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Items: 25


TGF-beta signaling and its targeted therapy in gastrointestinal cancers.

Gotovac JR, Fujihara KM, Phillips WA, Clemons NJ.

Discov Med. 2018 Sep;26(142):103-112. Review.


Preclinical models for the study of Barrett's carcinogenesis.

Read MD, Krishnadath KK, Clemons NJ, Phillips WA.

Ann N Y Acad Sci. 2018 Dec;1434(1):139-148. doi: 10.1111/nyas.13916. Epub 2018 Jul 5. Review.


Bridging the molecular divide: alcohol-induced downregulation of PAX9 and tumour development.

Fujihara KM, Clemons NJ.

J Pathol. 2018 Apr;244(4):386-388. doi: 10.1002/path.5041. Epub 2018 Feb 26.


Inhibiting system xC- and glutathione biosynthesis - a potential Achilles' heel in mutant-p53 cancers.

Clemons NJ, Liu DS, Duong CP, Phillips WA.

Mol Cell Oncol. 2017 Jul 5;4(5):e1344757. doi: 10.1080/23723556.2017.1344757. eCollection 2017.


Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation.

Liu DS, Duong CP, Haupt S, Montgomery KG, House CM, Azar WJ, Pearson HB, Fisher OM, Read M, Guerra GR, Haupt Y, Cullinane C, Wiman KG, Abrahmsen L, Phillips WA, Clemons NJ.

Nat Commun. 2017 Mar 28;8:14844. doi: 10.1038/ncomms14844.


Preclinical models of esophageal adenocarcinoma for drug development.

Liu DS, Duong CP, Phillips WA, Clemons NJ.

Discov Med. 2016 Dec;22(123):371-379. Review.


Novel metastatic models of esophageal adenocarcinoma derived from FLO-1 cells highlight the importance of E-cadherin in cancer metastasis.

Liu DS, Hoefnagel SJ, Fisher OM, Krishnadath KK, Montgomery KG, Busuttil RA, Colebatch AJ, Read M, Duong CP, Phillips WA, Clemons NJ.

Oncotarget. 2016 Dec 13;7(50):83342-83358. doi: 10.18632/oncotarget.13391.


The Genetics of Barrett's Esophagus: A Familial and Population-Based Perspective.

To H, Clemons NJ, Duong CP, Trainer AH, Phillips WA.

Dig Dis Sci. 2016 Jul;61(7):1826-34. doi: 10.1007/s10620-016-4109-2. Epub 2016 Mar 12. Review.


The prognostic value of TP53 mutations in oesophageal adenocarcinoma: a systematic review and meta-analysis.

Fisher OM, Lord SJ, Falkenback D, Clemons NJ, Eslick GD, Lord RV.

Gut. 2017 Mar;66(3):399-410. doi: 10.1136/gutjnl-2015-310888. Epub 2016 Jan 5. Review.


APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma.

Liu DS, Read M, Cullinane C, Azar WJ, Fennell CM, Montgomery KG, Haupt S, Haupt Y, Wiman KG, Duong CP, Clemons NJ, Phillips WA.

Gut. 2015 Oct;64(10):1506-16. doi: 10.1136/gutjnl-2015-309770. Epub 2015 Jul 17.


Intramuscular Transplantation Improves Engraftment Rates for Esophageal Patient-Derived Tumor Xenografts.

Read M, Liu D, Duong CP, Cullinane C, Murray WK, Fennell CM, Shortt J, Westerman D, Burton P, Clemons NJ, Phillips WA.

Ann Surg Oncol. 2016 Jan;23(1):305-11. doi: 10.1245/s10434-015-4425-3. Epub 2015 Feb 18.


Translational research on Barrett's esophagus.

Baruah A, Buttar N, Chandra R, Chen X, Clemons NJ, Compare D, El-Rifai W, Gu J, Houchen CW, Koh SY, Li W, Nardone G, Phillips WA, Sharma A, Singh I, Upton MP, Vega KJ, Wu X.

Ann N Y Acad Sci. 2014 Sep;1325:170-86. doi: 10.1111/nyas.12531.


Hedgehog signaling regulates FOXA2 in esophageal embryogenesis and Barrett's metaplasia.

Wang DH, Tiwari A, Kim ME, Clemons NJ, Regmi NL, Hodges WA, Berman DM, Montgomery EA, Watkins DN, Zhang X, Zhang Q, Jie C, Spechler SJ, Souza RF.

