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Items: 1 to 50 of 69

1.

Cohesin complex-associated holoprosencephaly.

Kruszka P, Berger SI, Casa V, Dekker MR, Gaesser J, Weiss K, Martinez AF, Murdock DR, Louie RJ, Prijoles EJ, Lichty AW, Brouwer OF, Zonneveld-Huijssoon E, Stephan MJ, Hogue J, Hu P, Tanima-Nagai M, Everson JL, Prasad C, Cereda A, Iascone M, Schreiber A, Zurcher V, Corsten-Janssen N, Escobar L, Clegg NJ, Delgado MR, Hajirnis O, Balasubramanian M, Kayserili H, Deardorff M, Poot RA, Wendt KS, Lipinski RJ, Muenke M.

Brain. 2019 Sep 1;142(9):2631-2643. doi: 10.1093/brain/awz210.

PMID:
31334757
2.

In-depth investigations of adolescents and adults with holoprosencephaly identify unique characteristics.

Weiss K, Kruszka P, Guillen Sacoto MJ, Addissie YA, Hadley DW, Hadsall CK, Stokes B, Hu P, Roessler E, Solomon B, Wiggs E, Thurm A, Hufnagel RB, Zein WM, Hahn JS, Stashinko E, Levey E, Baldwin D, Clegg NJ, Delgado MR, Muenke M.

Genet Med. 2018 Jan;20(1):14-23. doi: 10.1038/gim.2017.68. Epub 2017 Jun 22.

3.

Identifying Abundant Immunotherapy and Other Targets in Solid Tumors: Integrating RNA-seq and Mass Spectrometry Proteomics Data Sets.

Zhao W, Fitzgibbon M, Bergan L, Clegg N, Crispin D, Mills GB, McIntosh M.

Cancer J. 2017 Mar/Apr;23(2):108-114. doi: 10.1097/PPO.0000000000000258. Review.

4.

Biallelic mutations in human DCC cause developmental split-brain syndrome.

Jamuar SS, Schmitz-Abe K, D'Gama AM, Drottar M, Chan WM, Peeva M, Servattalab S, Lam AN, Delgado MR, Clegg NJ, Zayed ZA, Dogar MA, Alorainy IA, Jamea AA, Abu-Amero K, Griebel M, Ward W, Lein ES, Markianos K, Barkovich AJ, Robson CD, Grant PE, Bosley TM, Engle EC, Walsh CA, Yu TW.

Nat Genet. 2017 Apr;49(4):606-612. doi: 10.1038/ng.3804. Epub 2017 Feb 27.

5.

Motion tracking and electromyography-assisted identification of mirror hand contributions to functional near-infrared spectroscopy images acquired during a finger-tapping task performed by children with cerebral palsy.

Hervey N, Khan B, Shagman L, Tian F, Delgado MR, Tulchin-Francis K, Shierk A, Roberts H, Smith L, Reid D, Clegg NJ, Liu H, MacFarlane D, Alexandrakis G.

Neurophotonics. 2014 Oct;1(2):025009. doi: 10.1117/1.NPh.1.2.025009. Epub 2014 Nov 11.

6.

Evaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy based on functional near-infrared spectroscopy.

Cao J, Khan B, Hervey N, Tian F, Delgado MR, Clegg NJ, Smith L, Roberts H, Tulchin-Francis K, Shierk A, Shagman L, MacFarlane D, Liu H, Alexandrakis G.

J Biomed Opt. 2015 Apr;20(4):046009. doi: 10.1117/1.JBO.20.4.046009.

7.

The role of follicular helper T cells and the germinal center in HIV-1 gp120 DNA prime and gp120 protein boost vaccination.

Hollister K, Chen Y, Wang S, Wu H, Mondal A, Clegg N, Lu S, Dent A.

Hum Vaccin Immunother. 2014;10(7):1985-92. doi: 10.4161/hv.28659.

8.

The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis.

Lucas JM, Heinlein C, Kim T, Hernandez SA, Malik MS, True LD, Morrissey C, Corey E, Montgomery B, Mostaghel E, Clegg N, Coleman I, Brown CM, Schneider EL, Craik C, Simon JA, Bedalov A, Nelson PS.

