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Items: 41

1.

Celastrol Induced Weight Loss is Driven by Hypophagia and Independent From UCP1.

Pfuhlmann K, Schriever SC, Baumann P, Kabra DG, Harrison L, Mazibuko-Mbeje SE, Contreras RE, Kyriakou E, Simonds SE, Tiganis T, Cowley MA, Woods SC, Jastroch M, Clemmensen C, De Angelis M, Schramm KW, Sattler M, Messias AC, Tschöp MH, Pfluger PT.

Diabetes. 2018 Aug 28. pii: db180146. doi: 10.2337/db18-0146. [Epub ahead of print]

PMID:
30158241
2.

Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans.

Morville T, Sahl RE, Trammell SA, Svenningsen JS, Gillum MP, Helge JW, Clemmensen C.

JCI Insight. 2018 Aug 9;3(15). pii: 122737. doi: 10.1172/jci.insight.122737. [Epub ahead of print]

3.

Anti-Obesity Therapy: from Rainbow Pills to Polyagonists.

Müller TD, Clemmensen C, Finan B, DiMarchi RD, Tschöp MH.

Pharmacol Rev. 2018 Oct;70(4):712-746. doi: 10.1124/pr.117.014803. Review.

PMID:
30087160
4.

Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs.

Renner S, Blutke A, Dobenecker B, Dhom G, Müller TD, Finan B, Clemmensen C, Bernau M, Novak I, Rathkolb B, Senf S, Zöls S, Roth M, Götz A, Hofmann SM, Hrabĕ de Angelis M, Wanke R, Kienzle E, Scholz AM, DiMarchi R, Ritzmann M, Tschöp MH, Wolf E.

Mol Metab. 2018 Oct;16:180-190. doi: 10.1016/j.molmet.2018.06.015. Epub 2018 Jun 28.

5.

Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood-brain barrier in leptin resistant mice.

Kleinert M, Kotzbeck P, Altendorfer-Kroath T, Birngruber T, Tschöp MH, Clemmensen C.

Mol Metab. 2018 Jul;13:77-82. doi: 10.1016/j.molmet.2018.04.008. Epub 2018 Apr 27.

6.

Exercise increases circulating GDF15 in humans.

Kleinert M, Clemmensen C, Sjøberg KA, Carl CS, Jeppesen JF, Wojtaszewski JFP, Kiens B, Richter EA.

Mol Metab. 2018 Mar;9:187-191. doi: 10.1016/j.molmet.2017.12.016. Epub 2018 Jan 17.

7.

Animal models of obesity and diabetes mellitus.

Kleinert M, Clemmensen C, Hofmann SM, Moore MC, Renner S, Woods SC, Huypens P, Beckers J, de Angelis MH, Schürmann A, Bakhti M, Klingenspor M, Heiman M, Cherrington AD, Ristow M, Lickert H, Wolf E, Havel PJ, Müller TD, Tschöp MH.

Nat Rev Endocrinol. 2018 Mar;14(3):140-162. doi: 10.1038/nrendo.2017.161. Epub 2018 Jan 19. Review.

PMID:
29348476
8.

Emerging Poly-Agonists for Obesity and Type 2 Diabetes.

Kleinert M, Clemmensen C, Stemmer K, Müller TD, DiMarchi RD, Tschöp MH.

Obesity (Silver Spring). 2017 Oct;25(10):1647-1649. doi: 10.1002/oby.21932. No abstract available.

9.

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.

Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph SS, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Krueger M, Koch M, Vettorazzi S, Li P, Hofmann SM, Bakhti M, Bastidas-Ponce A, Lickert H, Strom TM, Gailus-Durner V, Bechmann I, Perez-Tilve D, Tuckermann J, Hrabě de Angelis M, Sandoval D, Cota D, Latz E, Seeley RJ, Müller TD, DiMarchi RD, Finan B, Tschöp MH.

Cell Metab. 2017 Oct 3;26(4):620-632.e6. doi: 10.1016/j.cmet.2017.08.023. Epub 2017 Sep 21.

10.

GLP-1/glucagon receptor co-agonism for treatment of obesity.

