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Items: 46

1.

Variable effects of local management on coral defenses against a thermally regulated bleaching pathogen.

Beatty DS, Valayil JM, Clements CS, Ritchie KB, Stewart FJ, Hay ME.

Sci Adv. 2019 Oct 2;5(10):eaay1048. doi: 10.1126/sciadv.aay1048. eCollection 2019 Oct.

2.

Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways.

Clements CS, Bikkul MU, Ofosu W, Eskiw C, Tree D, Makarov E, Kill IR, Bridger JM.

Biogerontology. 2019 Jun;20(3):337-358. doi: 10.1007/s10522-019-09807-4. Epub 2019 Apr 30.

3.

The prevalence of methicillin-resistant Staphylococcus aureus among diabetic patients: a meta-analysis.

Stacey HJ, Clements CS, Welburn SC, Jones JD.

Acta Diabetol. 2019 Aug;56(8):907-921. doi: 10.1007/s00592-019-01301-0. Epub 2019 Apr 6.

4.

Biodiversity enhances coral growth, tissue survivorship and suppression of macroalgae.

Clements CS, Hay ME.

Nat Ecol Evol. 2019 Feb;3(2):178-182. doi: 10.1038/s41559-018-0752-7. Epub 2019 Jan 7.

5.

A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists.

Patil R, Mohanty B, Liu B, Chandrashekaran IR, Headey SJ, Williams ML, Clements CS, Ilyichova O, Doak BC, Genissel P, Weaver RJ, Vuillard L, Halls ML, Porter CJH, Scanlon MJ.

J Biol Chem. 2019 Mar 8;294(10):3720-3734. doi: 10.1074/jbc.RA118.006848. Epub 2018 Dec 31.

PMID:
30598509
6.

Intergenerational effects of macroalgae on a reef coral: major declines in larval survival but subtle changes in microbiomes.

Beatty DS, Clements CS, Stewart FJ, Hay ME.

Mar Ecol Prog Ser. 2018;589:97-114. doi: 10.3354/meps12465. Epub 2018 Feb 23.

7.

Spatial and temporal limits of coral-macroalgal competition: the negative impacts of macroalgal density, proximity, and history of contact.

Clements CS, Rasher DB, Hoey AS, Bonito VE, Hay ME.

Mar Ecol Prog Ser. 2018;586:11-20. doi: 10.3354/meps12410. Epub 2018 Jan 11.

8.

Overlooked coral predators suppress foundation species as reefs degrade.

Clements CS, Hay ME.

Ecol Appl. 2018 Oct;28(7):1673-1682. doi: 10.1002/eap.1765. Epub 2018 Jul 26.

9.

Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson-Gilford progeria syndrome fibroblasts.

Bikkul MU, Clements CS, Godwin LS, Goldberg MW, Kill IR, Bridger JM.

Biogerontology. 2018 Dec;19(6):579-602. doi: 10.1007/s10522-018-9758-4. Epub 2018 Jun 15.

10.

A conserved energetic footprint underpins recognition of human leukocyte antigen-E by two distinct αβ T cell receptors.

Sullivan LC, Walpole NG, Farenc C, Pietra G, Sum MJW, Clements CS, Lee EJ, Beddoe T, Falco M, Mingari MC, Moretta L, Gras S, Rossjohn J, Brooks AG.

J Biol Chem. 2017 Dec 22;292(51):21149-21158. doi: 10.1074/jbc.M117.807719. Epub 2017 Sep 25.

11.

Size matters: Predator outbreaks threaten foundation species in small Marine Protected Areas.

Clements CS, Hay ME.

PLoS One. 2017 Feb 6;12(2):e0171569. doi: 10.1371/journal.pone.0171569. eCollection 2017.

12.

Visualizing the Spatial Relationship of the Genome with the Nuclear Envelope Using Fluorescence In Situ Hybridization.

Clements CS, Bikkul U, Ahmed MH, Foster HA, Godwin LS, Bridger JM.

Methods Mol Biol. 2016;1411:387-406. doi: 10.1007/978-1-4939-3530-7_24.

PMID:
27147055
13.

Competitors as accomplices: seaweed competitors hide corals from predatory sea stars.

