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The impact of three discharge coding methods on the accuracy of diagnostic coding and hospital reimbursement for inpatient medical care.

Tsopra R, Peckham D, Beirne P, Rodger K, Callister M, White H, Jais JP, Ghosh D, Whitaker P, Clifton IJ, Wyatt JC.

Int J Med Inform. 2018 Jul;115:35-42. doi: 10.1016/j.ijmedinf.2018.03.015. Epub 2018 Mar 27.


Intravenous fosfomycin for pulmonary exacerbation of cystic fibrosis: Real life experience of a large adult CF centre.

Spoletini G, Kennedy M, Flint L, Graham T, Etherington C, Shaw N, Whitaker P, Denton M, Clifton I, Peckham D.

Pulm Pharmacol Ther. 2018 Jun;50:82-87. doi: 10.1016/j.pupt.2018.04.007. Epub 2018 Apr 13.


Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.

Yeh TL, Leissing TM, Abboud MI, Thinnes CC, Atasoylu O, Holt-Martyn JP, Zhang D, Tumber A, Lippl K, Lohans CT, Leung IKH, Morcrette H, Clifton IJ, Claridge TDW, Kawamura A, Flashman E, Lu X, Ratcliffe PJ, Chowdhury R, Pugh CW, Schofield CJ.

Chem Sci. 2017 Nov 1;8(11):7651-7668. doi: 10.1039/c7sc02103h. Epub 2017 Sep 11.


Cytomegalovirus-associated pulmonary exacerbation in patients with cystic fibrosis.

Sawant A, Spoletini G, Whitaker P, Etherington C, Clifton I, Peckham D.

ERJ Open Res. 2018 Jan 10;4(1). pii: 00111-2017. doi: 10.1183/23120541.00111-2017. eCollection 2018 Jan.


Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non-Heme Iron Oxidases.

McNeill LA, Brown TJN, Sami M, Clifton IJ, Burzlaff NI, Claridge TDW, Adlington RM, Baldwin JE, Rutledge PJ, Schofield CJ.

Chemistry. 2017 Sep 18;23(52):12815-12824. doi: 10.1002/chem.201701592. Epub 2017 Aug 21.


13C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions.

Lohans CT, Wang DY, Jorgensen C, Cahill ST, Clifton IJ, McDonough MA, Oswin HP, Spencer J, Domene C, Claridge TDW, Brem J, Schofield CJ.

Org Biomol Chem. 2017 Jul 19;15(28):6024-6032. doi: 10.1039/c7ob01514c.


Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition.

Li GB, Brem J, Lesniak R, Abboud MI, Lohans CT, Clifton IJ, Yang SY, Jiménez-Castellanos JC, Avison MB, Spencer J, McDonough MA, Schofield CJ.

Chem Commun (Camb). 2017 May 30;53(43):5806-5809. doi: 10.1039/c7cc02394d.


The EMBARC European Bronchiectasis Registry: protocol for an international observational study.

Chalmers JD, Aliberti S, Polverino E, Vendrell M, Crichton M, Loebinger M, Dimakou K, Clifton I, van der Eerden M, Rohde G, Murris-Espin M, Masefield S, Gerada E, Shteinberg M, Ringshausen F, Haworth C, Boersma W, Rademacher J, Hill AT, Aksamit T, O'Donnell A, Morgan L, Milenkovic B, Tramma L, Neves J, Menendez R, Paggiaro P, Botnaru V, Skrgat S, Wilson R, Goeminne P, De Soyza A, Welte T, Torres A, Elborn JS, Blasi F.

ERJ Open Res. 2016 Jan 20;2(1). pii: 00081-2015. eCollection 2016 Jan.


Survival of Mycobacterium abscessus isolated from people with cystic fibrosis in artificially generated aerosols.

Fletcher LA, Chen Y, Whitaker P, Denton M, Peckham DG, Clifton IJ.

Eur Respir J. 2016 Dec;48(6):1789-1791. doi: 10.1183/13993003.00849-2016. Epub 2016 Sep 22. No abstract available.


Impact of omalizumab on treatment of severe allergic asthma in UK clinical practice: a UK multicentre observational study (the APEX II study).

Niven RM, Saralaya D, Chaudhuri R, Masoli M, Clifton I, Mansur AH, Hacking V, McLain-Smith S, Menzies-Gow A.

