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Substrate Tolerance of Bacterial Glycosyltransferase MurG: Novel Fluorescence-Based Assays.

Mitachi K, Yun HG, Gillman CD, Skorupinska-Tudek K, Swiezewska E, Clemons WM Jr, Kurosu M.

ACS Infect Dis. 2019 Dec 11. doi: 10.1021/acsinfecdis.9b00242. [Epub ahead of print]


A practical synthesis of a novel DPAGT1 inhibitor, aminouridyl phenoxypiperidinbenzyl butanamide (APPB) for in vivo studies.

Mitachi K, Kurosu SM, Gillman CD, Yun HG, Clemons WM Jr, Kurosu M.

MethodsX. 2019 Sep 27;6:2305-2321. doi: 10.1016/j.mex.2019.09.031. eCollection 2019.


Semisynthesis of an Anticancer DPAGT1 Inhibitor from a Muraymycin Biosynthetic Intermediate.

Mitachi K, Kurosu SM, Eslamimehr S, Lemieux MR, Ishizaki Y, Clemons WM Jr, Kurosu M.

Org Lett. 2019 Feb 15;21(4):876-879. doi: 10.1021/acs.orglett.8b03716. Epub 2019 Jan 30.


Novel FR-900493 Analogues That Inhibit the Outgrowth of Clostridium difficile Spores.

Mitachi K, Yun HG, Kurosu SM, Eslamimehr S, Lemieux MR, Klaić L, Clemons WM Jr, Kurosu M.

ACS Omega. 2018 Feb 28;3(2):1726-1739. doi: 10.1021/acsomega.7b01740. Epub 2018 Feb 9.


A statistical model for improved membrane protein expression using sequence-derived features.

Saladi SM, Javed N, Müller A, Clemons WM Jr.

J Biol Chem. 2018 Mar 30;293(13):4913-4927. doi: 10.1074/jbc.RA117.001052. Epub 2018 Jan 29.


Complexity in targeting membrane proteins.

Fry MY, Clemons WM Jr.

Science. 2018 Jan 26;359(6374):390-391. doi: 10.1126/science.aar5992. No abstract available.


Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35.

Mock JY, Xu Y, Ye Y, Clemons WM Jr.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11679-11684. doi: 10.1073/pnas.1702940114. Epub 2017 Oct 17.


Improving membrane protein expression by optimizing integration efficiency.

Niesen MJM, Marshall SS, Miller TF 3rd, Clemons WM Jr.

J Biol Chem. 2017 Nov 24;292(47):19537-19545. doi: 10.1074/jbc.M117.813469. Epub 2017 Sep 16.


A Link between Integral Membrane Protein Expression and Simulated Integration Efficiency.

Marshall SS, Niesen MJM, Müller A, Tiemann K, Saladi SM, Galimidi RP, Zhang B, Clemons WM Jr, Miller TF 3rd.

Cell Rep. 2016 Aug 23;16(8):2169-2177. doi: 10.1016/j.celrep.2016.07.042. Epub 2016 Aug 11.


Mechanism of Assembly of a Substrate Transfer Complex during Tail-anchored Protein Targeting.

Gristick HB, Rome ME, Chartron JW, Rao M, Hess S, Shan SO, Clemons WM Jr.

J Biol Chem. 2015 Dec 11;290(50):30006-17. doi: 10.1074/jbc.M115.677328. Epub 2015 Oct 7.


Chemoenzymatic syntheses of water-soluble lipid I fluorescent probes.

Mitachi K, Siricilla S, Klaic L, Clemons WM Jr, Kurosu M.

Tetrahedron Lett. 2015 Jun 3;56(23):3441-3446.


Capturing the signal.

Mock JY, Clemons WM.

Elife. 2015 Jul 9;4. doi: 10.7554/eLife.09315.


A cationic cysteine-hydrazide as an enrichment tool for the mass spectrometric characterization of bacterial free oligosaccharides.

Jang KS, Nani RR, Kalli A, Levin S, Müller A, Hess S, Reisman SE, Clemons WM Jr.

Anal Bioanal Chem. 2015 Aug;407(20):6181-90. doi: 10.1007/s00216-015-8798-8. Epub 2015 Jun 23.


Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.

Mock JY, Chartron JW, Zaslaver M, Xu Y, Ye Y, Clemons WM Jr.

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):106-11. doi: 10.1073/pnas.1402745112. Epub 2014 Dec 22.


Ultrastructure and complex polar architecture of the human pathogen Campylobacter jejuni.

Müller A, Beeby M, McDowall AW, Chow J, Jensen GJ, Clemons WM Jr.

