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Fluid overload as a therapeutic target for the preservative management of chronic kidney disease.

Palmer BF, Clegg DJ.

Curr Opin Nephrol Hypertens. 2019 Nov 9. doi: 10.1097/MNH.0000000000000563. [Epub ahead of print]


Potassium binding for conservative and preservative management of chronic kidney disease.

Clegg DJ, Palmer BF.

Curr Opin Nephrol Hypertens. 2019 Nov 9. doi: 10.1097/MNH.0000000000000564. [Epub ahead of print]


Imaging Metabolically Active Fat: A Literature Review and Mechanistic Insights.

Frankl J, Sherwood A, Clegg DJ, Scherer PE, Öz OK.

Int J Mol Sci. 2019 Nov 5;20(21). pii: E5509. doi: 10.3390/ijms20215509. Review.


The Effects of Timing of Soft Tissue Coverage on Outcomes After Reconstruction of Type IIIB Open Tibia Fractures.

Clegg DJ, Rosenbaum PF, Harley BJ.

Orthopedics. 2019 Sep 1;42(5):260-266. doi: 10.3928/01477447-20190723-01. Epub 2019 Jul 29.


Hyperchloremic normal gap metabolic acidosis.

Palmer BF, Clegg DJ.

Minerva Endocrinol. 2019 Jul 24. doi: 10.23736/S0391-1977.19.03059-1. [Epub ahead of print]


Strategies to Counter Weight Loss-Induced Reductions in Metabolic Rate.

Palmer BF, Clegg DJ.

Curr Sports Med Rep. 2019 Jul;18(7):258-265. doi: 10.1249/JSR.0000000000000610.


Activation of NPRs and UCP1-independent pathway following CB1R antagonist treatment is associated with adipose tissue beiging in fat-fed male dogs.

Iyer MS, Paszkiewicz RL, Bergman RN, Richey JM, Woolcott OO, Asare-Bediako I, Wu Q, Kim SP, Stefanovski D, Kolka CM, Clegg DJ, Kabir M.

Am J Physiol Endocrinol Metab. 2019 Sep 1;317(3):E535-E547. doi: 10.1152/ajpendo.00539.2018. Epub 2019 Jun 25.


Physiology and Pathophysiology of Potassium Homeostasis: Core Curriculum 2019.

Palmer BF, Clegg DJ.

Am J Kidney Dis. 2019 Nov;74(5):682-695. doi: 10.1053/j.ajkd.2019.03.427. Epub 2019 Jun 19. Review.


Estradiol stimulates adipogenesis and Slc2a4/GLUT4 expression via ESR1-mediated activation of CEBPA.

Fatima LA, Campello RS, Barreto-Andrade JN, Passarelli M, Santos RS, Clegg DJ, Machado UF.

Mol Cell Endocrinol. 2019 Dec 1;498:110447. doi: 10.1016/j.mce.2019.05.006. Epub 2019 May 14.


Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction.

Xu Y, Nedungadi TP, Zhu L, Sobhani N, Irani BG, Davis KE, Zhang X, Zou F, Gent LM, Hahner LD, Khan SA, Elias CF, Elmquist JK, Clegg DJ.

Cell Metab. 2019 May 7;29(5):1232. doi: 10.1016/j.cmet.2019.04.006. No abstract available.


Cardiovascular Benefits of a Diet Enriched in Fruits and Vegetables.

Palmer BF, Clegg DJ.

Am J Nephrol. 2019;49(6):435-437. doi: 10.1159/000500044. Epub 2019 Apr 17. No abstract available.


The Use of Selected Urine Chemistries in the Diagnosis of Kidney Disorders.

Palmer BF, Clegg DJ.

Clin J Am Soc Nephrol. 2019 Feb 7;14(2):306-316. doi: 10.2215/CJN.10330818. Epub 2019 Jan 9. Erratum in: Clin J Am Soc Nephrol. 2019 Aug 7;14(8):1241.


Plant-Based Diets in CKD.

