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Brain macrophages harbor latent, infectious simian immunodeficiency virus.

Abreu C, Shirk EN, Queen SE, Beck SE, Mangus LM, Pate KAM, Mankowski JL, Gama L, Clements JE.

AIDS. 2019 Dec 1;33 Suppl 2:S181-S188. doi: 10.1097/QAD.0000000000002269.


HIV persistence in the central nervous system during antiretroviral therapy: evidence and implications.

Spudich S, Clements JE.

AIDS. 2019 Dec 1;33 Suppl 2:S103-S106. doi: 10.1097/QAD.0000000000002439. No abstract available.


Myeloid and CD4 T Cells Comprise the Latent Reservoir in Antiretroviral Therapy-Suppressed SIVmac251-Infected Macaques.

Abreu CM, Veenhuis RT, Avalos CR, Graham S, Parrilla DR, Ferreira EA, Queen SE, Shirk EN, Bullock BT, Li M, Metcalf Pate KA, Beck SE, Mangus LM, Mankowski JL, Mac Gabhann F, O'Connor SL, Gama L, Clements JE.

mBio. 2019 Aug 20;10(4). pii: e01659-19. doi: 10.1128/mBio.01659-19.


The Landscape of Persistent Viral Genomes in ART-Treated SIV, SHIV, and HIV-2 Infections.

Bender AM, Simonetti FR, Kumar MR, Fray EJ, Bruner KM, Timmons AE, Tai KY, Jenike KM, Antar AAR, Liu PT, Ho YC, Raugi DN, Seydi M, Gottlieb GS, Okoye AA, Del Prete GQ, Picker LJ, Mankowski JL, Lifson JD, Siliciano JD, Laird GM, Barouch DH, Clements JE, Siliciano RF.

Cell Host Microbe. 2019 Jul 10;26(1):73-85.e4. doi: 10.1016/j.chom.2019.06.005.


Tunable Synthesis of Hollow Metal-Nitrogen-Carbon Capsules for Efficient Oxygen Reduction Catalysis in Proton Exchange Membrane Fuel Cells.

Yang H, Chen X, Chen WT, Wang Q, Cuello NC, Nafady A, Al-Enizi AM, Waterhouse GIN, Goenaga GA, Zawodzinski TA, Kruger PE, Clements JE, Zhang J, Tian H, Telfer SG, Ma S.

ACS Nano. 2019 Jul 23;13(7):8087-8098. doi: 10.1021/acsnano.9b02930. Epub 2019 Jun 24.


Infectious Virus Persists in CD4+ T Cells and Macrophages in Antiretroviral Therapy-Suppressed Simian Immunodeficiency Virus-Infected Macaques.

Abreu CM, Veenhuis RT, Avalos CR, Graham S, Queen SE, Shirk EN, Bullock BT, Li M, Metcalf Pate KA, Beck SE, Mangus LM, Mankowski JL, Clements JE, Gama L.

J Virol. 2019 Jul 17;93(15). pii: e00065-19. doi: 10.1128/JVI.00065-19. Print 2019 Aug 1.


Heteroatom substitution effects in spin crossover dinuclear complexes.

Zaiter S, Kirk C, Taylor M, Klein YM, Housecroft CE, Sciortino NF, Clements JE, Cooper RI, Kepert CJ, Neville SM.

Dalton Trans. 2019 Jun 7;48(21):7337-7343. doi: 10.1039/c8dt05010d. Epub 2019 Mar 18.


HIV Eradication Strategies: Implications for the Central Nervous System.

Veenhuis RT, Clements JE, Gama L.

Curr HIV/AIDS Rep. 2019 Feb;16(1):96-104. doi: 10.1007/s11904-019-00428-7. Review.


CCR2 Signaling Selectively Regulates IFN-α: Role of β-Arrestin 2 in IFNAR1 Internalization.

Williams DW, Askew LC, Jones E, Clements JE.

J Immunol. 2019 Jan 1;202(1):105-118. doi: 10.4049/jimmunol.1800598. Epub 2018 Nov 30.


Guest-Adaptable Spin Crossover Properties in a Dinuclear Species Underpinned by Supramolecular Interactions.

Clements JE, Airey PR, Ragon F, Shang V, Kepert CJ, Neville SM.

Inorg Chem. 2018 Dec 3;57(23):14930-14938. doi: 10.1021/acs.inorgchem.8b02625. Epub 2018 Nov 20.


A Quantitative Approach to SIV Functional Latency in Brain Macrophages.

Abreu C, Shirk EN, Queen SE, Mankowski JL, Gama L, Clements JE.

J Neuroimmune Pharmacol. 2019 Mar;14(1):23-32. doi: 10.1007/s11481-018-9803-8. Epub 2018 Aug 30. Review.