Clements CS, Hay ME.

Proc Biol Sci. 2015 Sep 7;282(1814). doi: 10.1098/rspb.2015.0714.

14.

The structure of the atypical killer cell immunoglobulin-like receptor, KIR2DL4.

Moradi S, Berry R, Pymm P, Hitchen C, Beckham SA, Wilce MC, Walpole NG, Clements CS, Reid HH, Perugini MA, Brooks AG, Rossjohn J, Vivian JP.

J Biol Chem. 2015 Apr 17;290(16):10460-71. doi: 10.1074/jbc.M114.612291. Epub 2015 Mar 10.

15.

A structural basis for antigen presentation by the MHC class Ib molecule, Qa-1b.

Zeng L, Sullivan LC, Vivian JP, Walpole NG, Harpur CM, Rossjohn J, Clements CS, Brooks AG.

J Immunol. 2012 Jan 1;188(1):302-10. doi: 10.4049/jimmunol.1102379. Epub 2011 Nov 30.

16.

Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B.

Vivian JP, Duncan RC, Berry R, O'Connor GM, Reid HH, Beddoe T, Gras S, Saunders PM, Olshina MA, Widjaja JM, Harpur CM, Lin J, Maloveste SM, Price DA, Lafont BA, McVicar DW, Clements CS, Brooks AG, Rossjohn J.

Nature. 2011 Oct 23;479(7373):401-5. doi: 10.1038/nature10517.

17.

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.

Burrows SR, Chen Z, Archbold JK, Tynan FE, Beddoe T, Kjer-Nielsen L, Miles JJ, Khanna R, Moss DJ, Liu YC, Gras S, Kostenko L, Brennan RM, Clements CS, Brooks AG, Purcell AW, McCluskey J, Rossjohn J.

Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10608-13. doi: 10.1073/pnas.1004926107. Epub 2010 May 18.

18.

Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition.

Theodossis A, Guillonneau C, Welland A, Ely LK, Clements CS, Williamson NA, Webb AI, Wilce JA, Mulder RJ, Dunstone MA, Doherty PC, McCluskey J, Purcell AW, Turner SJ, Rossjohn J.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5534-9. doi: 10.1073/pnas.1000032107. Epub 2010 Mar 8.

19.

The structure and stability of the monomorphic HLA-G are influenced by the nature of the bound peptide.

Walpole NG, Kjer-Nielsen L, Kostenko L, McCluskey J, Brooks AG, Rossjohn J, Clements CS.

J Mol Biol. 2010 Mar 26;397(2):467-80. doi: 10.1016/j.jmb.2010.01.052. Epub 2010 Feb 1.

20.

T cell allorecognition via molecular mimicry.

Macdonald WA, Chen Z, Gras S, Archbold JK, Tynan FE, Clements CS, Bharadwaj M, Kjer-Nielsen L, Saunders PM, Wilce MC, Crawford F, Stadinsky B, Jackson D, Brooks AG, Purcell AW, Kappler JW, Burrows SR, Rossjohn J, McCluskey J.

Immunity. 2009 Dec 18;31(6):897-908. doi: 10.1016/j.immuni.2009.09.025.

21.

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.

Beddoe T, Chen Z, Clements CS, Ely LK, Bushell SR, Vivian JP, Kjer-Nielsen L, Pang SS, Dunstone MA, Liu YC, Macdonald WA, Perugini MA, Wilce MC, Burrows SR, Purcell AW, Tiganis T, Bottomley SP, McCluskey J, Rossjohn J.

Immunity. 2009 Jun 19;30(6):777-88. doi: 10.1016/j.immuni.2009.03.018. Epub 2009 May 21.

22.

A long, naturally presented immunodominant epitope from NY-ESO-1 tumor antigen: implications for cancer vaccine design.

Ebert LM, Liu YC, Clements CS, Robson NC, Jackson HM, Markby JL, Dimopoulos N, Tan BS, Luescher IF, Davis ID, Rossjohn J, Cebon J, Purcell AW, Chen W.

Cancer Res. 2009 Feb 1;69(3):1046-54. doi: 10.1158/0008-5472.CAN-08-2926. Epub 2009 Jan 27. Erratum in: Cancer Res. 2009 May 15;69(10):4553.