BMJ Open. 2016 Aug 9;6(8):e011857. doi: 10.1136/bmjopen-2016-011857.


Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates.

Brem J, Cain R, Cahill S, McDonough MA, Clifton IJ, Jiménez-Castellanos JC, Avison MB, Spencer J, Fishwick CW, Schofield CJ.

Nat Commun. 2016 Aug 8;7:12406. doi: 10.1038/ncomms12406.


Improving end-of-life communication between primary and secondary care within respiratory medicine.

Boland AC, Hodgekiss C, Hicks F, Edwards A, Clifton IJ.

Eur Respir J. 2016 Feb;47(2):658-60. doi: 10.1183/13993003.01549-2015. Epub 2015 Dec 2. No abstract available.


Ribosomal oxygenases are structurally conserved from prokaryotes to humans.

Chowdhury R, Sekirnik R, Brissett NC, Krojer T, Ho CH, Ng SS, Clifton IJ, Ge W, Kershaw NJ, Fox GC, Muniz JRC, Vollmar M, Phillips C, Pilka ES, Kavanagh KL, von Delft F, Oppermann U, McDonough MA, Doherty AJ, Schofield CJ.

Nature. 2014 Jun 19;510(7505):422-426. doi: 10.1038/nature13263. Epub 2014 May 11.


Omalizumab for the treatment of severe persistent allergic asthma: a systematic review and economic evaluation.

Norman G, Faria R, Paton F, Llewellyn A, Fox D, Palmer S, Clifton I, Paton J, Woolacott N, McKenna C.

Health Technol Assess. 2013 Nov;17(52):1-342. doi: 10.3310/hta17520. Review.


The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site.

Clifton IJ, Ge W, Adlington RM, Baldwin JE, Rutledge PJ.

FEBS Lett. 2013 Aug 19;587(16):2705-9. doi: 10.1016/j.febslet.2013.07.016. Epub 2013 Jul 13.


The interaction of isopenicillin N synthase with homologated substrate analogues δ-(L-α-aminoadipoyl)-L-homocysteinyl-D-Xaa characterised by protein crystallography.

Daruzzaman A, Clifton IJ, Adlington RM, Baldwin JE, Rutledge PJ.

Chembiochem. 2013 Mar 18;14(5):599-606. doi: 10.1002/cbic.201200728. Epub 2013 Mar 6.


The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue.

Daruzzaman A, Clifton IJ, Adlington RM, Baldwin JE, Rutledge PJ.

Arch Biochem Biophys. 2013 Feb 1;530(1):48-53. doi: 10.1016/ Epub 2012 Dec 19.


Inhaler technique and training in people with chronic obstructive pulmonary disease and asthma.

Capstick TG, Clifton IJ.

Expert Rev Respir Med. 2012 Feb;6(1):91-101; quiz 102-3. doi: 10.1586/ers.11.89. Review.


Cytomegalovirus pneumonia in an immunocompetent adult: a case report.

Barclay A, Naseer R, McGann H, Clifton I.

Acute Med. 2011;10(4):197-9.


The crystal structure of isopenicillin N synthase with δ-((L)-α-aminoadipoyl)-(L)-cysteinyl-(D)-methionine reveals thioether coordination to iron.

Clifton IJ, Ge W, Adlington RM, Baldwin JE, Rutledge PJ.

Arch Biochem Biophys. 2011 Dec 15;516(2):103-7. doi: 10.1016/ Epub 2011 Oct 6.


The Effect of Sub-MIC β-Lactam Antibiotic Exposure of Pseudomonas aeruginosa Strains from People with Cystic Fibrosis in a Desiccation Survival Model.

Clifton IJ, Denton M, M'zali F, Peckham DG.

Int J Microbiol. 2011;2011:712618. doi: 10.1155/2011/712618. Epub 2011 Sep 29.


Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates.

Iqbal A, Clifton IJ, Chowdhury R, Ivison D, Domene C, Schofield CJ.

Org Biomol Chem. 2011 Sep 21;9(18):6219-25. doi: 10.1039/c1ob05554b. Epub 2011 Jul 28.


Pharmacokinetics of oral voriconazole in patients with cystic fibrosis.

Clifton IJ, Whitaker P, Metcalfe R, Phillip M, Shaw N, Conway SP, Peckham DG.

