Miller S, Watson SJ, Akil H.

Eur J Neurosci. 2011 Sep;34(6):994-1005. doi: 10.1111/j.1460-9568.2011.07811.x. Epub 2011 Aug 22.


Inborn differences in environmental reactivity predict divergent diurnal behavioral, endocrine, and gene expression rhythms.

Kerman IA, Clinton SM, Simpson DN, Bedrosian TA, Bernard R, Akil H, Watson SJ.

Psychoneuroendocrinology. 2012 Feb;37(2):256-69. doi: 10.1016/j.psyneuen.2011.06.010. Epub 2011 Jul 20.


Fibroblast growth factor-2 (FGF2) augmentation early in life alters hippocampal development and rescues the anxiety phenotype in vulnerable animals.

Turner CA, Clinton SM, Thompson RC, Watson SJ Jr, Akil H.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):8021-5. doi: 10.1073/pnas.1103732108. Epub 2011 Apr 25.


Effects of a selectively bred novelty-seeking phenotype on the motivation to take cocaine in male and female rats.

Cummings JA, Gowl BA, Westenbroek C, Clinton SM, Akil H, Becker JB.

Biol Sex Differ. 2011 Mar 11;2:3. doi: 10.1186/2042-6410-2-3.


Novelty-seeking behavior predicts vulnerability in a rodent model of depression.

Stedenfeld KA, Clinton SM, Kerman IA, Akil H, Watson SJ, Sved AF.

Physiol Behav. 2011 May 3;103(2):210-6. doi: 10.1016/j.physbeh.2011.02.001. Epub 2011 Feb 12.


A selective role for dopamine in stimulus-reward learning.

Flagel SB, Clark JJ, Robinson TE, Mayo L, Czuj A, Willuhn I, Akers CA, Clinton SM, Phillips PE, Akil H.

Nature. 2011 Jan 6;469(7328):53-7. doi: 10.1038/nature09588. Epub 2010 Dec 8.


Neural and environmental factors impacting maternal behavior differences in high- versus low-novelty-seeking rats.

Clinton SM, Bedrosian TA, Abraham AD, Watson SJ, Akil H.

Horm Behav. 2010 Apr;57(4-5):463-73. doi: 10.1016/j.yhbeh.2010.02.004. Epub 2010 Feb 13.


Impact of cocaine on adult hippocampal neurogenesis in an animal model of differential propensity to drug abuse.

García-Fuster MJ, Perez JA, Clinton SM, Watson SJ, Akil H.

Eur J Neurosci. 2010 Jan;31(1):79-89.


An animal model of genetic vulnerability to behavioral disinhibition and responsiveness to reward-related cues: implications for addiction.

Flagel SB, Robinson TE, Clark JJ, Clinton SM, Watson SJ, Seeman P, Phillips PE, Akil H.

Neuropsychopharmacology. 2010 Jan;35(2):388-400. doi: 10.1038/npp.2009.142.


A new role for FGF2 as an endogenous inhibitor of anxiety.

Perez JA, Clinton SM, Turner CA, Watson SJ, Akil H.

J Neurosci. 2009 May 13;29(19):6379-87. doi: 10.1523/JNEUROSCI.4829-08.2009.


Molecular diversity of a North Carolina wastewater treatment plant as revealed by pyrosequencing.

Sanapareddy N, Hamp TJ, Gonzalez LC, Hilger HA, Fodor AA, Clinton SM.

Appl Environ Microbiol. 2009 Mar;75(6):1688-96. doi: 10.1128/AEM.01210-08. Epub 2008 Dec 29.


Neonatal FGF2 alters cocaine self-administration in the adult rat.

Turner CA, Capriles N, Flagel SB, Perez JA, Clinton SM, Watson SJ, Akil H.

Pharmacol Biochem Behav. 2009 Mar;92(1):100-4. doi: 10.1016/j.pbb.2008.10.018. Epub 2008 Nov 5.


Cocaine interacts with the novelty-seeking trait to modulate FGFR1 gene expression in the rat.

Turner CA, Flagel SB, Clinton SM, Akil H, Watson SJ.

Neurosci Lett. 2008 Dec 3;446(2-3):105-7. doi: 10.1016/j.neulet.2008.09.037.


Effect of cocaine on Fas-associated protein with death domain in the rat brain: individual differences in a model of differential vulnerability to drug abuse.

García-Fuster MJ, Clinton SM, Watson SJ, Akil H.

Neuropsychopharmacology. 2009 Apr;34(5):1123-34. doi: 10.1038/npp.2008.88. Epub 2008 Jun 25.


The effects of novelty-seeking phenotypes and sex differences on acquisition of cocaine self-administration in selectively bred High-Responder and Low-Responder rats.

Davis BA, Clinton SM, Akil H, Becker JB.

Pharmacol Biochem Behav. 2008 Sep;90(3):331-8. doi: 10.1016/j.pbb.2008.03.008. Epub 2008 Mar 25.


Individual differences in novelty-seeking and emotional reactivity correlate with variation in maternal behavior.

Clinton SM, Vázquez DM, Kabbaj M, Kabbaj MH, Watson SJ, Akil H.

Horm Behav. 2007 May;51(5):655-64. Epub 2007 Mar 27.


Up-regulation of NMDA receptor subunit and post-synaptic density protein expression in the thalamus of elderly patients with schizophrenia.

Clinton SM, Haroutunian V, Meador-Woodruff JH.

J Neurochem. 2006 Aug;98(4):1114-25. Epub 2006 Jun 6.

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