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Items: 38

1.

ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage.

Willan J, Cleasby AJ, Flores-Rodriguez N, Stefani F, Rinaldo C, Pisciottani A, Grant E, Woodman P, Bryant HE, Ciani B.

Oncogenesis. 2019 Apr 15;8(5):29. doi: 10.1038/s41389-019-0136-0.

2.

Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design.

O'Reilly M, Cleasby A, Davies TG, Hall RJ, Ludlow RF, Murray CW, Tisi D, Jhoti H.

Drug Discov Today. 2019 May;24(5):1081-1086. doi: 10.1016/j.drudis.2019.03.009. Epub 2019 Mar 14.

3.

The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors.

Deaton DN, Do Y, Holt J, Jeune MR, Kramer HF, Larkin AL, Orband-Miller LA, Peckham GE, Poole C, Price DJ, Schaller LT, Shen Y, Shewchuk LM, Stewart EL, Stuart JD, Thomson SA, Ward P, Wilson JW, Xu T, Guss JH, Musetti C, Rendina AR, Affleck K, Anders D, Hancock AP, Hobbs H, Hodgson ST, Hutchinson J, Leveridge MV, Nicholls H, Smith IED, Somers DO, Sneddon HF, Uddin S, Cleasby A, Mortenson PN, Richardson C, Saxty G.

Bioorg Med Chem. 2019 Apr 15;27(8):1456-1478. doi: 10.1016/j.bmc.2019.02.017. Epub 2019 Feb 11.

PMID:
30858025
4.

Construction of an instant structured illumination microscope.

Curd A, Cleasby A, Makowska K, York A, Shroff H, Peckham M.

Methods. 2015 Oct 15;88:37-47. doi: 10.1016/j.ymeth.2015.07.012. Epub 2015 Jul 22.

5.

Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors.

Murray CW, Berdini V, Buck IM, Carr ME, Cleasby A, Coyle JE, Curry JE, Day JE, Day PJ, Hearn K, Iqbal A, Lee LY, Martins V, Mortenson PN, Munck JM, Page LW, Patel S, Roomans S, Smith K, Tamanini E, Saxty G.

ACS Med Chem Lett. 2015 Jun 4;6(7):798-803. doi: 10.1021/acsmedchemlett.5b00143. eCollection 2015 Jul 9.

6.

Nature's lessons in design: nanomachines to scaffold, remodel and shape membrane compartments.

Beales PA, Ciani B, Cleasby AJ.

Phys Chem Chem Phys. 2015 Jun 28;17(24):15489-507. doi: 10.1039/c5cp00480b. Epub 2015 Mar 25. Review.

7.

Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO.

Cleasby A, Yon J, Day PJ, Richardson C, Tickle IJ, Williams PA, Callahan JF, Carr R, Concha N, Kerns JK, Qi H, Sweitzer T, Ward P, Davies TG.

PLoS One. 2014 Jun 4;9(6):e98896. doi: 10.1371/journal.pone.0098896. eCollection 2014.

8.

Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket.

Saalau-Bethell SM, Berdini V, Cleasby A, Congreve M, Coyle JE, Lock V, Murray CW, O'Brien MA, Rich SJ, Sambrook T, Vinkovic M, Yon JR, Jhoti H.

ChemMedChem. 2014 Apr;9(4):823-32. doi: 10.1002/cmdc.201300480. Epub 2014 Feb 24.

9.

Potent, selective inhibitors of fibroblast growth factor receptor define fibroblast growth factor dependence in preclinical cancer models.

Squires M, Ward G, Saxty G, Berdini V, Cleasby A, King P, Angibaud P, Perera T, Fazal L, Ross D, Jones CG, Madin A, Benning RK, Vickerstaffe E, O'Brien A, Frederickson M, Reader M, Hamlett C, Batey MA, Rich S, Carr M, Miller D, Feltell R, Thiru A, Bethell S, Devine LA, Graham BL, Pike A, Cosme J, Lewis EJ, Freyne E, Lyons J, Irving J, Murray C, Newell DR, Thompson NT.

Mol Cancer Ther. 2011 Sep;10(9):1542-52. doi: 10.1158/1535-7163.MCT-11-0426. Epub 2011 Jul 15.

10.

Crystal structure of Schistosoma purine nucleoside phosphorylase complexed with a novel monocyclic inhibitor.