J Antimicrob Chemother. 2011 Oct;66(10):2438-40. doi: 10.1093/jac/dkr300. Epub 2011 Jul 25. No abstract available.


Isopenicillin N synthase binds δ-(L-α-aminoadipoyl)-L-cysteinyl-D-thia-allo-isoleucine through both sulfur atoms.

Clifton IJ, Ge W, Adlington RM, Baldwin JE, Rutledge PJ.

Chembiochem. 2011 Aug 16;12(12):1881-5. doi: 10.1002/cbic.201100149. Epub 2011 Jun 15.


Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).

Chowdhury R, Flashman E, Mecinović J, Kramer HB, Kessler BM, Frapart YM, Boucher JL, Clifton IJ, McDonough MA, Schofield CJ.

J Mol Biol. 2011 Jul 8;410(2):268-79. doi: 10.1016/j.jmb.2011.04.075. Epub 2011 May 13.


The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.

Chowdhury R, Yeoh KK, Tian YM, Hillringhaus L, Bagg EA, Rose NR, Leung IK, Li XS, Woon EC, Yang M, McDonough MA, King ON, Clifton IJ, Klose RJ, Claridge TD, Ratcliffe PJ, Schofield CJ, Kawamura A.

EMBO Rep. 2011 May;12(5):463-9. doi: 10.1038/embor.2011.43. Epub 2011 Apr 1.


Structural studies on human 2-oxoglutarate dependent oxygenases.

McDonough MA, Loenarz C, Chowdhury R, Clifton IJ, Schofield CJ.

Curr Opin Struct Biol. 2010 Dec;20(6):659-72. doi: 10.1016/ Epub 2010 Sep 29. Review.


Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.

Conejo-Garcia A, McDonough MA, Loenarz C, McNeill LA, Hewitson KS, Ge W, Liénard BM, Schofield CJ, Clifton IJ.

Bioorg Med Chem Lett. 2010 Oct 15;20(20):6125-8. doi: 10.1016/j.bmcl.2010.08.032. Epub 2010 Aug 10.


Defining routes of airborne transmission of Pseudomonas aeruginosa in people with cystic fibrosis.

Clifton IJ, Peckham DG.

Expert Rev Respir Med. 2010 Aug;4(4):519-29. doi: 10.1586/ers.10.42. Review.


Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase.

Ge W, Clifton IJ, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ.

Biochem Biophys Res Commun. 2010 Aug 6;398(4):659-64. doi: 10.1016/j.bbrc.2010.06.129. Epub 2010 Jul 13.


Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.

Rose NR, Woon EC, Kingham GL, King ON, Mecinović J, Clifton IJ, Ng SS, Talib-Hardy J, Oppermann U, McDonough MA, Schofield CJ.

J Med Chem. 2010 Feb 25;53(4):1810-8. doi: 10.1021/jm901680b.


The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase.

Ge W, Clifton IJ, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ.

Org Biomol Chem. 2010 Jan 7;8(1):122-7. doi: 10.1039/b910170e. Epub 2009 Oct 29.


Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway.

Iqbal A, Arunlanantham H, Brown T Jr, Chowdhury R, Clifton IJ, Kershaw NJ, Hewitson KS, McDonough MA, Schofield CJ.

Proteins. 2010 May 1;78(6):1398-407. doi: 10.1002/prot.22653.


An aerobiological model of aerosol survival of different strains of Pseudomonas aeruginosa isolated from people with cystic fibrosis.

Clifton IJ, Fletcher LA, Beggs CB, Denton M, Conway SP, Peckham DG.

J Cyst Fibros. 2010 Jan;9(1):64-8. doi: 10.1016/j.jcf.2009.11.004. Epub 2009 Nov 27.


Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue.

Ge W, Clifton IJ, Howard-Jones AR, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ.

Chembiochem. 2009 Aug 17;10(12):2025-31. doi: 10.1002/cbic.200900080.


Acute Burkholderia cenocepacia pyomyositis in a patient with cystic fibrosis.

El-Laboudi AH, Etherington C, Whitaker P, Clifton IJ, Conway SP, Denton M, Peckham DG.

J Cyst Fibros. 2009 Jul;8(4):273-5. doi: 10.1016/j.jcf.2009.04.007. Epub 2009 May 17.


