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Melanoma to Vitiligo: The Melanocyte in Biology & Medicine-Joint Montagna Symposium on the Biology of Skin/PanAmerican Society for Pigment Cell Research Annual Meeting.

Leachman SA, Hornyak TJ, Barsh G, Bastian BC, Brash DE, Cleaver JE, Cooper CD, D'Orazio JA, Fujita M, Holmen SL, Indra AK, Kraemer KH, Le Poole IC, Lo RS, Lund AW, Manga P, Pavan WJ, Setaluri V, Stemwedel CE, Kulesz-Martin MF.

J Invest Dermatol. 2019 Jul 23. pii: S0022-202X(19)32550-3. doi: 10.1016/j.jid.2019.03.1164. [Epub ahead of print] No abstract available.


PHIP as a therapeutic target for driver-negative subtypes of melanoma, breast, and lung cancer.

de Semir D, Bezrookove V, Nosrati M, Dar AA, Wu C, Shen J, Rieken C, Venkatasubramanian M, Miller JR 3rd, Desprez PY, McAllister S, Soroceanu L, Debs RJ, Salomonis N, Schadendorf D, Cleaver JE, Kashani-Sabet M.

Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5766-E5775. doi: 10.1073/pnas.1804779115. Epub 2018 Jun 4.


Why Cockayne syndrome patients do not get cancer despite their DNA repair deficiency.

Reid-Bayliss KS, Arron ST, Loeb LA, Bezrookove V, Cleaver JE.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10151-6. doi: 10.1073/pnas.1610020113. Epub 2016 Aug 19.


Sources and consequences of oxidative damage from mitochondria and neurotransmitter signaling.

Brennan-Minnella AM, Arron ST, Chou KM, Cunningham E, Cleaver JE.

Environ Mol Mutagen. 2016 Jun;57(5):322-30. doi: 10.1002/em.21995. Epub 2016 Jan 14. Review.


BPTF transduces MITF-driven prosurvival signals in melanoma cells.

Dar AA, Majid S, Bezrookove V, Phan B, Ursu S, Nosrati M, De Semir D, Sagebiel RW, Miller JR 3rd, Debs R, Cleaver JE, Kashani-Sabet M.

Proc Natl Acad Sci U S A. 2016 May 31;113(22):6254-8. doi: 10.1073/pnas.1606027113. Epub 2016 May 16.


Absence of skin cancer in the DNA repair-deficient disease Cockayne Syndrome (CS): A survey study.

Zhang WR, Garrett GL, Cleaver JE, Arron ST.

J Am Acad Dermatol. 2016 Jun;74(6):1270-2. doi: 10.1016/j.jaad.2016.01.003. No abstract available.


Selective Sentinel Lymph Node Dissection in Lower Extremity Melanoma.

Miranda SG, Parrett BM, Li RR, Lee G, Chang T, Fadaki N, Cardona-Huerta S, Cleaver JE, Kashani-Sabet M, Leong SP.

Plast Reconstr Surg. 2016 Mar;137(3):1031-8. doi: 10.1097/01.prs.0000479990.65243.eb. Erratum in: Plast Reconstr Surg. 2016 Apr;137(4):1357.


Profile of Tomas Lindahl, Paul Modrich, and Aziz Sancar, 2015 Nobel Laureates in Chemistry.

Cleaver JE.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):242-5. doi: 10.1073/pnas.1521829112. Epub 2015 Dec 29. No abstract available.


Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination.

Sanborn JZ, Chung J, Purdom E, Wang NJ, Kakavand H, Wilmott JS, Butler T, Thompson JF, Mann GJ, Haydu LE, Saw RP, Busam KJ, Lo RS, Collisson EA, Hur JS, Spellman PT, Cleaver JE, Gray JW, Huh N, Murali R, Scolyer RA, Bastian BC, Cho RJ.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):10995-1000. doi: 10.1073/pnas.1508074112. Epub 2015 Aug 18.


The risk of melanoma in pilots and cabin crew: UV measurements in flying airplanes.

Sanlorenzo M, Vujic I, Posch C, Cleaver JE, Quaglino P, Ortiz-Urda S.

JAMA Dermatol. 2015 Apr;151(4):450-2. doi: 10.1001/jamadermatol.2014.4643. No abstract available.


Transcription restores DNA repair to heterochromatin, determining regional mutation rates in cancer genomes.

