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Items: 42

1.

Evaluation of resistance to HIV-1 infection ex vivo of PBMCs isolated from patients with chronic myeloid leukemia treated with different tyrosine kinase inhibitors.

Bermejo M, Ambrosioni J, Bautista G, Climent N, Mateos E, Rovira C, Rodríguez-Mora S, López-Huertas MR, García-Gutiérrez V, Steegmann JL, Duarte R, Cervantes F, Plana M, Miró JM, Alcamí J, Coiras M.

Biochem Pharmacol. 2018 Oct;156:248-264. doi: 10.1016/j.bcp.2018.08.031. Epub 2018 Aug 22.

PMID:
30142322
2.

Loading dendritic cells with gold nanoparticles (GNPs) bearing HIV-peptides and mannosides enhance HIV-specific T cell responses.

Climent N, García I, Marradi M, Chiodo F, Miralles L, Maleno MJ, Gatell JM, García F, Penadés S, Plana M.

Nanomedicine. 2018 Feb;14(2):339-351. doi: 10.1016/j.nano.2017.11.009. Epub 2017 Nov 20.

PMID:
29157976
3.

Human CD6 Down-Modulation following T-Cell Activation Compromises Lymphocyte Survival and Proliferative Responses.

Carrasco E, Escoda-Ferran C, Climent N, Miró-Julià C, Simões IT, Martínez-Florensa M, Sarukhan A, Carreras E, Lozano F.

Front Immunol. 2017 Jun 30;8:769. doi: 10.3389/fimmu.2017.00769. eCollection 2017.

4.

Impact of long-term antiretroviral therapy interruption and resumption on viral reservoir in HIV-1 infected patients.

Montserrat M, Plana M, Guardo AC, Andrés C, Climent N, Gallart T, Leal L, Gatell JM, Sánchez-Palomino S, García F.

AIDS. 2017 Aug 24;31(13):1895-1897. doi: 10.1097/QAD.0000000000001560.

PMID:
28590333
5.

Increased expression with differential subcellular location of cytidine deaminase APOBEC3G in human CD4(+) T-cell activation and dendritic cell maturation.

Oliva H, Pacheco R, Martinez-Navio JM, Rodríguez-García M, Naranjo-Gómez M, Climent N, Prado C, Gil C, Plana M, García F, Miró JM, Franco R, Borras FE, Navaratnam N, Gatell JM, Gallart T.

Immunol Cell Biol. 2016 Aug;94(7):689-700. doi: 10.1038/icb.2016.28. Epub 2016 Mar 18.

PMID:
26987686
6.

Dasatinib inhibits HIV-1 replication through the interference of SAMHD1 phosphorylation in CD4+ T cells.

Bermejo M, López-Huertas MR, García-Pérez J, Climent N, Descours B, Ambrosioni J, Mateos E, Rodríguez-Mora S, Rus-Bercial L, Benkirane M, Miró JM, Plana M, Alcamí J, Coiras M.

Biochem Pharmacol. 2016 Apr 15;106:30-45. doi: 10.1016/j.bcp.2016.02.002. Epub 2016 Feb 4.

PMID:
26851491
7.

Directing vaccine immune responses to mucosa by nanosized particulate carriers encapsulating NOD ligands.

Pavot V, Climent N, Rochereau N, Garcia F, Genin C, Tiraby G, Vernejoul F, Perouzel E, Lioux T, Verrier B, Paul S.

Biomaterials. 2016 Jan;75:327-339. doi: 10.1016/j.biomaterials.2015.10.034. Epub 2015 Nov 3.

PMID:
26539801
8.

Adenosine deaminase regulates Treg expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1.

Naval-Macabuhay I, Casanova V, Navarro G, García F, León A, Miralles L, Rovira C, Martinez-Navio JM, Gallart T, Mallol J, Gatell JM, Lluís C, Franco R, McCormick PJ, Climent N.

J Leukoc Biol. 2016 Feb;99(2):349-59. doi: 10.1189/jlb.3A1214-580RR. Epub 2015 Aug 26.

PMID:
26310829
9.

HIV-1 Reservoir Dynamics after Vaccination and Antiretroviral Therapy Interruption Are Associated with Dendritic Cell Vaccine-Induced T Cell Responses.

Andrés C, Plana M, Guardo AC, Alvarez-Fernández C, Climent N, Gallart T, León A, Clotet B, Autran B, Chomont N, Gatell JM, Sánchez-Palomino S, García F.

J Virol. 2015 Sep;89(18):9189-99. doi: 10.1128/JVI.01062-15. Epub 2015 Jun 24.

10.

