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Items: 22


An integrative systems approach identifies novel candidates in Marfan syndrome-related pathophysiology.

Bhushan R, Altinbas L, Jäger M, Zaradzki M, Lehmann D, Timmermann B, Clayton NP, Zhu Y, Kallenbach K, Kararigas G, Robinson PN.

J Cell Mol Med. 2019 Apr;23(4):2526-2535. doi: 10.1111/jcmm.14137. Epub 2019 Jan 24.


Preparation of Three-dimensional (3-D) Human Liver (HepaRG) Cultures for Histochemical and Immunohistochemical Staining and Light Microscopic Evaluation.

Clayton NP, Burwell A, Jensen H, Williams BF, Brown QD, Ovwigho P, Ramaiahgari S, Hermon T, Dixon D.

Toxicol Pathol. 2018 Aug;46(6):653-659. doi: 10.1177/0192623318789069. Epub 2018 Aug 8.


Immunohistochemistry in Investigative and Toxicologic Pathology.

Janardhan KS, Jensen H, Clayton NP, Herbert RA.

Toxicol Pathol. 2018 Jul;46(5):488-510. doi: 10.1177/0192623318776907. Epub 2018 Jul 2. Review.


Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics.

Chen JC, King OD, Zhang Y, Clayton NP, Spencer C, Wentworth BM, Emerson CP Jr, Wagner KR.

Mol Ther. 2016 Aug;24(8):1405-11. doi: 10.1038/mt.2016.111. Epub 2016 Jun 3.


Renal Cell Carcinomas in Vinylidene Chloride-exposed Male B6C3F1 Mice Are Characterized by Oxidative Stress and TP53 Pathway Dysregulation.

Hayes SA, Pandiri AR, Ton TV, Hong HH, Clayton NP, Shockley KR, Peddada SD, Gerrish K, Wyde M, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2016 Jan;44(1):71-87. doi: 10.1177/0192623315610820. Epub 2015 Dec 17.


Fibrillin-1 Regulates Skeletal Stem Cell Differentiation by Modulating TGFβ Activity Within the Marrow Niche.

Smaldone S, Clayton NP, del Solar M, Pascual G, Cheng SH, Wentworth BM, Schaffler MB, Ramirez F.

J Bone Miner Res. 2016 Jan;31(1):86-97. doi: 10.1002/jbmr.2598. Epub 2015 Aug 17.


Dimorphic effects of transforming growth factor-β signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndrome.

Cook JR, Clayton NP, Carta L, Galatioto J, Chiu E, Smaldone S, Nelson CA, Cheng SH, Wentworth BM, Ramirez F.

Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):911-7. doi: 10.1161/ATVBAHA.114.305150. Epub 2015 Jan 22.


Histopathological and Immunohistochemical Characterization of Methyl Eugenol-induced Nonneoplastic and Neoplastic Neuroendocrine Cell Lesions in Glandular Stomach of Rats.

Janardhan KS, Rebolloso Y, Hurlburt G, Olson D, Lyght O, Clayton NP, Gruebbel M, Picut C, Shackelford C, Herbert RA.

Toxicol Pathol. 2015 Jul;43(5):681-93. doi: 10.1177/0192623314560030. Epub 2014 Dec 1.


Antisense Oligonucleotide-mediated Suppression of Muscle Glycogen Synthase 1 Synthesis as an Approach for Substrate Reduction Therapy of Pompe Disease.

Clayton NP, Nelson CA, Weeden T, Taylor KM, Moreland RJ, Scheule RK, Phillips L, Leger AJ, Cheng SH, Wentworth BM.

Mol Ther Nucleic Acids. 2014 Oct 28;3:e206. doi: 10.1038/mtna.2014.57.


Gene expression of mesothelioma in vinylidene chloride-exposed F344/N rats reveal immune dysfunction, tissue damage, and inflammation pathways.

Blackshear PE, Pandiri AR, Nagai H, Bhusari S, Hong HH, Ton TV, Clayton NP, Wyde M, Shockley KR, Peddada SD, Gerrish KE, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2015 Feb;43(2):171-85. doi: 10.1177/0192623314537885. Epub 2014 Jun 23.


