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Items: 1 to 50 of 54

1.

A PI3K p110β-Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis.

Yuzugullu H, Baitsch L, Von T, Steiner A, Tong H, Ni J, Clayton LK, Bronson R, Roberts TM, Gritsman K, Zhao JJ.

Nat Commun. 2015 Oct 7;6:8501. doi: 10.1038/ncomms9501.

2.

IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor.

Schuster M, Glauben R, Plaza-Sirvent C, Schreiber L, Annemann M, Floess S, Kühl AA, Clayton LK, Sparwasser T, Schulze-Osthoff K, Pfeffer K, Huehn J, Siegmund B, Schmitz I.

Immunity. 2012 Dec 14;37(6):998-1008. doi: 10.1016/j.immuni.2012.08.023. Epub 2012 Nov 29.

3.

Impaired B cell development and function in the absence of IkappaBNS.

Touma M, Keskin DB, Shiroki F, Saito I, Koyasu S, Reinherz EL, Clayton LK.

J Immunol. 2011 Oct 15;187(8):3942-52. doi: 10.4049/jimmunol.1002109. Epub 2011 Sep 7.

4.

PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla.

Choi YI, Duke-Cohan JS, Ahmed WB, Handley MA, Mann F, Epstein JA, Clayton LK, Reinherz EL.

Immunity. 2008 Dec 19;29(6):888-98. doi: 10.1016/j.immuni.2008.10.008. Epub 2008 Nov 27.

5.

Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption.

Touma M, Antonini V, Kumar M, Osborn SL, Bobenchik AM, Keskin DB, Connolly JE, Grusby MJ, Reinherz EL, Clayton LK.

J Immunol. 2007 Aug 1;179(3):1681-92.

6.

Importance of the CD3gamma ectodomain terminal beta-strand and membrane proximal stalk in thymic development and receptor assembly.

Touma M, Sun ZY, Clayton LK, Marissen WE, Kruisbeek AM, Wagner G, Reinherz EL.

J Immunol. 2007 Mar 15;178(6):3668-79.

7.

The TCR C beta FG loop regulates alpha beta T cell development.

Touma M, Chang HC, Sasada T, Handley M, Clayton LK, Reinherz EL.

J Immunol. 2006 Jun 1;176(11):6812-23.

8.

Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.

Rosenbauer F, Owens BM, Yu L, Tumang JR, Steidl U, Kutok JL, Clayton LK, Wagner K, Scheller M, Iwasaki H, Liu C, Hackanson B, Akashi K, Leutz A, Rothstein TL, Plass C, Tenen DG.

Nat Genet. 2006 Jan;38(1):27-37. Epub 2005 Nov 27.

PMID:
16311598
9.

Gene expression analysis of thymocyte selection in vivo.

Schmitz I, Clayton LK, Reinherz EL.

Int Immunol. 2003 Oct;15(10):1237-48.

PMID:
13679393
10.

Disparate peptide-dependent thymic selection outcomes in beta2M-deficient mice versus TAP-1-deficient mice: implications for repertoire formation.

Sasada T, Yang Y, Lai CC, Touma M, Clayton LK, Liu JH, Parisini E, Wang JH, Reinherz EL.

Eur J Immunol. 2003 Feb;33(2):368-80.

11.

Involvement of the TCR Cbeta FG loop in thymic selection and T cell function.

Sasada T, Touma M, Chang HC, Clayton LK, Wang JH, Reinherz EL.

J Exp Med. 2002 Jun 3;195(11):1419-31.

12.

Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor.

Fiorini E, Schmitz I, Marissen WE, Osborn SL, Touma M, Sasada T, Reche PA, Tibaldi EV, Hussey RE, Kruisbeek AM, Reinherz EL, Clayton LK.

Mol Cell. 2002 Mar;9(3):637-48.

13.

AND-34, a novel p130Cas-binding thymic stromal cell protein regulated by adhesion and inflammatory cytokines.

Cai D, Clayton LK, Smolyar A, Lerner A.

J Immunol. 1999 Aug 15;163(4):2104-12.

14.

Double-positive thymocytes resistant to antigen-MHC-induced negative selection lack active caspase.

Ghendler Y, Mizoguchi E, Bhan AK, Clayton LK.

Int Immunol. 1998 Jun;10(6):767-74.