No lung cancer at resection of PET positive lesions: an audit of the lung cancer multidisciplinary team.

Clifton IJ, Scarsbrook AF, Muers MF.

Eur Respir J. 2009 Apr;33(4):941-2. doi: 10.1183/09031936.00176708. No abstract available.


Nutritional decline in cystic fibrosis related diabetes: the effect of intensive nutritional intervention.

White H, Pollard K, Etherington C, Clifton I, Morton AM, Owen D, Conway SP, Peckham DG.

J Cyst Fibros. 2009 May;8(3):179-85. doi: 10.1016/j.jcf.2008.12.002.


Anatomy of a simple acyl intermediate in enzyme catalysis: combined biophysical and modeling studies on ornithine acetyl transferase.

Iqbal A, Clifton IJ, Bagonis M, Kershaw NJ, Domene C, Claridge TD, Wharton CW, Schofield CJ.

J Am Chem Soc. 2009 Jan 21;131(2):749-57. doi: 10.1021/ja807215u.


Isopenicillin N synthase mediates thiolate oxidation to sulfenate in a depsipeptide substrate analogue: implications for oxygen binding and a link to nitrile hydratase?

Ge W, Clifton IJ, Stok JE, Adlington RM, Baldwin JE, Rutledge PJ.

J Am Chem Soc. 2008 Aug 6;130(31):10096-102. doi: 10.1021/ja8005397. Epub 2008 Jul 12.


A laminar flow model of aerosol survival of epidemic and non-epidemic strains of Pseudomonas aeruginosa isolated from people with cystic fibrosis.

Clifton IJ, Fletcher LA, Beggs CB, Denton M, Peckham DG.

BMC Microbiol. 2008 Jun 26;8:105. doi: 10.1186/1471-2180-8-105.


Mechanisms and structures of crotonase superfamily enzymes--how nature controls enolate and oxyanion reactivity.

Hamed RB, Batchelar ET, Clifton IJ, Schofield CJ.

Cell Mol Life Sci. 2008 Aug;65(16):2507-27. doi: 10.1007/s00018-008-8082-6. Review.


A cyclobutanone analogue mimics penicillin in binding to isopenicillin N synthase.

Stewart AC, Clifton IJ, Adlington RM, Baldwin JE, Rutledge PJ.

Chembiochem. 2007 Nov 5;8(16):2003-7.


Concurrent pulmonary zygomycosis and Mycobacterium tuberculosis infection: a case report.

Patel T, Clifton IJ, Kastelik JA, Peckham DG.

J Med Case Rep. 2007 May 3;1:17.


Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight.

Howard-Jones AR, Elkins JM, Clifton IJ, Roach PL, Adlington RM, Baldwin JE, Rutledge PJ.

Biochemistry. 2007 Apr 24;46(16):4755-62. Epub 2007 Mar 31.


Ten years of viral and non-bacterial serology in adults with cystic fibrosis.

Clifton IJ, Kastelik JA, Peckham DG, Hale A, Denton M, Etherington C, Conway SP.

Epidemiol Infect. 2008 Jan;136(1):128-34. Epub 2007 Mar 12.


An unusual cause of hypercalcaemia in a patient with cystic fibrosis.

Clifton IJ, Morton AM, Peckham DG, Conway SP.

J Cyst Fibros. 2007 Sep;6(5):369-70. Epub 2007 Jan 30. No abstract available.


Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates.

Hewitson KS, Liénard BM, McDonough MA, Clifton IJ, Butler D, Soares AS, Oldham NJ, McNeill LA, Schofield CJ.

J Biol Chem. 2007 Feb 2;282(5):3293-301. Epub 2006 Nov 29.


Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.

McNeill LA, Flashman E, Buck MR, Hewitson KS, Clifton IJ, Jeschke G, Claridge TD, Ehrismann D, Oldham NJ, Schofield CJ.

Mol Biosyst. 2005 Oct;1(4):321-4. Epub 2005 Aug 22.


Measurement of urinary N-acetyl-b-D-glucosaminidase in adult patients with cystic fibrosis: before, during and after treatment with intravenous antibiotics.

Etherington C, Bosomworth M, Clifton I, Peckham DG, Conway SP.

J Cyst Fibros. 2007 Jan;6(1):67-73. Epub 2006 Jul 17.

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