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Relevance of the Antioxidant Properties of Methotrexate and Doxycycline to their Treatment of Cardiovascular Disease.

Clemens DL, Duryee MJ, Hall JH, Thiele GM, Mikuls TR, Klassen LW, Zimmerman MC, Anderson DR.

Pharmacol Ther. 2019 Oct 15:107413. doi: 10.1016/j.pharmthera.2019.107413. [Epub ahead of print]


Intracellular Photothermal Delivery for Suspension Cells Using Sharp Nanoscale Tips in Microwells.

Man T, Zhu X, Chow YT, Dawson ER, Wen X, Patananan AN, Liu TL, Zhao C, Wu C, Hong JS, Chung PS, Clemens DL, Lee BY, Weiss PS, Teitell MA, Chiou PY.

ACS Nano. 2019 Sep 24;13(9):10835-10844. doi: 10.1021/acsnano.9b06025. Epub 2019 Sep 10.


Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis.

Liu X, Clemens DL, Grunkemeyer JA, Price JD, O'Connell K, Chapman NM, Storz P, Wen H, Cox JL, Reid WL, Hollingsworth MA, Thayer S.

Sci Rep. 2019 Jul 23;9(1):10656. doi: 10.1038/s41598-019-46933-y.


Artificial intelligence enabled parabolic response surface platform identifies ultra-rapid near-universal TB drug treatment regimens comprising approved drugs.

Clemens DL, Lee BY, Silva A, Dillon BJ, Masleša-Galić S, Nava S, Ding X, Ho CM, Horwitz MA.

PLoS One. 2019 May 10;14(5):e0215607. doi: 10.1371/journal.pone.0215607. eCollection 2019. Erratum in: PLoS One. 2019 May 30;14(5):e0217670.


Novel Antioxidant Properties of Doxycycline.

Clemens DL, Duryee MJ, Sarmiento C, Chiou A, McGowan JD, Hunter CD, Schlichte SL, Tian J, Klassen LW, O'Dell JR, Thiele GM, Mikuls TR, Zimmerman MC, Anderson DR.

Int J Mol Sci. 2018 Dec 17;19(12). pii: E4078. doi: 10.3390/ijms19124078.


Nanoparticle Formulation of Moxifloxacin and Intramuscular Route of Delivery Improve Antibiotic Pharmacokinetics and Treatment of Pneumonic Tularemia in a Mouse Model.

Clemens DL, Lee BY, Plamthottam S, Tullius MV, Wang R, Yu CJ, Li Z, Dillon BJ, Zink JI, Horwitz MA.

ACS Infect Dis. 2019 Feb 8;5(2):281-291. doi: 10.1021/acsinfecdis.8b00268. Epub 2018 Dec 10.


Ultra-rapid near universal TB drug regimen identified via parabolic response surface platform cures mice of both conventional and high susceptibility.

Lee BY, Clemens DL, Silva A, Dillon BJ, Masleša-Galić S, Nava S, Ho CM, Horwitz MA.

PLoS One. 2018 Nov 14;13(11):e0207469. doi: 10.1371/journal.pone.0207469. eCollection 2018.


Facile Strategy Enabling Both High Loading and High Release Amounts of the Water-Insoluble Drug Clofazimine Using Mesoporous Silica Nanoparticles.

Chen W, Cheng CA, Lee BY, Clemens DL, Huang WY, Horwitz MA, Zink JI.

ACS Appl Mater Interfaces. 2018 Sep 26;10(38):31870-31881. doi: 10.1021/acsami.8b09069. Epub 2018 Sep 13.


The Francisella Type VI Secretion System.

Clemens DL, Lee BY, Horwitz MA.

Front Cell Infect Microbiol. 2018 Apr 23;8:121. doi: 10.3389/fcimb.2018.00121. eCollection 2018. Review.


Increased ethanol-inducible cytochrome P450-2E1 and cytochrome P450 isoforms in exosomes of alcohol-exposed rodents and patients with alcoholism through oxidative and endoplasmic reticulum stress.

Cho YE, Mezey E, Hardwick JP, Salem N Jr, Clemens DL, Song BJ.

Hepatol Commun. 2017 Jul 13;1(7):675-690. doi: 10.1002/hep4.1066. eCollection 2017 Sep.


Direct antioxidant properties of methotrexate: Inhibition of malondialdehyde-acetaldehyde-protein adduct formation and superoxide scavenging.