Cancer Discov. 2014 Nov;4(11):1310-25. doi: 10.1158/2159-8290.CD-13-1010. Epub 2014 Aug 13.

9.

Insights into the role of Bcl6 in follicular Th cells using a new conditional mutant mouse model.

Hollister K, Kusam S, Wu H, Clegg N, Mondal A, Sawant DV, Dent AL.

J Immunol. 2013 Oct 1;191(7):3705-11. doi: 10.4049/jimmunol.1300378. Epub 2013 Aug 26.

10.

Genotypic and phenotypic analysis of 396 individuals with mutations in Sonic Hedgehog.

Solomon BD, Bear KA, Wyllie A, Keaton AA, Dubourg C, David V, Mercier S, Odent S, Hehr U, Paulussen A, Clegg NJ, Delgado MR, Bale SJ, Lacbawan F, Ardinger HH, Aylsworth AS, Bhengu NL, Braddock S, Brookhyser K, Burton B, Gaspar H, Grix A, Horovitz D, Kanetzke E, Kayserili H, Lev D, Nikkel SM, Norton M, Roberts R, Saal H, Schaefer GB, Schneider A, Smith EK, Sowry E, Spence MA, Shalev SA, Steiner CE, Thompson EM, Winder TL, Balog JZ, Hadley DW, Zhou N, Pineda-Alvarez DE, Roessler E, Muenke M.

J Med Genet. 2012 Jul;49(7):473-9. doi: 10.1136/jmedgenet-2012-101008.

PMID:
22791840
11.

ARN-509: a novel antiandrogen for prostate cancer treatment.

Clegg NJ, Wongvipat J, Joseph JD, Tran C, Ouk S, Dilhas A, Chen Y, Grillot K, Bischoff ED, Cai L, Aparicio A, Dorow S, Arora V, Shao G, Qian J, Zhao H, Yang G, Cao C, Sensintaffar J, Wasielewska T, Herbert MR, Bonnefous C, Darimont B, Scher HI, Smith-Jones P, Klang M, Smith ND, De Stanchina E, Wu N, Ouerfelli O, Rix PJ, Heyman RA, Jung ME, Sawyers CL, Hager JH.

Cancer Res. 2012 Mar 15;72(6):1494-503. doi: 10.1158/0008-5472.CAN-11-3948. Epub 2012 Jan 20.

12.

Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers.

Kumar A, White TA, MacKenzie AP, Clegg N, Lee C, Dumpit RF, Coleman I, Ng SB, Salipante SJ, Rieder MJ, Nickerson DA, Corey E, Lange PH, Morrissey C, Vessella RL, Nelson PS, Shendure J.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17087-92. doi: 10.1073/pnas.1108745108. Epub 2011 Sep 26.

13.

Holoprosencephaly in a family segregating novel variants in ZIC2 and GLI2.

Wannasilp N, Solomon BD, Warren-Mora N, Clegg NJ, Delgado MR, Lacbawan F, Hu P, Winder TL, Roessler E, Muenke M.

Am J Med Genet A. 2011 Apr;155A(4):860-4. doi: 10.1002/ajmg.a.33903. Epub 2011 Mar 17.

PMID:
21416594
14.

MYC cooperates with AKT in prostate tumorigenesis and alters sensitivity to mTOR inhibitors.

Clegg NJ, Couto SS, Wongvipat J, Hieronymus H, Carver BS, Taylor BS, Ellwood-Yen K, Gerald WL, Sander C, Sawyers CL.

PLoS One. 2011 Mar 4;6(3):e17449. doi: 10.1371/journal.pone.0017449.

15.

Use of trihexyphenidyl in children with cerebral palsy.

Carranza-del Rio J, Clegg NJ, Moore A, Delgado MR.

Pediatr Neurol. 2011 Mar;44(3):202-6. doi: 10.1016/j.pediatrneurol.2010.09.008.

PMID:
21310336
16.

Quantification of functional near infrared spectroscopy to assess cortical reorganization in children with cerebral palsy.

