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Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance.

Flores A, Argetsinger LS, Stadler LKJ, Malaga AE, Vander PB, DeSantis LC, Joe RM, Cline JM, Keogh JM, Henning E, Barroso I, Mendes de Oliveira E, Chandrashekar G, Clutter ES, Hu Y, Stuckey J, Farooqi IS, Myers MG Jr, Carter-Su C.

Diabetes. 2019 Aug 22. pii: db190608. doi: 10.2337/db19-0608. [Epub ahead of print]


Co-administering Melatonin With an Estradiol-Progesterone Menopausal Hormone Therapy Represses Mammary Cancer Development in a Mouse Model of HER2-Positive Breast Cancer.

Dodda BR, Bondi CD, Hasan M, Clafshenkel WP, Gallagher KM, Kotlarczyk MP, Sethi S, Buszko E, Latimer JJ, Cline JM, Witt-Enderby PA, Davis VL.

Front Oncol. 2019 Jul 9;9:525. doi: 10.3389/fonc.2019.00525. eCollection 2019.


Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.

Claus C, Ferrara C, Xu W, Sam J, Lang S, Uhlenbrock F, Albrecht R, Herter S, Schlenker R, Hüsser T, Diggelmann S, Challier J, Mössner E, Hosse RJ, Hofer T, Brünker P, Joseph C, Benz J, Ringler P, Stahlberg H, Lauer M, Perro M, Chen S, Küttel C, Bhavani Mohan PL, Nicolini V, Birk MC, Ongaro A, Prince C, Gianotti R, Dugan G, Whitlow CT, Solingapuram Sai KK, Caudell DL, Burgos-Rodriguez AG, Cline JM, Hettich M, Ceppi M, Giusti AM, Crameri F, Driessen W, Morcos PN, Freimoser-Grundschober A, Levitsky V, Amann M, Grau-Richards S, von Hirschheydt T, Tournaviti S, Mølhøj M, Fauti T, Heinzelmann-Schwarz V, Teichgräber V, Colombetti S, Bacac M, Zippelius A, Klein C, Umaña P.

Sci Transl Med. 2019 Jun 12;11(496). pii: eaav5989. doi: 10.1126/scitranslmed.aav5989.


Monocyte Polarization is Altered by Total-Body Irradiation in Male Rhesus Macaques: Implications for Delayed Effects of Acute Radiation Exposure.

Michalson KT, Macintyre AN, Sempowski GD, Bourland JD, Howard TD, Hawkins GA, Dugan GO, Cline JM, Register TC.

Radiat Res. 2019 Aug;192(2):121-134. doi: 10.1667/RR15310.1. Epub 2019 Jun 4.


Transcriptional Profiling of Non-Human Primate Lymphoid Organ Responses to Total-Body Irradiation.

Caudell DL, Michalson KT, Andrews RN, Snow WW, Bourland JD, DeBo RJ, Cline JM, Sempowski GD, Register TC.

Radiat Res. 2019 Jul;192(1):40-52. doi: 10.1667/RR15100.1. Epub 2019 May 6.


Late effects of total body irradiation on hematopoietic recovery and immune function in rhesus macaques.

Hale LP, Rajam G, Carlone GM, Jiang C, Owzar K, Dugan G, Caudell D, Chao N, Cline JM, Register TC, Sempowski GD.

PLoS One. 2019 Feb 13;14(2):e0210663. doi: 10.1371/journal.pone.0210663. eCollection 2019.


Estradiol Treatment Initiated Early After Ovariectomy Regulates Myocardial Gene Expression and Inhibits Diastolic Dysfunction in Female Cynomolgus Monkeys: Potential Roles for Calcium Homeostasis and Extracellular Matrix Remodeling.

Michalson KT, Groban L, Howard TD, Shively CA, Sophonsritsuk A, Appt SE, Cline JM, Clarkson TB, Carr JJ, Kitzman DW, Register TC.

J Am Heart Assoc. 2018 Nov 6;7(21):e009769. doi: 10.1161/JAHA.118.009769.