Clegg DJ, Hill Gallant KM.

Clin J Am Soc Nephrol. 2019 Jan 7;14(1):141-143. doi: 10.2215/CJN.08960718. Epub 2018 Dec 26. No abstract available.


Activation of estrogen receptor alpha induces beiging of adipocytes.

Santos RS, Frank AP, Fátima LA, Palmer BF, Öz OK, Clegg DJ.

Mol Metab. 2018 Dec;18:51-59. doi: 10.1016/j.molmet.2018.09.002. Epub 2018 Sep 15.


Determinants of body fat distribution in humans may provide insight about obesity-related health risks.

Frank AP, de Souza Santos R, Palmer BF, Clegg DJ.

J Lipid Res. 2019 Oct;60(10):1710-1719. doi: 10.1194/jlr.R086975. Epub 2018 Aug 10.


Sex and media: Considerations for cell culture studies.

De Souza Santos R, Frank AP, Palmer BF, Clegg DJ.

ALTEX. 2018;35(4):435-440. doi: 10.14573/altex.1806151. Epub 2018 Jul 27.


An integrated view of sex differences in metabolic physiology and disease.

Clegg DJ, Mauvais-Jarvis F.

Mol Metab. 2018 Sep;15:1-2. doi: 10.1016/j.molmet.2018.06.011. Epub 2018 Jun 21. No abstract available.


Female Sex and Gender in Lung/Sleep Health and Disease. Increased Understanding of Basic Biological, Pathophysiological, and Behavioral Mechanisms Leading to Better Health for Female Patients with Lung Disease.

Han MK, Arteaga-Solis E, Blenis J, Bourjeily G, Clegg DJ, DeMeo D, Duffy J, Gaston B, Heller NM, Hemnes A, Henske EP, Jain R, Lahm T, Lancaster LH, Lee J, Legato MJ, McKee S, Mehra R, Morris A, Prakash YS, Stampfli MR, Gopal-Srivastava R, Laposky AD, Punturieri A, Reineck L, Tigno X, Clayton J.

Am J Respir Crit Care Med. 2018 Oct 1;198(7):850-858. doi: 10.1164/rccm.201801-0168WS. Review.


Impact of estrogens and estrogen receptor-α in brain lipid metabolism.

Morselli E, Santos RS, Gao S, Ávalos Y, Criollo A, Palmer BF, Clegg DJ.

Am J Physiol Endocrinol Metab. 2018 Jul 1;315(1):E7-E14. doi: 10.1152/ajpendo.00473.2017. Epub 2018 Mar 6. Review.


Altered Prostaglandin Signaling as a Cause of Thiazide-Induced Hyponatremia.

Palmer BF, Clegg DJ.

Am J Kidney Dis. 2018 Jun;71(6):769-771. doi: 10.1053/j.ajkd.2017.11.026. Epub 2018 Feb 28. No abstract available.


Renal Considerations in the Treatment of Hypertension.

Palmer BF, Clegg DJ.

Am J Hypertens. 2018 Mar 10;31(4):394-401. doi: 10.1093/ajh/hpy013. Review.


Electrolyte Disturbances in Chronic Alcohol-Use Disorder.

Palmer BF, Clegg DJ.

N Engl J Med. 2018 Jan 11;378(2):203-204. doi: 10.1056/NEJMc1714331. No abstract available.


Diet-induced glucose homeostasis dysregulation is enhanced by taurine supplementation in ovariectomized mice.

de Souza Santos R, Camargo RL, Vanzela EC, Batista TM, Morato PN, Leite NC, Rovani JC, García-Arévalo M, Clegg DJ, Carneiro EM.

Amino Acids. 2018 Apr;50(3-4):469-477. doi: 10.1007/s00726-017-2533-z. Epub 2017 Dec 27.


Diagnosis and treatment of hyperkalemia.

Palmer BF, Clegg DJ.

Cleve Clin J Med. 2017 Dec;84(12):934-942. doi: 10.3949/ccjm.84a.17056. Review.