Tian F, Delgado MR, Dhamne SC, Khan B, Alexandrakis G, Romero MI, Smith L, Reid D, Clegg NJ, Liu H.

Opt Express. 2010 Dec 6;18(25):25973-86. doi: 10.1364/OE.18.025973.

17.

The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression.

Sharma A, Yeow WS, Ertel A, Coleman I, Clegg N, Thangavel C, Morrissey C, Zhang X, Comstock CE, Witkiewicz AK, Gomella L, Knudsen ES, Nelson PS, Knudsen KE.

J Clin Invest. 2010 Dec;120(12):4478-92. doi: 10.1172/JCI44239. Epub 2010 Nov 22.

18.

Identification of abnormal motor cortex activation patterns in children with cerebral palsy by functional near-infrared spectroscopy.

Khan B, Tian F, Behbehani K, Romero MI, Delgado MR, Clegg NJ, Smith L, Reid D, Liu H, Alexandrakis G.

J Biomed Opt. 2010 May-Jun;15(3):036008. doi: 10.1117/1.3432746.

19.

Septopreoptic holoprosencephaly: a mild subtype associated with midline craniofacial anomalies.

Hahn JS, Barnes PD, Clegg NJ, Stashinko EE.

AJNR Am J Neuroradiol. 2010 Oct;31(9):1596-601. doi: 10.3174/ajnr.A2123. Epub 2010 May 20.

20.

Reliability of the Tardieu Scale for assessing spasticity in children with cerebral palsy.

Gracies JM, Burke K, Clegg NJ, Browne R, Rushing C, Fehlings D, Matthews D, Tilton A, Delgado MR.

Arch Phys Med Rehabil. 2010 Mar;91(3):421-8. doi: 10.1016/j.apmr.2009.11.017.

PMID:
20298834
21.

Parental perspectives on living with a child with HoPE.

Stashinko EE, Harley LA, Steele RA, Clegg NJ.

Am J Med Genet C Semin Med Genet. 2010 Feb 15;154C(1):197-201. doi: 10.1002/ajmg.c.30237. Review.

PMID:
20104617
22.

Management of children with holoprosencephaly.

Levey EB, Stashinko E, Clegg NJ, Delgado MR.

Am J Med Genet C Semin Med Genet. 2010 Feb 15;154C(1):183-90. doi: 10.1002/ajmg.c.30254. Review.

PMID:
20104615
23.

TGIF Mutations in Human Holoprosencephaly: Correlation between Genotype and Phenotype.

Keaton AA, Solomon BD, Kauvar EF, El-Jaick KB, Gropman AL, Zafer Y, Meck JM, Bale SJ, Grange DK, Haddad BR, Gowans GC, Clegg NJ, Delgado MR, Hahn JS, Pineda-Alvarez DE, Lacbawan F, Vélez JI, Roessler E, Muenke M.

Mol Syndromol. 2010;1(5):211-222. Epub 2011 May 18.

24.

Mutations in ZIC2 in human holoprosencephaly: description of a novel ZIC2 specific phenotype and comprehensive analysis of 157 individuals.

Solomon BD, Lacbawan F, Mercier S, Clegg NJ, Delgado MR, Rosenbaum K, Dubourg C, David V, Olney AH, Wehner LE, Hehr U, Bale S, Paulussen A, Smeets HJ, Hardisty E, Tylki-Szymanska A, Pronicka E, Clemens M, McPherson E, Hennekam RC, Hahn J, Stashinko E, Levey E, Wieczorek D, Roeder E, Schell-Apacik CC, Booth CW, Thomas RL, Kenwrick S, Cummings DA, Bous SM, Keaton A, Balog JZ, Hadley D, Zhou N, Long R, Vélez JI, Pineda-Alvarez DE, Odent S, Roessler E, Muenke M.

J Med Genet. 2010 Aug;47(8):513-24. doi: 10.1136/jmg.2009.073049. Epub 2009 Dec 2.

25.

Anti-androgens and androgen-depleting therapies in prostate cancer: new agents for an established target.

Chen Y, Clegg NJ, Scher HI.