IL-1β Stimulates Brain-Derived Neurotrophic Factor Production in Eutopic Endometriosis Stromal Cell Cultures: A Model for Cytokine Regulation of Neuroangiogenesis.

Yu J, Francisco AMC, Patel BG, Cline JM, Zou E, Berga SL, Taylor RN.

Am J Pathol. 2018 Oct;188(10):2281-2292. doi: 10.1016/j.ajpath.2018.06.011. Epub 2018 Jul 20.


Fibronectin Produced by Cerebral Endothelial and Vascular Smooth Muscle Cells Contributes to Perivascular Extracellular Matrix in Late-Delayed Radiation-Induced Brain Injury.

Andrews RN, Caudell DL, Metheny-Barlow LJ, Peiffer AM, Tooze JA, Bourland JD, Hampson RE, Deadwyler SA, Cline JM.

Radiat Res. 2018 Oct;190(4):361-373. doi: 10.1667/RR14961.1. Epub 2018 Jul 17.


Cortical Thinning and Structural Bone Changes in Non-Human Primates after Single-Fraction Whole-Chest Irradiation.

Farris M, McTyre ER, Okoukoni C, Dugan G, Johnson BJ, Blackstock AW, Munley MT, Bourland JD, Cline JM, Willey JS.

Radiat Res. 2018 Jul;190(1):63-71. doi: 10.1667/RR15007.1. Epub 2018 May 8.


Labyrinthitis Ossificans in a Cynomolgus Macaque (Macaca fascicularis).

Balamayooran G, Atkins HM, Whitlow CT, Aycock ST, Nader MA, Cline JM, Caudell DL.

Comp Med. 2018 Apr 12. doi: 10.30802/AALAS-CM-17-000070. [Epub ahead of print]


Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation.

Cline JM, Dugan G, Bourland JD, Perry DL, Stitzel JD, Weaver AA, Jiang C, Tovmasyan A, Owzar K, Spasojevic I, Batinic-Haberle I, Vujaskovic Z.

Antioxidants (Basel). 2018 Mar 7;7(3). pii: E40. doi: 10.3390/antiox7030040.


Is electroweak baryogenesis dead?

Cline JM.

Philos Trans A Math Phys Eng Sci. 2018 Mar 6;376(2114). pii: 20170116. doi: 10.1098/rsta.2017.0116. Review.


Whole thorax irradiation of non-human primates induces persistent nuclear damage and gene expression changes in peripheral blood cells.

Ghandhi SA, Turner HC, Shuryak I, Dugan GO, Bourland JD, Olson JD, Tooze JA, Morton SR, Batinic-Haberle I, Cline JM, Amundson SA.

PLoS One. 2018 Jan 19;13(1):e0191402. doi: 10.1371/journal.pone.0191402. eCollection 2018.


Phosphorylation of the Unique C-Terminal Tail of the Alpha Isoform of the Scaffold Protein SH2B1 Controls the Ability of SH2B1α To Enhance Nerve Growth Factor Function.

Joe RM, Flores A, Doche ME, Cline JM, Clutter ES, Vander PB, Riedel H, Argetsinger LS, Carter-Su C.

Mol Cell Biol. 2018 Feb 27;38(6). pii: e00277-17. doi: 10.1128/MCB.00277-17. Print 2018 Mar 15.


Changes in microvascular density differentiate metabolic health outcomes in monkeys with prior radiation exposure and subsequent skeletal muscle ECM remodeling.

Fanning KM, Pfisterer B, Davis AT, Presley TD, Williams IM, Wasserman DH, Cline JM, Kavanagh K.

Am J Physiol Regul Integr Comp Physiol. 2017 Sep 1;313(3):R290-R297. doi: 10.1152/ajpregu.00108.2017. Epub 2017 Jul 12.


Cerebrovascular Remodeling and Neuroinflammation is a Late Effect of Radiation-Induced Brain Injury in Non-Human Primates.

