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PET Imaging of Pancreatic Dopamine D3/D2 receptor density with 11C (+)-PHNO in Type-1 Diabetes Mellitus.

Bini J, Sanchez-Rangel E, Gallezot JD, Naganawa M, Nabulsi NB, Lim K, Nahafzadeh S, Shirali A, Ropchan J, Matuskey D, Huang H, Herold K, Harris PE, Sherwin RS, Carson RE, Cline GW.

J Nucl Med. 2019 Oct 10. pii: jnumed.119.234013. doi: 10.2967/jnumed.119.234013. [Epub ahead of print]


Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates.

Goedeke L, Peng L, Montalvo-Romeral V, Butrico GM, Dufour S, Zhang XM, Perry RJ, Cline GW, Kievit P, Chng K, Petersen KF, Shulman GI.

Sci Transl Med. 2019 Oct 2;11(512). pii: eaay0284. doi: 10.1126/scitranslmed.aay0284.


Adaptive Protein Translation by the Integrated Stress Response Maintains the Proliferative and Migratory Capacity of Lung Adenocarcinoma Cells.

Albert AE, Adua SJ, Cai WL, Arnal-Estapé A, Cline GW, Liu Z, Zhao M, Cao PD, Mariappan M, Nguyen DX.

Mol Cancer Res. 2019 Sep 24. doi: 10.1158/1541-7786.MCR-19-0245. [Epub ahead of print]


Regulation of hepatic mitochondrial oxidation by glucose-alanine cycling during starvation in humans.

Petersen KF, Dufour S, Cline GW, Shulman GI.

J Clin Invest. 2019 Nov 1;129(11):4671-4675. doi: 10.1172/JCI129913.


The effects of increased acetate turnover on glucose-induced insulin secretion in lean and obese humans.

Petersen KF, Impellizeri A, Cline GW, Shulman GI.

J Clin Transl Sci. 2019 Feb;3(1):18-20. doi: 10.1017/cts.2018.342.


Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance.

Camporez JP, Lyu K, Goldberg EL, Zhang D, Cline GW, Jurczak MJ, Dixit VD, Petersen KF, Shulman GI.

J Physiol. 2019 Aug;597(15):3885-3903. doi: 10.1113/JP277270. Epub 2019 Jul 4.


A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology.

Chen H, Nwe PK, Yang Y, Rosen CE, Bielecka AA, Kuchroo M, Cline GW, Kruse AC, Ring AM, Crawford JM, Palm NW.

Cell. 2019 May 16;177(5):1217-1231.e18. doi: 10.1016/j.cell.2019.03.036. Epub 2019 Apr 18.


Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action.

Abulizi A, Camporez JP, Jurczak MJ, Høyer KF, Zhang D, Cline GW, Samuel VT, Shulman GI, Vatner DF.

FASEB J. 2019 Jul;33(7):8174-8185. doi: 10.1096/fj.201802706R. Epub 2019 Mar 28.


A role for foregut tyrosine metabolism in glucose tolerance.

Korner J, Cline GW, Slifstein M, Barba P, Rayat GR, Febres G, Leibel RL, Maffei A, Harris PE.

Mol Metab. 2019 May;23:37-50. doi: 10.1016/j.molmet.2019.02.008. Epub 2019 Feb 27.


Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.

Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI.

Nat Med. 2019 Mar;25(3):526-528. doi: 10.1038/s41591-018-0220-6.


PEPCK1 Antisense Oligonucleotide Prevents Adiposity and Impairs Hepatic Glycogen Synthesis in High-Fat Male Fed Rats.

Beddow SA, Gattu AK, Vatner DF, Paolella L, Alqarzaee A, Tashkandi N, Popov VB, Church CD, Rodeheffer MS, Cline GW, Geisler JG, Bhanot S, Samuel VT.

Endocrinology. 2019 Jan 1;160(1):205-219. doi: 10.1210/en.2018-00630.


Clinical and scientific value in the pursuit of quantification of beta cells in the pancreas by PET imaging.

Cline GW, McCarthy TJ, Carson RE, Calle RA.

Diabetologia. 2018 Dec;61(12):2671-2673. doi: 10.1007/s00125-018-4718-8. Epub 2018 Aug 22. No abstract available.


Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.

Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI.