Sex, Gender, and Transgender: Metabolic Impact of Cross Hormone Therapy.

de Souza Santos R, Frank AP, Nelson MD, Garcia MM, Palmer BF, Clegg DJ.

Adv Exp Med Biol. 2017;1043:611-627. doi: 10.1007/978-3-319-70178-3_27. Review.


Estrogen receptor 1 (ESR1) regulates VEGFA in adipose tissue.

Fatima LA, Campello RS, Santos RS, Freitas HS, Frank AP, Machado UF, Clegg DJ.

Sci Rep. 2017 Dec 1;7(1):16716. doi: 10.1038/s41598-017-16686-7.


Hyperkalemia across the Continuum of Kidney Function.

Palmer BF, Clegg DJ.

Clin J Am Soc Nephrol. 2018 Jan 6;13(1):155-157. doi: 10.2215/CJN.09340817. Epub 2017 Nov 7. No abstract available.


The impact of sex and sex hormones on cell function.

de Souza Santos R, Frank AP, Clegg DJ.

Steroids. 2017 Dec;128:72-74. doi: 10.1016/j.steroids.2017.10.017. Epub 2017 Nov 10.


Treatment of Abnormalities of Potassium Homeostasis in CKD.

Palmer BF, Clegg DJ.

Adv Chronic Kidney Dis. 2017 Sep;24(5):319-324. doi: 10.1053/j.ackd.2017.06.001. Review.


Do estrogens enhance activation of brown and beiging of adipose tissues?

Frank AP, Palmer BF, Clegg DJ.

Physiol Behav. 2018 Apr 1;187:24-31. doi: 10.1016/j.physbeh.2017.09.026. Epub 2017 Oct 6. Review.


Electrolyte Disturbances in Patients with Chronic Alcohol-Use Disorder.

Palmer BF, Clegg DJ.

N Engl J Med. 2017 Oct 5;377(14):1368-1377. doi: 10.1056/NEJMra1704724. Review. No abstract available.


The effects of 17 alpha-estradiol to inhibit inflammation in vitro.

Santos RS, de Fatima LA, Frank AP, Carneiro EM, Clegg DJ.

Biol Sex Differ. 2017 Sep 6;8(1):30. doi: 10.1186/s13293-017-0151-9.


Challenges in Treating Cardiovascular Disease: Restricting Sodium and Managing Hyperkalemia.

Clegg DJ, Cody M, Palmer BF.

Mayo Clin Proc. 2017 Aug;92(8):1248-1260. doi: 10.1016/j.mayocp.2017.04.006. Review.


Non-shivering thermogenesis as a mechanism to facilitate sustainable weight loss.

Palmer BF, Clegg DJ.

Obes Rev. 2017 Aug;18(8):819-831. doi: 10.1111/obr.12563. Epub 2017 May 25. Review.


Overweight postmenopausal women with different plasma estradiol concentrations present with a similar pattern of energy expenditure and substrate oxidation rate before and after a fatty meal challenge.

de Souza Santos R, Feijó da Silva Santos A, Clegg DJ, Iannetta O, Marchini JS, Marques Miguel Suen V.

Clin Nutr ESPEN. 2016 Oct;15:21-27. doi: 10.1016/j.clnesp.2016.05.003. Epub 2016 Jun 2.


Thiazide-Associated Hyponatremia: A Major Dilemma Affecting Treatment.

Palmer BF, Clegg DJ.

Am J Nephrol. 2017;45(5):417-419. doi: 10.1159/000471494. Epub 2017 Apr 19. No abstract available.


The effects of oestrogens and their receptors on cardiometabolic health.

Morselli E, Santos RS, Criollo A, Nelson MD, Palmer BF, Clegg DJ.

Nat Rev Endocrinol. 2017 Jun;13(6):352-364. doi: 10.1038/nrendo.2017.12. Epub 2017 Mar 17. Review.


Ventromedial hypothalamic glucose sensing and glucose homeostasis vary throughout the estrous cycle.