Lancet Oncol. 2009 Oct;10(10):981-91. doi: 10.1016/S1470-2045(09)70229-3.

26.

Development of a second-generation antiandrogen for treatment of advanced prostate cancer.

Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, Wongvipat J, Smith-Jones PM, Yoo D, Kwon A, Wasielewska T, Welsbie D, Chen CD, Higano CS, Beer TM, Hung DT, Scher HI, Jung ME, Sawyers CL.

Science. 2009 May 8;324(5928):787-90. doi: 10.1126/science.1168175. Epub 2009 Apr 9.

27.

Clinical spectrum of SIX3-associated mutations in holoprosencephaly: correlation between genotype, phenotype and function.

Lacbawan F, Solomon BD, Roessler E, El-Jaick K, Domené S, Vélez JI, Zhou N, Hadley D, Balog JZ, Long R, Fryer A, Smith W, Omar S, McLean SD, Clarkson K, Lichty A, Clegg NJ, Delgado MR, Levey E, Stashinko E, Potocki L, Vanallen MI, Clayton-Smith J, Donnai D, Bianchi DW, Juliusson PB, Njølstad PR, Brunner HG, Carey JC, Hehr U, Müsebeck J, Wieacker PF, Postra A, Hennekam RC, van den Boogaard MJ, van Haeringen A, Paulussen A, Herbergs J, Schrander-Stumpel CT, Janecke AR, Chitayat D, Hahn J, McDonald-McGinn DM, Zackai EH, Dobyns WB, Muenke M.

J Med Genet. 2009 Jun;46(6):389-98. doi: 10.1136/jmg.2008.063818. Epub 2009 Apr 2.

28.

Service reform. We shall bring mental health under our wing.

Clegg N.

Health Serv J. 2008 Sep 11:16-7. No abstract available.

PMID:
18833622
29.

Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract.

Cvoro A, Paruthiyil S, Jones JO, Tzagarakis-Foster C, Clegg NJ, Tatomer D, Medina RT, Tagliaferri M, Schaufele F, Scanlan TS, Diamond MI, Cohen I, Leitman DC.

Endocrinology. 2007 Feb;148(2):538-47. Epub 2006 Nov 9.

PMID:
17095596
30.

Combining results of microarray experiments: a rank aggregation approach.

DeConde RP, Hawley S, Falcon S, Clegg N, Knudsen B, Etzioni R.

Stat Appl Genet Mol Biol. 2006;5:Article15. Epub 2006 Jun 20.

PMID:
17049026
31.

Factor analysis of neuroanatomical and clinical characteristics of holoprosencephaly.

Hahn JS, Barkovich AJ, Stashinko EE, Kinsman SL, Delgado MR, Clegg NJ.

Brain Dev. 2006 Aug;28(7):413-9. Epub 2006 Feb 28.

PMID:
16503393
32.

Endocrine disorders associated with holoprosencephaly.

Hahn JS, Hahn SM, Kammann H, Barkovich AJ, Clegg NJ, Delgado MR, Levey E.

J Pediatr Endocrinol Metab. 2005 Oct;18(10):935-41.

PMID:
16355806
33.

Differential response of estrogen receptor subtypes to 1,3-diarylindene and 2,3-diarylindene ligands.

Clegg NJ, Paruthiyil S, Leitman DC, Scanlan TS.

J Med Chem. 2005 Sep 22;48(19):5989-6003.

PMID:
16162002
34.

Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries.

Matsumura M, Bhatt AS, Andress D, Clegg N, Takayama TK, Craik CS, Nelson PS.

Prostate. 2005 Jan 1;62(1):1-13.

PMID:
15389820
35.

A retrospective survey of perinatal risk factors of 104 living children with holoprosencephaly.

Stashinko EE, Clegg NJ, Kammann HA, Sweet VT, Delgado MR, Hahn JS, Levey EB.

Am J Med Genet A. 2004 Jul 15;128A(2):114-9.

PMID:
15213999
36.

Characterization and comparative analyses of transcriptomes from the normal and neoplastic human prostate.

Clegg N, Abbott D, Ferguson C, Coleman R, Nelson PS.