Nat Med. 2018 Sep;24(9):1384-1394. doi: 10.1038/s41591-018-0125-4. Epub 2018 Jul 23. Erratum in: Nat Med. 2019 Mar;25(3):526-528.


Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents.

Goedeke L, Bates J, Vatner DF, Perry RJ, Wang T, Ramirez R, Li L, Ellis MW, Zhang D, Wong KE, Beysen C, Cline GW, Ray AS, Shulman GI.

Hepatology. 2018 Dec;68(6):2197-2211. doi: 10.1002/hep.30097.


Decreased VMAT2 in the pancreas of humans with type 2 diabetes mellitus measured in vivo by PET imaging.

Cline GW, Naganawa M, Chen L, Chidsey K, Carvajal-Gonzalez S, Pawlak S, Rossulek M, Zhang Y, Bini J, McCarthy TJ, Carson RE, Calle RA.

Diabetologia. 2018 Dec;61(12):2598-2607. doi: 10.1007/s00125-018-4624-0. Epub 2018 May 2.


In vivo studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia.

Qiu Y, Perry RJ, Camporez JG, Zhang XM, Kahn M, Cline GW, Shulman GI, Vatner DF.

Biochem J. 2018 Mar 20;475(6):1063-1074. doi: 10.1042/BCJ20180063.


Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes.

Naganawa M, Lim K, Nabulsi NB, Lin SF, Labaree D, Ropchan J, Herold KC, Huang Y, Harris P, Ichise M, Cline GW, Carson RE.

Mol Imaging Biol. 2018 Oct;20(5):835-845. doi: 10.1007/s11307-018-1170-6.


Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI.

Nat Commun. 2018 Jan 31;9(1):498. doi: 10.1038/s41467-018-03023-3.


Evaluation of PET Brain Radioligands for Imaging Pancreatic β-Cell Mass: Potential Utility of 11C-(+)-PHNO.

Bini J, Naganawa M, Nabulsi N, Huang Y, Ropchan J, Lim K, Najafzadeh S, Herold KC, Cline GW, Carson RE.

J Nucl Med. 2018 Aug;59(8):1249-1254. doi: 10.2967/jnumed.117.197285. Epub 2018 Jan 25.


Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation.

Perry RJ, Wang Y, Cline GW, Rabin-Court A, Song JD, Dufour S, Zhang XM, Petersen KF, Shulman GI.

Cell. 2018 Jan 11;172(1-2):234-248.e17. doi: 10.1016/j.cell.2017.12.001. Epub 2018 Jan 4.


Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes.

Perry RJ, Peng L, Cline GW, Wang Y, Rabin-Court A, Song JD, Zhang D, Zhang XM, Nozaki Y, Dufour S, Petersen KF, Shulman GI.

Cell Metab. 2018 Jan 9;27(1):210-217.e3. doi: 10.1016/j.cmet.2017.10.004. Epub 2017 Nov 9.


Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

Perry RJ, Peng L, Cline GW, Butrico GM, Wang Y, Zhang XM, Rothman DL, Petersen KF, Shulman GI.

Nat Commun. 2017 Oct 6;8(1):798. doi: 10.1038/s41467-017-01143-w. Erratum in: Nat Commun. 2018 Jan 31;9(1):498.


Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages.

Araldi E, Fernández-Fuertes M, Canfrán-Duque A, Tang W, Cline GW, Madrigal-Matute J, Pober JS, Lasunción MA, Wu D, Fernández-Hernando C, Suárez Y.

Cell Rep. 2017 Jun 27;19(13):2743-2755. doi: 10.1016/j.celrep.2017.05.093.


Inter-relations between 3-hydroxypropionate and propionate metabolism in rat liver: relevance to disorders of propionyl-CoA metabolism.

Wilson KA, Han Y, Zhang M, Hess JP, Chapman KA, Cline GW, Tochtrop GP, Brunengraber H, Zhang GF.

Am J Physiol Endocrinol Metab. 2017 Oct 1;313(4):E413-E428. doi: 10.1152/ajpendo.00105.2017. Epub 2017 Jun 20.


Mechanism for leptin's acute insulin-independent effect to reverse diabetic ketoacidosis.

Perry RJ, Peng L, Abulizi A, Kennedy L, Cline GW, Shulman GI.

J Clin Invest. 2017 Feb 1;127(2):657-669. doi: 10.1172/JCI88477. Epub 2017 Jan 23.


A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo.