CCR2 on Peripheral Blood CD14+CD16+ Monocytes Correlates with Neuronal Damage, HIV-Associated Neurocognitive Disorders, and Peripheral HIV DNA: reseeding of CNS reservoirs?

Veenstra M, Byrd DA, Inglese M, Buyukturkoglu K, Williams DW, Fleysher L, Li M, Gama L, León-Rivera R, Calderon TM, Clements JE, Morgello S, Berman JW.

J Neuroimmune Pharmacol. 2019 Mar;14(1):120-133. doi: 10.1007/s11481-018-9792-7. Epub 2018 Jul 6.


SIV Latency in Macrophages in the CNS.

Gama L, Abreu C, Shirk EN, Queen SE, Beck SE, Metcalf Pate KA, Bullock BT, Zink MC, Mankowski JL, Clements JE.

Curr Top Microbiol Immunol. 2018;417:111-130. doi: 10.1007/82_2018_89. Review.


Lymphocyte-Dominant Encephalitis and Meningitis in Simian Immunodeficiency Virus-Infected Macaques Receiving Antiretroviral Therapy.

Mangus LM, Beck SE, Queen SE, Brill SA, Shirk EN, Metcalf Pate KA, Muth DC, Adams RJ, Gama L, Clements JE, Mankowski JL.

Am J Pathol. 2018 Jan;188(1):125-134. doi: 10.1016/j.ajpath.2017.08.035. Epub 2017 Dec 8.


Mechanisms of CNS Viral Seeding by HIV+ CD14+ CD16+ Monocytes: Establishment and Reseeding of Viral Reservoirs Contributing to HIV-Associated Neurocognitive Disorders.

Veenstra M, León-Rivera R, Li M, Gama L, Clements JE, Berman JW.

mBio. 2017 Oct 24;8(5). pii: e01280-17. doi: 10.1128/mBio.01280-17.


An SIV/macaque model targeted to study HIV-associated neurocognitive disorders.

Beck SE, Queen SE, Metcalf Pate KA, Mangus LM, Abreu CM, Gama L, Witwer KW, Adams RJ, Zink MC, Clements JE, Mankowski JL.

J Neurovirol. 2018 Apr;24(2):204-212. doi: 10.1007/s13365-017-0582-4. Epub 2017 Oct 3. Review.


Brain Macrophages in Simian Immunodeficiency Virus-Infected, Antiretroviral-Suppressed Macaques: a Functional Latent Reservoir.

Avalos CR, Abreu CM, Queen SE, Li M, Price S, Shirk EN, Engle EL, Forsyth E, Bullock BT, Mac Gabhann F, Wietgrefe SW, Haase AT, Zink MC, Mankowski JL, Clements JE, Gama L.

mBio. 2017 Aug 15;8(4). pii: e01186-17. doi: 10.1128/mBio.01186-17.


HIV Infection of Macrophages: Implications for Pathogenesis and Cure.

Clayton KL, Garcia JV, Clements JE, Walker BD.

Pathog Immun. 2017;2(2):179-192. doi: 10.20411/pai.v2i2.204. Epub 2017 May 24.


HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation.

Gannon PJ, Akay-Espinoza C, Yee AC, Briand LA, Erickson MA, Gelman BB, Gao Y, Haughey NJ, Zink MC, Clements JE, Kim NS, Van De Walle G, Jensen BK, Vassar R, Pierce RC, Gill AJ, Kolson DL, Diehl JA, Mankowski JL, Jordan-Sciutto KL.

Am J Pathol. 2017 Jan;187(1):91-109. doi: 10.1016/j.ajpath.2016.09.006.


Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaques.

Gama L, Abreu CM, Shirk EN, Price SL, Li M, Laird GM, Pate KA, Wietgrefe SW, O'Connor SL, Pianowski L, Haase AT, Van Lint C, Siliciano RF, Clements JE; LRA-SIV Study Group.

AIDS. 2017 Jan 2;31(1):5-14.


HIV Suppression Restores the Lung Mucosal CD4+ T-Cell Viral Immune Response and Resolves CD8+ T-Cell Alveolitis in Patients at Risk for HIV-Associated Chronic Obstructive Pulmonary Disease.

Popescu I, Drummond MB, Gama L, Lambert A, Hoji A, Coon T, Merlo CA, Wise RA, Keruly J, Clements JE, Kirk GD, McDyer JF.

J Infect Dis. 2016 Nov 15;214(10):1520-1530. Epub 2016 Sep 9.


Hysteretic Four-Step Spin Crossover within a Three-Dimensional Porous Hofmann-like Material.

Clements JE, Price JR, Neville SM, Kepert CJ.