Zimmerman MC, Clemens DL, Duryee MJ, Sarmiento C, Chiou A, Hunter CD, Tian J, Klassen LW, O'Dell JR, Thiele GM, Mikuls TR, Anderson DR.

Redox Biol. 2017 Oct;13:588-593. doi: 10.1016/j.redox.2017.07.018. Epub 2017 Aug 2.


A Pathogen-Specific Cargo Delivery Platform Based on Mesoporous Silica Nanoparticles.

Ruehle B, Clemens DL, Lee BY, Horwitz MA, Zink JI.

J Am Chem Soc. 2017 May 17;139(19):6663-6668. doi: 10.1021/jacs.7b01278. Epub 2017 May 5.


A combination of dietary N-3 fatty acids and a cyclooxygenase-1 inhibitor attenuates nonalcoholic fatty liver disease in mice.

Saraswathi V, Perriotte-Olson C, Ganesan M, Desouza CV, Alnouti Y, Duryee MJ, Thiele GM, Nordgren TM, Clemens DL.

J Nutr Biochem. 2017 Apr;42:149-159. doi: 10.1016/j.jnutbio.2017.01.011. Epub 2017 Jan 27.


Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time.

Lee BY, Clemens DL, Silva A, Dillon BJ, Masleša-Galić S, Nava S, Ding X, Ho CM, Horwitz MA.

Nat Commun. 2017 Jan 24;8:14183. doi: 10.1038/ncomms14183.


Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice.

Lee BY, Li Z, Clemens DL, Dillon BJ, Hwang AA, Zink JI, Horwitz MA.

Small. 2016 Jul;12(27):3690-702. doi: 10.1002/smll.201600892. Epub 2016 Jun 1.


The Involvement of Acetaldehyde in Ethanol-Induced Cell Cycle Impairment.

Scheer MA, Schneider KJ, Finnigan RL, Maloney EP, Wells MA, Clemens DL.

Biomolecules. 2016 Mar 31;6(2). pii: E17. doi: 10.3390/biom6020017.


Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model.

Silva A, Lee BY, Clemens DL, Kee T, Ding X, Ho CM, Horwitz MA.

Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):E2172-9. doi: 10.1073/pnas.1600812113. Epub 2016 Mar 28.


Alcoholic pancreatitis: New insights into the pathogenesis and treatment.

Clemens DL, Schneider KJ, Arkfeld CK, Grode JR, Wells MA, Singh S.

World J Gastrointest Pathophysiol. 2016 Feb 15;7(1):48-58. doi: 10.4291/wjgp.v7.i1.48. Review.


Retinoid regulation of antiviral innate immunity in hepatocytes.

Cho NE, Bang BR, Gurung P, Li M, Clemens DL, Underhill TM, James LP, Chase JR, Saito T.

Hepatology. 2016 Jun;63(6):1783-95. doi: 10.1002/hep.28380. Epub 2016 Jan 21.


Downregulation of the small GTPase SAR1A: a key event underlying alcohol-induced Golgi fragmentation in hepatocytes.

Petrosyan A, Cheng PW, Clemens DL, Casey CA.

Sci Rep. 2015 Nov 26;5:17127. doi: 10.1038/srep17127.


Tuberculosis: pH-Responsive Isoniazid-Loaded Nanoparticles Markedly Improve Tuberculosis Treatment in Mice (Small 38/2015).

Hwang AA, Lee BY, Clemens DL, Dillon BJ, Zink JI, Horwitz MA.

Small. 2015 Oct;11(38):5065. doi: 10.1002/smll.201570235.


Mesoporous Silica Nanoparticles with pH-Sensitive Nanovalves for Delivery of Moxifloxacin Provide Improved Treatment of Lethal Pneumonic Tularemia.

Li Z, Clemens DL, Lee BY, Dillon BJ, Horwitz MA, Zink JI.

ACS Nano. 2015 Nov 24;9(11):10778-89. doi: 10.1021/acsnano.5b04306. Epub 2015 Oct 9.


pH-Responsive Isoniazid-Loaded Nanoparticles Markedly Improve Tuberculosis Treatment in Mice.

Hwang AA, Lee BY, Clemens DL, Dillon BJ, Zink JI, Horwitz MA.

Small. 2015 Oct;11(38):5066-78. doi: 10.1002/smll.201500937. Epub 2015 Jul 20.