Zheng CL, Wang NJ, Chung J, Moslehi H, Sanborn JZ, Hur JS, Collisson EA, Vemula SS, Naujokas A, Chiotti KE, Cheng JB, Fassihi H, Blumberg AJ, Bailey CV, Fudem GM, Mihm FG, Cunningham BB, Neuhaus IM, Liao W, Oh DH, Cleaver JE, LeBoit PE, Costello JF, Lehmann AR, Gray JW, Spellman PT, Arron ST, Huh N, Purdom E, Cho RJ.

Cell Rep. 2014 Nov 20;9(4):1228-34. doi: 10.1016/j.celrep.2014.10.031. Epub 2014 Nov 20.


The risk of melanoma in airline pilots and cabin crew: a meta-analysis.

Sanlorenzo M, Wehner MR, Linos E, Kornak J, Kainz W, Posch C, Vujic I, Johnston K, Gho D, Monico G, McGrath JT, Osella-Abate S, Quaglino P, Cleaver JE, Ortiz-Urda S.

JAMA Dermatol. 2015 Jan;151(1):51-8. doi: 10.1001/jamadermatol.2014.1077. Review.


Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage.

Cleaver JE, Brennan-Minnella AM, Swanson RA, Fong KW, Chen J, Chou KM, Chen YW, Revet I, Bezrookove V.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13487-92. doi: 10.1073/pnas.1414135111. Epub 2014 Aug 18.


Tritiated thymidine: xeroderma pigmentosum and DNA repair.

Cleaver JE.

FASEB J. 2014 Jul;28(7):2742-5. doi: 10.1096/fj.14-0702ufm. No abstract available.


Prognostic impact of PHIP copy number in melanoma: linkage to ulceration.

Bezrookove V, De Semir D, Nosrati M, Tong S, Wu C, Thummala S, Dar AA, Leong SPL, Cleaver JE, Sagebiel RW, Miller JR 3rd, Kashani-Sabet M.

J Invest Dermatol. 2014 Mar;134(3):783-790. doi: 10.1038/jid.2013.369. Epub 2013 Sep 4.


Is head and neck melanoma different from trunk and extremity melanomas with respect to sentinel lymph node status and clinical outcome?

Fadaki N, Li R, Parrett B, Sanders G, Thummala S, Martineau L, Cardona-Huerta S, Miranda S, Cheng ST, Miller JR 3rd, Singer M, Cleaver JE, Kashani-Sabet M, Leong SP.

Ann Surg Oncol. 2013 Sep;20(9):3089-97. doi: 10.1245/s10434-013-2977-7. Epub 2013 May 7.


Conceptual developments in the causes of Cockayne syndrome.

Cleaver JE, Bezrookove V, Revet I, Huang EJ.

Mech Ageing Dev. 2013 May-Jun;134(5-6):284-90. doi: 10.1016/j.mad.2013.02.005. Epub 2013 Feb 18. Review.


The effect of delay time between primary melanoma biopsy and sentinel lymph node dissection on sentinel node status, recurrence, and survival.

Parrett BM, Accortt NA, Li R, Dosanjh AS, Thummala S, Kullar R, Cleaver JE, Kashani-Sabet M, Leong SP.

Melanoma Res. 2012 Oct;22(5):386-91. doi: 10.1097/CMR.0b013e32835861f6.


Photosensitivity syndrome brings to light a new transcription-coupled DNA repair cofactor.

Cleaver JE.

Nat Genet. 2012 Apr 26;44(5):477-8. doi: 10.1038/ng.2255.


Vitamin D receptor mediates DNA repair and is UV inducible in intact epidermis but not in cultured keratinocytes.

Demetriou SK, Ona-Vu K, Teichert AE, Cleaver JE, Bikle DD, Oh DH.

J Invest Dermatol. 2012 Aug;132(8):2097-100. doi: 10.1038/jid.2012.107. Epub 2012 Apr 12. No abstract available.


Dysmyelination not demyelination causes neurological symptoms in preweaned mice in a murine model of Cockayne syndrome.

Revet I, Feeney L, Tang AA, Huang EJ, Cleaver JE.

Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4627-32. doi: 10.1073/pnas.1202621109. Epub 2012 Mar 5.


Targeting protein-trafficking pathways alters melanoma treatment sensitivity.