PMID:
9678757
15.
16.

Double-positive T cell receptor(high) thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection.

Ghendler Y, Hussey RE, Witte T, Mizoguchi E, Clayton LK, Bhan AK, Koyasu S, Chang HC, Reinherz EL.

Eur J Immunol. 1997 Sep;27(9):2279-89.

PMID:
9341770
17.

T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection.

Clayton LK, Ghendler Y, Mizoguchi E, Patch RJ, Ocain TD, Orth K, Bhan AK, Dixit VM, Reinherz EL.

EMBO J. 1997 May 1;16(9):2282-93.

18.

Cross-linking of T-cell receptors on double-positive thymocytes induces a cytokine-mediated stromal activation process linked to cell death.

Lerner A, Clayton LK, Mizoguchi E, Ghendler Y, van Ewijk W, Koyasu S, Bhan AK, Reinherz EL.

EMBO J. 1996 Nov 1;15(21):5876-87.

19.

Delineation of a T-cell activation motif required for binding of protein tyrosine kinases containing tandem SH2 domains.

Koyasu S, Tse AG, Moingeon P, Hussey RE, Mildonian A, Hannisian J, Clayton LK, Reinherz EL.

Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6693-7.

20.

Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouse.

Koyasu S, Hussey RE, Clayton LK, Lerner A, Pedersen R, Delany-Heiken P, Chau F, Reinherz EL.

EMBO J. 1994 Feb 15;13(4):784-97.

21.

CD3 zeta/eta/theta locus is colinear with and transcribed antisense to the gene encoding the transcription factor Oct-1.

Lerner A, D'Adamio L, Diener AC, Clayton LK, Reinherz EL.

J Immunol. 1993 Sep 15;151(6):3152-62.

PMID:
8376772
22.

Overexpression of CD3 eta during thymic development does not alter the negative selection process.

Hussey RE, Clayton LK, Diener A, McConkey DJ, Howard FD, Rodewald HR, D'Adamio L, Dallenbach F, Stein H, Schmidt EV, et al.

J Immunol. 1993 Feb 15;150(4):1183-94.

PMID:
8094404
23.
24.

Human immunodeficiency virus gp120 binding C'C" ridge of CD4 domain 1 is also involved in interaction with class II major histocompatibility complex molecules.

Moebius U, Clayton LK, Abraham S, Diener A, Yunis JJ, Harrison SC, Reinherz EL.

Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):12008-12.

25.
27.
28.

Phosphorylation of multiple CD3 zeta tyrosine residues leads to formation of pp21 in vitro and in vivo. Structural changes upon T cell receptor stimulation.

Koyasu S, McConkey DJ, Clayton LK, Abraham S, Yandava B, Katagiri T, Moingeon P, Yamamoto T, Reinherz EL.

J Biol Chem. 1992 Feb 15;267(5):3375-81.

29.
30.

T-cell-receptor isoforms.

Clayton LK, Lerner A, Diener AC, Hussey RE, Koyasu S, Reinherz EL.

Int J Cancer Suppl. 1992;7:1-5. Review.

PMID:
1428396
31.

Cellular myosin heavy chain in human leukocytes: isolation of 5' cDNA clones, characterization of the protein, chromosomal localization, and upregulation during myeloid differentiation.

Toothaker LE, Gonzalez DA, Tung N, Lemons RS, Le Beau MM, Arnaout MA, Clayton LK, Tenen DG.

Blood. 1991 Oct 1;78(7):1826-33.

PMID:
1912569
32.

CD3 eta and CD3 zeta are alternatively spliced products of a common genetic locus and are transcriptionally and/or post-transcriptionally regulated during T-cell development.

Clayton LK, D'Adamio L, Howard FD, Sieh M, Hussey RE, Koyasu S, Reinherz EL.

Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5202-6.

33.

Differential signal transduction via T-cell receptor CD3 zeta 2, CD3 zeta-eta, and CD3 eta 2 isoforms.

Bauer A, McConkey DJ, Howard FD, Clayton LK, Novick D, Koyasu S, Reinherz EL.

Proc Natl Acad Sci U S A. 1991 May 1;88(9):3842-6.

34.

T-cell receptor isoforms and signal transduction.

Koyasu S, D'Adamio L, Clayton LK, Reinherz EL.