Sánchez-Garrido MA, Brandt SJ, Clemmensen C, Müller TD, DiMarchi RD, Tschöp MH.

Diabetologia. 2017 Oct;60(10):1851-1861. doi: 10.1007/s00125-017-4354-8. Epub 2017 Jul 21. Review.

PMID:
28733905
11.

Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice.

Jall S, Sachs S, Clemmensen C, Finan B, Neff F, DiMarchi RD, Tschöp MH, Müller TD, Hofmann SM.

Mol Metab. 2017 Mar 1;6(5):440-446. doi: 10.1016/j.molmet.2017.02.002. eCollection 2017 May.

12.

Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis.

Fischer K, Ruiz HH, Jhun K, Finan B, Oberlin DJ, van der Heide V, Kalinovich AV, Petrovic N, Wolf Y, Clemmensen C, Shin AC, Divanovic S, Brombacher F, Glasmacher E, Keipert S, Jastroch M, Nagler J, Schramm KW, Medrikova D, Collden G, Woods SC, Herzig S, Homann D, Jung S, Nedergaard J, Cannon B, Tschöp MH, Müller TD, Buettner C.

Nat Med. 2017 May;23(5):623-630. doi: 10.1038/nm.4316. Epub 2017 Apr 17.

13.

The New Biology and Pharmacology of Glucagon.

Müller TD, Finan B, Clemmensen C, DiMarchi RD, Tschöp MH.

Physiol Rev. 2017 Apr;97(2):721-766. doi: 10.1152/physrev.00025.2016. Review.

14.

Gut-Brain Cross-Talk in Metabolic Control.

Clemmensen C, Müller TD, Woods SC, Berthoud HR, Seeley RJ, Tschöp MH.

Cell. 2017 Feb 23;168(5):758-774. doi: 10.1016/j.cell.2017.01.025. Review.

15.

Robust GLP-1 secretion by basic L-amino acids does not require the GPRC6A receptor.

Clemmensen C, Jørgensen CV, Smajilovic S, Bräuner-Osborne H.

Diabetes Obes Metab. 2017 Apr;19(4):599-603. doi: 10.1111/dom.12845. Epub 2017 Jan 19.

PMID:
27943578
16.

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.

Finan B, Clemmensen C, Zhu Z, Stemmer K, Gauthier K, Müller L, De Angelis M, Moreth K, Neff F, Perez-Tilve D, Fischer K, Lutter D, Sánchez-Garrido MA, Liu P, Tuckermann J, Malehmir M, Healy ME, Weber A, Heikenwalder M, Jastroch M, Kleinert M, Jall S, Brandt S, Flamant F, Schramm KW, Biebermann H, Döring Y, Weber C, Habegger KM, Keuper M, Gelfanov V, Liu F, Köhrle J, Rozman J, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Hofmann SM, Yang B, Tschöp MH, DiMarchi R, Müller TD.

Cell. 2016 Oct 20;167(3):843-857.e14. doi: 10.1016/j.cell.2016.09.014. Epub 2016 Oct 6.

17.

Fibroblast activation protein (FAP) as a novel metabolic target.

Sánchez-Garrido MA, Habegger KM, Clemmensen C, Holleman C, Müller TD, Perez-Tilve D, Li P, Agrawal AS, Finan B, Drucker DJ, Tschöp MH, DiMarchi RD, Kharitonenkov A.

Mol Metab. 2016 Jul 16;5(10):1015-1024. doi: 10.1016/j.molmet.2016.07.003. eCollection 2016 Oct.

18.

Determination of thyroid hormones in mouse tissues by isotope-dilution microflow liquid chromatography-mass spectrometry method.

De Angelis M, Giesert F, Finan B, Clemmensen C, Müller TD, Vogt-Weisenhorn D, Tschöp MH, Schramm KW.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 15;1033-1034:413-420. doi: 10.1016/j.jchromb.2016.08.037. Epub 2016 Aug 26.

PMID:
27649501
19.

Unimolecular Polypharmacy for Treatment of Diabetes and Obesity.