J Clin Invest. 2014 Sep;124(9):3767-80. doi: 10.1172/JCI66603. Epub 2014 Aug 1.


Advances in understanding the pathogenesis of Barrett's esophagus.

Clemons NJ, Koh SY, Phillips WA.

Discov Med. 2014 Jan;17(91):7-14. Review.


Barrett's esophagus: cancer and molecular biology.

Gibson MK, Dhaliwal AS, Clemons NJ, Phillips WA, Dvorak K, Tong D, Law S, Pirchi ED, Räsänen J, Krasna MJ, Parikh K, Krishnadath KK, Chen Y, Griffiths L, Colleypriest BJ, Farrant JM, Tosh D, Das KM, Bajpai M.

Ann N Y Acad Sci. 2013 Oct;1300:296-314. doi: 10.1111/nyas.12252. Review.


Characterization of a novel tumorigenic esophageal adenocarcinoma cell line: OANC1.

Clemons NJ, Do H, Fennell C, Deb S, Fellowes A, Dobrovic A, Phillips WA.

Dig Dis Sci. 2014 Jan;59(1):78-88.


Molecular changes in the phosphatidylinositide 3-kinase (PI3K) pathway are common in gastric cancer.

Tran TN, Brettingham-Moore K, Duong CP, Mitchell C, Clemons NJ, Phillips WA.

J Surg Oncol. 2013 Aug;108(2):113-20. doi: 10.1002/jso.23357. Epub 2013 Jun 28.


Signaling pathways in the molecular pathogenesis of adenocarcinomas of the esophagus and gastroesophageal junction.

Clemons NJ, Phillips WA, Lord RV.

Cancer Biol Ther. 2013 Sep;14(9):782-95. doi: 10.4161/cbt.25362. Epub 2013 Jun 17. Review.


Sox9 drives columnar differentiation of esophageal squamous epithelium: a possible role in the pathogenesis of Barrett's esophagus.

Clemons NJ, Wang DH, Croagh D, Tikoo A, Fennell CM, Murone C, Scott AM, Watkins DN, Phillips WA.

Am J Physiol Gastrointest Liver Physiol. 2012 Dec 15;303(12):G1335-46. doi: 10.1152/ajpgi.00291.2012. Epub 2012 Oct 11.


Nitric oxide-mediated invasion in Barrett's high-grade dysplasia and adenocarcinoma.

Clemons NJ, Shannon NB, Abeyratne LR, Walker CE, Saadi A, O'Donovan ML, Lao-Sirieix PP, Fitzgerald RC.

Carcinogenesis. 2010 Sep;31(9):1669-75. doi: 10.1093/carcin/bgq130. Epub 2010 Jun 27.


Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia.

Wang DH, Clemons NJ, Miyashita T, Dupuy AJ, Zhang W, Szczepny A, Corcoran-Schwartz IM, Wilburn DL, Montgomery EA, Wang JS, Jenkins NA, Copeland NA, Harmon JW, Phillips WA, Watkins DN.

Gastroenterology. 2010 May;138(5):1810-22. doi: 10.1053/j.gastro.2010.01.048. Epub 2010 Feb 4.


Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers.

Saadi A, Shannon NB, Lao-Sirieix P, O'Donovan M, Walker E, Clemons NJ, Hardwick JS, Zhang C, Das M, Save V, Novelli M, Balkwill F, Fitzgerald RC.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2177-82. doi: 10.1073/pnas.0909797107. Epub 2010 Jan 13.


Nitric oxide and acid induce double-strand DNA breaks in Barrett's esophagus carcinogenesis via distinct mechanisms.

Clemons NJ, McColl KE, Fitzgerald RC.

Gastroenterology. 2007 Oct;133(4):1198-209. Epub 2007 Jul 3.


TRAIL-induced apoptosis is enhanced by heat shock protein 70 expression.

Clemons NJ, Anderson RL.

Cell Stress Chaperones. 2006 Winter;11(4):343-55.


Hsp72 inhibits Fas-mediated apoptosis upstream of the mitochondria in type II cells.

Clemons NJ, Buzzard K, Steel R, Anderson RL.

J Biol Chem. 2005 Mar 11;280(10):9005-12. Epub 2005 Jan 4.

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