Detection of HIV-1-specific T-cell immune responses in highly HIV-exposed uninfected individuals by in-vitro dendritic cell co-culture.

Guardo AC, Ruiz-Riol M, Fernández E, Maleno MJ, Bargalló ME, León A, Climent N, García F, Gatell JM, Brander C, Plana M.

AIDS. 2015 Jul 17;29(11):1309-18. doi: 10.1097/QAD.0000000000000728.

PMID:
26091301
11.

Safety and immunogenicity of a modified vaccinia Ankara-based HIV-1 vaccine (MVA-B) in HIV-1-infected patients alone or in combination with a drug to reactivate latent HIV-1.

Mothe B, Climent N, Plana M, Rosàs M, Jiménez JL, Muñoz-Fernández MÁ, Puertas MC, Carrillo J, Gonzalez N, León A, Pich J, Arnaiz JA, Gatell JM, Clotet B, Blanco J, Alcamí J, Martinez-Picado J, Alvarez-Fernández C, Sánchez-Palomino S, Guardo AC, Peña J, Benito JM, Rallón N, Gómez CE, Perdiguero B, García-Arriaza J, Esteban M, López Bernaldo de Quirós JC, Brander C, García F; RISVAC-03 Study Group.

J Antimicrob Chemother. 2015;70(6):1833-42. doi: 10.1093/jac/dkv046. Epub 2015 Feb 26.

PMID:
25724985
12.

Dendrimers as nonviral vectors in dendritic cell-based immunotherapies against human immunodeficiency virus: steps toward their clinical evaluation.

Vacas-Córdoba E, Climent N, De La Mata FJ, Plana M, Gómez R, Pion M, García F, Muñoz-Fernández MÁ.

Nanomedicine (Lond). 2014 Dec;9(17):2683-702. doi: 10.2217/nnm.14.172. Review.

PMID:
25529571
13.

Loading dendritic cells with PLA-p24 nanoparticles or MVA expressing HIV genes induces HIV-1-specific T cell responses.

Climent N, Munier S, Piqué N, García F, Pavot V, Primard C, Casanova V, Gatell JM, Verrier B, Gallart T.

Vaccine. 2014 Oct 29;32(47):6266-76. doi: 10.1016/j.vaccine.2014.09.010. Epub 2014 Sep 19.

PMID:
25240755
14.

Dendritic cell based vaccines for HIV infection: the way ahead.

García F, Plana M, Climent N, León A, Gatell JM, Gallart T.

Hum Vaccin Immunother. 2013 Nov;9(11):2445-52. Epub 2013 Aug 2. Review.

15.

A dendritic cell-based vaccine elicits T cell responses associated with control of HIV-1 replication.

García F, Climent N, Guardo AC, Gil C, León A, Autran B, Lifson JD, Martínez-Picado J, Dalmau J, Clotet B, Gatell JM, Plana M, Gallart T; DCV2/MANON07-ORVACS Study Group.

Sci Transl Med. 2013 Jan 2;5(166):166ra2. doi: 10.1126/scitranslmed.3004682.

16.

Adenosine deaminase enhances the immunogenicity of human dendritic cells from healthy and HIV-infected individuals.

Casanova V, Naval-Macabuhay I, Massanella M, Rodríguez-García M, Blanco J, Gatell JM, García F, Gallart T, Lluis C, Mallol J, Franco R, Climent N, McCormick PJ.

PLoS One. 2012;7(12):e51287. doi: 10.1371/journal.pone.0051287. Epub 2012 Dec 11.

17.

An old enzyme for current needs: adenosine deaminase and a dendritic cell vaccine for HIV.

Martinez-Navio JM, Climent N, Gallart T, Lluis C, Franco R.

Immunol Cell Biol. 2012 Jul;90(6):594-600. doi: 10.1038/icb.2011.81. Epub 2011 Sep 20.

PMID:
21931337
18.

Ex vivo production of autologous whole inactivated HIV-1 for clinical use in therapeutic vaccines.

Gil C, Climent N, García F, Hurtado C, Nieto-Márquez S, León A, García MT, Rovira C, Miralles L, Dalmau J, Pumarola T, Almela M, Martinez-Picado J, Lifson JD, Zamora L, Miró JM, Brander C, Clotet B, Gallart T, Gatell JM.

Vaccine. 2011 Aug 5;29(34):5711-24. doi: 10.1016/j.vaccine.2011.05.096. Epub 2011 Jun 14.

PMID:
21679735
19.

Dendritic cells exposed to MVA-based HIV-1 vaccine induce highly functional HIV-1-specific CD8(+) T cell responses in HIV-1-infected individuals.