Spontaneous mesotheliomas in F344/N rats are characterized by dysregulation of cellular growth and immune function pathways.

Blackshear PE, Pandiri AR, Ton TV, Clayton NP, Shockley KR, Peddada SD, Gerrish KE, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2014 Jul;42(5):863-76. doi: 10.1177/0192623313501894. Epub 2013 Aug 26.


Characterization of four new mouse cytochrome P450 enzymes of the CYP2J subfamily.

Graves JP, Edin ML, Bradbury JA, Gruzdev A, Cheng J, Lih FB, Masinde TA, Qu W, Clayton NP, Morrison JP, Tomer KB, Zeldin DC.

Drug Metab Dispos. 2013 Apr;41(4):763-73. doi: 10.1124/dmd.112.049429. Epub 2013 Jan 11.


Systemic delivery of a Peptide-linked morpholino oligonucleotide neutralizes mutant RNA toxicity in a mouse model of myotonic dystrophy.

Leger AJ, Mosquea LM, Clayton NP, Wu IH, Weeden T, Nelson CA, Phillips L, Roberts E, Piepenhagen PA, Cheng SH, Wentworth BM.

Nucleic Acid Ther. 2013 Apr;23(2):109-17. doi: 10.1089/nat.2012.0404. Epub 2013 Jan 11.


Inhibiting TGF-β activity improves respiratory function in mdx mice.

Nelson CA, Hunter RB, Quigley LA, Girgenrath S, Weber WD, McCullough JA, Dinardo CJ, Keefe KA, Ceci L, Clayton NP, McVie-Wylie A, Cheng SH, Leonard JP, Wentworth BM.

Am J Pathol. 2011 Jun;178(6):2611-21. doi: 10.1016/j.ajpath.2011.02.024.


Useful immunohistochemical markers of tumor differentiation.

Painter JT, Clayton NP, Herbert RA.

Toxicol Pathol. 2010 Jan;38(1):131-41. doi: 10.1177/0192623309356449. Epub 2009 Dec 22.


Gene expression studies demonstrate that the K-ras/Erk MAP kinase signal transduction pathway and other novel pathways contribute to the pathogenesis of cumene-induced lung tumors.

Wakamatsu N, Collins JB, Parker JS, Tessema M, Clayton NP, Ton TV, Hong HH, Belinsky S, Devereux TR, Sills RC, Lahousse SA.

Toxicol Pathol. 2008 Jul;36(5):743-52. doi: 10.1177/0192623308320801. Epub 2008 Jul 22.


Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from B6C3F1 mice exposed to cumene.

Hong HH, Ton TV, Kim Y, Wakamatsu N, Clayton NP, Chan PC, Sills RC, Lahousse SA.

Toxicol Pathol. 2008 Jul;36(5):720-6. doi: 10.1177/0192623308320280. Epub 2008 Jul 22.


Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract.

Clayton NP, Yoshizawa K, Kissling GE, Burka LT, Chan PC, Nyska A.

Exp Toxicol Pathol. 2007 Jan;58(4):223-36. Epub 2006 Oct 23.


Chemical-induced atrial thrombosis in NTP rodent studies.

Yoshizawa K, Kissling GE, Johnson JA, Clayton NP, Flagler ND, Nyska A.

Toxicol Pathol. 2005;33(5):517-32. Review.


Genetic alterations in brain tumors following 1,3-butadiene exposure in B6C3F1 mice.

Kim Y, Hong HH, Lachat Y, Clayton NP, Devereux TR, Melnick RL, Hegi ME, Sills RC.

Toxicol Pathol. 2005;33(3):307-12.


Identification and localization of five CYP2Cs in murine extrahepatic tissues and their metabolism of arachidonic acid to regio- and stereoselective products.

Tsao CC, Coulter SJ, Chien A, Luo G, Clayton NP, Maronpot R, Goldstein JA, Zeldin DC.

J Pharmacol Exp Ther. 2001 Oct;299(1):39-47.


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