Huang ZM, Chinen M, Chang PJ, Xie T, Zhong L, Demetriou S, Patel MP, Scherzer R, Sviderskaya EV, Bennett DC, Millhauser GL, Oh DH, Cleaver JE, Wei ML.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):553-8. doi: 10.1073/pnas.1118366109. Epub 2011 Dec 27.


Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.

Wang NJ, Sanborn Z, Arnett KL, Bayston LJ, Liao W, Proby CM, Leigh IM, Collisson EA, Gordon PB, Jakkula L, Pennypacker S, Zou Y, Sharma M, North JP, Vemula SS, Mauro TM, Neuhaus IM, Leboit PE, Hur JS, Park K, Huh N, Kwok PY, Arron ST, Massion PP, Bale AE, Haussler D, Cleaver JE, Gray JW, Spellman PT, South AP, Aster JC, Blacklow SC, Cho RJ.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17761-6. doi: 10.1073/pnas.1114669108. Epub 2011 Oct 17.


Temporal dissection of tumorigenesis in primary cancers.

Durinck S, Ho C, Wang NJ, Liao W, Jakkula LR, Collisson EA, Pons J, Chan SW, Lam ET, Chu C, Park K, Hong SW, Hur JS, Huh N, Neuhaus IM, Yu SS, Grekin RC, Mauro TM, Cleaver JE, Kwok PY, LeBoit PE, Getz G, Cibulskis K, Aster JC, Huang H, Purdom E, Li J, Bolund L, Arron ST, Gray JW, Spellman PT, Cho RJ.

Cancer Discov. 2011 Jul;1(2):137-43. doi: 10.1158/2159-8290.CD-11-0028. Epub 2011 Jun 29.


I never expected to have such an interesting career, meet so many stimulating people and see so many exotic places.

Cleaver JE.

DNA Repair (Amst). 2011 Sep 5;10(9):906-14. No abstract available.


Phosphorylated H2Ax is not an unambiguous marker for DNA double-strand breaks.

Cleaver JE, Feeney L, Revet I.

Cell Cycle. 2011 Oct 1;10(19):3223-4. doi: 10.4161/cc.10.19.17448. Epub 2011 Oct 1. No abstract available.


γH2Ax: biomarker of damage or functional participant in DNA repair "all that glitters is not gold!".

Cleaver JE.

Photochem Photobiol. 2011 Nov-Dec;87(6):1230-9. doi: 10.1111/j.1751-1097.2011.00995.x. Epub 2011 Oct 3. Review.


Functional relevance of the histone gammaH2Ax in the response to DNA damaging agents.

Revet I, Feeney L, Bruguera S, Wilson W, Dong TK, Oh DH, Dankort D, Cleaver JE.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):8663-7. doi: 10.1073/pnas.1105866108. Epub 2011 May 9.


The DNA damage-binding protein XPC is a frequent target for inactivation in squamous cell carcinomas.

de Feraudy S, Ridd K, Richards LM, Kwok PY, Revet I, Oh D, Feeney L, Cleaver JE.

Am J Pathol. 2010 Aug;177(2):555-62. doi: 10.2353/ajpath.2010.090925. Epub 2010 Jul 8.


A minority of foci or pan-nuclear apoptotic staining of gammaH2AX in the S phase after UV damage contain DNA double-strand breaks.

de Feraudy S, Revet I, Bezrookove V, Feeney L, Cleaver JE.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6870-5. doi: 10.1073/pnas.1002175107. Epub 2010 Mar 29.


Diagnosing xeroderma pigmentosum group C by immunohistochemistry.

de Feraudy S, Boubakour-Azzouz I, Fraitag S, Berneburg M, Chan L, Chew K, Clericuzio CL, Cunningham B, Tope WD, Cleaver JE.

Am J Dermatopathol. 2010 Apr;32(2):109-17. doi: 10.1097/DAD.0b013e3181af0a5e.


Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity.

Cleaver JE, Lam ET, Revet I.

Nat Rev Genet. 2009 Nov;10(11):756-68. doi: 10.1038/nrg2663. Epub 2009 Oct 7. Review.


Histone H2AX phosphorylation in response to changes in chromatin structure induced by altered osmolarity.

Baure J, Izadi A, Suarez V, Giedzinski E, Cleaver JE, Fike JR, Limoli CL.