Pereira HM, Berdini V, Ferri MR, Cleasby A, Garratt RC.

Acta Trop. 2010 May;114(2):97-102. doi: 10.1016/j.actatropica.2010.01.010. Epub 2010 Feb 1.

PMID:
20122887
11.

Crystal structure of human CDK4 in complex with a D-type cyclin.

Day PJ, Cleasby A, Tickle IJ, O'Reilly M, Coyle JE, Holding FP, McMenamin RL, Yon J, Chopra R, Lengauer C, Jhoti H.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4166-70. doi: 10.1073/pnas.0809645106. Epub 2009 Feb 23.

12.

Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode.

Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19.

PMID:
18006306
13.

Crystal structure of calf spleen purine nucleoside phosphorylase complexed to a novel purine analogue.

Pereira HM, Berdini V, Cleasby A, Garratt RC.

FEBS Lett. 2007 Oct 30;581(26):5082-6. Epub 2007 Oct 2.

14.

Fragment-based screening using X-ray crystallography and NMR spectroscopy.

Jhoti H, Cleasby A, Verdonk M, Williams G.

Curr Opin Chem Biol. 2007 Oct;11(5):485-93. Epub 2007 Sep 11. Review.

PMID:
17851109
15.

Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP.

Day P, Sharff A, Parra L, Cleasby A, Williams M, Hörer S, Nar H, Redemann N, Tickle I, Yon J.

Acta Crystallogr D Biol Crystallogr. 2007 May;63(Pt 5):587-96. Epub 2007 Apr 21.

PMID:
17452784
16.

Application of fragment screening by X-ray crystallography to beta-secretase.

Murray CW, Callaghan O, Chessari G, Cleasby A, Congreve M, Frederickson M, Hartshorn MJ, McMenamin R, Patel S, Wallis N.

J Med Chem. 2007 Mar 22;50(6):1116-23. Epub 2007 Feb 22.

PMID:
17315856
17.

Structures for the potential drug target purine nucleoside phosphorylase from Schistosoma mansoni causal agent of schistosomiasis.

Pereira HD, Franco GR, Cleasby A, Garratt RC.

J Mol Biol. 2005 Oct 28;353(3):584-99. Epub 2005 Sep 2.

PMID:
16182308
18.

The discovery of novel protein kinase inhibitors by using fragment-based high-throughput x-ray crystallography.

Gill A, Cleasby A, Jhoti H.

Chembiochem. 2005 Mar;6(3):506-12. Review.

PMID:
15696598
19.

Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation.

Gill AL, Frederickson M, Cleasby A, Woodhead SJ, Carr MG, Woodhead AJ, Walker MT, Congreve MS, Devine LA, Tisi D, O'Reilly M, Seavers LC, Davis DJ, Curry J, Anthony R, Padova A, Murray CW, Carr RA, Jhoti H.

J Med Chem. 2005 Jan 27;48(2):414-26.

PMID:
15658855
20.

Fragment-based lead discovery using X-ray crystallography.

Hartshorn MJ, Murray CW, Cleasby A, Frederickson M, Tickle IJ, Jhoti H.

J Med Chem. 2005 Jan 27;48(2):403-13.

PMID:
15658854
21.

Apo and inhibitor complex structures of BACE (beta-secretase).

Patel S, Vuillard L, Cleasby A, Murray CW, Yon J.

J Mol Biol. 2004 Oct 15;343(2):407-16.

PMID:
15451669
22.

Cloning, expression and preliminary crystallographic studies of the potential drug target purine nucleoside phosphorylase from Schistosoma mansoni.

Pereira HM, Cleasby A, Pena S SD, Franco G GR, Garratt RC.

Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):1096-9. Epub 2003 May 23.

PMID:
12777786
23.

X-ray crystal structure of human dopamine sulfotransferase, SULT1A3. Molecular modeling and quantitative structure-activity relationship analysis demonstrate a molecular basis for sulfotransferase substrate specificity.

Dajani R, Cleasby A, Neu M, Wonacott AJ, Jhoti H, Hood AM, Modi S, Hersey A, Taskinen J, Cooke RM, Manchee GR, Coughtrie MW.

J Biol Chem. 1999 Dec 31;274(53):37862-8.

24.

Crystal structures of thrombin complexed to a novel series of synthetic inhibitors containing a 5,5-trans-lactone template.

Jhoti H, Cleasby A, Reid S, Thomas PJ, Weir M, Wonacott A.