Angew Chem Int Ed Engl. 2016 Nov 21;55(48):15105-15109. doi: 10.1002/anie.201605418. Epub 2016 Oct 21.


Splenic Damage during SIV Infection: Role of T-Cell Depletion and Macrophage Polarization and Infection.

Williams DW, Engle EL, Shirk EN, Queen SE, Gama L, Mankowski JL, Zink MC, Clements JE.

Am J Pathol. 2016 Aug;186(8):2068-2087. doi: 10.1016/j.ajpath.2016.03.019. Epub 2016 Jun 18.


Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques.

Avalos CR, Price SL, Forsyth ER, Pin JN, Shirk EN, Bullock BT, Queen SE, Li M, Gellerup D, O'Connor SL, Zink MC, Mankowski JL, Gama L, Clements JE.

J Virol. 2016 May 27;90(12):5643-5656. doi: 10.1128/JVI.00290-16. Print 2016 Jun 15.


A Murine Viral Outgrowth Assay to Detect Residual HIV Type 1 in Patients With Undetectable Viral Loads.

Metcalf Pate KA, Pohlmeyer CW, Walker-Sperling VE, Foote JB, Najarro KM, Cryer CG, Salgado M, Gama L, Engle EL, Shirk EN, Queen SE, Chioma S, Vermillion MS, Bullock B, Li M, Lyons CE, Adams RJ, Zink MC, Clements JE, Mankowski JL, Blankson JN.

J Infect Dis. 2015 Nov 1;212(9):1387-96. doi: 10.1093/infdis/jiv230. Epub 2015 Apr 15.


Paving the path to HIV neurotherapy: Predicting SIV CNS disease.

Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Christine Zink M, Mankowski JL.

Eur J Pharmacol. 2015 Jul 15;759:303-12. doi: 10.1016/j.ejphar.2015.03.018. Epub 2015 Mar 24. Review.


Activation-induced cell death drives profound lung CD4(+) T-cell depletion in HIV-associated chronic obstructive pulmonary disease.

Popescu I, Drummond MB, Gama L, Coon T, Merlo CA, Wise RA, Clements JE, Kirk GD, McDyer JF.

Am J Respir Crit Care Med. 2014 Oct 1;190(7):744-55. doi: 10.1164/rccm.201407-1226OC.


Perturbation of spin crossover behavior by covalent post-synthetic modification of a porous metal-organic framework.

Clements JE, Price JR, Neville SM, Kepert CJ.

Angew Chem Int Ed Engl. 2014 Sep 15;53(38):10164-8. doi: 10.1002/anie.201402951. Epub 2014 Jul 24.


Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: inhibition of de novo infection and activation of viral LTR.

Abreu CM, Price SL, Shirk EN, Cunha RD, Pianowski LF, Clements JE, Tanuri A, Gama L.

PLoS One. 2014 May 14;9(5):e97257. doi: 10.1371/journal.pone.0097257. eCollection 2014.


TRIM19-positive and TRIM19-negative cells in and around a perivascular cuff of CD68-positive macrophages.

Witwer KW, Gama L, Mankowski JL, Zink MC, Clements JE.

AIDS Res Hum Retroviruses. 2014 Apr;30(4):333-4. doi: 10.1089/aid.2014.0029. No abstract available.


Tristetraprolin expression and microRNA-mediated regulation during simian immunodeficiency virus infection of the central nervous system.

Liu J, Sisk JM, Gama L, Clements JE, Witwer KW.

Mol Brain. 2013 Sep 2;6:40. doi: 10.1186/1756-6606-6-40.


RON receptor tyrosine kinase, a negative regulator of inflammation, is decreased during simian immunodeficiency virus-associated central nervous system disease.

Cary DC, Clements JE, Henderson AJ.

J Immunol. 2013 Oct 15;191(8):4280-7. doi: 10.4049/jimmunol.1300797. Epub 2013 Sep 16.


Quantitation of gene expression in formaldehyde-fixed and fluorescence-activated sorted cells.

Russell JN, Clements JE, Gama L.

PLoS One. 2013 Sep 2;8(9):e73849. doi: 10.1371/journal.pone.0073849. eCollection 2013.


SIV replication is directly downregulated by four antiviral miRNAs.

Sisk JM, Witwer KW, Tarwater PM, Clements JE.

Retrovirology. 2013 Aug 29;10:95. doi: 10.1186/1742-4690-10-95.


miRNA profiles of monocyte-lineage cells are consistent with complicated roles in HIV-1 restriction.

Sisk JM, Clements JE, Witwer KW.

Viruses. 2012 Sep 25;4(10):1844-64. doi: 10.3390/v4101844. Erratum in: Viruses. 2013 Mar;5(3):901.