Curr Opin Immunol. 1991 Feb;3(1):32-9. Review.

PMID:
1828948
36.

Molecular cloning of the CD3 eta subunit identifies a CD3 zeta-related product in thymus-derived cells.

Jin YJ, Clayton LK, Howard FD, Koyasu S, Sieh M, Steinbrich R, Tarr GE, Reinherz EL.

Proc Natl Acad Sci U S A. 1990 May;87(9):3319-23.

37.

The structural biology of CD2.

Moingeon P, Chang HC, Sayre PH, Clayton LK, Alcover A, Gardner P, Reinherz EL.

Immunol Rev. 1989 Oct;111:111-44. Review.

PMID:
2576417
38.

Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding.

Clayton LK, Sieh M, Pious DA, Reinherz EL.

Nature. 1989 Jun 15;339(6225):548-51.

PMID:
2543930
39.

The biology of human CD2.

Reinherz EL, Chang HC, Clayton LK, Gardner P, Howard FD, Koyasu S, Jin YJ, Moingeon P, Sayre PH.

Cold Spring Harb Symp Quant Biol. 1989;54 Pt 2:611-25. Review. No abstract available.

PMID:
2577023
40.

Expression of a functional CD3-Ti antigen/MHC receptor in the absence of surface CD2. Analysis with clonal Jurkat cell mutants.

Moingeon P, Alcover A, Clayton LK, Chang HC, Transy C, Reinherz EL.

J Exp Med. 1988 Dec 1;168(6):2077-90.

41.

Substitution of murine for human CD4 residues identifies amino acids critical for HIV-gp120 binding.

Clayton LK, Hussey RE, Steinbrich R, Ramachandran H, Husain Y, Reinherz EL.

Nature. 1988 Sep 22;335(6188):363-6.

PMID:
2843773
42.

Molecular cloning of the common acute lymphoblastic leukemia antigen (CALLA) identifies a type II integral membrane protein.

Shipp MA, Richardson NE, Sayre PH, Brown NR, Masteller EL, Clayton LK, Ritz J, Reinherz EL.

Proc Natl Acad Sci U S A. 1988 Jul;85(13):4819-23.

43.

Interdependence of CD3-Ti and CD2 activation pathways in human T lymphocytes.

Alcover A, Alberini C, Acuto O, Clayton LK, Transy C, Spagnoli GC, Moingeon P, Lopez P, Reinherz EL.

EMBO J. 1988 Jul;7(7):1973-7.

44.

The gene for T11 (CD2) maps to chromosome 1 in humans and to chromosome 3 in mice.

Clayton LK, Ramachandran H, Pravtcheva D, Chen YF, Diamond DJ, Ruddle FH, Reinherz EL.

J Immunol. 1988 May 15;140(10):3617-21.

PMID:
2896210
45.

Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes.

Diamond DJ, Clayton LK, Sayre PH, Reinherz EL.

Proc Natl Acad Sci U S A. 1988 Mar;85(5):1615-9.

46.

Murine and human T11 (CD2) cDNA sequences suggest a common signal transduction mechanism.

Clayton LK, Sayre PH, Novotny J, Reinherz EL.

Eur J Immunol. 1987 Sep;17(9):1367-70.

PMID:
2820751
47.

Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes.

Sayre PH, Chang HC, Hussey RE, Brown NR, Richardson NE, Spagnoli G, Clayton LK, Reinherz EL.

Proc Natl Acad Sci U S A. 1987 May;84(9):2941-5.

48.

Leukocytes from four patients with complete or partial Leu-CAM deficiency contain the common beta-subunit precursor and beta-subunit messenger RNA.

Dana N, Clayton LK, Tennen DG, Pierce MW, Lachmann PJ, Law SA, Arnaout MA.

J Clin Invest. 1987 Mar;79(3):1010-5.

49.

Clonal composition of T cells in lymphomatoid papulosis.

Kadin ME, Vonderheid EC, Sako D, Clayton LK, Olbricht S.

Am J Pathol. 1987 Jan;126(1):13-7.

50.

Human complement receptor type 3.

Arnaout MA, Pierce MW, Dana N, Clayton LK.

Methods Enzymol. 1987;150:602-15. No abstract available.

PMID:
3323792

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