Santiago AM, Clegg DJ, Routh VH.

Physiol Behav. 2016 Dec 1;167:248-254. doi: 10.1016/j.physbeh.2016.09.021. Epub 2016 Sep 22.


Physiology and pathophysiology of potassium homeostasis.

Palmer BF, Clegg DJ.

Adv Physiol Educ. 2016 Dec;40(4):480-490. Review.


GPR30 regulates diet-induced adiposity in female mice and adipogenesis in vitro.

Wang A, Luo J, Moore W, Alkhalidy H, Wu L, Zhang J, Zhen W, Wang Y, Clegg DJ, Bin Xu, Cheng Z, McMillan RP, Hulver MW, Liu D.

Sci Rep. 2016 Oct 4;6:34302. doi: 10.1038/srep34302.


Estrogens modulate ventrolateral ventromedial hypothalamic glucose-inhibited neurons.

Santiago AM, Clegg DJ, Routh VH.

Mol Metab. 2016 Aug 20;5(10):823-833. doi: 10.1016/j.molmet.2016.08.002. eCollection 2016 Oct.


Sexually dimorphic brain fatty acid composition in low and high fat diet-fed mice.

Rodriguez-Navas C, Morselli E, Clegg DJ.

Mol Metab. 2016 Jun 30;5(8):680-689. doi: 10.1016/j.molmet.2016.06.014. eCollection 2016 Aug.


Sex and Gender: Critical Variables in Pre-Clinical and Clinical Medical Research.

Morselli E, Frank AP, Santos RS, Fátima LA, Palmer BF, Clegg DJ.

Cell Metab. 2016 Sep 13;24(3):520. doi: 10.1016/j.cmet.2016.08.007. Epub 2016 Sep 13. No abstract available.


Gonadal dysfunction in chronic kidney disease.

Palmer BF, Clegg DJ.

Rev Endocr Metab Disord. 2017 Mar;18(1):117-130. doi: 10.1007/s11154-016-9385-9. Review.


JAMA PATIENT PAGE. Dietary Guidelines for Americans--Eat Less Salt.

Frank AP, Clegg DJ.

JAMA. 2016 Aug 16;316(7):782. doi: 10.1001/jama.2016.0970. No abstract available.


Sex and Gender: Critical Variables in Pre-Clinical and Clinical Medical Research.

Morselli E, Frank AP, Santos RS, Fátima LA, Palmer BF, Clegg DJ.

Cell Metab. 2016 Aug 9;24(2):203-9. doi: 10.1016/j.cmet.2016.07.017. Review. Erratum in: Cell Metab. 2016 Sep 13;24(3):520.


Renal Denervation Reverses Hepatic Insulin Resistance Induced by High-Fat Diet.

Iyer MS, Bergman RN, Korman JE, Woolcott OO, Kabir M, Victor RG, Clegg DJ, Kolka C.

Diabetes. 2016 Nov;65(11):3453-3463. Epub 2016 Aug 5.


Transwomen and the Metabolic Syndrome: Is Orchiectomy Protective?

Nelson MD, Szczepaniak LS, Wei J, Szczepaniak E, Sánchez FJ, Vilain E, Stern JH, Bergman RN, Bairey Merz CN, Clegg DJ.

Transgend Health. 2016 Aug 1;1(1):165-171. doi: 10.1089/trgh.2016.0016. eCollection 2016.


Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R, Mihailov E, Pers TH, Rüeger S, Teumer A, Ehret GB, Ferreira T, Heard-Costa NL, Karjalainen J, Lagou V, Mahajan A, Neinast MD, Prokopenko I, Simino J, Teslovich TM, Jansen R, Westra HJ, White CC, Absher D, Ahluwalia TS, Ahmad S, Albrecht E, Alves AC, Bragg-Gresham JL, de Craen AJ, Bis JC, Bonnefond A, Boucher G, Cadby G, Cheng YC, Chiang CW, Delgado G, Demirkan A, Dueker N, Eklund N, Eiriksdottir G, Eriksson J, Feenstra B, Fischer K, Frau F, Galesloot TE, Geller F, Goel A, Gorski M, Grammer TB, Gustafsson S, Haitjema S, Hottenga JJ, Huffman JE, Jackson AU, Jacobs KB, Johansson Å, Kaakinen M, Kleber ME, Lahti J, Mateo Leach I, Lehne B, Liu Y, Lo KS, Lorentzon M, Luan J, Madden PA, Mangino M, McKnight B, Medina-Gomez C, Monda KL, Montasser ME, Müller G, Müller-Nurasyid M, Nolte IM, Panoutsopoulou K, Pascoe L, Paternoster L, Rayner NW, Renström F, Rizzi F, Rose LM, Ryan KA, Salo P, Sanna S, Scharnagl H, Shi J, Smith AV, Southam L, Stančáková A, Steinthorsdottir V, Strawbridge RJ, Sung YJ, Tachmazidou I, Tanaka T, Thorleifsson G, Trompet S, Pervjakova N, Tyrer JP, Vandenput L, van der Laan SW, van der Velde N, van Setten J, van Vliet-Ostaptchouk JV, Verweij N, Vlachopoulou E, Waite LL, Wang SR, Wang Z, Wild SH, Willenborg C, Wilson JF, Wong A, Yang J, Yengo L, Yerges-Armstrong LM, Yu L, Zhang W, Zhao JH, Andersson EA, Bakker SJ, Baldassarre D, Banasik K, Barcella M, Barlassina C, Bellis C, Benaglio P, Blangero J, Blüher M, Bonnet F, Bonnycastle LL, Boyd HA, Bruinenberg M, Buchman AS, Campbell H, Chen YI, Chines PS, Claudi-Boehm S, Cole J, Collins FS, de Geus EJ, de Groot LC, Dimitriou M, Duan J, Enroth S, Eury E, Farmaki AE, Forouhi NG, Friedrich N, Gejman PV, Gigante B, Glorioso N, Go AS, Gottesman O, Gräßler J, Grallert H, Grarup N, Gu YM, Broer L, Ham AC, Hansen T, Harris TB, Hartman CA, Hassinen M, Hastie N, Hattersley AT, Heath AC, Henders AK, Hernandez D, Hillege H, Holmen O, Hovingh KG, Hui J, Husemoen LL, Hutri-Kähönen N, Hysi PG, Illig T, De Jager PL, Jalilzadeh S, Jørgensen T, Jukema JW, Juonala M, Kanoni S, Karaleftheri M, Khaw KT, Kinnunen L, Kittner SJ, Koenig W, Kolcic I, Kovacs P, Krarup NT, Kratzer W, Krüger J, Kuh D, Kumari M, Kyriakou T, Langenberg C, Lannfelt L, Lanzani C, Lotay V, Launer LJ, Leander K, Lindström J, Linneberg A, Liu YP, Lobbens S, Luben R, Lyssenko V, Männistö S, Magnusson PK, McArdle WL, Menni C, Merger S, Milani L, Montgomery GW, Morris AP, Narisu N, Nelis M, Ong KK, Palotie A, Pérusse L, Pichler I, Pilia MG, Pouta A, Rheinberger M, Ribel-Madsen R, Richards M, Rice KM, Rice TK, Rivolta C, Salomaa V, Sanders AR, Sarzynski MA, Scholtens S, Scott RA, Scott WR, Sebert S, Sengupta S, Sennblad B, Seufferlein T, Silveira A, Slagboom PE, Smit JH, Sparsø TH, Stirrups K, Stolk RP, Stringham HM, Swertz MA, Swift AJ, Syvänen AC, Tan