Perry RJ, Peng L, Cline GW, Petersen KF, Shulman GI.

Cell Metab. 2017 Mar 7;25(3):749-756. doi: 10.1016/j.cmet.2016.12.017. Epub 2017 Jan 19.


Evaluation of pancreatic VMAT2 binding with active and inactive enantiomers of 18F-FP-DTBZ in baboons.

Naganawa M, Lin SF, Lim K, Labaree D, Ropchan J, Harris P, Huang Y, Ichise M, Carson RE, Cline GW.

Nucl Med Biol. 2016 Dec;43(12):743-751. doi: 10.1016/j.nucmedbio.2016.08.018. Epub 2016 Sep 2.


Hypophosphatemia promotes lower rates of muscle ATP synthesis.

Pesta DH, Tsirigotis DN, Befroy DE, Caballero D, Jurczak MJ, Rahimi Y, Cline GW, Dufour S, Birkenfeld AL, Rothman DL, Carpenter TO, Insogna K, Petersen KF, Bergwitz C, Shulman GI.

FASEB J. 2016 Oct;30(10):3378-3387. Epub 2016 Jun 23.


Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome.

Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, Petersen KF, Kibbey RG, Goodman AL, Shulman GI.

Nature. 2016 Jun 9;534(7606):213-7. doi: 10.1038/nature18309.


Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism.

Madiraju AK, Alves T, Zhao X, Cline GW, Zhang D, Bhanot S, Samuel VT, Kibbey RG, Shulman GI.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3423-30. doi: 10.1073/pnas.1606022113. Epub 2016 May 31.


Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice.

Costa DK, Huckestein BR, Edmunds LR, Petersen MC, Nasiri A, Butrico GM, Abulizi A, Harmon DB, Lu C, Mantell BS, Hartman DJ, Camporez JP, O'Doherty RM, Cline GW, Shulman GI, Jurczak MJ.

Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1):E105-16. doi: 10.1152/ajpendo.00042.2016. Epub 2016 May 10.


Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism.

Perry RJ, Borders CB, Cline GW, Zhang XM, Alves TC, Petersen KF, Rothman DL, Kibbey RG, Shulman GI.

J Biol Chem. 2016 Jun 3;291(23):12161-70. doi: 10.1074/jbc.M116.720631. Epub 2016 Mar 21.


Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake.

Haskins JW, Zhang S, Means RE, Kelleher JK, Cline GW, Canfrán-Duque A, Suárez Y, Stern DF.

Sci Signal. 2015 Nov 3;8(401):ra111. doi: 10.1126/scisignal.aac5124.


Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle.

Alves TC, Pongratz RL, Zhao X, Yarborough O, Sereda S, Shirihai O, Cline GW, Mason G, Kibbey RG.

Cell Metab. 2015 Nov 3;22(5):936-47. doi: 10.1016/j.cmet.2015.08.021. Epub 2015 Sep 24.


Effect of aging on muscle mitochondrial substrate utilization in humans.

Petersen KF, Morino K, Alves TC, Kibbey RG, Dufour S, Sono S, Yoo PS, Cline GW, Shulman GI.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11330-4. doi: 10.1073/pnas.1514844112. Epub 2015 Aug 24. Erratum in: Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5762.


Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.

Perry RJ, Camporez JG, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, Birnbaum MJ, Davis RJ, Cline GW, Petersen KF, Shulman GI.

Cell. 2015 Feb 12;160(4):745-758. doi: 10.1016/j.cell.2015.01.012. Epub 2015 Feb 5.


Reply to Constantin-Teodosiu et al.: mice with genetic PDH activation are not protected from high-fat diet-induced muscle insulin resistance.

Petersen MC, Rahimi Y, Camporez JP, Pesta D, Perry RJ, Jurczak MJ, Cline GW, Shulman GI.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):E825. doi: 10.1073/pnas.1423574112. Epub 2015 Jan 23. No abstract available.


Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.

Vatner DF, Majumdar SK, Kumashiro N, Petersen MC, Rahimi Y, Gattu AK, Bears M, Camporez JP, Cline GW, Jurczak MJ, Samuel VT, Shulman GI.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1143-8. doi: 10.1073/pnas.1423952112. Epub 2015 Jan 6.


Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance.