Climent N, Guerra S, García F, Rovira C, Miralles L, Gómez CE, Piqué N, Gil C, Gatell JM, Esteban M, Gallart T.

PLoS One. 2011;6(5):e19644. doi: 10.1371/journal.pone.0019644. Epub 2011 May 18.

20.

A therapeutic dendritic cell-based vaccine for HIV-1 infection.

García F, Climent N, Assoumou L, Gil C, González N, Alcamí J, León A, Romeu J, Dalmau J, Martínez-Picado J, Lifson J, Autran B, Costagliola D, Clotet B, Gatell JM, Plana M, Gallart T; DCV2/MANON07- AIDS Vaccine Research Objective Study Group.

J Infect Dis. 2011 Feb 15;203(4):473-8. doi: 10.1093/infdis/jiq077. Epub 2011 Jan 13.

21.

Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4+ T cells.

Martinez-Navio JM, Casanova V, Pacheco R, Naval-Macabuhay I, Climent N, Garcia F, Gatell JM, Mallol J, Gallart T, Lluis C, Franco R.

J Leukoc Biol. 2011 Jan;89(1):127-36. doi: 10.1189/jlb.1009696. Epub 2010 Oct 19.

PMID:
20959412
22.

Selective induction of host genes by MVA-B, a candidate vaccine against HIV/AIDS.

Guerra S, González JM, Climent N, Reyburn H, López-Fernández LA, Nájera JL, Gómez CE, García F, Gatell JM, Gallart T, Esteban M.

J Virol. 2010 Aug;84(16):8141-52. doi: 10.1128/JVI.00749-10. Epub 2010 Jun 9.

23.

Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression.

Rodríguez-García M, Climent N, Oliva H, Casanova V, Franco R, Leon A, Gatell JM, García F, Gallart T.

PLoS One. 2010 Feb 25;5(2):e9436. doi: 10.1371/journal.pone.0009436.

24.

Immunological dysfunction in HIV-1-infected individuals caused by impairment of adenosine deaminase-induced costimulation of T-cell activation.

Martinez-Navio JM, Climent N, Pacheco R, Garcia F, Plana M, Nomdedeu M, Oliva H, Rovira C, Miralles L, Gatell JM, Gallart T, Mallol J, Lluis C, Franco R.

Immunology. 2009 Nov;128(3):393-404. doi: 10.1111/j.1365-2567.2009.03121.x.

25.

Adenosine deaminase enhances T-cell response elicited by dendritic cells loaded with inactivated HIV.

Climent N, Martinez-Navio JM, Gil C, Garcia F, Rovira C, Hurtado C, Miralles L, Gatell JM, Gallart T, Mallol J, Lluis C, Franco R.

Immunol Cell Biol. 2009 Nov-Dec;87(8):634-9. doi: 10.1038/icb.2009.53. Epub 2009 Aug 11.

PMID:
19668260
26.

Assessment of migration of HIV-1-loaded dendritic cells labeled with 111In-oxine used as a therapeutic vaccine in HIV-1-infected patients.

Ruiz A, Nomdedeu M, Ortega M, Lejeune M, Setoain J, Climent N, Fumero E, Plana M, León A, Alós L, Piera C, Lomeña F, Gatell JM, Gallart T, García F.

Immunotherapy. 2009 May;1(3):347-54. doi: 10.2217/imt.09.5.

PMID:
20635955
27.

Impact of alpha-defensins1-3 on the maturation and differentiation of human monocyte-derived DCs. Concentration-dependent opposite dual effects.

Rodríguez-García M, Oliva H, Climent N, Escribese MM, García F, Moran TM, Gatell JM, Gallart T.

Clin Immunol. 2009 Jun;131(3):374-84. doi: 10.1016/j.clim.2009.01.012. Epub 2009 Feb 23.

PMID:
19237318
28.

Monocytes are major players in the prognosis and risk of infection after acute stroke.

Urra X, Cervera A, Obach V, Climent N, Planas AM, Chamorro A.

Stroke. 2009 Apr;40(4):1262-8. doi: 10.1161/STROKEAHA.108.532085. Epub 2009 Jan 22.

PMID:
19164783
29.

HIV-1 upregulates intercellular adhesion molecule-1 gene expression in lymphoid tissue of patients with chronic HIV-1 infection.

Garrido M, Mozos A, Martínez A, García F, Serafín A, Morente V, Caballero M, Gil C, Fumero E, Miró JM, Climent N, Gatell JM, Alos L.

J Acquir Immune Defic Syndr. 2007 Nov 1;46(3):268-74.

PMID:
17786132
30.