23.

The shaping of T cell receptor recognition by self-tolerance.

Gras S, Burrows SR, Kjer-Nielsen L, Clements CS, Liu YC, Sullivan LC, Bell MJ, Brooks AG, Purcell AW, McCluskey J, Rossjohn J.

Immunity. 2009 Feb 20;30(2):193-203. doi: 10.1016/j.immuni.2008.11.011. Epub 2009 Jan 22.

24.

Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition.

Archbold JK, Macdonald WA, Gras S, Ely LK, Miles JJ, Bell MJ, Brennan RM, Beddoe T, Wilce MC, Clements CS, Purcell AW, McCluskey J, Burrows SR, Rossjohn J.

J Exp Med. 2009 Jan 16;206(1):209-19. doi: 10.1084/jem.20082136. Epub 2009 Jan 12.

25.

The major histocompatibility complex class Ib molecule HLA-E at the interface between innate and adaptive immunity.

Sullivan LC, Clements CS, Rossjohn J, Brooks AG.

Tissue Antigens. 2008 Nov;72(5):415-24. doi: 10.1111/j.1399-0039.2008.01138.x. Review.

PMID:
18946929
26.

Subtle changes in peptide conformation profoundly affect recognition of the non-classical MHC class I molecule HLA-E by the CD94-NKG2 natural killer cell receptors.

Hoare HL, Sullivan LC, Clements CS, Ely LK, Beddoe T, Henderson KN, Lin J, Reid HH, Brooks AG, Rossjohn J.

J Mol Biol. 2008 Apr 11;377(5):1297-303. doi: 10.1016/j.jmb.2008.01.098. Epub 2008 Feb 12. Review.

PMID:
18339401
27.

CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence.

Petrie EJ, Clements CS, Lin J, Sullivan LC, Johnson D, Huyton T, Heroux A, Hoare HL, Beddoe T, Reid HH, Wilce MC, Brooks AG, Rossjohn J.

J Exp Med. 2008 Mar 17;205(3):725-35. doi: 10.1084/jem.20072525. Epub 2008 Mar 10.

28.

The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition.

Sullivan LC, Clements CS, Beddoe T, Johnson D, Hoare HL, Lin J, Huyton T, Hopkins EJ, Reid HH, Wilce MC, Kabat J, Borrego F, Coligan JE, Rossjohn J, Brooks AG.

Immunity. 2007 Dec;27(6):900-11.

29.

Alterations to nuclear architecture and genome behavior in senescent cells.

Mehta IS, Figgitt M, Clements CS, Kill IR, Bridger JM.

Ann N Y Acad Sci. 2007 Apr;1100:250-63. Review.

PMID:
17460187
30.

Structural studies on HLA-G: implications for ligand and receptor binding.

Clements CS, Kjer-Nielsen L, McCluskey J, Rossjohn J.

Hum Immunol. 2007 Apr;68(4):220-6. Epub 2006 Oct 27. Review.

PMID:
17400055
31.

Specificity on a knife-edge: the alphabeta T cell receptor.

Clements CS, Dunstone MA, Macdonald WA, McCluskey J, Rossjohn J.

Curr Opin Struct Biol. 2006 Dec;16(6):787-95. Epub 2006 Sep 29. Review.

PMID:
17011774
32.

Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction.

Ely LK, Beddoe T, Clements CS, Matthews JM, Purcell AW, Kjer-Nielsen L, McCluskey J, Rossjohn J.

Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6641-6. Epub 2006 Apr 14.

33.

The production, purification and crystallization of a soluble form of the nonclassical MHC HLA-G: the essential role of cobalt.

Clements CS, Kjer-Nielsen L, Kostenko L, McCluskey J, Rossjohn J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jan 1;62(Pt 1):70-3. Epub 2005 Dec 16.

34.

A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.

Kjer-Nielsen L, Borg NA, Pellicci DG, Beddoe T, Kostenko L, Clements CS, Williamson NA, Smyth MJ, Besra GS, Reid HH, Bharadwaj M, Godfrey DI, Rossjohn J, McCluskey J.