Tissue-specific interferon alpha subtype response to SIV infection in brain, spleen, and lung.

Zaritsky LA, Dery A, Leong WY, Gama L, Clements JE.

J Interferon Cytokine Res. 2013 Jan;33(1):24-33. doi: 10.1089/jir.2012.0018. Epub 2012 Oct 10.


Early emergence and selection of a SIV-LTR C/EBP site variant in SIV-infected macaques that increases virus infectivity.

Ravimohan S, Gama L, Engle EL, Zink MC, Clements JE.

PLoS One. 2012;7(8):e42801. doi: 10.1371/journal.pone.0042801. Epub 2012 Aug 27. Erratum in: PLoS One. 2013;8(3). doi: 10.1371/annotation/050af66e-a935-46e6-96ec-5ac7e0fc4dfc.


Detection of microbial translocation in HIV and SIV infection using the Limulus amebocyte lysate assay is masked by serum and plasma.

Balagopal A, Gama L, Franco V, Russell JN, Quinn J, Higgins Y, Smeaton LM, Clements JE, Thomas DL, Gupta A; NWCS 319 and ACTG 5175 study team.

PLoS One. 2012;7(8):e41258. Epub 2012 Aug 1.


Evidence for miRNA expression differences of HIV-1-positive, treatment-naive patients and elite suppressors: a re-analysis.

Witwer KW, Clements JE.

Blood. 2012 Jun 28;119(26):6395-6. doi: 10.1182/blood-2012-02-412742. No abstract available.


Canonical type I IFN signaling in simian immunodeficiency virus-infected macrophages is disrupted by astrocyte-secreted CCL2.

Zaritsky LA, Gama L, Clements JE.

J Immunol. 2012 Apr 15;188(8):3876-85. doi: 10.4049/jimmunol.1103024. Epub 2012 Mar 9.


Expansion of a subset of CD14highCD16negCCR2low/neg monocytes functionally similar to myeloid-derived suppressor cells during SIV and HIV infection.

Gama L, Shirk EN, Russell JN, Carvalho KI, Li M, Queen SE, Kalil J, Zink MC, Clements JE, Kallas EG.

J Leukoc Biol. 2012 May;91(5):803-16. doi: 10.1189/jlb.1111579. Epub 2012 Feb 24.


Relationships of PBMC microRNA expression, plasma viral load, and CD4+ T-cell count in HIV-1-infected elite suppressors and viremic patients.

Witwer KW, Watson AK, Blankson JN, Clements JE.

Retrovirology. 2012 Jan 12;9:5. doi: 10.1186/1742-4690-9-5.


Induction of innate immune responses by SIV in vivo and in vitro: differential expression and function of RIG-I and MDA5.

Co JG, Witwer KW, Gama L, Zink MC, Clements JE.

J Infect Dis. 2011 Oct 1;204(7):1104-14. doi: 10.1093/infdis/jir469.


A plasma microRNA signature of acute lentiviral infection: biomarkers of central nervous system disease.

Witwer KW, Sarbanes SL, Liu J, Clements JE.

AIDS. 2011 Nov 13;25(17):2057-67. doi: 10.1097/QAD.0b013e32834b95bf.


Regulation of CCL2 expression by an upstream TALE homeodomain protein-binding site that synergizes with the site created by the A-2578G SNP.

Page SH, Wright EK Jr, Gama L, Clements JE.

PLoS One. 2011;6(7):e22052. doi: 10.1371/journal.pone.0022052. Epub 2011 Jul 8.


Human immunodeficiency virus infection of human astrocytes disrupts blood-brain barrier integrity by a gap junction-dependent mechanism.

Eugenin EA, Clements JE, Zink MC, Berman JW.

J Neurosci. 2011 Jun 29;31(26):9456-65. doi: 10.1523/JNEUROSCI.1460-11.2011.


Replication-competent simian immunodeficiency virus (SIV) Gag escape mutations archived in latent reservoirs during antiretroviral treatment of SIV-infected macaques.

Queen SE, Mears BM, Kelly KM, Dorsey JL, Liao Z, Dinoso JB, Gama L, Adams RJ, Zink MC, Clements JE, Kent SJ, Mankowski JL.

J Virol. 2011 Sep;85(17):9167-75. doi: 10.1128/JVI.00366-11. Epub 2011 Jun 29.


SIV/macaque model of HIV infection in cocaine users: minimal effects of cocaine on behavior, virus replication, and CNS inflammation.

Weed M, Adams RJ, Hienz RD, Meulendyke KA, Linde ME, Clements JE, Mankowski JL, Zink MC.

J Neuroimmune Pharmacol. 2012 Jun;7(2):401-11. doi: 10.1007/s11481-011-9281-8. Epub 2011 May 28.

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