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Inhibition of dicer activity in lepidopteran and dipteran cells by baculovirus-mediated expression of Flock House virus B2.

Hodgson JJ, Wenger LW, Clem RJ, Passarelli AL.

Sci Rep. 2019 Oct 10;9(1):14494. doi: 10.1038/s41598-019-50851-4.


Identification and initial characterization of matrix metalloproteinases in the yellow fever mosquito, Aedes aegypti.

Kantor AM, Dong S, Held NL, Ishimwe E, Passarelli AL, Clem RJ, Franz AW.

Insect Mol Biol. 2017 Feb;26(1):113-126. doi: 10.1111/imb.12275. Epub 2016 Nov 7.


Multifaceted biological insights from a draft genome sequence of the tobacco hornworm moth, Manduca sexta.

Kanost MR, Arrese EL, Cao X, Chen YR, Chellapilla S, Goldsmith MR, Grosse-Wilde E, Heckel DG, Herndon N, Jiang H, Papanicolaou A, Qu J, Soulages JL, Vogel H, Walters J, Waterhouse RM, Ahn SJ, Almeida FC, An C, Aqrawi P, Bretschneider A, Bryant WB, Bucks S, Chao H, Chevignon G, Christen JM, Clarke DF, Dittmer NT, Ferguson LCF, Garavelou S, Gordon KHJ, Gunaratna RT, Han Y, Hauser F, He Y, Heidel-Fischer H, Hirsh A, Hu Y, Jiang H, Kalra D, Klinner C, König C, Kovar C, Kroll AR, Kuwar SS, Lee SL, Lehman R, Li K, Li Z, Liang H, Lovelace S, Lu Z, Mansfield JH, McCulloch KJ, Mathew T, Morton B, Muzny DM, Neunemann D, Ongeri F, Pauchet Y, Pu LL, Pyrousis I, Rao XJ, Redding A, Roesel C, Sanchez-Gracia A, Schaack S, Shukla A, Tetreau G, Wang Y, Xiong GH, Traut W, Walsh TK, Worley KC, Wu D, Wu W, Wu YQ, Zhang X, Zou Z, Zucker H, Briscoe AD, Burmester T, Clem RJ, Feyereisen R, Grimmelikhuijzen CJP, Hamodrakas SJ, Hansson BS, Huguet E, Jermiin LS, Lan Q, Lehman HK, Lorenzen M, Merzendorfer H, Michalopoulos I, Morton DB, Muthukrishnan S, Oakeshott JG, Palmer W, Park Y, Passarelli AL, Rozas J, Schwartz LM, Smith W, Southgate A, Vilcinskas A, Vogt R, Wang P, Werren J, Yu XQ, Zhou JJ, Brown SJ, Scherer SE, Richards S, Blissard GW.

Insect Biochem Mol Biol. 2016 Sep;76:118-147. doi: 10.1016/j.ibmb.2016.07.005. Epub 2016 Aug 12.


Generating a host range-expanded recombinant baculovirus.

Wu C, Deng Z, Long Z, Cai Y, Ying Z, Yin H, Yuan M, Clem RJ, Yang K, Pang Y.

Sci Rep. 2016 Jun 20;6:28072. doi: 10.1038/srep28072.


Genome sequence of Perigonia lusca single nucleopolyhedrovirus: insights into the evolution of a nucleotide metabolism enzyme in the family Baculoviridae.

Ardisson-Araújo DM, Lima RN, Melo FL, Clem RJ, Huang N, Báo SN, Sosa-Gómez DR, Ribeiro BM.

Sci Rep. 2016 Jun 7;6:24612. doi: 10.1038/srep24612.


Infection pattern and transmission potential of chikungunya virus in two New World laboratory-adapted Aedes aegypti strains.

Dong S, Kantor AM, Lin J, Passarelli AL, Clem RJ, Franz AW.

Sci Rep. 2016 Apr 22;6:24729. doi: 10.1038/srep24729.


Arboviruses and apoptosis: the role of cell death in determining vector competence.

Clem RJ.

J Gen Virol. 2016 May;97(5):1033-1036. doi: 10.1099/jgv.0.000429. Epub 2016 Feb 12. Review.


A Betabaculovirus-Encoded gp64 Homolog Codes for a Functional Envelope Fusion Protein.

Ardisson-Araújo DM, Melo FL, Clem RJ, Wolff JL, Ribeiro BM.

J Virol. 2015 Nov 4;90(3):1668-72. doi: 10.1128/JVI.02491-15. Print 2016 Feb 1.


Tissue Barriers to Arbovirus Infection in Mosquitoes.

Franz AW, Kantor AM, Passarelli AL, Clem RJ.

Viruses. 2015 Jul 8;7(7):3741-67. doi: 10.3390/v7072795. Review.


The immune signaling pathways of Manduca sexta.

Cao X, He Y, Hu Y, Wang Y, Chen YR, Bryant B, Clem RJ, Schwartz LM, Blissard G, Jiang H.