Rahimi Y, Camporez JP, Petersen MC, Pesta D, Perry RJ, Jurczak MJ, Cline GW, Shulman GI.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16508-13. doi: 10.1073/pnas.1419104111. Epub 2014 Nov 3.


Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.

Colegio OR, Chu NQ, Szabo AL, Chu T, Rhebergen AM, Jairam V, Cyrus N, Brokowski CE, Eisenbarth SC, Phillips GM, Cline GW, Phillips AJ, Medzhitov R.

Nature. 2014 Sep 25;513(7519):559-63. doi: 10.1038/nature13490. Epub 2014 Jul 13.


Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis.

Perry RJ, Zhang XM, Zhang D, Kumashiro N, Camporez JP, Cline GW, Rothman DL, Shulman GI.

Nat Med. 2014 Jul;20(7):759-63. doi: 10.1038/nm.3579. Epub 2014 Jun 15.


Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.

Madiraju AK, Erion DM, Rahimi Y, Zhang XM, Braddock DT, Albright RA, Prigaro BJ, Wood JL, Bhanot S, MacDonald MJ, Jurczak MJ, Camporez JP, Lee HY, Cline GW, Samuel VT, Kibbey RG, Shulman GI.

Nature. 2014 Jun 26;510(7506):542-6. doi: 10.1038/nature13270. Epub 2014 May 21.


A role for mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) in the regulation of hepatic gluconeogenesis.

Stark R, Guebre-Egziabher F, Zhao X, Feriod C, Dong J, Alves TC, Ioja S, Pongratz RL, Bhanot S, Roden M, Cline GW, Shulman GI, Kibbey RG.

J Biol Chem. 2014 Mar 14;289(11):7257-63. doi: 10.1074/jbc.C113.544759. Epub 2014 Feb 4.


Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy.

Befroy DE, Perry RJ, Jain N, Dufour S, Cline GW, Trimmer JK, Brosnan J, Rothman DL, Petersen KF, Shulman GI.

Nat Med. 2014 Jan;20(1):98-102. doi: 10.1038/nm.3415. Epub 2013 Dec 8.


Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler.

Perry RJ, Kim T, Zhang XM, Lee HY, Pesta D, Popov VB, Zhang D, Rahimi Y, Jurczak MJ, Cline GW, Spiegel DA, Shulman GI.

Cell Metab. 2013 Nov 5;18(5):740-8. doi: 10.1016/j.cmet.2013.10.004.


A β-peptide agonist of the GLP-1 receptor, a class B GPCR.

Denton EV, Craig CJ, Pongratz RL, Appelbaum JS, Doerner AE, Narayanan A, Shulman GI, Cline GW, Schepartz A.

Org Lett. 2013 Oct 18;15(20):5318-21. doi: 10.1021/ol402568j. Epub 2013 Oct 2.


Mitochondrial phosphate transport during nutrient stimulation of INS-1E insulinoma cells.

Quan X, Das R, Xu S, Cline GW, Wiederkehr A, Wollheim CB, Park KS.

Mol Cell Endocrinol. 2013 Dec 5;381(1-2):198-209. doi: 10.1016/j.mce.2013.08.003. Epub 2013 Aug 9.


cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid catabolism to regulate glucose homeostasis.

Erion DM, Kotas ME, McGlashon J, Yonemitsu S, Hsiao JJ, Nagai Y, Iwasaki T, Murray SF, Bhanot S, Cline GW, Samuel VT, Shulman GI, Gillum MP.

J Biol Chem. 2013 May 31;288(22):16167-76. doi: 10.1074/jbc.M113.460246. Epub 2013 Apr 17.


Role of caspase-1 in regulation of triglyceride metabolism.

Kotas ME, Jurczak MJ, Annicelli C, Gillum MP, Cline GW, Shulman GI, Medzhitov R.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4810-5. doi: 10.1073/pnas.1301996110. Epub 2013 Mar 4.


Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance.

Kumashiro N, Beddow SA, Vatner DF, Majumdar SK, Cantley JL, Guebre-Egziabher F, Fat I, Guigni B, Jurczak MJ, Birkenfeld AL, Kahn M, Perler BK, Puchowicz MA, Manchem VP, Bhanot S, Still CD, Gerhard GS, Petersen KF, Cline GW, Shulman GI, Samuel VT.

Diabetes. 2013 Jul;62(7):2183-94. doi: 10.2337/db12-1311. Epub 2013 Feb 19.

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