Microbiologyopen. 2014 Oct;3(5):702-10. doi: 10.1002/mbo3.200. Epub 2014 Jul 25.


Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4.

Gristick HB, Rao M, Chartron JW, Rome ME, Shan SO, Clemons WM Jr.

Nat Struct Mol Biol. 2014 May;21(5):437-42. doi: 10.1038/nsmb.2813. Epub 2014 Apr 13.


USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.

Liu Y, Soetandyo N, Lee JG, Liu L, Xu Y, Clemons WM Jr, Ye Y.

Elife. 2014;3:e01369. doi: 10.7554/eLife.01369. Epub 2014 Jan 14.


Comprehensive proteomic profiling of outer membrane vesicles from Campylobacter jejuni.

Jang KS, Sweredoski MJ, Graham RL, Hess S, Clemons WM Jr.

J Proteomics. 2014 Feb 26;98:90-8. doi: 10.1016/j.jprot.2013.12.014. Epub 2013 Dec 29.


Precise timing of ATPase activation drives targeting of tail-anchored proteins.

Rome ME, Rao M, Clemons WM, Shan SO.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7666-71. doi: 10.1073/pnas.1222054110. Epub 2013 Apr 22.


The glove-like structure of the conserved membrane protein TatC provides insight into signal sequence recognition in twin-arginine translocation.

Ramasamy S, Abrol R, Suloway CJ, Clemons WM Jr.

Structure. 2013 May 7;21(5):777-88. doi: 10.1016/j.str.2013.03.004. Epub 2013 Apr 11.


Structures of the Sgt2/SGTA dimerization domain with the Get5/UBL4A UBL domain reveal an interaction that forms a conserved dynamic interface.

Chartron JW, VanderVelde DG, Clemons WM Jr.

Cell Rep. 2012 Dec 27;2(6):1620-32. doi: 10.1016/j.celrep.2012.10.010. Epub 2012 Nov 8.


Minimal requirements for inhibition of MraY by lysis protein E from bacteriophage ΦX174.

Tanaka S, Clemons WM Jr.

Mol Microbiol. 2012 Sep;85(5):975-85. doi: 10.1111/j.1365-2958.2012.08153.x. Epub 2012 Jul 13.


The complex process of GETting tail-anchored membrane proteins to the ER.

Chartron JW, Clemons WM Jr, Suloway CJ.

Curr Opin Struct Biol. 2012 Apr;22(2):217-24. doi: 10.1016/ Epub 2012 Mar 21. Review.


Get5 carboxyl-terminal domain is a novel dimerization motif that tethers an extended Get4/Get5 complex.

Chartron JW, VanderVelde DG, Rao M, Clemons WM Jr.

J Biol Chem. 2012 Mar 9;287(11):8310-7. doi: 10.1074/jbc.M111.333252. Epub 2012 Jan 17.


Tail-anchor targeting by a Get3 tetramer: the structure of an archaeal homologue.

Suloway CJ, Rome ME, Clemons WM Jr.

EMBO J. 2012 Feb 1;31(3):707-19. doi: 10.1038/emboj.2011.433. Epub 2011 Nov 29.


A structural model of the Sgt2 protein and its interactions with chaperones and the Get4/Get5 complex.

Chartron JW, Gonzalez GM, Clemons WM Jr.

J Biol Chem. 2011 Sep 30;286(39):34325-34. doi: 10.1074/jbc.M111.277798. Epub 2011 Aug 10.


Structural characterization of the Get4/Get5 complex and its interaction with Get3.

Chartron JW, Suloway CJ, Zaslaver M, Clemons WM Jr.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12127-32. doi: 10.1073/pnas.1006036107. Epub 2010 Jun 16.


Model for eukaryotic tail-anchored protein binding based on the structure of Get3.

Suloway CJ, Chartron JW, Zaslaver M, Clemons WM Jr.

Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14849-54. doi: 10.1073/pnas.0907522106. Epub 2009 Aug 14.


Structure of the twin-arginine signal-binding protein DmsD from Escherichia coli.

Ramasamy SK, Clemons WM Jr.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Aug 1;65(Pt 8):746-50. doi: 10.1107/S1744309109023811. Epub 2009 Jul 21.


Ribosome binding of a single copy of the SecY complex: implications for protein translocation.

Ménétret JF, Schaletzky J, Clemons WM Jr, Osborne AR, Skånland SS, Denison C, Gygi SP, Kirkpatrick DS, Park E, Ludtke SJ, Rapoport TA, Akey CW.

Mol Cell. 2007 Dec 28;28(6):1083-92.