Insect Biochem Mol Biol. 2015 Jul;62:64-74. doi: 10.1016/j.ibmb.2015.03.006. Epub 2015 Apr 7.


Heritable CRISPR/Cas9-mediated genome editing in the yellow fever mosquito, Aedes aegypti.

Dong S, Lin J, Held NL, Clem RJ, Passarelli AL, Franz AW.

PLoS One. 2015 Mar 27;10(3):e0122353. doi: 10.1371/journal.pone.0122353. eCollection 2015.


Reaching the melting point: Degradative enzymes and protease inhibitors involved in baculovirus infection and dissemination.

Ishimwe E, Hodgson JJ, Clem RJ, Passarelli AL.

Virology. 2015 May;479-480:637-49. doi: 10.1016/j.virol.2015.01.027. Epub 2015 Feb 25. Review.


Rapid selection against arbovirus-induced apoptosis during infection of a mosquito vector.

O'Neill K, Olson BJ, Huang N, Unis D, Clem RJ.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):E1152-61. doi: 10.1073/pnas.1424469112. Epub 2015 Feb 23.


Viral IAPs, then and now.

Clem RJ.

Semin Cell Dev Biol. 2015 Mar;39:72-9. doi: 10.1016/j.semcdb.2015.01.011. Epub 2015 Jan 31. Review.


Functional characterization of hesp018, a baculovirus-encoded serpin gene.

Ardisson-Araujo DM, Rohrmann GF, Ribeiro BM, Clem RJ.

J Gen Virol. 2015 May;96(Pt 5):1150-60. doi: 10.1099/vir.0.000041. Epub 2015 Jan 8.


Baculoviruses: sophisticated pathogens of insects.

Clem RJ, Passarelli AL.

PLoS Pathog. 2013;9(11):e1003729. doi: 10.1371/journal.ppat.1003729. Epub 2013 Nov 14. Review. No abstract available.


The baculovirus sulfhydryl oxidase Ac92 (P33) interacts with the Spodoptera frugiperda P53 protein and oxidizes it in vitro.

Wu W, Clem RJ, Rohrmann GF, Passarelli AL.

Virology. 2013 Dec;447(1-2):197-207. doi: 10.1016/j.virol.2013.09.006. Epub 2013 Oct 1.


SfDronc, an initiator caspase involved in apoptosis in the fall armyworm Spodoptera frugiperda.

Huang N, Civciristov S, Hawkins CJ, Clem RJ.

Insect Biochem Mol Biol. 2013 May;43(5):444-54. doi: 10.1016/j.ibmb.2013.02.005. Epub 2013 Mar 5.


P53-mediated rapid induction of apoptosis conveys resistance to viral infection in Drosophila melanogaster.

Liu B, Behura SK, Clem RJ, Schneemann A, Becnel J, Severson DW, Zhou L.

PLoS Pathog. 2013 Feb;9(2):e1003137. doi: 10.1371/journal.ppat.1003137. Epub 2013 Feb 7.


Caspase inhibitors of the P35 family are more active when purified from yeast than bacteria.

Brand IL, Civciristov S, Taylor NL, Talbo GH, Pantaki-Eimany D, Levina V, Clem RJ, Perugini MA, Kvansakul M, Hawkins CJ.

PLoS One. 2012;7(6):e39248. doi: 10.1371/journal.pone.0039248. Epub 2012 Jun 14.


Effects of manipulating apoptosis on Sindbis virus infection of Aedes aegypti mosquitoes.

Wang H, Gort T, Boyle DL, Clem RJ.

J Virol. 2012 Jun;86(12):6546-54. doi: 10.1128/JVI.00125-12. Epub 2012 Mar 21.


Functional and biochemical characterization of the baculovirus caspase inhibitor MaviP35.

Brand IL, Green MM, Civciristov S, Pantaki-Eimany D, George C, Gort TR, Huang N, Clem RJ, Hawkins CJ.

Cell Death Dis. 2011 Dec 15;2:e242. doi: 10.1038/cddis.2011.127.


Baculovirus infection induces a DNA damage response that is required for efficient viral replication.

Huang N, Wu W, Yang K, Passarelli AL, Rohrmann GF, Clem RJ.

J Virol. 2011 Dec;85(23):12547-56. doi: 10.1128/JVI.05766-11. Epub 2011 Sep 14.


Characterization of cDNAs encoding p53 of Bombyx mori and Spodoptera frugiperda.

Huang N, Clem RJ, Rohrmann GF.

Insect Biochem Mol Biol. 2011 Aug;41(8):613-9. doi: 10.1016/j.ibmb.2011.03.014. Epub 2011 Apr 8.


The role of IAP antagonist proteins in the core apoptosis pathway of the mosquito disease vector Aedes aegypti.

Wang H, Clem RJ.

Apoptosis. 2011 Mar;16(3):235-48. doi: 10.1007/s10495-011-0575-3.


Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens.