Mutagenesis. 2009 Mar;24(2):161-7. doi: 10.1093/mutage/gen064. Epub 2008 Dec 8.


Physical and functional interaction between DDB and XPA in nucleotide excision repair.

Wakasugi M, Kasashima H, Fukase Y, Imura M, Imai R, Yamada S, Cleaver JE, Matsunaga T.

Nucleic Acids Res. 2009 Feb;37(2):516-25. doi: 10.1093/nar/gkn964. Epub 2008 Dec 4.


In memoriam Sheldon Wolff (1929-2008).

Cleaver JE, Morgan WF.

Radiat Res. 2008 Oct;170(4):549-51. No abstract available.


Human DNA polymerase eta activity and translocation is regulated by phosphorylation.

Chen YW, Cleaver JE, Hatahet Z, Honkanen RE, Chang JY, Yen Y, Chou KM.

Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16578-83. doi: 10.1073/pnas.0808589105. Epub 2008 Oct 22.


Clinical implications of the basic defects in Cockayne syndrome and xeroderma pigmentosum and the DNA lesions responsible for cancer, neurodegeneration and aging.

Cleaver JE, Revet I.

Mech Ageing Dev. 2008 Jul-Aug;129(7-8):492-7. doi: 10.1016/j.mad.2008.01.005. Epub 2008 Feb 3.


Diagnosis of Xeroderma Pigmentosum and Related DNA Repair-Deficient Cutaneous Diseases.

Cleaver JE.

Curr Med Lit Dermatol. 2008;13(2):41-48. No abstract available.


p53 suppression overwhelms DNA polymerase eta deficiency in determining the cellular UV DNA damage response.

Laposa RR, Feeney L, Crowley E, de Feraudy S, Cleaver JE.

DNA Repair (Amst). 2007 Dec 1;6(12):1794-804. Epub 2007 Sep 5.


Pol eta is required for DNA replication during nucleotide deprivation by hydroxyurea.

de Feraudy S, Limoli CL, Giedzinski E, Karentz D, Marti TM, Feeney L, Cleaver JE.

Oncogene. 2007 Aug 23;26(39):5713-21. Epub 2007 Mar 19.


Increased apoptosis, p53 up-regulation, and cerebellar neuronal degeneration in repair-deficient Cockayne syndrome mice.

Laposa RR, Huang EJ, Cleaver JE.

Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1389-94. Epub 2007 Jan 17.


Cockayne syndrome exhibits dysregulation of p21 and other gene products that may be independent of transcription-coupled repair.

Cleaver JE, Hefner E, Laposa RR, Karentz D, Marti T.

Neuroscience. 2007 Apr 14;145(4):1300-8. Epub 2006 Oct 19.


Xeroderma pigmentosum group C in an isolated region of Guatemala.

Cleaver JE, Feeney L, Tang JY, Tuttle P.

J Invest Dermatol. 2007 Feb;127(2):493-6. Epub 2006 Sep 21. No abstract available.


Cells have long experience of dealing with UVC light.

Cleaver JE.

Nature. 2006 Jul 20;442(7100):244. No abstract available.


Genes and pathways downstream of telomerase in melanoma metastasis.

Bagheri S, Nosrati M, Li S, Fong S, Torabian S, Rangel J, Moore DH, Federman S, Laposa RR, Baehner FL, Sagebiel RW, Cleaver JE, Haqq C, Debs RJ, Blackburn EH, Kashani-Sabet M.

Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11306-11. Epub 2006 Jul 17.


Adenovirus mediated transduction of the human DNA polymerase eta cDNA.

Lima-Bessa KM, Chiganças V, Stary A, Kannouche P, Sarasin A, Armelini MG, de Fátima Jacysyn J, Amarante-Mendes GP, Cordeiro-Stone M, Cleaver JE, Menck CF.

DNA Repair (Amst). 2006 Aug 13;5(8):925-34. Epub 2006 Jun 23.


H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks.

Marti TM, Hefner E, Feeney L, Natale V, Cleaver JE.

Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9891-6. Epub 2006 Jun 20.


A novel role of DNA polymerase eta in modulating cellular sensitivity to chemotherapeutic agents.

Chen YW, Cleaver JE, Hanaoka F, Chang CF, Chou KM.

Mol Cancer Res. 2006 Apr;4(4):257-65.

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