Massively parallel delivery of large cargo into mammalian cells with light pulses.

Wu YC, Wu TH, Clemens DL, Lee BY, Wen X, Horwitz MA, Teitell MA, Chiou PY.

Nat Methods. 2015 May;12(5):439-44. doi: 10.1038/nmeth.3357. Epub 2015 Apr 6.


Atomic structure of T6SS reveals interlaced array essential to function.

Clemens DL, Ge P, Lee BY, Horwitz MA, Zhou ZH.

Cell. 2015 Feb 26;160(5):940-951. doi: 10.1016/j.cell.2015.02.005.


Free fatty acids enhance the oxidative damage induced by ethanol metabolism in an in vitro model.

Hernández I, Domínguez-Pérez M, Bucio L, Souza V, Miranda RU, Clemens DL, Gomez-Quiroz LE, Gutiérrez-Ruiz MC.

Food Chem Toxicol. 2015 Feb;76:109-15. doi: 10.1016/j.fct.2014.12.005. Epub 2014 Dec 17.


Molecular mechanisms of alcohol associated pancreatitis.

Clemens DL, Wells MA, Schneider KJ, Singh S.

World J Gastrointest Pathophysiol. 2014 Aug 15;5(3):147-57. doi: 10.4291/wjgp.v5.i3.147. Review.


GSH protects against oxidative stress and toxicity in VL-17A cells exposed to high glucose.

Kumar SM, Swaminathan K, Clemens DL, Dey A.

Eur J Nutr. 2015 Mar;54(2):223-34. doi: 10.1007/s00394-014-0703-2. Epub 2014 Apr 23.


Modulation of GSH with exogenous agents leads to changes in glyoxalase 1 enzyme activity in VL-17A cells exposed to chronic alcohol plus high glucose.

Kumar SM, Swaminathan K, Clemens DL, Dey A.

Food Funct. 2014 Feb;5(2):345-58. doi: 10.1039/c3fo60354g.


Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses.

Gillespie EJ, Ho CL, Balaji K, Clemens DL, Deng G, Wang YE, Elsaesser HJ, Tamilselvam B, Gargi A, Dixon SD, France B, Chamberlain BT, Blanke SR, Cheng G, de la Torre JC, Brooks DG, Jung ME, Colicelli J, Damoiseaux R, Bradley KA.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4904-12. doi: 10.1073/pnas.1302334110. Epub 2013 Nov 4.


Inhibition of CYP2E1 leads to decreased advanced glycated end product formation in high glucose treated ADH and CYP2E1 over-expressing VL-17A cells.

Swaminathan K, Kumar SM, Clemens DL, Dey A.

Biochim Biophys Acta. 2013 Oct;1830(10):4407-16. doi: 10.1016/j.bbagen.2013.05.022. Epub 2013 May 23.


Inhibition of CYP2E1 leads to decreased malondialdehyde-acetaldehyde adduct formation in VL-17A cells under chronic alcohol exposure.

Swaminathan K, Clemens DL, Dey A.

Life Sci. 2013 Mar 14;92(6-7):325-36. doi: 10.1016/j.lfs.2012.12.014. Epub 2013 Jan 24.


Multilevel regulation of autophagosome content by ethanol oxidation in HepG2 cells.

Thomes PG, Ehlers RA, Trambly CS, Clemens DL, Fox HS, Tuma DJ, Donohue TM.

Autophagy. 2013 Jan;9(1):63-73. doi: 10.4161/auto.22490. Epub 2012 Oct 22.


Hepatic mitochondrial dysfunction induced by fatty acids and ethanol.

Gyamfi D, Everitt HE, Tewfik I, Clemens DL, Patel VB.

Free Radic Biol Med. 2012 Dec 1;53(11):2131-45. doi: 10.1016/j.freeradbiomed.2012.09.024. Epub 2012 Sep 23.


Ethanol administration impairs pancreatic repair after injury.

Schneider KJ, Scheer M, Suhr M, Clemens DL.

Pancreas. 2012 Nov;41(8):1272-9. doi: 10.1097/MPA.0b013e31824bde37.


Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed rats.

Das S, Hajnóczky N, Antony AN, Csordás G, Gaspers LD, Clemens DL, Hoek JB, Hajnóczky G.

Pflugers Arch. 2012 Jul;464(1):101-9. doi: 10.1007/s00424-012-1100-4. Epub 2012 Apr 19.