Andrews RN, Metheny-Barlow LJ, Peiffer AM, Hanbury DB, Tooze JA, Bourland JD, Hampson RE, Deadwyler SA, Cline JM.

Radiat Res. 2017 May;187(5):599-611. doi: 10.1667/RR14616.1. Epub 2017 Mar 6.


Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys.

Kiguchi N, Ding H, Peters CM, Kock ND, Kishioka S, Cline JM, Wagner JD, Ko MC.

Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863(1):274-283. doi: 10.1016/j.bbadis.2016.10.007. Epub 2016 Oct 14.


Long-Term Cognitive Functioning in Single-Dose Total-Body Gamma-Irradiated Rhesus Monkeys ( Macaca mulatta ).

Hanbury DB, Peiffer AM, Dugan G, Andrews RN, Cline JM.

Radiat Res. 2016 Nov;186(5):447-454. Epub 2016 Oct 14.


Uvulopalatopharyngoplasty: Does Multilevel Surgery Increase Risk?

Baker AB, Xiao CC, O'Connell BP, Cline JM, Gillespie MB.

Otolaryngol Head Neck Surg. 2016 Dec;155(6):1053-1058. Epub 2016 Aug 23.


Late Effects of Total-Body Gamma Irradiation on Cardiac Structure and Function in Male Rhesus Macaques.

DeBo RJ, Lees CJ, Dugan GO, Caudell DL, Michalson KT, Hanbury DB, Kavanagh K, Cline JM, Register TC.

Radiat Res. 2016 Jul;186(1):55-64. doi: 10.1667/RR14357.1. Epub 2016 Jun 22.


Decidualization of Endometriosis in Macaques.

Atkins HM, Lombardini ED, Caudell DL, Appt SE, Dubois A, Cline JM.

Vet Pathol. 2016 Nov;53(6):1252-1258. Epub 2016 Jun 8.


U.S. Medical Support in a Developing World Health System - a Partnership Made in Africa for a "New Normal" Strategy.

Cline JM, Obuseh FA, Butler D.

Mil Med. 2016 Apr;181(4):294-6. doi: 10.7205/MILMED-D-15-00413. No abstract available.


Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques.

Dewi FN, Wood CE, Willson CJ, Register TC, Lees CJ, Howard TD, Huang Z, Murphy SK, Tooze JA, Chou JW, Miller LD, Cline JM.

Cancer Prev Res (Phila). 2016 May;9(5):385-95. doi: 10.1158/1940-6207.CAPR-15-0165. Epub 2016 Mar 22.


Hormone Receptor Expression in Spontaneous Uterine Adenocarcinoma in Fischer 344 Rats.

Willson CJ, Herbert RA, Cline JM.

Toxicol Pathol. 2015 Aug;43(6):865-71. doi: 10.1177/0192623315591839. Epub 2015 Jul 7.


Comparison of a ferret model with an inanimate simulator for training novices in techniques for intubating neonates.

Grayson JK, Shinn AM, Potts MV, Hatzfeld JJ, Cline JM.

J Am Assoc Lab Anim Sci. 2015 May;54(3):286-90.


Type 2 Diabetes is a Delayed Late Effect of Whole-Body Irradiation in Nonhuman Primates.

Kavanagh K, Dendinger MD, Davis AT, Register TC, DeBo R, Dugan G, Cline JM.

Radiat Res. 2015 Apr;183(4):398-406. doi: 10.1667/RR13916.1. Epub 2015 Mar 26.


Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques.

DeBo RJ, Register TC, Caudell DL, Sempowski GD, Dugan G, Gray S, Owzar K, Jiang C, Bourland JD, Chao NJ, Cline JM.

Int J Radiat Biol. 2015 Jun;91(6):510-8. doi: 10.3109/09553002.2015.1028597. Epub 2015 Apr 22.


Novel In Vivo model for combinatorial fluorescence labeling in mouse prostate.

Fang X, Gyabaah K, Nickkholgh B, Cline JM, Balaji KC.

Prostate. 2015 Jun 15;75(9):988-1000. doi: 10.1002/pros.22984. Epub 2015 Mar 8.