Tschöp MH, Finan B, Clemmensen C, Gelfanov V, Perez-Tilve D, Müller TD, DiMarchi RD.

Cell Metab. 2016 Jul 12;24(1):51-62. doi: 10.1016/j.cmet.2016.06.021. Review.

20.

Unforeseen role for glucocorticoids in combinatorial anti-obesity pharmacology.

Quarta C, Clemmensen C.

Mol Metab. 2016 May 24;5(7):435-436. doi: 10.1016/j.molmet.2016.05.009. eCollection 2016 Jul. No abstract available.

21.

Reappraisal of GIP Pharmacology for Metabolic Diseases.

Finan B, Müller TD, Clemmensen C, Perez-Tilve D, DiMarchi RD, Tschöp MH.

Trends Mol Med. 2016 May;22(5):359-376. doi: 10.1016/j.molmed.2016.03.005. Epub 2016 Mar 30. Review.

PMID:
27038883
22.

Renaissance of leptin for obesity therapy.

Quarta C, Sánchez-Garrido MA, Tschöp MH, Clemmensen C.

Diabetologia. 2016 May;59(5):920-7. doi: 10.1007/s00125-016-3906-7. Epub 2016 Mar 16. Review.

PMID:
26983921
23.

Hypothalamic leptin action is mediated by histone deacetylase 5.

Kabra DG, Pfuhlmann K, García-Cáceres C, Schriever SC, Casquero García V, Kebede AF, Fuente-Martin E, Trivedi C, Heppner K, Uhlenhaut NH, Legutko B, Kabra UD, Gao Y, Yi CX, Quarta C, Clemmensen C, Finan B, Müller TD, Meyer CW, Paez-Pereda M, Stemmer K, Woods SC, Perez-Tilve D, Schneider R, Olson EN, Tschöp MH, Pfluger PT.

Nat Commun. 2016 Feb 29;7:10782. doi: 10.1038/ncomms10782.

24.

Emerging opportunities for the treatment of metabolic diseases: Glucagon-like peptide-1 based multi-agonists.

Finan B, Clemmensen C, Müller TD.

Mol Cell Endocrinol. 2015 Dec 15;418 Pt 1:42-54. doi: 10.1016/j.mce.2015.07.003. Epub 2015 Jul 4. Review.

PMID:
26151488
25.

Current and Emerging Treatment Options in Diabetes Care.

Clemmensen C, Müller TD, Finan B, Tschöp MH, DiMarchi R.

Handb Exp Pharmacol. 2016;233:437-59. doi: 10.1007/164_2015_7. Review.

PMID:
25903416
26.

Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice.

Clemmensen C, Finan B, Fischer K, Tom RZ, Legutko B, Sehrer L, Heine D, Grassl N, Meyer CW, Henderson B, Hofmann SM, Tschöp MH, Van der Ploeg LH, Müller TD.

EMBO Mol Med. 2015 Mar;7(3):288-98. doi: 10.15252/emmm.201404508.

27.

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.

Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, Müller TD, Perez-Tilve D, DiMarchi RD, Tschöp MH.

Nat Med. 2015 Jan;21(1):27-36. doi: 10.1038/nm.3761. Epub 2014 Dec 8.

PMID:
25485909
28.

FXR is a molecular target for the effects of vertical sleeve gastrectomy.

Ryan KK, Tremaroli V, Clemmensen C, Kovatcheva-Datchary P, Myronovych A, Karns R, Wilson-Pérez HE, Sandoval DA, Kohli R, Bäckhed F, Seeley RJ.

Nature. 2014 May 8;509(7499):183-8. doi: 10.1038/nature13135. Epub 2014 Mar 26.

29.

Loss of melanocortin-4 receptor function attenuates HPA responses to psychological stress.

Ryan KK, Mul JD, Clemmensen C, Egan AE, Begg DP, Halcomb K, Seeley RJ, Herman JP, Ulrich-Lai YM.

Psychoneuroendocrinology. 2014 Apr;42:98-105. doi: 10.1016/j.psyneuen.2014.01.010. Epub 2014 Jan 22.

30.

GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet.

