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Items: 1 to 50 of 454

1.

Gut microbiota of obese subjects with Prader-Willi syndrome is linked to metabolic health.

Olsson LM, Poitou C, Tremaroli V, Coupaye M, Aron-Wisnewsky J, Bäckhed F, Clément K, Caesar R.

Gut. 2019 Oct 14. pii: gutjnl-2019-319322. doi: 10.1136/gutjnl-2019-319322. [Epub ahead of print]

2.

Elevated serum ceramides are linked with obesity-associated gut dysbiosis and impaired glucose metabolism.

Kayser BD, Prifti E, Lhomme M, Belda E, Dao MC, Aron-Wisnewsky J; MICRO-Obes Consortium, Kontush A, Zucker JD, Rizkalla SW, Dugail I, Clément K.

Metabolomics. 2019 Oct 11;15(11):140. doi: 10.1007/s11306-019-1596-0.

PMID:
31605240
3.

A place for vitamin supplementation and functional food in bariatric surgery?

Aron-Wisnewsky J, Clément K.

Curr Opin Clin Nutr Metab Care. 2019 Nov;22(6):442-448. doi: 10.1097/MCO.0000000000000602.

PMID:
31589176
4.

The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis.

Di Stefano B, Luo EC, Haggerty C, Aigner S, Charlton J, Brumbaugh J, Ji F, Rabano Jiménez I, Clowers KJ, Huebner AJ, Clement K, Lipchina I, de Kort MAC, Anselmo A, Pulice J, Gerli MFM, Gu H, Gygi SP, Sadreyev RI, Meissner A, Yeo GW, Hochedlinger K.

Cell Stem Cell. 2019 Nov 7;25(5):622-638.e13. doi: 10.1016/j.stem.2019.08.018. Epub 2019 Oct 3.

PMID:
31588046
5.

Deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis.

Marcelin G, Silveira ALM, Martins LB, Ferreira AV, Clément K.

J Clin Invest. 2019 Oct 1;129(10):4032-4040. doi: 10.1172/JCI129192. Review.

6.

Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity.

Bravo-San Pedro JM, Sica V, Martins I, Pol J, Loos F, Maiuri MC, Durand S, Bossut N, Aprahamian F, Anagnostopoulos G, Niso-Santano M, Aranda F, Ramírez-Pardo I, Lallement J, Denom J, Boedec E, Gorwood P, Ramoz N, Clément K, Pelloux V, Rohia A, Pattou F, Raverdy V, Caiazzo R, Denis RGP, Boya P, Galluzzi L, Madeo F, Migrenne-Li S, Cruciani-Guglielmacci C, Tavernarakis N, López-Otín C, Magnan C, Kroemer G.

Cell Metab. 2019 Oct 1;30(4):754-767.e9. doi: 10.1016/j.cmet.2019.07.010. Epub 2019 Aug 15.

PMID:
31422903
7.

Meta-analysis of the use of sterilized mosquito net mesh for inguinal hernia repair in less economically developed countries.

Ahmad MH, Pathak S, Clement KD, Aly EH.

BJS Open. 2019 Feb 27;3(4):429-435. doi: 10.1002/bjs5.50147. eCollection 2019 Aug. Review.

8.

Increased Glucose Variability Is Associated With Major Adverse Events After Coronary Artery Bypass.

Clement KC, Suarez-Pierre A, Sebestyen K, Alejo D, DiNatale J, Whitman GJR, Matthew TL, Lawton JS.

Ann Thorac Surg. 2019 Nov;108(5):1307-1313. doi: 10.1016/j.athoracsur.2019.06.046. Epub 2019 Aug 7.

PMID:
31400320
9.

Danger in the vapor? ECMO for adolescents with status asthmaticus after vaping.

Bradford LE, Rebuli ME, Ring BJ, Jaspers I, Clement KC, Loughlin CE.

J Asthma. 2019 Jul 27:1-5. doi: 10.1080/02770903.2019.1643361. [Epub ahead of print]

PMID:
31352844
10.

Improvement of non-invasive markers of NAFLD from an individualised, web-based exercise program.

Huber Y, Pfirrmann D, Gebhardt I, Labenz C, Gehrke N, Straub BK, Ruckes C, Bantel H, Belda E, Clément K, Leeming DJ, Karsdal MA, Galle PR, Simon P, Schattenberg JM.

Aliment Pharmacol Ther. 2019 Oct;50(8):930-939. doi: 10.1111/apt.15427. Epub 2019 Jul 25.

PMID:
31342533
11.