Pathology of fractionated whole-brain irradiation in rhesus monkeys ( Macaca mulatta ).

Hanbury DB, Robbins ME, Bourland JD, Wheeler KT, Peiffer AM, Mitchell EL, Daunais JB, Deadwyler SA, Cline JM.

Radiat Res. 2015 Mar;183(3):367-74. doi: 10.1667/RR13898.1. Epub 2015 Feb 17.


The dose-effect safety profile of skeletal muscle precursor cell therapy in a dog model of intrinsic urinary sphincter deficiency.

Williams JK, Eckman D, Dean A, Moradi M, Allickson J, Cline JM, Yoo JJ, Atala A.

Stem Cells Transl Med. 2015 Mar;4(3):286-94. doi: 10.5966/sctm.2014-0114. Epub 2015 Jan 30.


Assessment of Multiplate platelet aggregometry using citrate, heparin or hirudin in Rhesus macaques.

Dugan G, O'Donnell L, Hanbury DB, Cline JM, Caudell DL.

Platelets. 2015;26(8):730-5. doi: 10.3109/09537104.2014.988694. Epub 2014 Dec 30.


DMP1β, a splice isoform of the tumour suppressor DMP1 locus, induces proliferation and progression of breast cancer.

Maglic D, Stovall DB, Cline JM, Fry EA, Mallakin A, Taneja P, Caudell DL, Willingham MC, Sui G, Inoue K.

J Pathol. 2015 May;236(1):90-102. doi: 10.1002/path.4504. Epub 2015 Feb 9.


Comparison of the rotation-advancement and philtral ridge techniques for unilateral cleft lip repair.

Cline JM, Oyer SL, Javidnia H, Nguyen SA, Sykes JM, Kline RM, Patel KG.

Plast Reconstr Surg. 2014 Dec;134(6):1269-78. doi: 10.1097/PRS.0000000000000723.


Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1.

Pearce LR, Joe R, Doche ME, Su HW, Keogh JM, Henning E, Argetsinger LS, Bochukova EG, Cline JM, Garg S, Saeed S, Shoelson S, O'Rahilly S, Barroso I, Rui L, Farooqi IS, Carter-Su C.

Endocrinology. 2014 Sep;155(9):3219-26. doi: 10.1210/en.2014-1264. Epub 2014 Jun 27.


Tamoxifen-DNA adduct formation in monkey and human reproductive organs.

Hernandez-Ramon EE, Sandoval NA, John K, Cline JM, Wood CE, Woodward RA, Poirier MC.

Carcinogenesis. 2014 May;35(5):1172-6. doi: 10.1093/carcin/bgu029. Epub 2014 Feb 5.


Characterization of facial paresis in hemifacial microsomia.

Cline JM, Hicks KE, Patel KG.

Otolaryngol Head Neck Surg. 2014 Feb;150(2):188-93. doi: 10.1177/0194599813512775. Epub 2013 Nov 18. Review.


Targeted deletion of RasGRP1 impairs skin tumorigenesis.

Sharma A, Fonseca LL, Rajani C, Yanagida JK, Endo Y, Cline JM, Stone JC, Ji J, Ramos JW, Lorenzo PS.

Carcinogenesis. 2014 May;35(5):1084-91. doi: 10.1093/carcin/bgu016. Epub 2014 Jan 24.


Progestin effects on cell proliferation pathways in the postmenopausal mammary gland.

Wood CE, Branstetter D, Jacob AP, Cline JM, Register TC, Rohrbach K, Huang LY, Borgerink H, Dougall WC.

Breast Cancer Res. 2013;15(4):R62.


The effects of adenocaine (adenosine and lidocaine) on early post-resuscitation cardiac and neurological dysfunction in a porcine model of cardiac arrest.

Granfeldt A, Shi W, Schmarkey SL, Jiang R, Bone CC, Cline JM, Wogensen L, Dobson GP, Tønnesen E, Vinten-Johansen J.