Clemmensen C, Chabenne J, Finan B, Sullivan L, Fischer K, Küchler D, Sehrer L, Ograjsek T, Hofmann SM, Schriever SC, Pfluger PT, Pinkstaff J, Tschöp MH, Dimarchi R, Müller TD.

Diabetes. 2014 Apr;63(4):1422-7. doi: 10.2337/db13-1609. Epub 2013 Dec 30.

31.

The Pentapeptide RM-131 Promotes Food Intake and Adiposity in Wildtype Mice but Not in Mice Lacking the Ghrelin Receptor.

Fischer K, Finan B, Clemmensen C, van der Ploeg LH, Tschöp MH, Müller TD.

Front Nutr. 2015 Jan 12;1:31. doi: 10.3389/fnut.2014.00031. eCollection 2014.

32.

The GPCR, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function.

Clemmensen C, Smajilovic S, Wellendorph P, Bräuner-Osborne H.

Br J Pharmacol. 2014 Mar;171(5):1129-41. doi: 10.1111/bph.12365. Review.

33.

Oral L-arginine stimulates GLP-1 secretion to improve glucose tolerance in male mice.

Clemmensen C, Smajilovic S, Smith EP, Woods SC, Bräuner-Osborne H, Seeley RJ, D'Alessio DA, Ryan KK.

Endocrinology. 2013 Nov;154(11):3978-83. doi: 10.1210/en.2013-1529. Epub 2013 Aug 19.

34.

Enhanced voluntary wheel running in GPRC6A receptor knockout mice.

Clemmensen C, Pehmøller C, Klein AB, Ratner C, Wojtaszewski JF, Bräuner-Osborne H.

Physiol Behav. 2013 Jun 13;118:144-51. doi: 10.1016/j.physbeh.2013.05.015. Epub 2013 May 14.

PMID:
23680430
35.

Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice.

Clemmensen C, Smajilovic S, Madsen AN, Klein AB, Holst B, Bräuner-Osborne H.

J Endocrinol. 2013 Apr 15;217(2):151-60. doi: 10.1530/JOE-12-0550. Print 2013 May.

PMID:
23428581
36.

The L-α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release.

Smajilovic S, Clemmensen C, Johansen LD, Wellendorph P, Holst JJ, Thams PG, Ogo E, Bräuner-Osborne H.

Amino Acids. 2013 Feb;44(2):383-90. doi: 10.1007/s00726-012-1341-8. Epub 2012 Jun 20.

PMID:
22714012
37.

The microtubule-associated protein 1A (MAP1A) is an early molecular target of soluble Aβ-peptide.

Clemmensen C, Aznar S, Knudsen GM, Klein AB.

Cell Mol Neurobiol. 2012 May;32(4):561-6. doi: 10.1007/s10571-011-9796-9. Epub 2012 Jan 18.

PMID:
22252785
38.

L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances.

Clemmensen C, Madsen AN, Smajilovic S, Holst B, Bräuner-Osborne H.

Amino Acids. 2012 Sep;43(3):1265-75. doi: 10.1007/s00726-011-1199-1. Epub 2011 Dec 27.

PMID:
22200933
39.

Blood BDNF concentrations reflect brain-tissue BDNF levels across species.

Klein AB, Williamson R, Santini MA, Clemmensen C, Ettrup A, Rios M, Knudsen GM, Aznar S.

Int J Neuropsychopharmacol. 2011 Apr;14(3):347-53. doi: 10.1017/S1461145710000738. Epub 2010 Jul 7.

PMID:
20604989
40.

Coordinated increase in skeletal muscle fiber area and expression of IGF-I with resistance exercise in elderly post-operative patients.

Suetta C, Clemmensen C, Andersen JL, Magnusson SP, Schjerling P, Kjaer M.

Growth Horm IGF Res. 2010 Apr;20(2):134-40. doi: 10.1016/j.ghir.2009.11.005. Epub 2009 Dec 23.

PMID:
20031461
41.

[Holiday home with stress on "home"].

Clemmensen C.

Sygeplejersken. 1974 Jul 10;74(27):28-9. Danish. No abstract available.

PMID:
4496158

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