Human immature monocyte-derived dendritic cells produce and secrete alpha-defensins 1-3.

Rodríguez-García M, Oliva H, Climent N, García F, Gatell JM, Gallart T.

J Leukoc Biol. 2007 Nov;82(5):1143-6. Epub 2007 Aug 7.

PMID:
17684038
31.

Distinct gene expression profiling after infection of immature human monocyte-derived dendritic cells by the attenuated poxvirus vectors MVA and NYVAC.

Guerra S, Nájera JL, González JM, López-Fernández LA, Climent N, Gatell JM, Gallart T, Esteban M.

J Virol. 2007 Aug;81(16):8707-21. Epub 2007 May 30.

32.

Expression and function of the IL-2 receptor in activated human plasmacytoid dendritic cells.

Naranjo-Gómez M, Oliva H, Climent N, Fernández MA, Ruiz-Riol M, Bofill M, Gatell JM, Gallart T, Pujol-Borrell R, Borràs FE.

Eur J Immunol. 2007 Jul;37(7):1764-72.

33.

Glutamate released by dendritic cells as a novel modulator of T cell activation.

Pacheco R, Oliva H, Martinez-Navío JM, Climent N, Ciruela F, Gatell JM, Gallart T, Mallol J, Lluis C, Franco R.

J Immunol. 2006 Nov 15;177(10):6695-704.

34.

Tacrolimus treatment of plasmacytoid dendritic cells inhibits dinucleotide (CpG-)-induced tumour necrosis factor-alpha secretion.

Naranjo-Gómez M, Climent N, Cos J, Oliva H, Bofill M, Gatell JM, Gallart T, Pujol-Borrell R, Borràs FE.

Immunology. 2006 Dec;119(4):488-98. Epub 2006 Aug 24.

35.

Dynamics of T cells subsets and lymphoproliferative responses during structured treatment interruption cycles and after definitive interruption of HAART in early chronic HIV type-1-infected patients.

Libois A, López A, Garcia F, Castro P, Maleno MJ, García A, Climent N, Arnedo M, Gallart T, Gatell JM, Plana M.

AIDS Res Hum Retroviruses. 2006 Jul;22(7):657-66.

PMID:
16831090
36.

CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse.

Pacheco R, Martinez-Navio JM, Lejeune M, Climent N, Oliva H, Gatell JM, Gallart T, Mallol J, Lluis C, Franco R.

Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9583-8. Epub 2005 Jun 27.

37.

Therapeutic immunization with dendritic cells loaded with heat-inactivated autologous HIV-1 in patients with chronic HIV-1 infection.

García F, Lejeune M, Climent N, Gil C, Alcamí J, Morente V, Alós L, Ruiz A, Setoain J, Fumero E, Castro P, López A, Cruceta A, Piera C, Florence E, Pereira A, Libois A, González N, Guilá M, Caballero M, Lomeña F, Joseph J, Miró JM, Pumarola T, Plana M, Gatell JM, Gallart T.

J Infect Dis. 2005 May 15;191(10):1680-5. Epub 2005 Apr 11.

PMID:
15838795
38.

Genetic characterization of the Klebsiella pneumoniae waa gene cluster, involved in core lipopolysaccharide biosynthesis.

Regué M, Climent N, Abitiu N, Coderch N, Merino S, Izquierdo L, Altarriba M, Tomás JM.

J Bacteriol. 2001 Jun;183(12):3564-73.

39.

Genetic analysis of the Serratia marcescens N28b O4 antigen gene cluster.

Saigí F, Climent N, Piqué N, Sanchez C, Merino S, Rubirés X, Aguilar A, Tomás JM, Regué M.

J Bacteriol. 1999 Mar;181(6):1883-91.

40.

A gene (wbbL) from Serratia marcescens N28b (O4) complements the rfb-50 mutation of Escherichia coli K-12 derivatives.

Rubirés X, Saigi F, Piqué N, Climent N, Merino S, Albertí S, Tomás JM, Regué M.

J Bacteriol. 1997 Dec;179(23):7581-6.

41.

Molecular characterization of a 17-kDa outer-membrane protein from Klebsiella pneumoniae.

Climent N, Ferrer S, Rubires X, Merino S, Tomás JM, Regué M.

Res Microbiol. 1997 Feb;148(2):133-43.

PMID:
9765794
42.

Cloning and characterization of two Serratia marcescens genes involved in core lipopolysaccharide biosynthesis.

Guasch JF, Piqué N, Climent N, Ferrer S, Merino S, Rubires X, Tomas JM, Regué M.

J Bacteriol. 1996 Oct;178(19):5741-7.

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