Akkermansia muciniphila abundance is lower in severe obesity, but its increased level after bariatric surgery is not associated with metabolic health improvement.

Dao MC, Belda E, Prifti E, Everard A, Kayser BD, Bouillot JL, Chevallier JM, Pons N, Le Chatelier E, Ehrlich SD, Doré J, Aron-Wisnewsky J, Zucker JD, Cani PD, Clément K.

Am J Physiol Endocrinol Metab. 2019 Sep 1;317(3):E446-E459. doi: 10.1152/ajpendo.00140.2019. Epub 2019 Jul 2.

PMID:
31265324
12.

Fecal Microbiota Transplantation: a Future Therapeutic Option for Obesity/Diabetes?

Aron-Wisnewsky J, Clément K, Nieuwdorp M.

Curr Diab Rep. 2019 Jun 27;19(8):51. doi: 10.1007/s11892-019-1180-z. Review.

PMID:
31250122
13.

Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery.

Debédat J, Clément K, Aron-Wisnewsky J.

Curr Obes Rep. 2019 Sep;8(3):229-242. doi: 10.1007/s13679-019-00351-3. Review.

PMID:
31197613
14.

Magnetic Resonance Imaging-targeted Biopsy Versus Systematic Biopsy in the Detection of Prostate Cancer: A Systematic Review and Meta-analysis.

Kasivisvanathan V, Stabile A, Neves JB, Giganti F, Valerio M, Shanmugabavan Y, Clement KD, Sarkar D, Philippou Y, Thurtle D, Deeks J, Emberton M, Takwoingi Y, Moore CM.

Eur Urol. 2019 Sep;76(3):284-303. doi: 10.1016/j.eururo.2019.04.043. Epub 2019 May 24. Review.

PMID:
31130434
15.

Increased glucose variability is associated with atrial fibrillation after coronary artery bypass.

Clement KC, Alejo D, DiNatale J, Whitman GJR, Matthew TL, Clement SC, Lawton JS.

J Card Surg. 2019 Jul;34(7):549-554. doi: 10.1111/jocs.14071. Epub 2019 May 17.

PMID:
31099438
16.

Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia.

Gaiti F, Chaligne R, Gu H, Brand RM, Kothen-Hill S, Schulman RC, Grigorev K, Risso D, Kim KT, Pastore A, Huang KY, Alonso A, Sheridan C, Omans ND, Biederstedt E, Clement K, Wang L, Felsenfeld JA, Bhavsar EB, Aryee MJ, Allan JN, Furman R, Gnirke A, Wu CJ, Meissner A, Landau DA.

Nature. 2019 May;569(7757):576-580. doi: 10.1038/s41586-019-1198-z. Epub 2019 May 15.

PMID:
31092926
17.

Impact of bariatric surgery on type 2 diabetes: contribution of inflammation and gut microbiome?

Debédat J, Amouyal C, Aron-Wisnewsky J, Clément K.

Semin Immunopathol. 2019 Jul;41(4):461-475. doi: 10.1007/s00281-019-00738-3. Epub 2019 Apr 25. Review.

18.

Impact of bacterial probiotics on obesity, diabetes and non-alcoholic fatty liver disease related variables: a systematic review and meta-analysis of randomised controlled trials.

Koutnikova H, Genser B, Monteiro-Sepulveda M, Faurie JM, Rizkalla S, Schrezenmeir J, Clément K.

BMJ Open. 2019 Mar 30;9(3):e017995. doi: 10.1136/bmjopen-2017-017995.

19.

Highly efficient therapeutic gene editing of human hematopoietic stem cells.

Wu Y, Zeng J, Roscoe BP, Liu P, Yao Q, Lazzarotto CR, Clement K, Cole MA, Luk K, Baricordi C, Shen AH, Ren C, Esrick EB, Manis JP, Dorfman DM, Williams DA, Biffi A, Brugnara C, Biasco L, Brendel C, Pinello L, Tsai SQ, Wolfe SA, Bauer DE.

Nat Med. 2019 May;25(5):776-783. doi: 10.1038/s41591-019-0401-y. Epub 2019 Mar 25.

20.

CRISPResso2 provides accurate and rapid genome editing sequence analysis.

Clement K, Rees H, Canver MC, Gehrke JM, Farouni R, Hsu JY, Cole MA, Liu DR, Joung JK, Bauer DE, Pinello L.

Nat Biotechnol. 2019 Mar;37(3):224-226. doi: 10.1038/s41587-019-0032-3. No abstract available.

21.

A Data Integration Multi-Omics Approach to Study Calorie Restriction-Induced Changes in Insulin Sensitivity.