Resuscitation. 2013 Nov;84(11):1611-8. doi: 10.1016/j.resuscitation.2013.07.001. Epub 2013 Jul 11.


Do variations in mast cell hyperplasia account for differences in radiation-induced lung injury among different mouse strains, rats and nonhuman primates?

Down JD, Medhora M, Jackson IL, Cline JM, Vujaskovic Z.

Radiat Res. 2013 Aug;180(2):216-21. doi: 10.1667/RR3245.1. Epub 2013 Jul 2.


Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model.

Ethun KF, Wood CE, Cline JM, Register TC, Appt SE, Clarkson TB.

Menopause. 2013 Jul;20(7):777-84. doi: 10.1097/GME.0b013e31827ce57a.


Dietary soy effects on mammary gland development during the pubertal transition in nonhuman primates.

Dewi FN, Wood CE, Lees CJ, Willson CJ, Register TC, Tooze JA, Franke AA, Cline JM.

Cancer Prev Res (Phila). 2013 Aug;6(8):832-42. doi: 10.1158/1940-6207.CAPR-13-0128. Epub 2013 Jun 14.


The placenta in toxicology. Part I: Animal models in toxicology: placental morphology and tolerance molecules in the cynomolgus monkey (Macaca fascicularis).

Buse E, Häeger JD, Svensson-Arvelund J, Markert UR, Faas MM, Ernerudh J, Dixon D, Cline JM, Pfarrer C.

Toxicol Pathol. 2014;42(2):314-26. doi: 10.1177/0192623313482208. Epub 2013 Apr 2. Review.


The placenta in toxicology. Part IV: Battery of toxicological test systems based on human placenta.

Göhner C, Svensson-Arvelund J, Pfarrer C, Häger JD, Faas M, Ernerudh J, Cline JM, Dixon D, Buse E, Markert UR.

Toxicol Pathol. 2014;42(2):345-51. doi: 10.1177/0192623313482206. Epub 2013 Apr 2. Review.


The placenta in toxicology. Part II: Systemic and local immune adaptations in pregnancy.

Svensson-Arvelund J, Ernerudh J, Buse E, Cline JM, Haeger JD, Dixon D, Markert UR, Pfarrer C, De Vos P, Faas MM.

Toxicol Pathol. 2014;42(2):327-38. doi: 10.1177/0192623313482205. Epub 2013 Mar 26. Review.


The placenta in toxicology. Part III: Pathologic assessment of the placenta.

Cline JM, Dixon D, Ernerudh J, Faas MM, Göhner C, Häger JD, Markert UR, Pfarrer C, Svensson-Arvelund J, Buse E.

Toxicol Pathol. 2014;42(2):339-44. doi: 10.1177/0192623313482207. Epub 2013 Mar 26. Review.


17-β Estradiol reduces atherosclerosis without exacerbating lupus in ovariectomized systemic lupus erythematosus-susceptible LDLr(-/-) mice.

Shelton KA, Cline JM, Cann JA.

Atherosclerosis. 2013 Apr;227(2):228-35. doi: 10.1016/j.atherosclerosis.2012.12.031. Epub 2013 Jan 18.


Behavioral stress accelerates prostate cancer development in mice.

Hassan S, Karpova Y, Baiz D, Yancey D, Pullikuth A, Flores A, Register T, Cline JM, D'Agostino R Jr, Danial N, Datta SR, Kulik G.

J Clin Invest. 2013 Feb;123(2):874-86. doi: 10.1172/JCI63324. Epub 2013 Jan 25.


Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

Doche ME, Bochukova EG, Su HW, Pearce LR, Keogh JM, Henning E, Cline JM, Saeed S, Dale A, Cheetham T, Barroso I, Argetsinger LS, O'Rahilly S, Rui L, Carter-Su C, Farooqi IS.

J Clin Invest. 2012 Dec;122(12):4732-6. doi: 10.1172/JCI62696. Epub 2012 Nov 19. Erratum in: J Clin Invest. 2013 Jan 2;123(1):526. Saeed, Sadia [added].

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