Biochemistry. 1999 Jun 22;38(25):7969-77.

PMID:
10387040
25.

Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies.

Weir MP, Bethell SS, Cleasby A, Campbell CJ, Dennis RJ, Dix CJ, Finch H, Jhoti H, Mooney CJ, Patel S, Tang CM, Ward M, Wonacott AJ, Wharton CW.

Biochemistry. 1998 May 12;37(19):6645-57.

PMID:
9578548
26.

Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.

Taylor NR, Cleasby A, Singh O, Skarzynski T, Wonacott AJ, Smith PW, Sollis SL, Howes PD, Cherry PC, Bethell R, Colman P, Varghese J.

J Med Chem. 1998 Mar 12;41(6):798-807.

PMID:
9526556
27.

The x-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 angstrom resolution.

Cleasby A, Wonacott A, Skarzynski T, Hubbard RE, Davies GJ, Proudfoot AE, Bernard AR, Payton MA, Wells TN.

Nat Struct Biol. 1996 May;3(5):470-9.

PMID:
8612079
28.

Selenomethionine labelling of phosphomannose isomerase changes its kinetic properties.

Bernard AR, Wells TN, Cleasby A, Borlat F, Payton MA, Proudfoot AE.

Eur J Biochem. 1995 May 15;230(1):111-8.

29.

Crystallization and preliminary X-ray diffraction studies of human RANTES.

Shaw JP, Kryger G, Cleasby A, Wonacott A, Power CA, Proudfoot AE, Wells TN.

J Mol Biol. 1994 Sep 30;242(4):589-90.

PMID:
7523680
30.

Structural analysis of the catalytic domain of human fibroblast collagenase.

Lovejoy B, Cleasby A, Hassell AM, Luther MA, Weigl D, McGeehan G, Lambert MH, Jordan SR.

Ann N Y Acad Sci. 1994 Sep 6;732:375-8. No abstract available.

PMID:
7978813
31.

Crystallization and preliminary X-ray analysis of Candida albicans phosphomannose isomerase.

Tolley S, Davies G, Hubbard RE, Smith DJ, Proudfoot AE, Payton MA, Cleasby A, Wonacott A, Wells TN.

J Mol Biol. 1994 Apr 1;237(3):349-50.

PMID:
8145246
32.

Analysis of the structure of Pseudomonas glumae lipase.

Noble ME, Cleasby A, Johnson LN, Egmond MR, Frenken LG.

Protein Eng. 1994 Apr;7(4):559-62.

PMID:
8029212
33.

Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor.

Lovejoy B, Cleasby A, Hassell AM, Longley K, Luther MA, Weigl D, McGeehan G, McElroy AB, Drewry D, Lambert MH, et al.

Science. 1994 Jan 21;263(5145):375-7.

PMID:
8278810
34.

The crystal structure of triacylglycerol lipase from Pseudomonas glumae reveals a partially redundant catalytic aspartate.

Noble ME, Cleasby A, Johnson LN, Egmond MR, Frenken LG.

FEBS Lett. 1993 Sep 27;331(1-2):123-8.

35.

X-ray analyses of aspartic proteinases. V. Structure and refinement at 2.0 A resolution of the aspartic proteinase from Mucor pusillus.

Newman M, Watson F, Roychowdhury P, Jones H, Badasso M, Cleasby A, Wood SP, Tickle IJ, Blundell TL.

J Mol Biol. 1993 Mar 5;230(1):260-83.

PMID:
8450540
36.

Crystallization and preliminary X-ray study of a lipase from Pseudomonas glumae.

Cleasby A, Garman E, Egmond MR, Batenburg M.

J Mol Biol. 1992 Mar 5;224(1):281-2.

PMID:
1548708
37.

High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes.

Foundling SI, Cooper J, Watson FE, Cleasby A, Pearl LH, Sibanda BL, Hemmings A, Wood SP, Blundell TL, Valler MJ, et al.

Nature. 1987 May 28-Jun 3;327(6120):349-52.

PMID:
3295561
38.

The crystal structures of three non-pancreatic human insulins.

Chawdhury SA, Dodson EJ, Dodson GG, Reynolds CD, Tolley SP, Blundell TL, Cleasby A, Pitts JE, Tickle IJ, Wood SP.

Diabetologia. 1983 Dec;25(6):460-4.

PMID:
6363174

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