Dao MC, Sokolovska N, Brazeilles R, Affeldt S, Pelloux V, Prifti E, Chilloux J, Verger EO, Kayser BD, Aron-Wisnewsky J, Ichou F, Pujos-Guillot E, Hoyles L, Juste C, Doré J, Dumas ME, Rizkalla SW, Holmes BA, Zucker JD, Clément K; MICRO-Obes Consortium.

Front Physiol. 2019 Feb 5;9:1958. doi: 10.3389/fphys.2018.01958. eCollection 2018.

22.

Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing.

Kleinstiver BP, Sousa AA, Walton RT, Tak YE, Hsu JY, Clement K, Welch MM, Horng JE, Malagon-Lopez J, Scarfò I, Maus MV, Pinello L, Aryee MJ, Joung JK.

Nat Biotechnol. 2019 Mar;37(3):276-282. doi: 10.1038/s41587-018-0011-0. Epub 2019 Feb 11.

23.

Association between genetic obesity susceptibility and mother-reported eating behaviour in children up to 5 years.

de Lauzon-Guillain B, Koudou YA, Botton J, Forhan A, Carles S, Pelloux V, Clément K, Ong KK, Charles MA, Heude B; EDEN Mother-Child Cohort Study Group.

Pediatr Obes. 2019 May;14(5):e12496. doi: 10.1111/ijpo.12496. Epub 2019 Jan 31.

24.

Comparative Evaluation of Microbiota Engraftment Following Fecal Microbiota Transfer in Mice Models: Age, Kinetic and Microbial Status Matter.

Le Roy T, Debédat J, Marquet F, Da-Cunha C, Ichou F, Guerre-Millo M, Kapel N, Aron-Wisnewsky J, Clément K.

Front Microbiol. 2019 Jan 14;9:3289. doi: 10.3389/fmicb.2018.03289. eCollection 2018.

25.

Phosphatidylglycerols are induced by gut dysbiosis and inflammation, and favorably modulate adipose tissue remodeling in obesity.

Kayser BD, Lhomme M, Prifti E, Da Cunha C, Marquet F, Chain F, Naas I, Pelloux V, Dao MC, Kontush A, Rizkalla SW, Aron-Wisnewsky J, Bermúdez-Humarán LG, Oakley F, Langella P, Clément K, Dugail I.

FASEB J. 2019 Apr;33(4):4741-4754. doi: 10.1096/fj.201801897R. Epub 2019 Jan 4.

26.

Synergistic convergence of microbiota-specific systemic IgG and secretory IgA.

Fadlallah J, Sterlin D, Fieschi C, Parizot C, Dorgham K, El Kafsi H, Autaa G, Ghillani-Dalbin P, Juste C, Lepage P, Malphettes M, Galicier L, Boutboul D, Clément K, André S, Marquet F, Tresallet C, Mathian A, Miyara M, Oksenhendler E, Amoura Z, Yssel H, Larsen M, Gorochov G.

J Allergy Clin Immunol. 2019 Apr;143(4):1575-1585.e4. doi: 10.1016/j.jaci.2018.09.036. Epub 2018 Dec 13.

28.

CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data.

Hsu JY, Fulco CP, Cole MA, Canver MC, Pellin D, Sher F, Farouni R, Clement K, Guo JA, Biasco L, Orkin SH, Engreitz JM, Lander ES, Joung JK, Bauer DE, Pinello L.

Nat Methods. 2018 Dec;15(12):992-993. doi: 10.1038/s41592-018-0225-6. No abstract available.

29.

Early Laparoscopic Washout may Resolve Persistent Intra-abdominal Infection Post-appendicectomy.

Allaway MGR, Clement K, Eslick GD, Cox MR.

World J Surg. 2019 Apr;43(4):998-1006. doi: 10.1007/s00268-018-4871-8.

PMID:
30478686
30.

Targets and genomic constraints of ectopic Dnmt3b expression.

Zhang Y, Charlton J, Karnik R, Beerman I, Smith ZD, Gu H, Boyle P, Mi X, Clement K, Pop R, Gnirke A, Rossi DJ, Meissner A.

Elife. 2018 Nov 23;7. pii: e40757. doi: 10.7554/eLife.40757.

31.

Prediction of Long-Term Diabetes Remission After RYGB, Sleeve Gastrectomy, and Adjustable Gastric Banding Using DiaRem and Advanced-DiaRem Scores.

Dicker D, Golan R, Aron-Wisnewsky J, Zucker JD, Sokolowska N, Comaneshter DS, Yahalom R, Vinker S, Clément K, Rudich A.