Prostate. 2004 Aug 1;60(3):227-39.

PMID:
15176052
37.

Expressed sequence tag profiling identifies developmental and anatomic partitioning of gene expression in the mouse prostate.

Abbott DE, Pritchard C, Clegg NJ, Ferguson C, Dumpit R, Sikes RA, Nelson PS.

Genome Biol. 2003;4(12):R79. Epub 2003 Nov 28.

38.

Electroencephalography in holoprosencephaly: findings in children without epilepsy.

Hahn JS, Delgado MR, Clegg NJ, Sparagana SP, Gerace KL, Barkovich AJ, Olson DM.

Clin Neurophysiol. 2003 Oct;114(10):1908-17.

PMID:
14499753
39.

Molecular characterization of prostatic small-cell neuroendocrine carcinoma.

Clegg N, Ferguson C, True LD, Arnold H, Moorman A, Quinn JE, Vessella RL, Nelson PS.

Prostate. 2003 Apr 1;55(1):55-64.

PMID:
12640661
40.

Middle interhemispheric variant of holoprosencephaly associated with diffuse polymicrogyria.

Takanashi J, Barkovich AJ, Clegg NJ, Delgado MR.

AJNR Am J Neuroradiol. 2003 Mar;24(3):394-7.

41.
42.

MRI shows abnormal white matter maturation in classical holoprosencephaly.

Barkovich AJ, Simon EM, Glenn OA, Clegg NJ, Kinsman SL, Delgado M, Hahn JS.

Neurology. 2002 Dec 24;59(12):1968-71.

PMID:
12499493
43.

Middle interhemispheric variant of holoprosencephaly: a distinct cliniconeuroradiologic subtype.

Lewis AJ, Simon EM, Barkovich AJ, Clegg NJ, Delgado MR, Levey E, Hahn JS.

Neurology. 2002 Dec 24;59(12):1860-5.

PMID:
12499474
44.

Neuroanatomy of holoprosencephaly as predictor of function: beyond the face predicting the brain.

Plawner LL, Delgado MR, Miller VS, Levey EB, Kinsman SL, Barkovich AJ, Simon EM, Clegg NJ, Sweet VT, Stashinko EE, Hahn JS.

Neurology. 2002 Oct 8;59(7):1058-66.

PMID:
12370462
45.

The program of androgen-responsive genes in neoplastic prostate epithelium.

Nelson PS, Clegg N, Arnold H, Ferguson C, Bonham M, White J, Hood L, Lin B.

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11890-5. Epub 2002 Aug 16.

46.

A neuroendocrine/small cell prostate carcinoma xenograft-LuCaP 49.

True LD, Buhler K, Quinn J, Williams E, Nelson PS, Clegg N, Macoska JA, Norwood T, Liu A, Ellis W, Lange P, Vessella R.

Am J Pathol. 2002 Aug;161(2):705-15.

47.

Ligand-selective interactions of ER detected in living cells by fluorescence resonance energy transfer.

Weatherman RV, Chang CY, Clegg NJ, Carroll DC, Day RN, Baxter JD, McDonnell DP, Scanlan TS, Schaufele F.

Mol Endocrinol. 2002 Mar;16(3):487-96.

PMID:
11875107
48.

Digital expression profiles of the prostate androgen-response program.

Clegg N, Eroglu B, Ferguson C, Arnold H, Moorman A, Nelson PS.

J Steroid Biochem Mol Biol. 2002 Jan;80(1):13-23.

PMID:
11867260
49.

The middle interhemispheric variant of holoprosencephaly.

Simon EM, Hevner RF, Pinter JD, Clegg NJ, Delgado M, Kinsman SL, Hahn JS, Barkovich AJ.

AJNR Am J Neuroradiol. 2002 Jan;23(1):151-6. Erratum in: AJNR Am J Neuroradiol 2002 Apr;23(4):742.

50.

Analysis of the cerebral cortex in holoprosencephaly with attention to the sylvian fissures.

Barkovich AJ, Simon EM, Clegg NJ, Kinsman SL, Hahn JS.

AJNR Am J Neuroradiol. 2002 Jan;23(1):143-50.

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