Increased oxidative stress and toxicity in ADH and CYP2E1 overexpressing human hepatoma VL-17A cells exposed to high glucose.

Chandrasekaran K, Swaminathan K, Kumar SM, Clemens DL, Dey A.

Integr Biol (Camb). 2012 May;4(5):550-63. doi: 10.1039/c2ib00155a. Epub 2012 Mar 22.


Targeted intracellular delivery of antituberculosis drugs to Mycobacterium tuberculosis-infected macrophages via functionalized mesoporous silica nanoparticles.

Clemens DL, Lee BY, Xue M, Thomas CR, Meng H, Ferris D, Nel AE, Zink JI, Horwitz MA.

Antimicrob Agents Chemother. 2012 May;56(5):2535-45. doi: 10.1128/AAC.06049-11. Epub 2012 Feb 21.


In vitro evidence for chronic alcohol and high glucose mediated increased oxidative stress and hepatotoxicity.

Chandrasekaran K, Swaminathan K, Mathan Kumar S, Clemens DL, Dey A.

Alcohol Clin Exp Res. 2012 Jun;36(6):1004-12. doi: 10.1111/j.1530-0277.2011.01697.x. Epub 2012 Feb 6.


Ethanol metabolism activates cell cycle checkpoint kinase, Chk2.

Clemens DL, Schneider KJ, Nuss RF.

Alcohol. 2011 Dec;45(8):785-93. doi: 10.1016/j.alcohol.2011.07.005. Epub 2011 Sep 15.


Zinc deprivation mediates alcohol-induced hepatocyte IL-8 analog expression in rodents via an epigenetic mechanism.

Zhao Y, Zhong W, Sun X, Song Z, Clemens DL, Kang YJ, McClain CJ, Zhou Z.

Am J Pathol. 2011 Aug;179(2):693-702. doi: 10.1016/j.ajpath.2011.04.006. Epub 2011 Jun 2.


Elevated glutathione level does not protect against chronic alcohol mediated apoptosis in recombinant human hepatoma cell line VL-17A over-expressing alcohol metabolizing enzymes--alcohol dehydrogenase and Cytochrome P450 2E1.

Chandrasekaran K, Swaminathan K, Kumar SM, Chatterjee S, Clemens DL, Dey A.

Toxicol In Vitro. 2011 Jun;25(4):969-78. doi: 10.1016/j.tiv.2011.03.006. Epub 2011 Mar 23.


Knock down of GCN5 histone acetyltransferase by siRNA decreases ethanol-induced histone acetylation and affects differential expression of genes in human hepatoma cells.

Choudhury M, Pandey RS, Clemens DL, Davis JW, Lim RW, Shukla SD.

Alcohol. 2011 Jun;45(4):311-24. doi: 10.1016/j.alcohol.2010.12.003. Epub 2011 Mar 2.


Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice.

Ding WX, Li M, Chen X, Ni HM, Lin CW, Gao W, Lu B, Stolz DB, Clemens DL, Yin XM.

Gastroenterology. 2010 Nov;139(5):1740-52. doi: 10.1053/j.gastro.2010.07.041. Epub 2010 Jul 23.


Alcoholic pancreatitis: lessons from the liver.

Clemens DL, Mahan KJ.

World J Gastroenterol. 2010 Mar 21;16(11):1314-20. Review.


The Mycobacterium bovis bacille Calmette-Guerin phagosome proteome.

Lee BY, Jethwaney D, Schilling B, Clemens DL, Gibson BW, Horwitz MA.

Mol Cell Proteomics. 2010 Jan;9(1):32-53. doi: 10.1074/mcp.M900396-MCP200. Epub 2009 Oct 7.


Hepatocyte growth factor protects hepatocytes against oxidative injury induced by ethanol metabolism.

Valdés-Arzate A, Luna A, Bucio L, Licona C, Clemens DL, Souza V, Hernandez E, Kershenobich D, Gutiérrez-Ruiz MC, Gómez-Quiroz LE.

Free Radic Biol Med. 2009 Aug 15;47(4):424-30. doi: 10.1016/j.freeradbiomed.2009.05.014. Epub 2009 May 19.


Francisella tularensis phagosomal escape does not require acidification of the phagosome.

Clemens DL, Lee BY, Horwitz MA.

Infect Immun. 2009 May;77(5):1757-73. doi: 10.1128/IAI.01485-08. Epub 2009 Feb 23.

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