Modeling the effects of prl mutations on the Escherichia coli SecY complex.

Smith MA, Clemons WM Jr, DeMars CJ, Flower AM.

J Bacteriol. 2005 Sep;187(18):6454-65.


Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY.

Cannon KS, Or E, Clemons WM Jr, Shibata Y, Rapoport TA.

J Cell Biol. 2005 Apr 25;169(2):219-25.


Structural insight into the protein translocation channel.

Clemons WM Jr, Ménétret JF, Akey CW, Rapoport TA.

Curr Opin Struct Biol. 2004 Aug;14(4):390-6. Review.


A large conformational change of the translocation ATPase SecA.

Osborne AR, Clemons WM Jr, Rapoport TA.

Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10937-42. Epub 2004 Jul 15.


Crystal structure of the long-chain fatty acid transporter FadL.

van den Berg B, Black PN, Clemons WM Jr, Rapoport TA.

Science. 2004 Jun 4;304(5676):1506-9.


X-ray structure of a protein-conducting channel.

Van den Berg B, Clemons WM Jr, Collinson I, Modis Y, Hartmann E, Harrison SC, Rapoport TA.

Nature. 2004 Jan 1;427(6969):36-44. Epub 2003 Dec 3.


Phasing the 30S ribosomal subunit structure.

Brodersen DE, Clemons WM Jr, Carter AP, Wimberly BT, Ramakrishnan V.

Acta Crystallogr D Biol Crystallogr. 2003 Nov;59(Pt 11):2044-50. Epub 2003 Oct 23. Review.


Atomic structures of the 30S subunit and its complexes with ligands and antibiotics.

Brodersen DE, Carter AP, Clemons WM Jr, Morgan-Warren RJ, Murphy FV 4th, Ogle JM, Tarry MJ, Wimberly BT, Ramakrishnan V.

Cold Spring Harb Symp Quant Biol. 2001;66:17-32. Review. No abstract available.


Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 S RNA.

Brodersen DE, Clemons WM Jr, Carter AP, Wimberly BT, Ramakrishnan V.

J Mol Biol. 2002 Feb 22;316(3):725-68.


Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: purification, crystallization and structure determination.

Clemons WM Jr, Brodersen DE, McCutcheon JP, May JL, Carter AP, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V.

J Mol Biol. 2001 Jul 20;310(4):827-43.


Recognition of cognate transfer RNA by the 30S ribosomal subunit.

Ogle JM, Brodersen DE, Clemons WM Jr, Tarry MJ, Carter AP, Ramakrishnan V.

Science. 2001 May 4;292(5518):897-902.


Crystal structure of an initiation factor bound to the 30S ribosomal subunit.

Carter AP, Clemons WM Jr, Brodersen DE, Morgan-Warren RJ, Hartsch T, Wimberly BT, Ramakrishnan V.

Science. 2001 Jan 19;291(5503):498-501.


The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit.

Brodersen DE, Clemons WM Jr, Carter AP, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V.

Cell. 2000 Dec 22;103(7):1143-54.


Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics.

Carter AP, Clemons WM, Brodersen DE, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V.

Nature. 2000 Sep 21;407(6802):340-8.


Structure of the 30S ribosomal subunit.

Wimberly BT, Brodersen DE, Clemons WM Jr, Morgan-Warren RJ, Carter AP, Vonrhein C, Hartsch T, Ramakrishnan V.

Nature. 2000 Sep 21;407(6802):327-39.


Another piece of the ribosome: solution structure of S16 and its location in the 30S subunit.

Allard P, Rak AV, Wimberly BT, Clemons WM Jr, Kalinin A, Helgstrand M, Garber MB, Ramakrishnan V, Härd T.

Structure. 2000 Aug 15;8(8):875-82.


Crystal structure of the conserved subdomain of human protein SRP54M at 2.1 A resolution: evidence for the mechanism of signal peptide binding.

Clemons WM Jr, Gowda K, Black SD, Zwieb C, Ramakrishnan V.

J Mol Biol. 1999 Sep 24;292(3):697-705.


Structure of a bacterial 30S ribosomal subunit at 5.5 A resolution.

Clemons WM Jr, May JL, Wimberly BT, McCutcheon JP, Capel MS, Ramakrishnan V.

Nature. 1999 Aug 26;400(6747):833-40.


Location of translational initiation factor IF3 on the small ribosomal subunit.

McCutcheon JP, Agrawal RK, Philips SM, Grassucci RA, Gerchman SE, Clemons WM Jr, Ramakrishnan V, Frank J.

Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4301-6.

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