Obes Surg. 2019 Mar;29(3):796-804. doi: 10.1007/s11695-018-3583-3.

PMID:
30467708
32.

Resistance Training and Protein Supplementation Increase Strength After Bariatric Surgery: A Randomized Controlled Trial.

Oppert JM, Bellicha A, Roda C, Bouillot JL, Torcivia A, Clement K, Poitou C, Ciangura C.

Obesity (Silver Spring). 2018 Nov;26(11):1709-1720. doi: 10.1002/oby.22317.

33.

Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons.

Ichida JK, Staats KA, Davis-Dusenbery BN, Clement K, Galloway KE, Babos KN, Shi Y, Son EY, Kiskinis E, Atwater N, Gu H, Gnirke A, Meissner A, Eggan K.

Development. 2018 Nov 21;145(22). pii: dev168617. doi: 10.1242/dev.168617.

34.

In vivo CRISPR editing with no detectable genome-wide off-target mutations.

Akcakaya P, Bobbin ML, Guo JA, Malagon-Lopez J, Clement K, Garcia SP, Fellows MD, Porritt MJ, Firth MA, Carreras A, Baccega T, Seeliger F, Bjursell M, Tsai SQ, Nguyen NT, Nitsch R, Mayr LM, Pinello L, Bohlooly-Y M, Aryee MJ, Maresca M, Joung JK.

Nature. 2018 Sep;561(7723):416-419. doi: 10.1038/s41586-018-0500-9. Epub 2018 Sep 12.

35.

Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells.

Di Stefano B, Ueda M, Sabri S, Brumbaugh J, Huebner AJ, Sahakyan A, Clement K, Clowers KJ, Erickson AR, Shioda K, Gygi SP, Gu H, Shioda T, Meissner A, Takashima Y, Plath K, Hochedlinger K.

Nat Methods. 2018 Sep;15(9):732-740. doi: 10.1038/s41592-018-0104-1. Epub 2018 Aug 20.

36.

Long-term Relapse of Type 2 Diabetes After Roux-en-Y Gastric Bypass: Prediction and Clinical Relevance.

Debédat J, Sokolovska N, Coupaye M, Panunzi S, Chakaroun R, Genser L, de Turenne G, Bouillot JL, Poitou C, Oppert JM, Blüher M, Stumvoll M, Mingrone G, Ledoux S, Zucker JD, Clément K, Aron-Wisnewsky J.

Diabetes Care. 2018 Oct;41(10):2086-2095. doi: 10.2337/dc18-0567. Epub 2018 Aug 6.

PMID:
30082327
37.

Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming.

Schwarz BA, Cetinbas M, Clement K, Walsh RM, Cheloufi S, Gu H, Langkabel J, Kamiya A, Schorle H, Meissner A, Sadreyev RI, Hochedlinger K.

Cell Stem Cell. 2018 Aug 2;23(2):289-305.e5. doi: 10.1016/j.stem.2018.06.013. Epub 2018 Jul 12.

38.

Increased jejunal permeability in human obesity is revealed by a lipid challenge and is linked to inflammation and type 2 diabetes.

Genser L, Aguanno D, Soula HA, Dong L, Trystram L, Assmann K, Salem JE, Vaillant JC, Oppert JM, Laugerette F, Michalski MC, Wind P, Rousset M, Brot-Laroche E, Leturque A, Clément K, Thenet S, Poitou C.

J Pathol. 2018 Oct;246(2):217-230. doi: 10.1002/path.5134. Epub 2018 Aug 28.

PMID:
29984492
39.

Mucosal-associated invariant T (MAIT) cells are depleted and prone to apoptosis in cardiometabolic disorders.

Touch S, Assmann KE, Aron-Wisnewsky J, Marquet F, Rouault C, Fradet M, Mosbah H, Consortium M, Isnard R, Helft G, Lehuen A, Poitou C, Clément K, André S; MetaCardis Consortium.

FASEB J. 2018 Apr 27:fj201800052RR. doi: 10.1096/fj.201800052RR. [Epub ahead of print]

PMID:
29957059
40.

AmpUMI: design and analysis of unique molecular identifiers for deep amplicon sequencing.

Clement K, Farouni R, Bauer DE, Pinello L.

Bioinformatics. 2018 Jul 1;34(13):i202-i210. doi: 10.1093/bioinformatics/bty264.

41.

[Adipose tissue fibrosis: an aggravating factor in obesity].

Marcelin G, Clément K.