ST, Thorand B, Tönjes A, Tremblay A, Tsafantakis E, van der Most PJ, Völker U, Vohl MC, Vonk JM, Waldenberger M, Walker RW, Wennauer R, Widén E, Willemsen G, Wilsgaard T, Wright AF, Zillikens MC, van Dijk SC, van Schoor NM, Asselbergs FW, de Bakker PI, Beckmann JS, Beilby J, Bennett DA, Bergman RN, Bergmann S, Böger CA, Boehm BO, Boerwinkle E, Boomsma DI, Bornstein SR, Bottinger EP, Bouchard C, Chambers JC, Chanock SJ, Chasman DI, Cucca F, Cusi D, Dedoussis G, Erdmann J, Eriksson JG, Evans DA, de Faire U, Farrall M, Ferrucci L, Ford I, Franke L, Franks PW, Froguel P, Gansevoort RT, Gieger C, Grönberg H, Gudnason V, Gyllensten U, Hall P, Hamsten A, van der Harst P, Hayward C, Heliövaara M, Hengstenberg C, Hicks AA, Hingorani A, Hofman A, Hu F, Huikuri HV, Hveem K, James AL, Jordan JM, Jula A, Kähönen M, Kajantie E, Kathiresan S, Kiemeney LA, Kivimaki M, Knekt PB, Koistinen HA, Kooner JS, Koskinen S, Kuusisto J, Maerz W, Martin NG, Laakso M, Lakka TA, Lehtimäki T, Lettre G, Levinson DF, Lind L, Lokki ML, Mäntyselkä P, Melbye M, Metspalu A, Mitchell BD, Moll FL, Murray JC, Musk AW, Nieminen MS, Njølstad I, Ohlsson C, Oldehinkel AJ, Oostra BA, Palmer LJ, Pankow JS, Pasterkamp G, Pedersen NL, Pedersen O, Penninx BW, Perola M, Peters A, Polašek O, Pramstaller PP, Psaty BM, Qi L, Quertermous T, Raitakari OT, Rankinen T, Rauramaa R, Ridker PM, Rioux JD, Rivadeneira F, Rotter JI, Rudan I, den Ruijter HM, Saltevo J, Sattar N, Schunkert H, Schwarz PE, Shuldiner AR, Sinisalo J, Snieder H, Sørensen TI, Spector TD, Staessen JA, Stefania B, Thorsteinsdottir U, Stumvoll M, Tardif JC, Tremoli E, Tuomilehto J, Uitterlinden AG, Uusitupa M, Verbeek AL, Vermeulen SH, Viikari JS, Vitart V, Völzke H, Vollenweider P, Waeber G, Walker M, Wallaschofski H, Wareham NJ, Watkins H, Zeggini E; arcOGEN Consortium; CHARGE Consortium; DIAGRAM Consortium; GLGC Consortium; Global-BPGen Consortium; ICBP Consortium; MAGIC Consortium, Chakravarti A, Clegg DJ, Cupples LA, Gordon-Larsen P, Jaquish CE, Rao DC, Abecasis GR, Assimes TL, Barroso I, Berndt SI, Boehnke M, Deloukas P, Fox CS, Groop LC, Hunter DJ, Ingelsson E, Kaplan RC, McCarthy MI, Mohlke KL, O'Connell JR, Schlessinger D, Strachan DP, Stefansson K, van Duijn CM, Hirschhorn JN, Lindgren CM, Heid IM, North KE, Borecki IB, Kutalik Z, Loos RJ.

PLoS Genet. 2016 Jun 29;12(6):e1006166. doi: 10.1371/journal.pgen.1006166. eCollection 2016 Jun.


Female Mice Lacking Estrogen Receptor-α in Hypothalamic Proopiomelanocortin (POMC) Neurons Display Enhanced Estrogenic Response on Cortical Bone Mass.

Farman HH, Windahl SH, Westberg L, Isaksson H, Egecioglu E, Schele E, Ryberg H, Jansson JO, Tuukkanen J, Koskela A, Xie SK, Hahner L, Zehr J, Clegg DJ, Lagerquist MK, Ohlsson C.

Endocrinology. 2016 Aug;157(8):3242-52. doi: 10.1210/en.2016-1181. Epub 2016 Jun 2.

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