J Exp Med. 2006 Mar 20;203(3):661-73. Epub 2006 Feb 27.

35.

Structural basis for a major histocompatibility complex class Ib-restricted T cell response.

Hoare HL, Sullivan LC, Pietra G, Clements CS, Lee EJ, Ely LK, Beddoe T, Falco M, Kjer-Nielsen L, Reid HH, McCluskey J, Moretta L, Rossjohn J, Brooks AG.

Nat Immunol. 2006 Mar;7(3):256-64. Epub 2006 Feb 12.

PMID:
16474394
36.

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide.

Tynan FE, Burrows SR, Buckle AM, Clements CS, Borg NA, Miles JJ, Beddoe T, Whisstock JC, Wilce MC, Silins SL, Burrows JM, Kjer-Nielsen L, Kostenko L, Purcell AW, McCluskey J, Rossjohn J.

Nat Immunol. 2005 Nov;6(11):1114-22. Epub 2005 Sep 25.

PMID:
16186824
37.

Antagonism of antiviral and allogeneic activity of a human public CTL clonotype by a single altered peptide ligand: implications for allograft rejection.

Ely LK, Green KJ, Beddoe T, Clements CS, Miles JJ, Bottomley SP, Zernich D, Kjer-Nielsen L, Purcell AW, McCluskey J, Rossjohn J, Burrows SR.

J Immunol. 2005 May 1;174(9):5593-601.

38.

Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface.

Clements CS, Kjer-Nielsen L, Kostenko L, Hoare HL, Dunstone MA, Moses E, Freed K, Brooks AG, Rossjohn J, McCluskey J.

Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3360-5. Epub 2005 Feb 17.

39.

The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition.

Borg NA, Ely LK, Beddoe T, Macdonald WA, Reid HH, Clements CS, Purcell AW, Kjer-Nielsen L, Miles JJ, Burrows SR, McCluskey J, Rossjohn J.

Nat Immunol. 2005 Feb;6(2):171-80. Epub 2005 Jan 9.

PMID:
15640805
40.

The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis.

Clements CS, Reid HH, Beddoe T, Tynan FE, Perugini MA, Johns TG, Bernard CC, Rossjohn J.

Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11059-64. Epub 2003 Sep 5.

41.

A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition.

Macdonald WA, Purcell AW, Mifsud NA, Ely LK, Williams DS, Chang L, Gorman JJ, Clements CS, Kjer-Nielsen L, Koelle DM, Burrows SR, Tait BD, Holdsworth R, Brooks AG, Lovrecz GO, Lu L, Rossjohn J, McCluskey J.

J Exp Med. 2003 Sep 1;198(5):679-91. Epub 2003 Aug 25.

42.

A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity.

Kjer-Nielsen L, Clements CS, Purcell AW, Brooks AG, Whisstock JC, Burrows SR, McCluskey J, Rossjohn J.

Immunity. 2003 Jan;18(1):53-64.

43.

The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state.

Clements CS, Kjer-Nielsen L, MacDonald WA, Brooks AG, Purcell AW, McCluskey J, Rossjohn J.

Acta Crystallogr D Biol Crystallogr. 2002 Dec;58(Pt 12):2131-4. Epub 2002 Nov 23.

PMID:
12454477
44.

The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance.

Kjer-Nielsen L, Clements CS, Brooks AG, Purcell AW, McCluskey J, Rossjohn J.

Structure. 2002 Nov;10(11):1521-32.

45.

The structure of HLA-B8 complexed to an immunodominant viral determinant: peptide-induced conformational changes and a mode of MHC class I dimerization.

Kjer-Nielsen L, Clements CS, Brooks AG, Purcell AW, Fontes MR, McCluskey J, Rossjohn J.

J Immunol. 2002 Nov 1;169(9):5153-60.

46.

Identification of a dominant self-ligand bound to three HLA B44 alleles and the preliminary crystallographic analysis of recombinant forms of each complex.

Macdonald W, Williams DS, Clements CS, Gorman JJ, Kjer-Nielsen L, Brooks AG, McCluskey J, Rossjohn J, Purcell AW.

FEBS Lett. 2002 Sep 11;527(1-3):27-32.

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