Bartholomay LC, Waterhouse RM, Mayhew GF, Campbell CL, Michel K, Zou Z, Ramirez JL, Das S, Alvarez K, Arensburger P, Bryant B, Chapman SB, Dong Y, Erickson SM, Karunaratne SH, Kokoza V, Kodira CD, Pignatelli P, Shin SW, Vanlandingham DL, Atkinson PW, Birren B, Christophides GK, Clem RJ, Hemingway J, Higgs S, Megy K, Ranson H, Zdobnov EM, Raikhel AS, Christensen BM, Dimopoulos G, Muskavitch MA.

Science. 2010 Oct 1;330(6000):88-90. doi: 10.1126/science.1193162.


A caspase-like decoy molecule enhances the activity of a paralogous caspase in the yellow fever mosquito, Aedes aegypti.

Bryant B, Ungerer MC, Liu Q, Waterhouse RM, Clem RJ.

Insect Biochem Mol Biol. 2010 Jul;40(7):516-23. doi: 10.1016/j.ibmb.2010.04.011. Epub 2010 Apr 24.


A lepidopteran orthologue of reaper reveals functional conservation and evolution of IAP antagonists.

Bryant B, Zhang Y, Zhang C, Santos CP, Clem RJ, Zhou L.

Insect Mol Biol. 2009 Jun;18(3):341-51. doi: 10.1111/j.1365-2583.2009.00878.x.


Mutation of juxtamembrane cysteines in the tetraspanin CD81 affects palmitoylation and alters interaction with other proteins at the cell surface.

Delandre C, Penabaz TR, Passarelli AL, Chapes SK, Clem RJ.

Exp Cell Res. 2009 Jul 1;315(11):1953-63. doi: 10.1016/j.yexcr.2009.03.013. Epub 2009 Mar 25.


Caspase inhibitor P35 is required for the production of robust baculovirus virions in Trichoplusia ni TN-368 cells.

Bryant B, Clem RJ.

J Gen Virol. 2009 Mar;90(Pt 3):654-61. doi: 10.1099/vir.0.007419-0.


Macrophage cell lines use CD81 in cell growth regulation.

Mordica WJ, Woods KM, Clem RJ, Passarelli AL, Chapes SK.

In Vitro Cell Dev Biol Anim. 2009 May-Jun;45(5-6):213-25. doi: 10.1007/s11626-008-9167-0. Epub 2009 Jan 30.


Effects of inducing or inhibiting apoptosis on Sindbis virus replication in mosquito cells.

Wang H, Blair CD, Olson KE, Clem RJ.

J Gen Virol. 2008 Nov;89(Pt 11):2651-61. doi: 10.1099/vir.0.2008/005314-0.


Annotation and expression profiling of apoptosis-related genes in the yellow fever mosquito, Aedes aegypti.

Bryant B, Blair CD, Olson KE, Clem RJ.

Insect Biochem Mol Biol. 2008 Mar;38(3):331-45. doi: 10.1016/j.ibmb.2007.11.012. Epub 2007 Dec 7.


Baculoviruses and apoptosis: a diversity of genes and responses.

Clem RJ.

Curr Drug Targets. 2007 Oct;8(10):1069-74. Review.


The iap genes: unique arbitrators of cell death.

Clem RJ, Duckett CS.

Trends Cell Biol. 1997 Sep;7(9):337-9.


Analysis and functional annotation of expressed sequence tags from the fall armyworm Spodoptera frugiperda.

Deng Y, Dong Y, Thodima V, Clem RJ, Passarelli AL.

BMC Genomics. 2006 Oct 19;7:264.


Lack of involvement of mitochondrial factors in caspase activation in a Drosophila cell-free system.

Means JC, Muro I, Clem RJ.

Cell Death Differ. 2006 Jul;13(7):1222-34. Epub 2005 Dec 2.


The role of apoptosis in defense against baculovirus infection in insects.

Clem RJ.

Curr Top Microbiol Immunol. 2005;289:113-29. Review.


Cleavage of the apoptosis inhibitor DIAP1 by the apical caspase DRONC in both normal and apoptotic Drosophila cells.

Muro I, Means JC, Clem RJ.

J Biol Chem. 2005 May 13;280(19):18683-8. Epub 2005 Mar 17.


Mechanism of Dronc activation in Drosophila cells.

Muro I, Monser K, Clem RJ.

J Cell Sci. 2004 Oct 1;117(Pt 21):5035-41. Epub 2004 Sep 21.


Ubiquitin protein ligase activity of the anti-apoptotic baculovirus protein Op-IAP3.

Green MC, Monser KP, Clem RJ.

Virus Res. 2004 Sep 15;105(1):89-96.


Insect defenses against virus infection: the role of apoptosis.

Clarke TE, Clem RJ.

Int Rev Immunol. 2003 Sep-Dec;22(5-6):401-24. Review.


Improving baculovirus resistance to UV inactivation: increased virulence resulting from expression of a DNA repair enzyme.

Petrik DT, Iseli A, Montelone BA, Van Etten JL, Clem RJ.

J Invertebr Pathol. 2003 Jan;82(1):50-6.


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