Med Sci (Paris). 2018 May;34(5):424-431. doi: 10.1051/medsci/20183405015. Epub 2018 Jun 13. Review. French.

42.

Major microbiota dysbiosis in severe obesity: fate after bariatric surgery.

Aron-Wisnewsky J, Prifti E, Belda E, Ichou F, Kayser BD, Dao MC, Verger EO, Hedjazi L, Bouillot JL, Chevallier JM, Pons N, Le Chatelier E, Levenez F, Ehrlich SD, Dore J, Zucker JD, Clément K.

Gut. 2019 Jan;68(1):70-82. doi: 10.1136/gutjnl-2018-316103. Epub 2018 Jun 13.

PMID:
29899081
43.

Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars.

Luukkonen PK, Sädevirta S, Zhou Y, Kayser B, Ali A, Ahonen L, Lallukka S, Pelloux V, Gaggini M, Jian C, Hakkarainen A, Lundbom N, Gylling H, Salonen A, Orešič M, Hyötyläinen T, Orho-Melander M, Rissanen A, Gastaldelli A, Clément K, Hodson L, Yki-Järvinen H.

Diabetes Care. 2018 Aug;41(8):1732-1739. doi: 10.2337/dc18-0071. Epub 2018 May 29.

PMID:
29844096
44.

An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition.

Du P, Pirouz M, Choi J, Huebner AJ, Clement K, Meissner A, Hochedlinger K, Gregory RI.

Cell Stem Cell. 2018 Jun 1;22(6):851-864.e5. doi: 10.1016/j.stem.2018.04.021. Epub 2018 May 24.

45.

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency.

Clément K, Biebermann H, Farooqi IS, Van der Ploeg L, Wolters B, Poitou C, Puder L, Fiedorek F, Gottesdiener K, Kleinau G, Heyder N, Scheerer P, Blume-Peytavi U, Jahnke I, Sharma S, Mokrosinski J, Wiegand S, Müller A, Weiß K, Mai K, Spranger J, Grüters A, Blankenstein O, Krude H, Kühnen P.

Nat Med. 2018 May;24(5):551-555. doi: 10.1038/s41591-018-0015-9. Epub 2018 May 7.

PMID:
29736023
46.

Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade.

Shukla SA, Bachireddy P, Schilling B, Galonska C, Zhan Q, Bango C, Langer R, Lee PC, Gusenleitner D, Keskin DB, Babadi M, Mohammad A, Gnirke A, Clement K, Cartun ZJ, Van Allen EM, Miao D, Huang Y, Snyder A, Merghoub T, Wolchok JD, Garraway LA, Meissner A, Weber JS, Hacohen N, Neuberg D, Potts PR, Murphy GF, Lian CG, Schadendorf D, Hodi FS, Wu CJ.

Cell. 2018 Apr 19;173(3):624-633.e8. doi: 10.1016/j.cell.2018.03.026. Epub 2018 Apr 12.

47.

A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development.

Cesana M, Guo MH, Cacchiarelli D, Wahlster L, Barragan J, Doulatov S, Vo LT, Salvatori B, Trapnell C, Clement K, Cahan P, Tsanov KM, Sousa PM, Tazon-Vega B, Bolondi A, Giorgi FM, Califano A, Rinn JL, Meissner A, Hirschhorn JN, Daley GQ.

Cell Stem Cell. 2018 Apr 5;22(4):575-588.e7. doi: 10.1016/j.stem.2018.03.012.

48.

Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo".

Lareau CA, Clement K, Hsu JY, Pattanayak V, Joung JK, Aryee MJ, Pinello L.

Nat Methods. 2018 Apr;15(4):238-239. doi: 10.1038/nmeth.4541. Epub 2018 Mar 30. No abstract available.

PMID:
29600992
49.

Author Correction: Global delay in nascent strand DNA methylation.

Charlton J, Downing TL, Smith ZD, Gu H, Clement K, Pop R, Akopian V, Klages S, Santos DP, Tsankov AM, Timmermann B, Ziller MJ, Kiskinis E, Gnirke A, Meissner A.

Nat Struct Mol Biol. 2018 Apr;25(4):355. doi: 10.1038/s41594-018-0055-3.

PMID:
29581568
50.

Intergenerational response to the endocrine disruptor vinclozolin is influenced by maternal genotype and crossing scheme.

Pietryk EW, Clement K, Elnagheeb M, Kuster R, Kilpatrick K, Love MI, Ideraabdullah FY.

Reprod Toxicol. 2018 Jun;78:9-19. doi: 10.1016/j.reprotox.2018.03.005. Epub 2018 Mar 10.

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